Running Head: GRANT APPLICATION COVER LETTER AND ABSTRACT 1 GRANT APPLICATION LETTER AND ABSTRACT 3 Grant Application Letter and Abstract Arroxxiccia Thomas Walden University October 28, 2018 Arroxxiccia Thomas School of Health Sciences Walden University 100 Washington Avenue South. Suite 900 Minneapolis, MN 55401 October 28, 2018 Transitional Living Programs. Independent Living-South Carolina Department of Social Service. Josan Hayes Foundation. P.O. BOX 7924 Florence, SC 29730 RE: APPLICATION FOR FUND-RAISING ACTIVITY SUPPORT To Whom this may concern: I am a case manager at For-Profit Organization working on a Group Home Grant Project whose called “No Child Left Behind” and the main aim is to provide financial support to adulthood attained children with no financial support and providing support to facilities of children who ail on chronic diseases such as asthma, Aids and diabetes. My aim in writing this letter is to request for financial assistance that will raise funds which will enable my project to be a success. After doing a lot of research I have found that an increased number of children spend sleepless nights out on cold environment and since they are innocent children they all require a safe and secure place that will build their future. Some of the children in the resident placements have no family or any other kind of basic support and due to this am pleading for any kind of funding from families who are willing to be foster parents to these children. Most of the children are aging out of foster care and turning the age of 21, coming out to the world with no education or job experience will lower their self-esteem. My project aims at building a lot of group places or homes for these children where they will obtain an independent living hence equipping them with ways of being dependent. Looking at the number of groups' home around, I discovered there are no group homes of the females and only a limited number for the male. If you have any questions, comments or concerns, please feel free to give us a call Monday-Friday from 8:30am- 5:00p. We can also be reached via email at [email protected] I hope a lot of agencies, and companies, families looking forward to being foster parents and other aiders will come out and help towards my project. Looking forward to your kind consideration and support. Thank you. Yours Faithfully, Arroxxiccia Thomas Case manager. Abstract I am Arroxxiccia Thomas a case manager at For-Profit Organization, working on a Group Homes Grant Project which aims at raising funds that will be of support to homeless youths and children. Potential funders and aiders can use my e-mail address for communication since it's an easier and immediate means of interaction. This organization saw that a lot of children and youths suffered a lot due to the lack of support both financially and emotionally and also the number of adolescents' children in resident placements had highly increased. For-Profi.

1. Running Head: GRANT APPLICATION COVER LETTER AND
ABSTRACT
1
GRANT APPLICATION LETTER AND ABSTRACT
3
Grant Application Letter and Abstract
Arroxxiccia Thomas
Walden University
October 28, 2018
Arroxxiccia Thomas
School of Health Sciences
Walden University
100 Washington Avenue South. Suite 900
Minneapolis, MN 55401
October 28, 2018
Transitional Living Programs.
Independent Living-South Carolina Department of Social
Service.
Josan Hayes Foundation.
P.O. BOX 7924

2. Florence, SC 29730
RE: APPLICATION FOR FUND-RAISING ACTIVITY
SUPPORT
To Whom this may concern:
I am a case manager at For-Profit Organization working on a
Group Home Grant Project whose called “No Child Left
Behind” and the main aim is to provide financial support to
adulthood attained children with no financial support and
providing support to facilities of children who ail on chronic
diseases such as asthma, Aids and diabetes. My aim in writing
this letter is to request for financial assistance that will raise
funds which will enable my project to be a success.
After doing a lot of research I have found that an increased
number of children spend sleepless nights out on cold
environment and since they are innocent children they all
require a safe and secure place that will build their future. Some
of the children in the resident placements have no family or any
other kind of basic support and due to this am pleading for any
kind of funding from families who are willing to be foster
parents to these children.
Most of the children are aging out of foster care and turning the
age of 21, coming out to the world with no education or job
experience will lower their self-esteem. My project aims at
building a lot of group places or homes for these children where
they will obtain an independent living hence equipping them
with ways of being dependent.
Looking at the number of groups' home around, I discovered
there are no group homes of the females and only a limited
number for the male. If you have any questions, comments or
concerns, please feel free to give us a call Monday-Friday from

3. 8:30am- 5:00p. We can also be reached via email at
[email protected] I hope a lot of agencies, and companies,
families looking forward to being foster parents and other aiders
will come out and help towards my project.
Looking forward to your kind consideration and support. Thank
you.
Yours Faithfully,
Arroxxiccia Thomas
Case manager.
Abstract
I am Arroxxiccia Thomas a case manager at For-Profit
Organization, working on a Group Homes Grant Project which
aims at raising funds that will be of support to homeless youths
and children. Potential funders and aiders can use my e-mail
address for communication since it's an easier and immediate
means of interaction. This organization saw that a lot of
children and youths suffered a lot due to the lack of support
both financially and emotionally and also the number of
adolescents' children in resident placements had highly
increased. For-Profit Organization Discovered there is a need to
serve or help children from a residential setting who are
stepping down to a lower care level and a need to cover an
independent mode of living to adolescents who are aging out or
turning the age of 21 (Kramer-Simpson, & Simpson, S.2018).
Group Home Grant Project targets a population of 500 people
whose are a mixture of needy children and youths both males
and females. This aims at offering a sanctuary or a place where
the targeted population will view it as their home for a period of
one year. Most of these homeless and needy children have
inferior or low self-esteem because of lack of family love,
education and financial support hence the project also aims at

4. developing and raising their self-esteem within a period of one
year in order to enable them to feel being at the same level with
other children from other well-off families. The final aim of the
project is to provide work experience to children turning 21 or
children who are aging out of foster care within a one-year
period.
Through offering a one-year sanctuary for these children, the
project objective is to encourage the youths and children to
have self-dependence and being taught of how to manage their
own homes. The developed self-esteem will improve their
emotional and physical health hence reducing a lot of financial
expense that will be directed for health purposes. By providing
job experience, a lot of youths will be able to take care of them
financially which will reduce the burden in the residential
placements.
At the end Group Homes Grant Project, the organization's end
product is to see whether the offered sanctuary has encouraged
independents to the residents, physical and emotional health
improvement to the targeted youths after one year self-esteem
development and lastly whether the adolescents have lessened
burden in the residential place by the provision of one year job
experience (Kramer-Simpson, & Simpson, S.2018).
After coming up with a budget worksheet, the grand total direct
cost amounts to $51,300. This cost covers all requested
workforce salary and fringe benefits and all other expenses
within the project course. The subtotal of direct cost requested
salary $31,000 and requested fringe benefit $16,000 giving a
total of the amount requested to $47,000 while that of the
indirect cost requested salary and fringe benefits amounts to
$4,300. These workforces include the project director, project,
clinical and academic coordinators, and project evaluator
together with the project secretary.
Reference:
Kramer-Simpson, E., & Simpson, S. (2018). Technical

5. Communication Client Projects and Nonprofit Partnerships: The
Challenges and Opportunities of Community Engagement.
In Citizenship and Advocacy in Technical Communication (pp.
129-148). Routledge.
3335538 Topic: Week 10: Weighing the Evidence
Number of Pages: 1 (Double Spaced)
Number of sources: 3
Writing Style: APA
Type of document: Dissertation Chapter - Discussion
Academic Level:Master
Category: Nursing
VIP Support: N/A
Language Style: English (U.S.)
Order Instructions: ATTACHED
Please follow the instructions of the discussion. Included the
text book Polick & Beck (2017) in the references.I attached the
order 3335318 that is needed to complete this work.
When conducting original research, the final step researchers

6. must complete is weighing the evidence and interpreting the
meanings of their data, statistics, and analyses. This is the
culmination of the research process in which all of the research
methods and designs can be synthesized into a meaningful
conclusion. In this stage, researchers should formulate
explanations for what their data indicates, determine whether
the data answer their initial research question, identify areas of
uncertainty, and consider directions for further research.
In this Discussion, you focus on one of the research articles that
you identified for Part 2 of the Course Project (Literature
Review). You then explore the process of how the researchers
generated conclusions based on their data, consider other
possible interpretations of their data, and formulate ideas for
further research.
To prepare:
-Review this week’s Learning Resources, focusing on how
researchers find meaning in their data and generate sound
conclusions. Pay particular attention to Table 2 in the article,
“Study Design in Medical Research.”
-Revisit the 5 articles that you identified in Part 2 of the Course
Project(order 3335318). Select one to consider for the purpose
of this Discussion.
-Read sections of the chosen article where the data is presented,
analyzed, and interpreted for meaning. What reasoning process
did the researchers use to formulate their conclusions? What
explanation did they give to support their conclusions? Were
there any weaknesses in their analysis or conclusions?
Consider possible alternate conclusions that the researchers
could have drawn based on their data.

7. -Examine the findings that the article presents and consider how
well they addressed the researcher’s initial question(s). -What
additional research could be done to build on these findings and
gain a fuller understanding of the question?
Required Readings
Polit, D. F., & Beck, C. T. (2017). Nursing research: Generating
and assessing evidence for nursing practice (10th ed.).
Philadelphia, PA: Wolters Kluwer.
Review Chapter 2, Fig. 2.1
Chapter 29, “Systematic Reviews of Research Evidence: Meta-
analysis, Metasynthesis, and Mixed Studies Review”
This chapter focuses on the different types of systematic
reviews. The chapter discusses the advantages of this type of
analysis and the steps for conducting a meta-analysis or
metasynthesis.
Dingle, P. (2011). Statin statistics: Lies and deception. Positive
Health, 180, 1.
Retrieved from the Walden Library databases.
In this article, the author outlines how misleading statistics are
used to make false claims about the positive use of statin drugs
in order to retain a market share of sales for pharmaceutical
firms.
Katapodi, M. C., & Northouse, L. L. (2011). Comparative
effectiveness research: Using systematic reviews and meta-
analyses to synthesize empirical evidence. Research & Theory
for Nursing Practice, 25(3), 191–209.

8. Retrieved from the Walden Library databases.
The authors of this article assert that more comparative
effectiveness research (CER) is necessary to accommodate the
elevated demand for evidence-based health care practices. The
article supplies a summary of methodological issues relevant to
systematic reviews and meta-analyses used in the process of
CER.
Stichler, J. F. (2010). Evaluating the evidence in evidence-
based design. Journal of Nursing Administration, 40(9), 348–
351.
Retrieved from the Walden Library databases.
The quality of evidence used in EBP can vary considerably.
This article highlights the necessity of critically appraising
facility design research articles and using a hierarchical model
to rate the strength of evidence.
Bernd, R., du Prel, J.-B., & Blettner, M. (2009). Study design in
medical research: Part 2 of a series on the evaluation of
scientific publications. Deutsches Aerzteblatt International,
106(11), 184–189. Retrieved from
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2695375/pdf/Dts
ch_Arztebl_Int-106-0184.pdf
This article provides guidance in evaluating the study design of
scientific publications for reliability and credibility. The
authors suggest that the most important elements to consider are
the question to be answered, the study population, the unit of
analysis, the type of study, the measuring technique, and the
calculation of sample size.
Walden University. (n.d.a). Paper templates. Retrieved July 23,
2012, from http://writingcenter.waldenu.edu/57.htm

9. This website provides you access to the School of Nursing
Sample Paper, which will serve as a template for formatting
your papers.
Media
Laureate Education (Producer). (2012g). Hierarchy of evidence
pyramid. Baltimore, MD: Author.
This multimedia piece explains the hierarchy of evidence
pyramid. The piece offers definitions and key information for
each level of the pyramid.
Laureate Education (Producer). (2012n). Weighing the
evidence. Baltimore, MD: Author.
Note: The approximate length of this media piece is 6 minutes.
In this video, Dr. Kristen Mauk provides insight about how she
analyzed her data and interpreted meanings of what the data
showed. She describes how she drew conclusions based on the
results and how she explained unexpected findings that were
contrary to her initial hypotheses.
Running head: LITERATURE REVIEW 1
LITERATURE REVIEW 2
Project Part 2
Literature Review

10. Walden University
NURS- 6052C
September 24, 2018
Literature Review
Autism spectrum disorder (ASD) is a condition which is usually
developmental and tends to affect the behavior and
communication of a person. (National Institute of Mental Health
[NIMH], 2017). The reason as to why this kind of disorder is
considered as being developmental is because its symptoms
usually appear during the first two years of life. People who
have autism spectrum disorder typically have behaviors that are
restricted and repetitive as well as symptoms that affect the
ability of the person to properly function while at school, work
or even in other areas of life. (NIMH, 2017). Autism spectrum
disorder can affect any person regardless of their racial, ethnic
or economic group. Despite autism spectrum being considered
as a lifelong disorder treatment and services can assist in
improving the symptoms associated with this particular disorder
as well as the ability of a person to function. (Myers & Johnson,
2007). This review synthesizes information in some of the
articles whereby the authors of those particular articles tried to
evaluate whether the use of stem cell treatment is a more
appropriate method to use while treating children suffering from
autism spectrum disorder as compared to the administration of
food and drugs to help in preventing the adverse effects
associated with the autism spectrum disorder.
Synthesis of the Studies
Current investigative therapies which are aimed at reversing the
abnormalities which are associated with spectrum autism
disorder mainly aim at administering antibiotics, hyperbaric
oxygen, and anti-inflammatory oxygen. The therapeutic
approaches for autism can be largely classified under
educational, medical, allied health, behavioral and
complementary as well as alternative medicine interventions.

11. Presently, there is no defined mechanism of pathogenesis and
consequently treatment is limited to behavioral interventions.
Use of stem cells is being considered as better diagnosis method
compared to food and drug administration in the prevention of
adverse effects of autism. The main reason as to why the use of
stem cells from the umbilical cord tissue is that it has shown to
reduce inflammation in the autistic patient which in turn
alleviates symptoms of autism. Transplantation of stem cells
may offer an exceptional treatment strategy for spectrum autism
disorder due to the neural dysregulation and immune which are
observed in this condition. The degree of severity of the autism
symptoms has been associated or correlated with inflammatory
and neuroinflammatory cytokines which include macrophage-
derived chemokine as well as thymus and activation-regulated
chemokine. There are several immune disorders which are
associated with autism such as autoimmunity, immune
deficiencies, overactivation of certain immune populations and
allergy. This helps improve the health outcomes of the patient.
The stem cells are being used by the health providers to help in
the creation of new models of autism with an aim of testing the
effects that new drugs could possibly be having (Sharma et al.,
2013).
Conforming to precedent pre-clinical studies that have been
carried out it is evident that the mesenchymal stem cells have a
tendency to represent immune regulatory properties that are
significant through suppression of proliferation as well as
function of several major immune cells which includes B cells,
natural killer cells, T cells, inducing regulatory T cells and
modulating the activities of dendritic cells. Therapies that
employ the use of stem cells are usually in a better position of
inhibiting the release of pro-inflammatory cytokines and also
have strong immune suppressive activities. This does not only
help in the autologous transplantation but also help in
heterologous transplantation without the requirement of
pharmacological immune suppression (Lv et al., 2013).
According to the studies analyzed stem cell treatment is a more

12. appropriate diagnosis method as compared to the administration
of food and drug because stem cells are cells which are
undifferentiated and they are usually defined by their ability to
self-renew as well as differentiate into cells that are mature.
The stem cells are also preferable because they are highly
proliferative which implies that there are several numbers of
mature cells which can be generated from a given stem cell
source. The cell replacement therapy hypothesizes that new
retinal cells could be generated from stem cells to help ion
substituting the cells that have already been damaged by the
disorder (Siniscalco, Bradstreet, Sych & Antonucci, 2014). The
stem cells also have a protective effect which is usually referred
to as the paracrine effect. The protective effect of the stem cells
assists in modulating the microenvironment of the tissues that
have been affected by the disorder to help in protecting the cells
that have been injured, promote the survival rate as well as
activate any endogenous repair mechanism that is available. The
stem cells in the treatment of autism spectrum disorder usually
trigger the development of the brain and after that, the body of
the child proceeds in doing their work (Ng, Fortino, Pelaez, &
Cheung, 2014).
Inconsistencies and Contradictions in the Literature
One of the inconsistencies and contradictions found in the
literature is the fact that there is only one registered human trial
that has used MSCs to treat autism in children whereby there
were two components that were involved to have a better health
outcome. In this one study combined transplantation of MSCs
and mononuclear cells had therapeutic effects that were better
as compared to using transplantation of mononuclear cells
alone. Another controversy as per the studies used is that the
administration of the stem cells needs to be administered in a
given manner to achieve quality results. Although the outcome
after using the stem cell in treating autism in children can be
positive or negative the risk-benefit ratio of stem cell therapy in
autistic children appears to be favorable.
Preliminary Conclusions

13. In conclusion, the evidence in the researched literature and
journals provides a strong support for a change in practice
whereby health providers should start using stem cell treatment
to diagnose children suffering from Austin spectrum disorder as
compared to the use of food and drug administration. This
method helps in replacing the cells that have been damaged by
the disorder. From the literature it is evident that the applied
behavior analysis is a mode of treatment that is mainly based on
theories of learning and operant conditioning yet the disorder
could be as a result of an inborn disorder or because of the
genes of a person and therefore in such a case the stem cell
treatment is the most appropriate. Despite the literature
providing a strong support as to why health providers should
implement the use stem cells in the treatment of autism
spectrum disorder in children further research still need to be
carried out to help guide the health providers on the particular
symptoms of autism in children that can be addressed using this
mode of treatment. This is significant taking into account that
stem cells typically differentiate into different cell types needed
by the body such as oligodendrocytes, neurons, and blood cells.
References
Lv, Y. T., Zhang, Y., Liu, M., Ashwood, P., Cho, S. C., Huan,
Y., ... & Hu, X. (2013). Transplantation of human cord blood
mononuclear cells and umbilical cord-derived mesenchymal
stem cells in autism. Journal of translational medicine, 11(1),
196.
Myers, S. M., & Johnson, C. P. (2007). Management of children
with Autism Spectrum Disorder. Retrieved September 24,
2018 from
http://pediatrics.aappublications.org/content/120/5/1162
National Institute of Mental Health (2017). Autism spectrum

14. disorder. Retrieved September 24, 2018 from
https://www.nimh.nih.gov/health/topics/autism-spectrum-
disorders- asd/index.shtml
Ng, T. K., Fortino, V. R., Pelaez, D., & Cheung, H. S. (2014).
Progress of mesenchymal stem cell therapy for neural and
retinal diseases. World journal of stem cells, 6(2), 111.
Sharma, A., Gokulchandran, N., Sane, H., Nagrajan, A.,
Paranjape, A., Kulkarni, P., ... & Badhe, P. (2013). Autologous
bone marrow mononuclear cell therapy for autism: an open label
proof of concept study. Stem cells international, 2013.
Siniscalco, D., Bradstreet, J. J., Sych, N., & Antonucci, N.
(2014). Mesenchymal stem cells in treating autism: Novel
insights. World journal of stem cells, 6(2), 173.