This document discusses the U.S. Department of Energy's Environmental Management (EM) mission to clean up legacy waste from nuclear weapons production and research dating back to the Manhattan Project. EM oversees cleanup at 16 major sites around the country with an estimated remaining cost of $235 billion to complete by 2065. The document outlines EM's interest in using robotics and remote systems to improve worker safety, efficiency, and performance for hazardous cleanup tasks including decontamination, demolition, inspections of underground storage tanks and tunnels, and handling of radioactive and hazardous materials. It also discusses various operating domains where robotics could be applied, such as gloveboxes, hot cells, underground facilities, underwater locations, and aerial inspections.