Sanguine is developing a novel at-home clinical trial platform that leverages mobile/digital health technologies to increase efficiency and data collection for clinical research. Their platform provides medical staff to patients' homes in over 20 US cities and has worked with 25 global pharmaceutical companies. Sanguine uses partnerships and its technology platform to more quickly recruit patients, schedule home visits and sample collection to reduce the time and cost of clinical trials.

1. THE NEXT GENERATION IN CLINICAL RESEARCH
Q1
2015

2. Sanguine is
bridging the gap
between patients and pharmas in the clinical R&D
process by developing a novel @home clinical trial
platform that increases efficiency, transparency and
big data collection.
Our platform leverages advancements in
the shared economy and mobile / digital health
to deliver medical staff at the bedside in > 20 cities
the US and serve 25 of the global pharmas.
INTRODUCTION TO SANGUINE
ResearchKit

3. ABOUT SANGUINE
Established in 2010 to serve the global
clinical research market
> 300 pharmaceutical studies completed;
> 5,000 study volunteer inquiries;
> 2,000 applications for medical staff
Partnered with Mayo for biospecimen
processing and testing, and invested in
seed round
Experience working with the 20 largest
pharmaceutical & biotechnology
companies worldwide
our achievements

4. TRANSFORMATION OF CLINICAL RESEARCH
vertical to horizontal industry shift
THE OLD VERTICAL CLINICAL RESEARCH INDUSTRY THE NEW HORIZONTAL CLINICAL RESEARCH INDUSTRY
OPEN
APIs
SMARTPHONES/
WEARABLES
CLOSED
SYSTEMS
AT-HOME
TESTING
ACADEMIC
CLOSED
PRIVATE
SHARED
ECONOMY
MEDICAL OFFICES /
HOSPITALS
PATIENT
SELF REPORT
MEDICAL
RECORDS
NONPROFITS /
PATIENT ADVOCACY
SOCIAL
MEDIA
MDs
TECHNOLOGY
LAB SERVICES
OPERATIONS
DATA
REQUIREMENT
PATIENT
RECRUITMENT
TECHNOLOGY
LAB SERVICES
OPERATIONS
DATA
REQUIREMENT
PATIENT
RECRUITMENT
QUINTILES
PAREXEL
PPD
ICON

5. TRANSFORMATION OF CLINICAL RESEARCH
companies by category
AT-HOME
TESTING
TECHNOLOGY
LAB SERVICES
OPERATIONS
DATA
REQUIREMENT
PATIENT
RECRUITMENT

6. SANGUINE BUSINESS MODEL
providing clinical research services
PROJECT DESIGN
CONSULTATION
PATIENT
RECRUITMENT
KIT PRODUCTION
MOBILE STAFF
DEPLOYMENT
@HOME
BIOSPECIMEN
COLLECTION
PATIENT
MONITORING
SEQUENCING,
TESTING
PHARMA
REQUESTS PROJECT
START Researchers request specific studies
from Sanguine
Sanguine recruits patients for the
study via social web and NPO
partnerships
Sanguine's platform alerts Nurses on
system to schedule blood draws at
patient’s home
Mayo Clinic Bioservices performs
testing, DNA sequencing, and other
services using blood from the Nurses

7. AUTOMATED PLATFORM & ECOSYSTEM
collecting biological and clinical data faster than ever before
PATIENT
PHARMA
MEDICAL STAFF
Sanguine has developed a disruptive, scalable
platform serving the clinical research market
through @home health services
Platform enables seamless communication
and operations between pharma, patients,
and medical staff
Significantly reduces time and cost for
researchers to collect biological data
7

8. FASTER COLLECTION
Study enrollment through
self-scheduler results in
faster collection.
TIME POINT STUDIES
Safety, tolerability, or PK/PD
studies could benefit from more
time points.
LONGITUDINAL DRAWS
Post study surveillance or
longitudinal draws could be
easily administered using at-
home service.
VALUE PROPOSITION
faster collection, time point studies, longitudinal draws

9. TECHNOLOGY SOLUTIONS
RESEARCHER PORTAL MOBILE PHLEBOTOMY APPPATIENT PORTAL
SORP SangrePatient Portal
increasing effectiveness and efficiency

10. • Custom questionnaires
• Patient reported outcomes
• Rating Scales
• Co-Morbidities
• Treatment Efficacy
• Adverse Events
• Medical Record Summaries
• Clinical Testing
PARTICIPANT DATA
obtain essential study information

11. greater access through diverse recruiting methods
• Blogs
• Social media
• Patient forums
• Support groups
• Donor referrals to
friends & family
• Online advertisements
• Non-Profit partnerships
PATIENT PORTAL

12. STUDY DASHBOARD
View the status of all studies &
receive automatic notifications by
email.
VISIT SCHEDULE &
SAMPLE INFORMATION
Choose visit dates & sample quantity.
Access upcoming schedule & sample
information.
RESEARCHER PORTAL
stay informed and updated

13. MOBILE PHLEBOTOMY APP
access to major metropolitan cities around the nation
SANGRE
Phlebotomists receives draw information via Sangre (same day
delivery, patient information, etc.)
40+Cities Across
America

14. CASE STUDIES
fulfill needs with unique study designs
Multiple Time Point Biospecimen Collections
Event-Based Biomarker Monitoring
Disease Interception Studies
01
02
03

15. MULTIPLE TIMEPOINTS
BIOSPECIMEN COLLECTION
COHORT SELECTION
40 donors collected at 3 time
points, exclusions based on
medication & disease activity
PARTNERSHIP LAUNCH
Working with a sickle cell non-profit
organization, over 100 potential
participants were identified in just 4
weeks
COMPLETION
All 120 draws finished in 10 weeks!
STUDY
LAUNCHED
STUDY
COMPLETED
(10 WEEKS)
5 WEEKS
100 participants
recruited
partnered with sickle
cell non-profit
leveraging patient advocacy partners

16. SITE SUPPORT
Reduces site-work effort and
assist PI in performing
monitoring and specimen
collection services
EVENT-BASED MONITORING
Sanguine will implement patient
monitoring tools to alert mobile
staff when patients need to be
visited and specimens collected
AT-HOME PROCEDURES
Increase retention and study visit
compliance by going directly to patient's
homes to conduct biweekly study
procedures
EVENT-BASED BIOMARKER MONITORING
remote site monitoring

17. PARTICIPANT RECRUITING
Patients can be selected based on
disease history, propensity for
developing a disease or experiencing
certain symptoms
MONITORING
Participants will be followed over
several months or years to observe
how their disease progresses
COHORT
SELECTION
DISEASE INTERCEPTION STUDY
LONGITUDINAL
ASSESSMENT
TRIAL
ENROLLMENT
RANDOMIZATION
Selected participants will be sent to the
clinical site for physician visit and
enrollment into clinical trial
natural history study