This document discusses human schistosomiasis, also known as bilharzia. It is caused by blood flukes of the genus Schistosoma and transmitted through freshwater snails. Around 200 million people are infected globally, mainly in rural agricultural areas in tropical and subtropical countries. The three main species that infect humans are S. mansoni, S. haematobium, and S. japonicum, which are found in Africa, the Middle East, and parts of Asia, respectively. The lifecycle involves eggs passing from humans into water and infecting snails, which shed cercariae that penetrate human skin causing infection. Eggs trapped in tissues cause pathology such as liver damage
Schistosomiasis, also known as bilharzia or snail fever, is caused by parasitic flatworms of the genus Schistosoma. The disease infects the urinary tract and intestines through parasite eggs. There are several species of Schistosoma that cause disease in humans, including S. haematobium, S. mansoni, and S. japonicum. The parasites have complex life cycles involving freshwater snails and human hosts. Symptoms vary depending on the species and stage of infection, but often include abdominal pain, diarrhea, bloody stool or urine. Diagnosis is made by detecting parasite eggs in stool or urine samples under microscopy. Treatment involves praziqu
Measuring the impact of schistosomiasis infection on different blood parametersAlexander Decker
This study assessed the impact of Schistosoma mansoni infection on various blood parameters in 100 infected patients in Sudan. The results showed reductions in hemoglobin, red blood cell count, hematocrit, and other measures in infected individuals compared to a control group. Additionally, higher parasite densities were associated with greater reductions in most blood parameters, indicating more severe infection leads to more pronounced anemia and other blood abnormalities. The study concluded S. mansoni infection negatively impacts blood parameters important for assessing anemia and other health issues.
The document discusses various types of parasites including cestodes (tapeworms), trematodes (flukes), and nematodes (roundworms). It provides details on the lifecycles, transmission, clinical effects, and diagnosis of several medically important species within each group, such as Taenia saginata (beef tapeworm), Schistosoma (blood flukes), Ascaris lumbricoides (giant roundworm), and Enterobius vermicularis (pinworm). The document separates parasites by location in the body and includes diagrams to illustrate parasite lifecycles and stages of infection.
Trematodes, also known as flukes, are flatworm parasites that attach to their host using suckers. They have a digestive system consisting of a mouth and esophagus leading to intestinal caeca but no anus. Major groups of flukes include blood flukes, liver flukes, lung flukes, and intestinal flukes. The life cycle involves sexually mature adults in the definitive host shedding eggs, which are excreted and hatch in water, infecting an intermediate snail host and developing into cercariae that infect the definitive host directly or via an intermediate host. A notable example is Schistosoma, the blood flukes, which reside in blood vessels and cause schistosomias
This document discusses schistosomiasis, a parasitic disease caused by infection with Schistosoma blood flukes. It is most common in tropical and subtropical regions, infecting over 200 million people worldwide. The disease causes tissue damage as eggs released by adult worms become trapped in organs, eliciting an immune response that leads to granuloma formation and fibrosis. Chronic infection can result in serious complications affecting the liver, bladder, intestines and other organs. The life cycle requires freshwater snails as intermediate hosts and transmission occurs when larval forms penetrate human skin during water contact.
Schistosomiasis is caused by infection with Schistosoma blood flukes. It is estimated that 240-450 million people are currently infected, with over 800 million people at risk, especially in less developed countries. The life cycle of Schistosoma involves eggs released from infected humans and passing through water where they infect freshwater snails. Larvae emerge and can infect humans by penetrating the skin. In humans, the larvae mature into adult worms that reside in blood vessels and release eggs, causing tissue damage and pathology. Chronic infection can lead to liver and organ damage over time. Treatment involves praziquantel but control relies on improved sanitation and snail control.
This document discusses schistosomiasis, also known as bilharzia. It is caused by infection with Schistosoma blood flukes. There are over 200 million current cases globally, primarily in Africa, Asia, and South America. The parasite requires human and snail hosts to complete its lifecycle. Eggs released by adult flukes in the bloodstream cause tissue damage and an immune response, resulting in chronic symptoms. Clinical presentation depends on the infecting species and affected organ systems. Diagnosis is via egg detection in stool or urine, with antibody tests as a more sensitive option. Praziquantel is the treatment of choice.
This document discusses human schistosomiasis, also known as bilharzia. It is caused by blood flukes of the genus Schistosoma and transmitted through freshwater snails. Around 200 million people are infected globally, mainly in rural agricultural areas in tropical and subtropical countries. The three main species that infect humans are S. mansoni, S. haematobium, and S. japonicum, which are found in Africa, the Middle East, and parts of Asia, respectively. The lifecycle involves eggs passing from humans into water and infecting snails, which shed cercariae that penetrate human skin causing infection. Eggs trapped in tissues cause pathology such as liver damage
Schistosomiasis, also known as bilharzia or snail fever, is caused by parasitic flatworms of the genus Schistosoma. The disease infects the urinary tract and intestines through parasite eggs. There are several species of Schistosoma that cause disease in humans, including S. haematobium, S. mansoni, and S. japonicum. The parasites have complex life cycles involving freshwater snails and human hosts. Symptoms vary depending on the species and stage of infection, but often include abdominal pain, diarrhea, bloody stool or urine. Diagnosis is made by detecting parasite eggs in stool or urine samples under microscopy. Treatment involves praziqu
Measuring the impact of schistosomiasis infection on different blood parametersAlexander Decker
This study assessed the impact of Schistosoma mansoni infection on various blood parameters in 100 infected patients in Sudan. The results showed reductions in hemoglobin, red blood cell count, hematocrit, and other measures in infected individuals compared to a control group. Additionally, higher parasite densities were associated with greater reductions in most blood parameters, indicating more severe infection leads to more pronounced anemia and other blood abnormalities. The study concluded S. mansoni infection negatively impacts blood parameters important for assessing anemia and other health issues.
The document discusses various types of parasites including cestodes (tapeworms), trematodes (flukes), and nematodes (roundworms). It provides details on the lifecycles, transmission, clinical effects, and diagnosis of several medically important species within each group, such as Taenia saginata (beef tapeworm), Schistosoma (blood flukes), Ascaris lumbricoides (giant roundworm), and Enterobius vermicularis (pinworm). The document separates parasites by location in the body and includes diagrams to illustrate parasite lifecycles and stages of infection.
Trematodes, also known as flukes, are flatworm parasites that attach to their host using suckers. They have a digestive system consisting of a mouth and esophagus leading to intestinal caeca but no anus. Major groups of flukes include blood flukes, liver flukes, lung flukes, and intestinal flukes. The life cycle involves sexually mature adults in the definitive host shedding eggs, which are excreted and hatch in water, infecting an intermediate snail host and developing into cercariae that infect the definitive host directly or via an intermediate host. A notable example is Schistosoma, the blood flukes, which reside in blood vessels and cause schistosomias
This document discusses schistosomiasis, a parasitic disease caused by infection with Schistosoma blood flukes. It is most common in tropical and subtropical regions, infecting over 200 million people worldwide. The disease causes tissue damage as eggs released by adult worms become trapped in organs, eliciting an immune response that leads to granuloma formation and fibrosis. Chronic infection can result in serious complications affecting the liver, bladder, intestines and other organs. The life cycle requires freshwater snails as intermediate hosts and transmission occurs when larval forms penetrate human skin during water contact.
Schistosomiasis is caused by infection with Schistosoma blood flukes. It is estimated that 240-450 million people are currently infected, with over 800 million people at risk, especially in less developed countries. The life cycle of Schistosoma involves eggs released from infected humans and passing through water where they infect freshwater snails. Larvae emerge and can infect humans by penetrating the skin. In humans, the larvae mature into adult worms that reside in blood vessels and release eggs, causing tissue damage and pathology. Chronic infection can lead to liver and organ damage over time. Treatment involves praziquantel but control relies on improved sanitation and snail control.
This document discusses schistosomiasis, also known as bilharzia. It is caused by infection with Schistosoma blood flukes. There are over 200 million current cases globally, primarily in Africa, Asia, and South America. The parasite requires human and snail hosts to complete its lifecycle. Eggs released by adult flukes in the bloodstream cause tissue damage and an immune response, resulting in chronic symptoms. Clinical presentation depends on the infecting species and affected organ systems. Diagnosis is via egg detection in stool or urine, with antibody tests as a more sensitive option. Praziquantel is the treatment of choice.
Class Trematoda. Tapeworms as parasites of human beingEneutron
This document provides information on various medically important worms (helminths). It begins by classifying helminths into two phyla - Platyhelminthes and Nemathelminthes. Platyhelminthes includes the classes Trematoda (flukes) and Cestoidea (tapeworms). The document then describes the life cycles and characteristics of various trematode parasites, including Fasciola hepatica, Opisthorchis felineus, Clonorchis sinensis, Dicrocoelium lanceatum, and Paragonimus westermani. It also covers the blood flukes of the genus Schistosoma, which cause schistosomiasis
This document provides an overview of clinical parasitology and classifications of human parasites. It discusses nematodes (roundworms), cestodes (tapeworms), trematodes (flukes), and protozoa. For nematodes, it describes key intestinal roundworms like Ascaris lumbricoides and Enterobius vermicularis, as well as tissue/blood nematodes such as filarial worms. It also discusses cestodes like Taenia solium and Diphyllobothrium latum, and provides brief summaries of parasites' life cycles, symptoms, and treatments.
E. histolytica causes a range of diseases in humans. It can cause asymptomatic intestinal infection or symptomatic amebic colitis characterized by diarrhea, abdominal cramps and pain. Rarely, it can cause a severe, fulminant colitis with toxic megacolon. It is also known to cause amebic liver abscess when trophozoites spread from the intestine to the liver via the portal vein. E. histolytica exhibits a complex life cycle alternating between the infective cyst form and the invasive trophozoite form.
A comprehensive description of leischmaniasis with its types, transmission, epidemiology, pathogenesis, prevention and control. It also includes details regarding lab diagnosis, disease agent, vector and host.
Schistosomiasis is caused by five species of blood flukes in the genus Schistosoma. The adult worms live in veins and cause disease. Diagnosis involves examining stool for eggs. Symptoms range from initial fever to long-term issues like liver damage and portal hypertension. Praziquantel treatment can cure 85% of cases. Prevention relies on avoiding contact with infected freshwater in endemic areas and improving sanitation.
This document describes the characteristics of trematode parasites known as blood flukes. It discusses their morphology, life cycles, pathogenicity, and taxonomy. The key blood fluke genera include Schistosoma, which are dioecious flukes that cause schistosomiasis. The major Schistosoma species that infect humans are S. haematobium, S. mansoni, and S. japonicum. They have complex life cycles involving freshwater snail intermediate hosts.
: Parasitic water pollution in the Nile River (Schistosoma & Giardia lamblia)MenrvaSorial
Causative organism.
Geographical distribution.
Epidemiology & Risk factors.
Mode of Transmission.
Vector (if available).
Habitat.
Life cycle (including infective stage, Diagnostic stage, Final host, Intermediate host and Reservoir).
-According to your lab group assignment topic, you must mention at least two examples (Causative organisms) for the required type of parasitic infection and their prevalence in Egypt. -Then discuss briefly the mentioned examples covering all the following points:
As a pharmacist, how could you identify and confirm a patient with such disease?
(NB: Identification and confirmation include the signs and symptoms and the diagnostic tests in details)
What are the therapeutic options available (suggest a line of treatment).
How can we prevent & control such disease?
This document summarizes several protozoa that can cause diarrhea:
- Entamoeba histolytica causes amebiasis and can lead to liver abscesses. It is transmitted through contaminated food or water.
- Giardia lamblia causes giardiasis and is transmitted through contaminated water or food. It can cause diarrhea, cramps, and dehydration.
- Cryptosporidium parvum is an opportunistic infection that commonly causes watery diarrhea, nausea, and vomiting.
- Cyclospora cayetanensis causes gastroenteritis with watery diarrhea and is transmitted through contaminated food or water.
- Sarcocystis has a
Schistosomiasis is caused by infection with Schistosoma blood flukes. It is estimated that 240-450 million people have been infected, with over 800 million people at risk, especially in developing countries. The disease causes tissue damage and long-term health effects. It is most commonly found in tropical and subtropical areas where contact with infected freshwater snails can occur. The life cycle involves snail hosts that transmit larval forms that penetrate human skin, mature and reproduce in blood vessels, releasing eggs that cause immune responses and granuloma formation that lead to organ damage. Chronic infection can result in serious issues like liver fibrosis, bladder cancer, and female genital damage. Diagnosis involves detecting eggs in
lab of medical and health sciences by Abd Al Salam Najmsalamkrbooly
The three main blood flukes (Schistosoma species) that infect humans are S. mansoni, S. hematobium, and S. japonicum. They reside in the blood vessels of the definitive host and have separate sexes. The lifecycle involves an intermediate snail host that varies by species. Cercariae emerge from snails and can penetrate human skin, migrating through tissues and eventually residing in veins, where they pair and produce eggs. Eggs cause pathology and are excreted, potentially continuing the lifecycle if they reach water. Diagnosis involves finding eggs in stool, urine, or tissues depending on the infecting species.
This document describes several non-pathogenic and pathogenic amoeba species. It discusses their characteristics such as habitat, morphology of trophozoite and cyst stages, transmission methods, and prevalence in humans. Some notable amoeba discussed are Entamoeba coli and Entamoeba histolytica which are common gut commensals, as well as Naegleria fowleri and Acanthamoeba species which can cause infections in humans and are typically found in soil and water environments. The document provides detailed information on the life cycles, symptoms, and diagnosis of diseases caused by these pathogenic free-living amoeba.
SCHISTOSOMES - TREMATODES - by shanmukh tunuguntlatunuguntla0811
The three main Schistosoma species that commonly infect humans are S. haematobium, S. japonicum, and S. mansoni. Each species has distinct egg morphologies and causes different clinical manifestations depending on the organs infected. S. haematobium primarily infects the urinary system, while S. japonicum and S. mansoni typically infect the intestinal system. All three species have complex life cycles involving freshwater snail intermediate hosts and require contact with contaminated freshwater for transmission.
This document provides an overview of parasitology and summarizes key information about parasitic protozoans. It describes the life cycles of various protozoans including their modes of reproduction (e.g. fission, budding), hosts, and transmission. Representative parasitic protozoans are grouped by their structures and include flagellates like Giardia lamblia and Trichomonas vaginalis, amoeboid forms like Entamoeba histolytica, ciliates like Balantidium coli, and sporozoans like Plasmodium species which cause malaria. Details are provided on the life cycles and pathogenesis of several important protozoan parasites.
The document discusses several types of parasitic nematodes (roundworms) that infect humans, including Ascaris lumbricoides (the large roundworm), hookworms, Enterobius vermicularis (pinworm), Guinea worms, and Trichinella spiralis (trichina worm). It describes the life cycles, modes of transmission, symptoms, treatment and prevention of infections caused by these parasites.
Nematodes are roundworms that can infect humans. They are divided into three groups based on where they reside in the body: intestinal nematodes, intestinal-tissue nematodes, and blood-tissue nematodes. Some common intestinal nematodes discussed in the document include Ascaris lumbricoides (the large roundworm), Enterobius vermicularis (pinworm), Trichuris trichiura (whipworm), Ancylostoma duodenale and Necator americanus (hookworms), and Strongyloides stercoralis (threadworm). Their life cycles, epidemiology, clinical manifestations, diagnosis, treatment and prevention are described.
Nematodes are roundworms that can infect humans. They are divided into three groups based on their location in the body: intestinal nematodes, intestinal-tissue nematodes, and blood-tissue nematodes. Some common intestinal nematodes discussed in the document include Ascaris lumbricoides (the large roundworm), Enterobius vermicularis (pinworm), Trichuris trichiura (whipworm), Ancylostoma duodenale and Necator americanus (hookworms), and Strongyloides stercoralis (threadworm). These parasites have complex life cycles involving eggs, larvae, and adult worms that can cause diseases like ascariasis and hookworm infection
morphology and geographical distribution of the worm as well as epidemology, its lifecycle , its definitive and intermediate host,various life stages egg, cercarie ,adult worm, the disease schistosomiasis, its symptoms and control medication,diagnostic stages,management, bilharziasis
Class Trematoda. Tapeworms as parasites of human beingEneutron
This document provides information on various medically important worms (helminths). It begins by classifying helminths into two phyla - Platyhelminthes and Nemathelminthes. Platyhelminthes includes the classes Trematoda (flukes) and Cestoidea (tapeworms). The document then describes the life cycles and characteristics of various trematode parasites, including Fasciola hepatica, Opisthorchis felineus, Clonorchis sinensis, Dicrocoelium lanceatum, and Paragonimus westermani. It also covers the blood flukes of the genus Schistosoma, which cause schistosomiasis
This document provides an overview of clinical parasitology and classifications of human parasites. It discusses nematodes (roundworms), cestodes (tapeworms), trematodes (flukes), and protozoa. For nematodes, it describes key intestinal roundworms like Ascaris lumbricoides and Enterobius vermicularis, as well as tissue/blood nematodes such as filarial worms. It also discusses cestodes like Taenia solium and Diphyllobothrium latum, and provides brief summaries of parasites' life cycles, symptoms, and treatments.
E. histolytica causes a range of diseases in humans. It can cause asymptomatic intestinal infection or symptomatic amebic colitis characterized by diarrhea, abdominal cramps and pain. Rarely, it can cause a severe, fulminant colitis with toxic megacolon. It is also known to cause amebic liver abscess when trophozoites spread from the intestine to the liver via the portal vein. E. histolytica exhibits a complex life cycle alternating between the infective cyst form and the invasive trophozoite form.
A comprehensive description of leischmaniasis with its types, transmission, epidemiology, pathogenesis, prevention and control. It also includes details regarding lab diagnosis, disease agent, vector and host.
Schistosomiasis is caused by five species of blood flukes in the genus Schistosoma. The adult worms live in veins and cause disease. Diagnosis involves examining stool for eggs. Symptoms range from initial fever to long-term issues like liver damage and portal hypertension. Praziquantel treatment can cure 85% of cases. Prevention relies on avoiding contact with infected freshwater in endemic areas and improving sanitation.
This document describes the characteristics of trematode parasites known as blood flukes. It discusses their morphology, life cycles, pathogenicity, and taxonomy. The key blood fluke genera include Schistosoma, which are dioecious flukes that cause schistosomiasis. The major Schistosoma species that infect humans are S. haematobium, S. mansoni, and S. japonicum. They have complex life cycles involving freshwater snail intermediate hosts.
: Parasitic water pollution in the Nile River (Schistosoma & Giardia lamblia)MenrvaSorial
Causative organism.
Geographical distribution.
Epidemiology & Risk factors.
Mode of Transmission.
Vector (if available).
Habitat.
Life cycle (including infective stage, Diagnostic stage, Final host, Intermediate host and Reservoir).
-According to your lab group assignment topic, you must mention at least two examples (Causative organisms) for the required type of parasitic infection and their prevalence in Egypt. -Then discuss briefly the mentioned examples covering all the following points:
As a pharmacist, how could you identify and confirm a patient with such disease?
(NB: Identification and confirmation include the signs and symptoms and the diagnostic tests in details)
What are the therapeutic options available (suggest a line of treatment).
How can we prevent & control such disease?
This document summarizes several protozoa that can cause diarrhea:
- Entamoeba histolytica causes amebiasis and can lead to liver abscesses. It is transmitted through contaminated food or water.
- Giardia lamblia causes giardiasis and is transmitted through contaminated water or food. It can cause diarrhea, cramps, and dehydration.
- Cryptosporidium parvum is an opportunistic infection that commonly causes watery diarrhea, nausea, and vomiting.
- Cyclospora cayetanensis causes gastroenteritis with watery diarrhea and is transmitted through contaminated food or water.
- Sarcocystis has a
Schistosomiasis is caused by infection with Schistosoma blood flukes. It is estimated that 240-450 million people have been infected, with over 800 million people at risk, especially in developing countries. The disease causes tissue damage and long-term health effects. It is most commonly found in tropical and subtropical areas where contact with infected freshwater snails can occur. The life cycle involves snail hosts that transmit larval forms that penetrate human skin, mature and reproduce in blood vessels, releasing eggs that cause immune responses and granuloma formation that lead to organ damage. Chronic infection can result in serious issues like liver fibrosis, bladder cancer, and female genital damage. Diagnosis involves detecting eggs in
lab of medical and health sciences by Abd Al Salam Najmsalamkrbooly
The three main blood flukes (Schistosoma species) that infect humans are S. mansoni, S. hematobium, and S. japonicum. They reside in the blood vessels of the definitive host and have separate sexes. The lifecycle involves an intermediate snail host that varies by species. Cercariae emerge from snails and can penetrate human skin, migrating through tissues and eventually residing in veins, where they pair and produce eggs. Eggs cause pathology and are excreted, potentially continuing the lifecycle if they reach water. Diagnosis involves finding eggs in stool, urine, or tissues depending on the infecting species.
This document describes several non-pathogenic and pathogenic amoeba species. It discusses their characteristics such as habitat, morphology of trophozoite and cyst stages, transmission methods, and prevalence in humans. Some notable amoeba discussed are Entamoeba coli and Entamoeba histolytica which are common gut commensals, as well as Naegleria fowleri and Acanthamoeba species which can cause infections in humans and are typically found in soil and water environments. The document provides detailed information on the life cycles, symptoms, and diagnosis of diseases caused by these pathogenic free-living amoeba.
SCHISTOSOMES - TREMATODES - by shanmukh tunuguntlatunuguntla0811
The three main Schistosoma species that commonly infect humans are S. haematobium, S. japonicum, and S. mansoni. Each species has distinct egg morphologies and causes different clinical manifestations depending on the organs infected. S. haematobium primarily infects the urinary system, while S. japonicum and S. mansoni typically infect the intestinal system. All three species have complex life cycles involving freshwater snail intermediate hosts and require contact with contaminated freshwater for transmission.
This document provides an overview of parasitology and summarizes key information about parasitic protozoans. It describes the life cycles of various protozoans including their modes of reproduction (e.g. fission, budding), hosts, and transmission. Representative parasitic protozoans are grouped by their structures and include flagellates like Giardia lamblia and Trichomonas vaginalis, amoeboid forms like Entamoeba histolytica, ciliates like Balantidium coli, and sporozoans like Plasmodium species which cause malaria. Details are provided on the life cycles and pathogenesis of several important protozoan parasites.
The document discusses several types of parasitic nematodes (roundworms) that infect humans, including Ascaris lumbricoides (the large roundworm), hookworms, Enterobius vermicularis (pinworm), Guinea worms, and Trichinella spiralis (trichina worm). It describes the life cycles, modes of transmission, symptoms, treatment and prevention of infections caused by these parasites.
Nematodes are roundworms that can infect humans. They are divided into three groups based on where they reside in the body: intestinal nematodes, intestinal-tissue nematodes, and blood-tissue nematodes. Some common intestinal nematodes discussed in the document include Ascaris lumbricoides (the large roundworm), Enterobius vermicularis (pinworm), Trichuris trichiura (whipworm), Ancylostoma duodenale and Necator americanus (hookworms), and Strongyloides stercoralis (threadworm). Their life cycles, epidemiology, clinical manifestations, diagnosis, treatment and prevention are described.
Nematodes are roundworms that can infect humans. They are divided into three groups based on their location in the body: intestinal nematodes, intestinal-tissue nematodes, and blood-tissue nematodes. Some common intestinal nematodes discussed in the document include Ascaris lumbricoides (the large roundworm), Enterobius vermicularis (pinworm), Trichuris trichiura (whipworm), Ancylostoma duodenale and Necator americanus (hookworms), and Strongyloides stercoralis (threadworm). These parasites have complex life cycles involving eggs, larvae, and adult worms that can cause diseases like ascariasis and hookworm infection
morphology and geographical distribution of the worm as well as epidemology, its lifecycle , its definitive and intermediate host,various life stages egg, cercarie ,adult worm, the disease schistosomiasis, its symptoms and control medication,diagnostic stages,management, bilharziasis
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The pygmy halfbeak Dermogenys colletei, is known for its viviparous nature, this presents an intriguing case of relatively low fecundity, raising questions about potential compensatory reproductive strategies employed by this species. Our study delves into the examination of fecundity and the Gonadosomatic Index (GSI) in the Pygmy Halfbeak, D. colletei (Meisner, 2001), an intriguing viviparous fish indigenous to Sarawak, Borneo. We hypothesize that the Pygmy halfbeak, D. colletei, may exhibit unique reproductive adaptations to offset its low fecundity, thus enhancing its survival and fitness. To address this, we conducted a comprehensive study utilizing 28 mature female specimens of D. colletei, carefully measuring fecundity and GSI to shed light on the reproductive adaptations of this species. Our findings reveal that D. colletei indeed exhibits low fecundity, with a mean of 16.76 ± 2.01, and a mean GSI of 12.83 ± 1.27, providing crucial insights into the reproductive mechanisms at play in this species. These results underscore the existence of unique reproductive strategies in D. colletei, enabling its adaptation and persistence in Borneo's diverse aquatic ecosystems, and call for further ecological research to elucidate these mechanisms. This study lends to a better understanding of viviparous fish in Borneo and contributes to the broader field of aquatic ecology, enhancing our knowledge of species adaptations to unique ecological challenges.
Phenomics assisted breeding in crop improvementIshaGoswami9
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EWOCS-I: The catalog of X-ray sources in Westerlund 1 from the Extended Weste...Sérgio Sacani
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The use of Nauplii and metanauplii artemia in aquaculture (brine shrimp).pptxMAGOTI ERNEST
Although Artemia has been known to man for centuries, its use as a food for the culture of larval organisms apparently began only in the 1930s, when several investigators found that it made an excellent food for newly hatched fish larvae (Litvinenko et al., 2023). As aquaculture developed in the 1960s and ‘70s, the use of Artemia also became more widespread, due both to its convenience and to its nutritional value for larval organisms (Arenas-Pardo et al., 2024). The fact that Artemia dormant cysts can be stored for long periods in cans, and then used as an off-the-shelf food requiring only 24 h of incubation makes them the most convenient, least labor-intensive, live food available for aquaculture (Sorgeloos & Roubach, 2021). The nutritional value of Artemia, especially for marine organisms, is not constant, but varies both geographically and temporally. During the last decade, however, both the causes of Artemia nutritional variability and methods to improve poorquality Artemia have been identified (Loufi et al., 2024).
Brine shrimp (Artemia spp.) are used in marine aquaculture worldwide. Annually, more than 2,000 metric tons of dry cysts are used for cultivation of fish, crustacean, and shellfish larva. Brine shrimp are important to aquaculture because newly hatched brine shrimp nauplii (larvae) provide a food source for many fish fry (Mozanzadeh et al., 2021). Culture and harvesting of brine shrimp eggs represents another aspect of the aquaculture industry. Nauplii and metanauplii of Artemia, commonly known as brine shrimp, play a crucial role in aquaculture due to their nutritional value and suitability as live feed for many aquatic species, particularly in larval stages (Sorgeloos & Roubach, 2021).
1. SCHISTOSOMIASIS - A NEGLECTED TROPICAL DISEASE
SCHISTOMOSA HEAMATOBIUM
Presented by- DEBDATTA GHOSH
B.Sc. LIFE SCIENCES
4TH SEMESTER
22583073
2. BLOOD FLUKES
Schistosomes
Schistosomes are dioecious, (sexes are
separate) trematodes, which lead to
Schistosomiasis (bilharziasis).
Schistosomiasis is a water-borne disease
constituting an important public health
problem and affecting millions of persons in
Africa, Asia, and Latin America.
It is estimated that over 100 milion people are
infected with S. haematobium, S. mansoni,
and S. japonicum each.
Two other species of Schistosoma
parasitizing humans are S. mekongi and S.
intercalatum.
3. Features distinguishing schistosomes
from other trematodes
Schistosomes differ from the hermaphroditic trematodes
in many aspects.
• They are unisexual (diecious).
• They lack a muscular pharynx.
• Their intestinal caeca reunite after bifurcation to form a
single canal.
• They produce non-operculated eggs.
• They have no redia stage in larval development.
• The cercariae have forked tails and infect by
penetrating the unbroken skin of definitive hosts.
5. History and Distribution
This vesical blood fluke, formerly known as Bilharzia haematobium, has been endemic in
the Nile valley in Egypt for millenia. Its eggs have been found in the renal pelvis of an
Egyptian mummy dating from 1,250–1,000 BC. Schistosome antigens have been identified
by enzyme linked immuno sorbant assay (ELISA) in Egyptian mummies of the Predynastic
period, 3,100 BC.
The adult worm was described in 1851 by Bilharz in Cairo. Its life cycle, including the larval
stage in the snail, was worked out by Leiper in 1915 in Egypt.
Although maximally entrenched in the Nile valley, S. haematobium is also endemic in most
parts of Africa and in West Asia.
An isolated focus of endemicity in India was identified in Ratnagiri, south of Mumbai by
Gadgil and Shah in 1952.
About 200 million persons are at a risk of infection and 90 million are infected by S.
haematobium globally.
Habitat
The adult worms live in the vesical and pelvic plexuses of veins
6. Adult worm
The male is 10–15 mm long by 1 mm thick
and covered by a finely tuberculated
cuticle.
It has 2 muscular suckers, the oral sucker
being small and the ventral sucker large
and prominent. Beginning immediately
behind the ventral sucker and extending
to the caudal end is the gynecophoric
canal, in which the female worm is held
The adult female is long and slender, 20
mm by 0.25 mm with the cuticular
tubercles confined to the two ends.
The gravid worm contains 20–30 eggs in
its uterus at one time and may pass up to
300 eggs a day.
Egg
The eggs are ovoid, about 150 µm by 50
µm, nonoperculated, with a brownish
yellow transparent shell carrying a
terminal spine at one pole; the terminal
spine being characteristic of the species .
Mechanism of Egg Expulsion
The eggs are laid usually in the small venules of
the vesical and pelvic plexuses, though
sometimes they are laid in the mesenteric portal
system, pulmonary arterioles, and other ectopic
sites.
The eggs are laid one behind the other with the
spine pointing posteriorly
From the venules, the eggs make their way
through the vesical wall by the piercing action of
the spine, assisted by the mounting pressure
within the venules and a lytic substance released
by the eggs.
The eggs pass into the lumen of the urinary
bladder together with some extravasated blood.
They are discharged in the urine, particularly
towards the end of micturition.
For some unknown reasons, the eggs are passed
in urine more during midday than at any other
time of the day.
The eggs laid in ectopic sites generally die and
evoke local tissue reactions. They may be found,
for instance in rectal biopsies, but are seldom
passed live in feces.
7. Development in Snail
Inside the snail, the miracidia lose
their cilia and in about 4–8 weeks,
successively pass through the
stages of the first and second
generation sporocysts
Large number of cercariae are
produced by asexual reproduction
within the second generation
sporocyst.
The cercaria has an elongated ovoid
body and forked tail (furcocercous
cercaria) .
The cercariae escape from the snail.
Swarms of cercariae swim about in
water for 1–3 days. If during that
period they come into contact with
persons bathing or wading in the
water, they penetrate through their
unbroken skin. Skin penetration is
facilitated by lytic substances
secreted by penetration glands
present in the cercaria.
S. heamatobium passes its
life cycle in 2 hosts.
Definitive host: Humans are
the only natural definitive
hosts. No animal reservoir is
known.
Intermediate host: Fresh
water snails.
Infective form: Cercaria larva
The eggs that are passed
in urine are embryonated
and hatch in water under
suitable conditions to
release the free living
ciliated miracidia.
Miracidia swim about in
water and on
encountering a suitable
intermediate host,
penetrate into its tissues
and reach its liver . The
intermediate hosts are
snails of Bulinus species in
Africa. In India, the
intermediate host is the
limpet, Ferrisia tenuis.
Development in Man
On entering the skin, the cercariae shed
their tails and become schistosomulae
which enter the peripheral venules.
They then start a long migration, through
the vena cava into the right side of the
heart, the pulmonary circulation, the left
side of the heart, and the systemic
circulation, ultimately reaching the liver.
In the intrahepatic portal veins, the
schistosomulae grow and become
sexually differentiated adolescents
about 20 days after skin
penetration.They then start migrating
against the blood stream into the
inferior mesenteric veins, ultimately
reaching the vesical and pelvic venous
plexuses, where they mature, mate, and
begin laying eggs.
Eggs start appearing in urine usually 10–
12 weeks after cercarial penetration.
The adult worms may live for 20–30
years.
8.
9. PATHOGENECITY
Clinical illness caused by schistosomes can be classified
depending on the stages in the evolution of the infection,
as follows:
Skin penetration and incubation period
Egg deposition and extrusion
Tissue proliferation and repair.
The clinical features during the incubation
period may be local cercarial dermatitis or general
anaphylactic or toxic symptoms.
Cercarial dermatitis consists of transient itching and
petechial lesions at the site of entry of the cercariae
(swimmer’s itch)
This is seen more often in visitors to endemic areas than in locals who may be immune due to
repeated contacts.
It is particularly severe when infection occurs with cercariae of nonhuman schistosomes.
Anaphylactic or toxic symptoms include fever, headache, malaise, and urticaria.
This is accompanied by leucocytosis, eosinophilia, enlarged tender liver, and a palpable spleen.
This condition is more common in infection with S. japonicum (Katayama fever).
10. CLINICAL SIGNIFICANCE
Clinical features during oviposition include painless terminal hematuria (endemic
hematuria)
Hematuria is initially microscopic, but becomes gross, if infection is heavy.
Most patients develop frequency of micturition and burning.
Cystoscopy shows hyperplasia and inflammation of bladder mucosa, with minute papular
or vesicular lesions.
Clinical features during tissue proliferation and repair
In the chronic stage, there is generalized hyperplasia and fibrosis of the vesical mucosa
with a granular appearance (sandy patch).
At the sites of deposition of the eggs, dense infiltration with lymphocytes, plasma cells,
and eosinophils leads to pseudoabscesses.
Initially, the trigone is involved, but ultimately the entire mucosa becomes inflamed,
thickened, and ulcerated.
Secondary bacterial infection leads to chronic cystitis. Calculi form in the bladder due to
deposition of oxalate and uric acid crystals around the eggs and blood clots. There may
be obstructive hyperplasia of the ureters and urethra (hydroureter).
Chronic schistosomiasis has been associated with squamous cell carcinoma of the
bladder. Such malignancy is detected in a younger age group as compared to transitional
cell carcinoma of the bladder.
In fact, S. haematobium is now classified as a human carcinogen.
11. Importantly, bladder cancer is a frequent and
dire compli cation of chronic UGS. The
incidence of SCC associated to UGS is
estimated in 3–4 cases per 100,000 .
Untreated patients often develop
schistosome-related bladder cancer. The tu
mors are found in a relatively younger age
group, commonly present as well
differentiated SCC locally advanced and have
poor overall survival .
The severity and frequency of UGS se quelae
are related to the intensity and duration of
the infection. Genetic alterations,
chromosomal aberrations, and cytological
changes have been described in carcinomas
associ ated with UGS .
N-nitroso compounds have been implicated
as tentative etiologic agents in the process of
bladder carcinogenesis.
Elevated levels of DNA alkylation damage in
carcinomas associated with UGS and a high
frequency of G to A transitions in the H-ras gene
and in the CpG sequences of the p53 tumor
suppressor gene have also been reported.
These outcomes indicate that UGS-associated SCC
arises through a progressive accumulation of
genetic changes in epithelial cells. Positive
correlation between UGS and increased the levels
of oxidative stress accompanied by continuous DNA
damage and repair in urothelial carcinomas has
been observed by several groups.
More recently, it have been shown that schisto
some eggs co-cultured with informative human cell
lines promote proliferation of the urothelial cells
(HCV29 cell line) but inhibit cholangiocytes (H69
cells).
Moreover, the TP53 pathway was signi icantly
downregulated, and the estrogen receptor was
predicted to be downregulated in urothelial cells
exposed only to S. haematobium but not S. mansoni
eggs
MALIGNANCY