This document discusses the transformation of scholarly communication through open access publishing. It identifies three main disruptions: 1) The rise of megajournals like PLOS ONE which provide a cost-effective publishing model. 2) Direct funding of open access through initiatives like SciELO in Brazil. 3) Reforming research assessment away from journal-based metrics like the Impact Factor to alternative article-level metrics and indicators. Open access is driving changes that benefit authors, readers and the public interest in openly sharing research.