This study evaluated the causes of chronic kidney disease (CKD) in patients in Pakistan. Diabetic nephropathy was the leading cause of CKD (28% of cases), followed by glomerulonephritis (22%) and hypertension (14.6%). Most patients presented with late-stage CKD. Among those under 50, glomerulonephritis was most common (33.2%) while diabetic nephropathy was most frequent in those over 50 (39.6%). The high prevalence of diabetes, infections, and late detection of diseases contribute to the burden of CKD in Pakistan.