Presentation on knowledge synthesis methodologies with a focus on engineering, for University of Michigan, October 25, 2023. Overview of the broader context, then focuses in on systematic reviews and tech mining.
PF Anderson presents for OLLI-UM on February 25, 2021. Graphic Medicine describes the genre of comics and graphic novels around healthcare, as told from personal and professional perspectives. Many think of comics as for children, but that could be risky with some of these! The personal experiences described can be tender or gritty, and touch on topics such as specific conditions, social justice, dying, lived experiences, resilience. Visual aspects of storytelling take advantage of new literacies, offering insights not possible through other mediums.
Brief lightning talk for UofM THL, repeated for MLA Research Caucus on January 27, 2021. On the subject of using systematic review search skills in combination with non-systematic review research methodologies.
As part of the #GraphicMedLibs panel for the August 5, 2020 NNLM NER webinar on Graphic Medicine, PF Anderson discussed awareness of #OwnVoices issues in both comics creation and collections, along with strategies and tools to utilize the #OwnVoices movement in the creation of community and awareness of social justice themes in #GraphicMedicine. This presentation represents the work of PF Anderson (UM-THL) with collaborators Claire Myers (UMSI), Gina Genova (UMSI), Susan Brown (Ypsilanti District Library), and David Carter (UM-AAEL).
"Research core facilities are centralized shared research resources that provide access to instruments, technologies, services, as well as expert consultation..." That sounds a lot like a library to me. What would look different about libraries if we thought of them as a research core facility?
This was a presentation for a research lab at the University of Michigan, May 28, 2019.
A storytelling workshop collaboration with Melissa Cunningham (Office of Patient Experience), Alex Fox (School of Public Health), and Patricia F. Anderson (Taubman Health Sciences Library). The focus of the workshop was on tools and strategies for telling patient and healthcare stories.
Slide deck for the Dent 610 graduate level course on research methods, 2018 version; collaboratively developed by Mark MacEachern, Patricia F. Anderson, and Tyler Nix.
Presentation on knowledge synthesis methodologies with a focus on engineering, for University of Michigan, October 25, 2023. Overview of the broader context, then focuses in on systematic reviews and tech mining.
PF Anderson presents for OLLI-UM on February 25, 2021. Graphic Medicine describes the genre of comics and graphic novels around healthcare, as told from personal and professional perspectives. Many think of comics as for children, but that could be risky with some of these! The personal experiences described can be tender or gritty, and touch on topics such as specific conditions, social justice, dying, lived experiences, resilience. Visual aspects of storytelling take advantage of new literacies, offering insights not possible through other mediums.
Brief lightning talk for UofM THL, repeated for MLA Research Caucus on January 27, 2021. On the subject of using systematic review search skills in combination with non-systematic review research methodologies.
As part of the #GraphicMedLibs panel for the August 5, 2020 NNLM NER webinar on Graphic Medicine, PF Anderson discussed awareness of #OwnVoices issues in both comics creation and collections, along with strategies and tools to utilize the #OwnVoices movement in the creation of community and awareness of social justice themes in #GraphicMedicine. This presentation represents the work of PF Anderson (UM-THL) with collaborators Claire Myers (UMSI), Gina Genova (UMSI), Susan Brown (Ypsilanti District Library), and David Carter (UM-AAEL).
"Research core facilities are centralized shared research resources that provide access to instruments, technologies, services, as well as expert consultation..." That sounds a lot like a library to me. What would look different about libraries if we thought of them as a research core facility?
This was a presentation for a research lab at the University of Michigan, May 28, 2019.
A storytelling workshop collaboration with Melissa Cunningham (Office of Patient Experience), Alex Fox (School of Public Health), and Patricia F. Anderson (Taubman Health Sciences Library). The focus of the workshop was on tools and strategies for telling patient and healthcare stories.
Slide deck for the Dent 610 graduate level course on research methods, 2018 version; collaboratively developed by Mark MacEachern, Patricia F. Anderson, and Tyler Nix.
Presented at Meaningful Play 2018, East Lansing, Michigan. Please note, the website for the game (http://aberrantry.com/) is in development at this time. The game code is in GitHub, & a download link is available at the website.
A design thinking approach to rapidly developing comics concepts. Workshop presentation by PF Anderson, University of Michigan. Developed for the Office of Health Equity and Inclusion.
Using design thinking strategies to help bootstrap developing a comic concept. A workshop presentation by PF Anderson for Enriching Scholarship, 2018, at the University of Michigan.
Tips and tricks for writing abstracts for science research articles to maximise citations and impact. Presented at the University of Michigan in May 2018.
A basic introduction to rapid reviews, created for a graduate student workshop, March 2018, presented by PF Anderson from the University of Michigan. Includes links to more resources, standards and guidelines, tools, software, and more.
A strategic approach to crafting abstracts for life sciences research publications to maximize their discovery in search engines as well as utility and citability for audiences beyond other researchers. This workshop was designed for the University of Michigan North Campus Research Center community.
A session for the Dent 610 course at the University of Michigan, on research methods and processes. Specific focus of this session on systematic review methods and processes, especially through database searching.
A presentation by Dr. David Cheney for the Investing in Abilities 2017 lecture series, on emerging technologies and tech strategies for empowerment, especially focused on using education to crowdsource solutions to interesting problems and develop compassion and a sense of humanity.
A presentation by Dr. Michelle A. Meade for the Investing in Abilities 2017 lecture series, on emerging technologies and tech strategies for empowerment.
Slides for a lightning round talk presented at Comics and Medicine, Seattle, also known as Graphic Medicine Conference, 2017. The project presented was by PF Anderson, Elise Wescom, Kai Donovan, and Ruth Carlos, and originally published in the December 2016 issue of the Journal of the American College of Radiology (JACR).
A poster by Kai Donovan, Elise Wescom, Mark Chaffee, Jean Song, Breanna Hamm, and Chase Masters for the 2017 Annual Meeting of the Medical Library Association.
A poster by PF Anderson, Skye Bickett, Joanne Doucette, Pamela Herring, Andrea Kepsel, Tierney Lyons, Scott McLachlan, Carol Shannon, and Lin Wu for the 2017 Annual Meeting of the Medical Library Association.
A poster by PF Anderson, MILS; Elise Wescom, BFA; Kai Donovan, MA; and Ruth Carlos, MD, MS for the 2017 Annual Meeting of the Medical Library Association.
A poster by JJ Pionke, PF Anderson, Scott Lissner, Anna Ercoli Schnitzer, Stephanie Rosen, Lynne Cutler, and Jane Vincent for the 2017 Annual Meeting of the Medical Library Association.
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
More Related Content
More from University of Michigan Taubman Health Sciences Library
Presented at Meaningful Play 2018, East Lansing, Michigan. Please note, the website for the game (http://aberrantry.com/) is in development at this time. The game code is in GitHub, & a download link is available at the website.
A design thinking approach to rapidly developing comics concepts. Workshop presentation by PF Anderson, University of Michigan. Developed for the Office of Health Equity and Inclusion.
Using design thinking strategies to help bootstrap developing a comic concept. A workshop presentation by PF Anderson for Enriching Scholarship, 2018, at the University of Michigan.
Tips and tricks for writing abstracts for science research articles to maximise citations and impact. Presented at the University of Michigan in May 2018.
A basic introduction to rapid reviews, created for a graduate student workshop, March 2018, presented by PF Anderson from the University of Michigan. Includes links to more resources, standards and guidelines, tools, software, and more.
A strategic approach to crafting abstracts for life sciences research publications to maximize their discovery in search engines as well as utility and citability for audiences beyond other researchers. This workshop was designed for the University of Michigan North Campus Research Center community.
A session for the Dent 610 course at the University of Michigan, on research methods and processes. Specific focus of this session on systematic review methods and processes, especially through database searching.
A presentation by Dr. David Cheney for the Investing in Abilities 2017 lecture series, on emerging technologies and tech strategies for empowerment, especially focused on using education to crowdsource solutions to interesting problems and develop compassion and a sense of humanity.
A presentation by Dr. Michelle A. Meade for the Investing in Abilities 2017 lecture series, on emerging technologies and tech strategies for empowerment.
Slides for a lightning round talk presented at Comics and Medicine, Seattle, also known as Graphic Medicine Conference, 2017. The project presented was by PF Anderson, Elise Wescom, Kai Donovan, and Ruth Carlos, and originally published in the December 2016 issue of the Journal of the American College of Radiology (JACR).
A poster by Kai Donovan, Elise Wescom, Mark Chaffee, Jean Song, Breanna Hamm, and Chase Masters for the 2017 Annual Meeting of the Medical Library Association.
A poster by PF Anderson, Skye Bickett, Joanne Doucette, Pamela Herring, Andrea Kepsel, Tierney Lyons, Scott McLachlan, Carol Shannon, and Lin Wu for the 2017 Annual Meeting of the Medical Library Association.
A poster by PF Anderson, MILS; Elise Wescom, BFA; Kai Donovan, MA; and Ruth Carlos, MD, MS for the 2017 Annual Meeting of the Medical Library Association.
A poster by JJ Pionke, PF Anderson, Scott Lissner, Anna Ercoli Schnitzer, Stephanie Rosen, Lynne Cutler, and Jane Vincent for the 2017 Annual Meeting of the Medical Library Association.
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
Comparing Evolved Extractive Text Summary Scores of Bidirectional Encoder Rep...University of Maribor
Slides from:
11th International Conference on Electrical, Electronics and Computer Engineering (IcETRAN), Niš, 3-6 June 2024
Track: Artificial Intelligence
https://www.etran.rs/2024/en/home-english/
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
Thanks...!
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
1. Roles for Librarians in Systematic Reviews
24/24
Searching
10/24
Write Methods
& Results
10/24
Document
delivery
15/24
Concept
creation &
question
Formulation
1/24
DISSEMINATION
E Ginier, PF Anderson. An Evidence Mapping Approach to Discovering Roles of
Librarians in Systematic Reviews. 2017. www.mlanet.org/d/do/6882
This #VisualAbstract was created
by PF Anderson & Emily Ginier
@pfanderson & @emilyginier
24 articles reviewed
66 roles identified
7 process clusters
(from beginning to the
end of Review Process)
7/24
Project
Management
10/24
Citation
Software