Meloxicam prevents COX-2-mediated inflammation following laparotomy in mice but does not prevent pain. While meloxicam reduced post-surgical inflammation in a dose-dependent manner, as measured by a fluorescent COX-2 probe, it did not prevent pain-associated changes like weight loss, reduced activity, and increased Mouse Grimace Scale scores for at least 24 hours after surgery compared to saline-treated mice. This suggests that factors other than inflammation may contribute to post-surgical pain in mice, and meloxicam is not an effective analgesic for BALB/c mice following laparotomy despite preventing inflammation.
Anti inflammatory-and-anti-arthritic-efficacy-and-safety-of-purified-shilajit...Annex Publishers
Abstract
The objective of this investigation was to evaluate the efficacy and safety of purified Shilajit in moderately arthritic dogs. Ten client-owned dogs in a randomized double-blinded study received either a placebo or Shilajit (500 mg) twice daily for a period of five months. Dogs were evaluated each month for physical condition (body weight, body temperature, heart rate, and respiration rate) and pain associated with arthritis (overall pain, pain from limb manipulation, and pain after physical exertion). Serum samples collected from these dogs were examined each month for biomarkers of liver (bilirubin, ALT, and AST), kidney (BUN and creatinine) heart and muscle (creatine kinase) functions. The findings of this study revealed that dogs receiving Shilajit (Group-II) showed a significant (P< 0.05) reduction in pain from limb manipulation by day 60, and overall pain and pain after physical exertion by day 120. Maximum pain reduction, using all three criteria, was observed on day 150. Pain level remained significantly unchanged in dogs receiving the placebo. Dogs in either group showed no significant change (P>0.05) in physical parameters or serum markers, suggesting that Shilajit was well tolerated by moderately arthritic dogs. It was concluded that Shilajit significantly (P< 0.05) reduced pain in osteoarthritic dogs and markedly improved their daily life without any side effects.
Keywords: Purified Shilajit; Osteoarthritis in canine; Shilajit safety; Anti-arthritic nutraceutical
Anti inflammatory-and-anti-arthritic-efficacy-and-safety-of-purified-shilajit...Annex Publishers
Abstract
The objective of this investigation was to evaluate the efficacy and safety of purified Shilajit in moderately arthritic dogs. Ten client-owned dogs in a randomized double-blinded study received either a placebo or Shilajit (500 mg) twice daily for a period of five months. Dogs were evaluated each month for physical condition (body weight, body temperature, heart rate, and respiration rate) and pain associated with arthritis (overall pain, pain from limb manipulation, and pain after physical exertion). Serum samples collected from these dogs were examined each month for biomarkers of liver (bilirubin, ALT, and AST), kidney (BUN and creatinine) heart and muscle (creatine kinase) functions. The findings of this study revealed that dogs receiving Shilajit (Group-II) showed a significant (P< 0.05) reduction in pain from limb manipulation by day 60, and overall pain and pain after physical exertion by day 120. Maximum pain reduction, using all three criteria, was observed on day 150. Pain level remained significantly unchanged in dogs receiving the placebo. Dogs in either group showed no significant change (P>0.05) in physical parameters or serum markers, suggesting that Shilajit was well tolerated by moderately arthritic dogs. It was concluded that Shilajit significantly (P< 0.05) reduced pain in osteoarthritic dogs and markedly improved their daily life without any side effects.
Keywords: Purified Shilajit; Osteoarthritis in canine; Shilajit safety; Anti-arthritic nutraceutical
The Best Dietetic Priciples To Life Extension Textswissestetix
Das sind Textbausteine zum Vortrag "The Best Dietetic Priciples To Life Extension". Es werden Studien und Abstracts und sonstige Kommentare und Bemerkungen aufgefuehrt
Dr. Jay Calvert - Vaccination Against a Recently Emerged Virulent PRRS Virus ...John Blue
Vaccination Against a Recently Emerged Virulent PRRS Virus (RFLP 1-7-4) - Dr. Jay Calvert, Associate Research Fellow at Zoetis, from the 2015 North American PRRS Symposium, December 4 - 5, 2015, Chicago, IL, USA.
More presentations at http://www.swinecast.com/2015-north-american-prrs-symposium
The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
All manuscripts are subject to rapid peer review. Those of high quality (not previously published and not under consideration for publication in another journal) will be published without delay.
Effects of Noise Stress on Body Weight and Adrenal Gland Weight of Male Wista...BRNSS Publication Hub
The present study was designed to investigate the effects of varying intensities of noise stress onto the body and adrenal gland weight (absolute) of 17 weeks old (291–296) gram (g) Wistar rat. Animals were exposed to varying intensity of noise, i.e., 60 dB (Decibel), 80 dB, 100 dB, 120 dB, and 140 dB for 1 h (h)/day for 30 days. The dose of different noise intensities was delivered through a special fabricated noise chamber which had provided all daily needs of animal-like oxygen, food, and water. Food and water consumption behavior was recorded on 1st, 14th, and 29th days and body weight change recorded on 1st, 15th, and 30th days after the exposure of noise stress. Absolute adrenal glands weight was recorded on the 30th day. The results of the present study showed that the food, water consumption behavior, and body weight (g) of the experimental group EG1 (60 dB), EG2 (80 dB), EG3 (100 dB), EG4 (120 dB), and EG5 (140 dB) were found to be significantly (P < 0.001) decreased during 1st–14th days and during 15th–30th days a recovery which were observed in food, water consumption, and in body weight of the EG1 (60 dB), EG2 (80 dB), and EG3 (100 dB). A percentage (%) decrease was found, i.e., 0.76, 0.37, 3.87, 25.89, and 30.06% in body weight of EG1 (60 dB), EG2 (80 dB), EG3 (100 dB), EG4 (120 dB), and EG5 (140 dB) experimental groups, respectively.
Characteristics of Anatomical Parameters of Rat Testes in Normal Conditions a...YogeshIJTSRD
The aim is to study the anatomical parameters of the testes of rats in normal conditions and under irradiation in postnatal ontogenesis.Materials and methods. The study used 124 white outbred rats in newborns, 3, 6, 9, 12 months of age. The animals were divided into 2 groups control and experimental. The rats of the experimental group were irradiated for 20 days with a total dose of 4 Gy of ionizing radiation.Results. The morphometry of the testes showed that their weight, length, and thickness in postnatal ontogeny vary unevenly. Comparison of the rate of increase in body weight and length with the weight and volume of the testes shows that with an increase in their volume, body weight increases more than length.Conclusions. It was found that in the experimental group, the parameters of physical development lag behind intact animals. The lag is more pronounced in the 6 month period. Teshayev Shukhrat Jumayevich | Baymuradov Ravshan Radjabovich "Characteristics of Anatomical Parameters of Rat Testes in Normal Conditions and Under Irradiation in the Age Aspect" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Special Issue | International Research Development and Scientific Excellence in Academic Life , March 2021, URL: https://www.ijtsrd.com/papers/ijtsrd38744.pdf Paper Url: https://www.ijtsrd.com/medicine/other/38744/characteristics-of-anatomical-parameters-of-rat-testes-in-normal-conditions-and-under-irradiation-in-the-age-aspect/teshayev-shukhrat-jumayevich
Interaction between anxiolytic effects of magnesium oxide nanoparticles and e...Nanomedicine Journal (NMJ)
Abstract
Objective(s):
In recent years, nanotechnology has produced new forms of materials that are more effective than their predecessors. Magnesium is an essential element in the human body and certain studies have proved that its deficiency can induce anxiety in animals. In this study, the effect of magnesium oxide nanoparticles (MgO NPs) on anxiety, related behaviors, and interaction between their effects and anxiolytic effect of the exercises were examined in comparison to the conventional MgO (cMgO).
Materials and Methods:
Adult male Wistar rats weighing 190±20 gr were divided into control groups (receiving saline, without physical activity), and exercise groups (receiving cMgO and/or MgO NPs (1 mg/kg i.p.) daily for 6 weeks with or/and without exercise). Exercise groups were performing their daily physical activity protocol 30 minutes after injection. At the end of period, an elevated plus maze apparatus was used to evaluate the anxiety (%pen arm time (%OAT) and %open arm entries (%OAE) and locomotor activity.
Results:
Exercise significantly increased %OAT and %OAE (P<0.05). MgO NPs caused an increase in %OAT, while cMgO did not have any effect on %OAT or %OAE. There was no notable difference among anxiety parameters in exercise groups with or without taking MgO NPs.
Conclusion:
It seems that the anxiolytic effect of exercise and MgO NPs has been mediated through common mechanisms that were a part of the anxiety process of the central nervous system.
dkNET Webinar: A New Approach to the Study of Energy Balance and Obesity usin...dkNET
Abstract
We report a web-based tool for analysis of experiments using indirect calorimetry to measure physiological energy balance. CalR simplifies the process to import raw data files, generate plots, and determine the most appropriate statistical tests for interpretation. Analysis using the generalized linear model (which includes ANOVA and ANCOVA) allows for flexibility in interpreting diverse experimental designs, including those of obesity and thermogenesis. Users also may produce standardized output files for an experiment that can be shared and subsequently re-evaluated using CalR. This framework will provide the transparency necessary to enhance consistency, rigor, and reproducibility. The CalR analysis software will greatly increase the speed and efficiency with which metabolic experiments can be organized, analyzed per accepted norms, and reproduced and has become a standard tool for the field. CalR is accessible at https://CalRapp.org/
The top 4 key questions that our tool can answer:
1. Can I reproducibly and transparently analyze indirect calorimetry experiments in under 10 minutes?
2. How hard is it to use Analysis of Covariance (ANCOVA) to determine whether my groups of animals are significantly different?
3. Is there an automated, reproducible way to exclude “noisy” outlier data from our indirect calorimetry experiments?
4. What are the key factors in determining metabolic rate of mice?
Presenter: Alexander Banks, PhD, principal investigator and assistant professor at Harvard Medical School and the Beth Israel Deaconess Medical Center.
dkNET Webinar Information: https://dknet.org/about/webinar
Rodent Models of Pharmacotherapy and Chronotherapy for Obesity and Cardiometa...InsideScientific
Join Christopher Axelrod and Sander Kooijman, PhD for a discussion on their research into combatting obesity using various new therapies.
Key Topics Include:
Obesity is a chronic disease with limited treatment options that achieve long term weight control
Systemic mitochondrial uncoupling prevents weight gain without altering food intake and improves glucose metabolism independent of body weight
Mitochondrial-targeted drugs such as BAM15 may have clinical utility in the treatment of obesity and related diseases
Mimicked shift work resulted in obesity in male mice and poor blood glucose clearance in female mice
Understanding the circadian regulation of energy metabolism provides an opportunity to maximize the effectiveness of chronotherapy
Effect of food on pharmacokinetics of meloxicam ijsit 2.3.7IJSIT Editor
The primary objective of the study was to investigate the effect of food on the pharmacokinetics of
MELOXICAM. Cmax, Tmax and AUC of MELOXICAM were defined as the main parameters for the assessment
of bioavailability and bioequivalence of MELOXICAM administered in fasting and fed conditions. The 90% CI
for the fed/fasting MELOXICAM did not contained within the acceptance interval (80, 125) and, therefore, it
can be concluded that the rate of systemic exposure to MELOXICAM does not fit the claim of bioequivalence
between administration in fasting and fed conditions. This study has demonstrated that all the
pharmacokinetic parameters of both the treatments were statistically different from each other. In the fed
condition the values of Cmax and AUC were decreased while Tmax increases than that of fasting which
demonstrated that the extent of systemic exposure to MELOXICAM was affected by the delay in absorption of
MELOXICAM in the presence of food. None of the study volunteers reported any serious adverse effects
throughout the study. The only two AEs reported were mild and not related to the study medication. The AEs
reported were, according to the study medical expert, related to the sampling procedure and were self
limiting and did not require any treatment. There was no change in the vital signs of the volunteers
throughout the study period. The presented data are of major importance in identifying the optimal dosing
regimen for future clinical trials with oral MELOXICAM. In our study, only one type of food (a standardized
continental breakfast) was evaluated; further studies are needed to assess the effects of foods with different
compositions and contents on the bioavailability of MELOXICAM.
The Best Dietetic Priciples To Life Extension Textswissestetix
Das sind Textbausteine zum Vortrag "The Best Dietetic Priciples To Life Extension". Es werden Studien und Abstracts und sonstige Kommentare und Bemerkungen aufgefuehrt
Dr. Jay Calvert - Vaccination Against a Recently Emerged Virulent PRRS Virus ...John Blue
Vaccination Against a Recently Emerged Virulent PRRS Virus (RFLP 1-7-4) - Dr. Jay Calvert, Associate Research Fellow at Zoetis, from the 2015 North American PRRS Symposium, December 4 - 5, 2015, Chicago, IL, USA.
More presentations at http://www.swinecast.com/2015-north-american-prrs-symposium
The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
All manuscripts are subject to rapid peer review. Those of high quality (not previously published and not under consideration for publication in another journal) will be published without delay.
Effects of Noise Stress on Body Weight and Adrenal Gland Weight of Male Wista...BRNSS Publication Hub
The present study was designed to investigate the effects of varying intensities of noise stress onto the body and adrenal gland weight (absolute) of 17 weeks old (291–296) gram (g) Wistar rat. Animals were exposed to varying intensity of noise, i.e., 60 dB (Decibel), 80 dB, 100 dB, 120 dB, and 140 dB for 1 h (h)/day for 30 days. The dose of different noise intensities was delivered through a special fabricated noise chamber which had provided all daily needs of animal-like oxygen, food, and water. Food and water consumption behavior was recorded on 1st, 14th, and 29th days and body weight change recorded on 1st, 15th, and 30th days after the exposure of noise stress. Absolute adrenal glands weight was recorded on the 30th day. The results of the present study showed that the food, water consumption behavior, and body weight (g) of the experimental group EG1 (60 dB), EG2 (80 dB), EG3 (100 dB), EG4 (120 dB), and EG5 (140 dB) were found to be significantly (P < 0.001) decreased during 1st–14th days and during 15th–30th days a recovery which were observed in food, water consumption, and in body weight of the EG1 (60 dB), EG2 (80 dB), and EG3 (100 dB). A percentage (%) decrease was found, i.e., 0.76, 0.37, 3.87, 25.89, and 30.06% in body weight of EG1 (60 dB), EG2 (80 dB), EG3 (100 dB), EG4 (120 dB), and EG5 (140 dB) experimental groups, respectively.
Characteristics of Anatomical Parameters of Rat Testes in Normal Conditions a...YogeshIJTSRD
The aim is to study the anatomical parameters of the testes of rats in normal conditions and under irradiation in postnatal ontogenesis.Materials and methods. The study used 124 white outbred rats in newborns, 3, 6, 9, 12 months of age. The animals were divided into 2 groups control and experimental. The rats of the experimental group were irradiated for 20 days with a total dose of 4 Gy of ionizing radiation.Results. The morphometry of the testes showed that their weight, length, and thickness in postnatal ontogeny vary unevenly. Comparison of the rate of increase in body weight and length with the weight and volume of the testes shows that with an increase in their volume, body weight increases more than length.Conclusions. It was found that in the experimental group, the parameters of physical development lag behind intact animals. The lag is more pronounced in the 6 month period. Teshayev Shukhrat Jumayevich | Baymuradov Ravshan Radjabovich "Characteristics of Anatomical Parameters of Rat Testes in Normal Conditions and Under Irradiation in the Age Aspect" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Special Issue | International Research Development and Scientific Excellence in Academic Life , March 2021, URL: https://www.ijtsrd.com/papers/ijtsrd38744.pdf Paper Url: https://www.ijtsrd.com/medicine/other/38744/characteristics-of-anatomical-parameters-of-rat-testes-in-normal-conditions-and-under-irradiation-in-the-age-aspect/teshayev-shukhrat-jumayevich
Interaction between anxiolytic effects of magnesium oxide nanoparticles and e...Nanomedicine Journal (NMJ)
Abstract
Objective(s):
In recent years, nanotechnology has produced new forms of materials that are more effective than their predecessors. Magnesium is an essential element in the human body and certain studies have proved that its deficiency can induce anxiety in animals. In this study, the effect of magnesium oxide nanoparticles (MgO NPs) on anxiety, related behaviors, and interaction between their effects and anxiolytic effect of the exercises were examined in comparison to the conventional MgO (cMgO).
Materials and Methods:
Adult male Wistar rats weighing 190±20 gr were divided into control groups (receiving saline, without physical activity), and exercise groups (receiving cMgO and/or MgO NPs (1 mg/kg i.p.) daily for 6 weeks with or/and without exercise). Exercise groups were performing their daily physical activity protocol 30 minutes after injection. At the end of period, an elevated plus maze apparatus was used to evaluate the anxiety (%pen arm time (%OAT) and %open arm entries (%OAE) and locomotor activity.
Results:
Exercise significantly increased %OAT and %OAE (P<0.05). MgO NPs caused an increase in %OAT, while cMgO did not have any effect on %OAT or %OAE. There was no notable difference among anxiety parameters in exercise groups with or without taking MgO NPs.
Conclusion:
It seems that the anxiolytic effect of exercise and MgO NPs has been mediated through common mechanisms that were a part of the anxiety process of the central nervous system.
dkNET Webinar: A New Approach to the Study of Energy Balance and Obesity usin...dkNET
Abstract
We report a web-based tool for analysis of experiments using indirect calorimetry to measure physiological energy balance. CalR simplifies the process to import raw data files, generate plots, and determine the most appropriate statistical tests for interpretation. Analysis using the generalized linear model (which includes ANOVA and ANCOVA) allows for flexibility in interpreting diverse experimental designs, including those of obesity and thermogenesis. Users also may produce standardized output files for an experiment that can be shared and subsequently re-evaluated using CalR. This framework will provide the transparency necessary to enhance consistency, rigor, and reproducibility. The CalR analysis software will greatly increase the speed and efficiency with which metabolic experiments can be organized, analyzed per accepted norms, and reproduced and has become a standard tool for the field. CalR is accessible at https://CalRapp.org/
The top 4 key questions that our tool can answer:
1. Can I reproducibly and transparently analyze indirect calorimetry experiments in under 10 minutes?
2. How hard is it to use Analysis of Covariance (ANCOVA) to determine whether my groups of animals are significantly different?
3. Is there an automated, reproducible way to exclude “noisy” outlier data from our indirect calorimetry experiments?
4. What are the key factors in determining metabolic rate of mice?
Presenter: Alexander Banks, PhD, principal investigator and assistant professor at Harvard Medical School and the Beth Israel Deaconess Medical Center.
dkNET Webinar Information: https://dknet.org/about/webinar
Rodent Models of Pharmacotherapy and Chronotherapy for Obesity and Cardiometa...InsideScientific
Join Christopher Axelrod and Sander Kooijman, PhD for a discussion on their research into combatting obesity using various new therapies.
Key Topics Include:
Obesity is a chronic disease with limited treatment options that achieve long term weight control
Systemic mitochondrial uncoupling prevents weight gain without altering food intake and improves glucose metabolism independent of body weight
Mitochondrial-targeted drugs such as BAM15 may have clinical utility in the treatment of obesity and related diseases
Mimicked shift work resulted in obesity in male mice and poor blood glucose clearance in female mice
Understanding the circadian regulation of energy metabolism provides an opportunity to maximize the effectiveness of chronotherapy
Effect of food on pharmacokinetics of meloxicam ijsit 2.3.7IJSIT Editor
The primary objective of the study was to investigate the effect of food on the pharmacokinetics of
MELOXICAM. Cmax, Tmax and AUC of MELOXICAM were defined as the main parameters for the assessment
of bioavailability and bioequivalence of MELOXICAM administered in fasting and fed conditions. The 90% CI
for the fed/fasting MELOXICAM did not contained within the acceptance interval (80, 125) and, therefore, it
can be concluded that the rate of systemic exposure to MELOXICAM does not fit the claim of bioequivalence
between administration in fasting and fed conditions. This study has demonstrated that all the
pharmacokinetic parameters of both the treatments were statistically different from each other. In the fed
condition the values of Cmax and AUC were decreased while Tmax increases than that of fasting which
demonstrated that the extent of systemic exposure to MELOXICAM was affected by the delay in absorption of
MELOXICAM in the presence of food. None of the study volunteers reported any serious adverse effects
throughout the study. The only two AEs reported were mild and not related to the study medication. The AEs
reported were, according to the study medical expert, related to the sampling procedure and were self
limiting and did not require any treatment. There was no change in the vital signs of the volunteers
throughout the study period. The presented data are of major importance in identifying the optimal dosing
regimen for future clinical trials with oral MELOXICAM. In our study, only one type of food (a standardized
continental breakfast) was evaluated; further studies are needed to assess the effects of foods with different
compositions and contents on the bioavailability of MELOXICAM.
Intra-Articular Administration of Autologous Micro-Fragmented Adipose Tissue in Dogs with Spontaneous Osteoarthritis: Safety, Feasibility, and Clinical Outcomes
OFFER ZEIRA,a SIMONE SCACCIA,a LETIZIA PETTINARI,a ERICA GHEZZI,a NIMROD ASIAG,a LAURA MARTINELLI,a DANIELE ZAHIRPOUR,a MARIA P. DUMAS,a MARTIN KONAR,a DAVIDE M. LUPI,a LAURENCE FIETTE,b LUISA PASCUCCI,c LEONARDO LEONARDI,c ALISTAIR CLIFF,d GIULIO ALESSANDRI,e AUGUSTO PESSINA,f DANIELE SPAZIANTE,g MARINA ARALLAa
ABSTRACT Similar to the disease affecting humans, osteoarthritis (OA) is a painful musculoskeletal condition affecting 20% of the adult canine population. Several solutions have been proposed, but the results achieved to date are far from being satisfactory. New approaches, such as intra-articular delivery of cells (including mesenchymal stromal cells), have been proposed. Among the many sources, the adipose tissue is considered very promising. We evaluated the safety, feasibility, and efficacy of a single intra-articular injection of autologous and micro-fragmented adipose tissue (MFAT) in 130 dogs with spontaneous OA. MFAT was obtained using a minimally invasive technique in a closed system and injected in the intra- and/or peri-articular space. Clinical outcomes were determined using orthopedic examination and owners’ scores for up to 6 months. In 78% of the dogs, improvement in the orthopedic score was registered 1 month after treatment and continued gradually up to 6 months when 88% of the dogs improved, 11% did not change, and 1% worsened compared with baseline. Considering the owners’ scores at 6 months, 92% of the dogs significantly improved, 6% improved only slightly, and 2% worsened compared with baseline. No local or systemic major adverse effects were recorded. The results of this study suggest that MFAT injection in dogs with OA is safe, feasible, and beneficial. The procedure is time sparing and cost-effective. Post injection cytological investigation, together with the clinical evidence, suggests a long-term pain control role of this treatment. The spontaneous OA dog model has a key role in developing successful treatments for translational medicine. STEM CELLS TRANSLATIONAL MEDICINE 2018;00:1–10
Application of Pstim in Clinical Practice MaxiMedRx
The P-Stim and ANSiStim™ miniaturized device is designed to administer auricular point stimulation treatment over several days. The ear provides numerous points for stimulation within a small area. Stimulation is performed by electrical pulses emitted through strategically positioned needles. The ANSiscope device monitors the pain condition of the patient before, during and after the treatment.
The P-Stim and ANSiStim™ point stimulation therapy is mainly used to treat pain. Use of the device is recommended for pre-operative, intra-operative and post-operative pain therapy as well as for the treatment of chronic pain. DyAnsys is researching the possibilities of using this concept for the treatment of depression, addiction and allergy.
P-Stim and ANSiStim™ therapy allows continuous point stimulation over a period of several days while offering the patient a high degree of comfort and mobility. Use of the P-Stim and ANSiStim™ therapy provides advantages over drug therapy by minimizing possible side-effects caused by pain medications (i.e. opioid). In most cases, the patient continues to lead a normal life without side effects or any loss of quality of life.
botulinum toxin and appropriate modulation of spasticity giankaianieri
The aim of this study was to demonstrate high dosage and appropriate flexible intervals between infiltrations cause a significant clinical efficacy over time or a rise in adverse reactions