Number of project covering the development of rice bran from a waste material to a high value nutraceutical product with scientific evidence of potential health activity for Alzheimer's Disease
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Rice bran managment, from waste material to high value added nutraceutical pr
1. by
Health tech for Integrated Health Solutions
CEO Dr. Amr M. Helal
Rice Bran Nutraceuticals
from Waste material
to Products for Healthy aging
Faculty of Pharmacy –
Department of Pharmacognosy
Wednesday 27.4.2016
3. List of exporters for the selected product in 2013
Product : 1211 Medicinal plants
Value exported in 2013
(USD thousand)
Trade balance in 2013 (USD thousand)
World 3,399,350
China 1,196,725
India 207,758
Canada 184,930
United States of
America
168,286
Germany 148,372
Egypt 109,845
Korea, Republic of 109,379
4.
5. List of exporters for the selected product
Product: 13 Lac, gums, resins, vegetable saps and
extracts nes
HS4 Exporters
Exported value
in 2007
Exported value
in 2008
Exported value
in 2009
Exported value
in 2010
Exported value
in 2011
World 4,080,284 4,978,760 4,760,136 5,666,998 7,957,356
India 387,807 481,980 360,723 657,568 2,270,833
China 206,344 442,210 517,119 646,249 981,262
Germany 480,214 695,506 593,985 610,680 651,283
United States
of America
400,570 490,884 513,928 566,017 602,083
France 440,280 466,737 444,019 470,703 528,902
Denmark 256,802 114,709 99,732 257,890 282,579
Spain 226,808 243,348 208,551 237,168 256,736
Egypt 101 63,119 189,967 219,920 208,280
Italy 139,456 161,649 140,054 142,421 164,669
Philippines 70,653 97,559 86,391 116,682 156,295
6. List of exporters for the selected product in 2013
Product : 30 Pharmaceutical products
Trade Indicators
Value exported in 2013 (USD
thousand)
Trade balance in 2013 (USD thousand)
World 486,308,192
Germany 73,779,288
Israel 6,099,722
8. On going Success Story
Supported by EU- RDI/ IMC/ Others
Egyptian Partners
German University in Cairo
Faculty of Pharmacy Cairo U.
National Research center
Agriculture Research Center
Health Tech
Al Sonbolah Rice Mill
International Trade and
marketing
EU Partners
Goethe University
Muenster University
VIVA cell Biotechnology
FB- Food Germany
Analyze and realize (a&r)
Baspharma Holland
Holland Food Trade
Ainia (Spain)
11. is one of the most nutritive ingredients of the rice crop, where about
60% of the total nutritive value of rice itself resides
Rice BranPROTEIN
OIL DIETARY
FIBRE
VITAMINS &
MINERALS
GAMMA
ORYZANOL
ANTIOXIDANTS
TRACE
ELEMENTS
RICE BRAN
These components can be obtained from other sources in nature
separately, but Rice Bran is unique in having them all
12. Rice Bran Nutraceutical / Functional Food Values
Potent
Antioxidant
High Nutritional Value
Blood
Pressure
Blood
Cholesterol
Potential benefits of RICE BRAN
Blood Sugar
13. However due to non stabilization of Rice
Bran; it is still discarded or used as animal
feed despite its high content of bioactive
substances.
It all starts with IMC support for :
RICE BRAN INNOVATIVE STABILIZATION
14. Project Name Funding Authority Budget
Rice Bran Stabilization Unit (5-7-1)
Faculty of Agriculture, Mansoura
University
2007-2008
Industrial
Modernization
Centre (IMC)
70,000
L.E.
Rice Bran Stabilization Industrial Unit
(1-12-53)
Faculty of Agriculture, Mansoura
University
2009-2010
Industrial
Modernization
Centre (IMC)
700,000
L.E.
Rice Bran Phytochemical Study (3-7-
4)
National Research Centre
2008-2009
Industrial
Modernization
Centre (IMC)
100,000
L.E.
Rice Bran Industry Implementation
(5-7-2)
National Research Centre
Industrial
Modernization
Centre (IMC)
200,000
L.E.
15. Rice Bran Nutraceuticals
• Contract Number MED/2008/214-423
• Total cost of the action EURO 192000 (18 months)
• Project PI: Prof. Dr. M.T. Khyyal
• Project Partners: International trade and Marketing IT&M
(Coordinator), Faculty of Pharmacy; German University in
Cairo GUC; Faculty of Pharmacy; Johann Wolfgang Goethe
Unifersirty Frankfurt (GUF) ; VivaCell Biotechnology GmbH
VC (Germany)
16. • Egyptian rice bran was stabilized immediately after milling to
preserve its active constituents.
• An extract (RBEX) was prepared, analyzed phytochemicaly
and standardized to contain 2.05 % gamma-oryzanol.
• Other active constituents included tocotrienols, tocopherols
and policosanol.
• The extract was used to study the pharmacological
properties outlined below with a view of developing
nutraceutical formulations.
• RBEX was found to have therapeutic potentials in rheumatic
disorders, hypertension, Type 2 diabetes and Alzheimer &
neurodegenerative disorders.
POSTER ABSTRACT
17.
18.
19.
20.
21.
22.
23. Conclusions
Based on present experimental evidence, Egyptian
rice bran extract has therapeutic potentials in:
1. Rheumatic disorders: associated with its anti-
inflammatory, antioxidant activity and effect on
cytokines.
2. Hypertension: related to its antioxidant &
hypocholesterolemic activity.
3. Type 2 Diabetes: effect on insulin release and blood
glucose.
4. Alzheimer and neurodegenerative disorders:
mitochondrial protection.
28. -No signs of acute or sub –chronic oral toxicity was observed
over the range of
studied doses (2.0, 1.0 and 0.5 g/kg Rice bran oil extract)
- The doses selected are 20 , 10 and 5 times above the
therapeutic dose.
-Some significant histological and biochemical differences were
observed at the
2.0g/kg rice bran oil extract
-No signs of mutagenicity or genotoxicity was detected for the
rice bran oil extract at gene, DNA or chromosomal level using the
applied techniques in the present study
Conclusions
29. Rice Bran Formulations
• Contract Number: RDI2/S2/26
• Total cost of the action: EURO 104000 (15 months)
• Project PI: Dr. Amr M. Helal
• Project Partners and associates:
– Faculty of Pharmacy Cairo University
– Faculty of Pharmacy; Johann Wolfgang Goethe
University Frankfurt
– Analyze & Realize, Germany
– BasPharma, The Netherlands
30. • The overall objective of the project is
Innovative formulation for stabilized rice bran
extract with maximum therapeutic usefulness
for pharmaceutical, food, beverage and
cosmetic applications
• And the specific objective(s); Stabilized rice
bran prompt extraction at room temperature
and spray drying into instant water - soluble
formulation.
34. PorridgePlus - a food against dementia
Aim to develop a food product for elderly with
the objective to promote healthy brain aging
35. Aim of the Project:
• to develop a food product for elderly with the
objective to promote healthy brain aging.
This project primarily based on the findings that Rice
Bran Extract protects from mitochondrial dysfunction
in the brain.
• to develop a rice bran extract as a potential food
supplement to prevent neurodegeneration
“Together with partners from Egypt”
39. Nations’ s Wealth
Is not by what they have
Or what they know
But
By Knowing what to do
with what they have
40. Contact Data
• Address: 118 Mohy El Dein Abo El Ezz. Giza
POC 12411- EGYPT
• Tel: 00202 33045736
• Fax: 00202 33477755
• Email: dr.amrhelal@healhtech-eg.com
• Web site : www.healthtech-eg.com