Risk Factors of Rheumatoid Arthritis
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Rheumatoid arthritis is an immune disorder where the body's immune system attacks the lining of the joints, causing inflammation and damage over time. Women are more likely to develop it than men, and it most commonly develops between ages 40-60. Having a family history of rheumatoid arthritis also increases one's risk. Researchers have not identified a single cause but have linked several risk factors to its development.
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rheumatoid arthritis
Rheumatoid arthritis is an autoimmune disease that causes chronic inflammation of the joints, typically affecting the small joints in the hands and feet. It results in warm, swollen, and painful joints and symptoms often worsen with rest. While the cause is unknown, it involves the immune system attacking the synovium lining of joints, causing swelling and damage over time. Diagnosis involves evaluating symptoms, physical exam findings, and blood tests for rheumatoid factor or anti-CCP antibodies. Complications can include joint deformity and damage, as well as increased risk of osteoporosis, carpal tunnel syndrome, heart and lung problems.
rheumatoidarthritispptbyann-160402080357.pptx
Rheumatoid arthritis is a chronic autoimmune disease characterized by inflammation of the synovial tissue lining the joints. This inflammation causes the synovial tissue to thicken, resulting in swelling and stiffness of the joints. If untreated, rheumatoid arthritis can damage joints, cartilage, and bones, causing pain and loss of function. While the exact cause is unknown, genetic and environmental factors are thought to play a role. There is no cure for rheumatoid arthritis, but treatment aims to reduce inflammation, prevent further joint damage, and improve quality of life through medications, exercise, physical therapy, and surgery if needed.
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Rheumatoid arthritis is an autoimmune disease that causes inflammation of the joints. It most commonly affects the hands, feet, wrists, knees, ankles and elbows, usually symmetrically. Over time, joint damage occurs which can lead to deformity and loss of mobility. While there is no cure, early diagnosis and treatment can help control symptoms and slow progression. Treatment options include medications like NSAIDs, DMARDs and biologics, as well as physical therapy and surgery. Osteoarthritis is caused by breakdown of cartilage in the joints and is the most common form of arthritis, often affecting the hands, knees, hips and spine due to aging and mechanical stress on the joints.
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Rheumatoid arthritis is an autoimmune disease where the immune system mistakenly attacks the body's own tissues, causing chronic inflammation of the joints. It is characterized by inflammation of the tissue lining the joints and can affect other organs. Common symptoms include joint pain, stiffness, swelling and fatigue. While periods of remission are possible, rheumatoid arthritis is typically progressive and can lead to long-term joint damage and loss of function over time if left untreated. Physicians diagnose rheumatoid arthritis based on symptoms, physical exam findings, and blood tests/x-rays showing inflammation.
RHEUMATOID ARTHRITIS.pptx
Rheumatoid arthritis is a chronic inflammatory disease that causes pain, stiffness, and swelling in the joints. It occurs when the immune system mistakenly attacks the joints, causing inflammation and damage over time. Common symptoms include pain and stiffness in the small joints of the hands and feet that is usually worse in the morning. If not treated early, rheumatoid arthritis can lead to joint deformity and increased disability. The cause is unknown but is believed to involve genetic and environmental factors. Diagnosis involves physical exam, blood tests for rheumatoid factor and anti-CCP antibodies, and x-rays of affected joints.
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Rheumatoid arthritis is an autoimmune disease where the immune system mistakenly attacks the body's own tissues, causing chronic inflammation of the joints. It is characterized by inflammation of the tissue lining the joints and can affect other organs. Common symptoms include joint pain, stiffness, swelling and fatigue. While periods of remission are possible, rheumatoid arthritis is typically progressive and can lead to long-term joint damage and loss of function over time if left untreated. Physicians diagnose rheumatoid arthritis based on symptoms, physical exam findings, and blood tests/x-rays showing inflammation.
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Rheumatoid arthritis hydri
Rheumatoid arthritis is a chronic inflammatory disorder that attacks the synovium lining joints, causing them to become tender, warm, swollen and stiff, especially in the morning. It can damage other body systems over time. While its exact cause is unknown, genetic and environmental factors like smoking may play a role. Diagnosis involves examining symptoms, medical history, and test results. Treatment focuses on reducing inflammation and preventing further joint damage using medications like DMARDs.
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This document provides an outline for a presentation on rheumatoid arthritis. It includes sections on what rheumatoid arthritis is, causes and etiology, signs and symptoms, pathophysiology, diagnosis, risk factors, prevention, and treatment. The disease is described as an autoimmune disorder that causes chronic inflammation of the synovial joints, most commonly affecting adults over age 40. Potential causes discussed include age, obesity, family history, smoking, stress, and poor nutrition. Signs and symptoms noted are fatigue, pain, morning stiffness, and joint issues. The pathophysiology is explained through four stages of progression. Diagnosis involves blood tests, x-rays, MRI, and arthrocentesis. Risk factors, prevention methods, and
Ortholord Tablets: Nutritional Support for Rheumatoid Arthritis
Ortholord Tablets: Nutritional Support for Rheumatoid ArthritisAssociate Professor in VSB Coimbatore
Rheumatoid Arthritis (RA) is a chronic systemic autoimmune disease that primarily affects the lining of the synovial joints and is associated with progressive disability, premature death, and socioeconomic burdens. The aim of the study was to evaluate the clinical efficacy and safety of glucosamine phosphate, methylsulfonylmethane (MSM), Vitamin C, Curcuma, in the management of Rheumatoid Arthritis. All those patients fulfilling the inclusion criteria presenting with Rheumatoid Arthritis to emergency department or to the out-patient department of general medicine were enrolled in the study. It included 180 adult patients with Rheumatoid Arthritis of both the sexes. All the participants were evaluated by detailed history, clinical examination and severity assessment. Cases were excluded if there was insufficient clinical information to permit allocation of a priority level at diagnosis. Patients aged 25 years or above referred or diagnosed with Rheumatoid Arthritis at our outpatient clinic were included in the study. All together 180 patients were participated in this study, and the response was 100%. All families were approached. Glucosamine sulfate might provide some pain relief for people with Rheumatoid Arthritis. Glucosamine has been found to have positive effects on pain treatment & Relieving pain and improving physical function. MSM may help to relieve joint soreness, stiffness and swelling. MSM is to decrease joint or muscle pain. Collagen peptide significantly reducing pain and joint inflammation.Rheumatoid arthritis- diagnosis and treatment
Rheumatoid arthritis is a chronic inflammatory disorder that can affect more than just your joints. The condition can damage various body systems, including the skin, eyes, lungs, heart, and blood vessels.
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This presentation summarizes rheumatoid arthritis (RA). RA is an autoimmune disease where the immune system attacks healthy cells in the body, causing inflammation in joints. It most commonly affects the hands, wrists and knees. While its exact cause is unknown, RA is believed to have genetic and environmental risk factors. Symptoms include tender, warm, swollen joints and stiffness. RA is diagnosed through evaluating symptoms, physical exams, x-rays and lab tests. Treatments include medications like DMARDs and biologics to reduce inflammation and slow disease progression, as well as supportive therapies.
Arthritis
Arthritis
encompasses over 120 diseases and conditions that affect joints, the
surrounding tissues, and other connective tissues. The most common types of
arthritis are osteoarthritis, rheumatoid arthritis and fibromyalgia. Other
types include lupus, juvenile rheumatoid arthritis, gout, bursitis, rheumatic
fever and Lyme disease to mention a few. While anyone can be at risk for
developing arthritis, prevalence of this disease is higher among women than
among men.
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A grant of $1.8 million from the National Institutes of Health (NIH) will allow researchers at the Rutgers Cancer Institute of New Jersey to investigate a link between the protein Sox9 and lung cancer. Previously, the protein was shown to be an important part of the biological machinery that controls genetic activation, making it potentially a key part of the metastasis of lung cancer. It has also been linked with low rates of lung-cancer survival.
Drug Discovery: Target Identification and Validation
For many years, pharmaceutical research companies have developed new drugs using a standard drug discovery process. The process usually begins with extensive medical research about a particular disease, which provides researchers with a better understanding of the disease and how it affects the body. The next step of the drug discovery process typically involves target identification and target validation.
Drug Discovery - What Happens after FDA Approval?
Current drug discovery models require new compounds to pass early safety tests and clinical trials before Phase 3 trials demonstrate their safety and efficacy to large patient groups, earning FDA approval. Once approved, pharmaceutical companies can begin large-scale manufacturing in new facilities that must meet FDA manufacturing standards. Additional Phase 4 trials after approval further monitor long-term or subset effects, with any adverse reactions requiring reports to the FDA.
Prostate Cancer Treatment - Active Surveillance
Prostate cancer is commonly diagnosed in men over 50. If detected early, physicians may recommend active surveillance which involves close monitoring of cancer progression through regular PSA blood tests, ultrasounds, and rectal exams. This allows patients to delay more aggressive treatments like surgery and radiation therapy unless the cancer becomes more advanced or aggressive over time.
Chemotherapy and Prostate Cancer
Prostate cancer is one of the most common cancers in men over 50 and is highly treatable if diagnosed early, with active surveillance often sufficient to control early-stage disease. For more advanced prostate cancer, chemotherapy may help by using drugs that travel through the bloodstream to fight cancer in other organs. Doctors may prescribe chemotherapy like docetaxel and prednisone if prostate cancer spreads outside the prostate gland and stops responding to hormone therapy, replacing docetaxel if the initial treatment fails.
Temple director earns recognition for cancer work
Dr. E. Premkumar Reddy, director of experimental cancer therapeutics at Mount Sinai School of Medicine, was honored by Temple University School of Medicine for his 18 years heading their Fels Institute for Cancer Research and Molecular Biology. Temple University School of Medicine has a history in fighting cancer. In September 2013 they held a daylong symposium to honor Dr. Reddy, where nine of his colleagues spoke about cancer biology and treatments. Dr. Reddy himself thanked attendees and discussed an anti-cancer treatment he developed while at Temple.
Information on Zytiga
A biotech investor, Dr. Lindsay Rosenwald has contributed to the development of several key tools in the fight against cancer. As the initial backer and co-founder of Cougar Biotechnology, Inc., Dr. Lindsay Rosenwald helped to rescue the cancer drug that eventually became Zytiga from obscurity and ushered it through its early clinical trials.
More from Lindsay Rosenwald (7)
Researchers to Investigate Protein’s Role in Lung Cancer
Researchers to Investigate Protein’s Role in Lung Cancer
Drug Discovery: Target Identification and Validation
Drug Discovery: Target Identification and Validation
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Rasamanikya is a excellent preparation in the field of Rasashastra, it is used in various Kushtha Roga, Shwasa, Vicharchika, Bhagandara, Vatarakta, and Phiranga Roga. In this article Preparation& Comparative analytical profile for both Formulationon i.e Rasamanikya prepared by Kushmanda swarasa & Churnodhaka Shodita Haratala. The study aims to provide insights into the comparative efficacy and analytical aspects of these formulations for enhanced therapeutic outcomes.
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Non-respiratory Functions of the Lungs.pdf
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
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• Building trust with communities online and offline
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Physiology of Special Chemical Sensation of Taste
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
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Risk Factors of Rheumatoid Arthritis
- 1. Risk Factors of Rheumatoid ArthritisRisk Factors of Rheumatoid Arthritis
- 2. •A fairly common immune disorder in the United States, rheumatoid arthritis develops when the lining of the joint membranes comes under attack by the body’s own immune system. The attack results in significant inflammation, which can cause damage to the cartilage and bones contained within the joint. Over time, the joint falls out of alignment and begins to lose its shape.
- 3. •Researchers have not yet identified a singular precursor for the disorder. However, several risk factors have been strongly linked to its development. As a general rule, women are considerably more likely to develop rheumatoid arthritis than men. Furthermore, although the disease can occur at any age, most patients began developing rheumatoid arthritis between the ages of 40 and 60. As with many other disorders, individuals with a family history of rheumatoid arthritis are more likely to develop it.