Nano patches can be used to deliver vaccines through the skin for epicutaneous immunization. They have micro-projections containing the vaccine that deliver it into the epidermis, which is rich in immune cells called Langerhans cells. These cells then carry the antigen to lymph nodes where it stimulates antibody production. Nano patch vaccines could help reduce costs by providing needle-free delivery, making vaccination easier and safer especially in developing countries by eliminating needle stick injuries and reuse. Further research is still needed but nano patch vaccination shows potential for improved vaccine delivery and uptake.