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Uploaded byDivya Krishnan
Screening of anti ulcer drugs - Dr Divya Krishnan
This document discusses screening models for anti-ulcer agents. It outlines the requirements for an ideal screening model, including that it should be simple, reproducible, induce characteristic ulcers, involve different mechanisms of ulceration, and not allow spontaneous healing. The document states that rats are the ideal animal for screening due to their continuous acid secretion and resemblance to human stomach anatomy and nutrition. Several animal models are described, including the Shay rat pylorus ligation model, drug-induced gastric ulcer models in rats, acetic acid-induced chronic ulcers in rats, stress-induced ulcers in rats, and histamine-induced duodenal ulcers in guinea pigs. Recent advances involving gastrin transgenic mice and H
