This document discusses root resorption during orthodontic treatment. It defines root resorption as the pathological or physiological loss of cementum and dentin. It describes the histopathology of root resorption, noting that it is a form of pathological resorption caused by orthodontic forces that remove hyalinized areas in the periodontium. Factors that can contribute to root resorption during orthodontic treatment include the magnitude, type, and direction of orthodontic forces applied as well as the type of orthodontic appliance used. Patient factors like genetics, age, tooth vitality, and systemic conditions may also influence susceptibility to root resorption.