This document summarizes the results of a pilot randomized controlled trial of an SMS-based smoking cessation program in Turkey called SMS Turkey. 151 daily smokers were randomized to a control group or an intervention group that received text messages with tips, support and encouragement for quitting smoking over a period of 4 weeks. Preliminary results found higher rates of carbon monoxide-verified abstinence at 12 weeks in the intervention group compared to control, especially among female smokers and lighter smokers. The authors conclude the program shows promise and a larger randomized controlled trial is needed.
This is an informative presentation, providing an introduction to smoking cessation. Included: photos of smoking vs. non-smoking twins, healthy / disease free lungs vs. a smoker's lungs, video clips on the effects of smoking, including unseen dangers of smoking. Click on various images throughout the presentation for links to videos and websites. For more information on quitting smoking, please visit www.lung.org, or www.smokefree.gov.
This presentation about the National Mental Health Programme by Dr Geraldine Strathdee, National Clinical Director of Mental Health, NHS England, was delivered at the launch of the Strategic Clinical Network for Mental Health, Dementia and Neurological Conditions Yorkshire and the Humber on 17 September 2013.
Geraldine covers:
- How common is mental ill health
- What are we trying to achieve
- What are the priorities
- Progress update
- How can we help and what can we learn from Yorkshire and Humber
- We need your leadership, your expertise and your drive!
This is an informative presentation, providing an introduction to smoking cessation. Included: photos of smoking vs. non-smoking twins, healthy / disease free lungs vs. a smoker's lungs, video clips on the effects of smoking, including unseen dangers of smoking. Click on various images throughout the presentation for links to videos and websites. For more information on quitting smoking, please visit www.lung.org, or www.smokefree.gov.
This presentation about the National Mental Health Programme by Dr Geraldine Strathdee, National Clinical Director of Mental Health, NHS England, was delivered at the launch of the Strategic Clinical Network for Mental Health, Dementia and Neurological Conditions Yorkshire and the Humber on 17 September 2013.
Geraldine covers:
- How common is mental ill health
- What are we trying to achieve
- What are the priorities
- Progress update
- How can we help and what can we learn from Yorkshire and Humber
- We need your leadership, your expertise and your drive!
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
ABDOMINAL TRAUMA in pediatrics part one.drhasanrajab
Abdominal trauma in pediatrics refers to injuries or damage to the abdominal organs in children. It can occur due to various causes such as falls, motor vehicle accidents, sports-related injuries, and physical abuse. Children are more vulnerable to abdominal trauma due to their unique anatomical and physiological characteristics. Signs and symptoms include abdominal pain, tenderness, distension, vomiting, and signs of shock. Diagnosis involves physical examination, imaging studies, and laboratory tests. Management depends on the severity and may involve conservative treatment or surgical intervention. Prevention is crucial in reducing the incidence of abdominal trauma in children.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMSAkankshaAshtankar
MIP 201T & MPH 202T
ADVANCED BIOPHARMACEUTICS & PHARMACOKINETICS : UNIT 5
APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMS By - AKANKSHA ASHTANKAR
Here is the updated list of Top Best Ayurvedic medicine for Gas and Indigestion and those are Gas-O-Go Syp for Dyspepsia | Lavizyme Syrup for Acidity | Yumzyme Hepatoprotective Capsules etc
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Results of a pilot randomized controlled trial of SMS Turkey, a text messaging-based smoking cessation program
1. 15TH WORLD CONFERENCE ON TOBACCO OR HEALTH
SINGAPORE
RESULTS OF A PILOT RANDOMIZED CONTROLLED TRIAL
OF SMS TURKEY, A TEXT MESSAGING-BASED SMOKING
CESSATION PROGRAM
MARCH 21, 2012 1:45 – 3:15 PM
ABSTRACT #OP-136
Michele Ybarra MPH PhD 1
Tulay Bagci Bosi PhD 2
Tonya Prescott BA 1
Josephine Korchmaros PhD 1
Jodi S Holtrop PhD 3
A.K. Salih Emri MD 2
1 Center for Innovative Public Health Research
2 Hacettepe University
3 Michigan State University
* Thank you for your interest in this
presentation. Please note that analyses
included herein are preliminary. More
recent, finalized analyses may be available
by contacting CiPHR for further
information.
2. ACKNOWLEDGEMENTS
Funding: The project described was supported by
Award Number R01TW007918 from the Fogarty
International Center. The content is solely the
responsibility of the authors and does not necessarily
represent the official views of the Fogerty
International Center or the National Institutes of
Health.
Declaration of Interest: The authors have no
competing interests to declare.
3. STUDY MOTIVATION
44% of men and 12% of women smoke daily in
Turkey. (MoH Turkey, 2010)
Over half of smokers report a desire to quit and
45% have made a quit attempt in the past year.
(MoH Turkey, 2010)
Few are linked into cessation services however,
reducing the likelihood of their cessation success
(Akala & El-Saharty, 2006).
Cell phones are 3.8 times more common than
landline phones (CIA World Factbook, 2011). We
posit text messaging can be used to deliver
smoking cessation programs in Turkey.
4. SMS TURKEY (CEBINZ BIRYAKIN DIYOR):
NUMBER OF MESSAGES
Pre-Quit (Day 1 – 13): 3 messages/day
Day before quit day (Day 14): 5 messages
Quit day and Day 2 post-quit: 8 messages/day
(both Early quit and relapse)
Day 3 – Day 4 post-quit: 6 messages
Day 5 post quit: 5 messages
Day 6 post-quit: 4 messages
Day 7 post-quit: 3 messages
(both Late quit and encouragement)
Day 8 – Day 21 post-quit: 2 messages/day
Day 22 – Day 28 post-quit: 1 message/day
5. SMS TURKEY (CEBINZ BIRYAKIN DIYOR):
MESSAGE TYPES
Preparation: When and why do you smoke? Start a
smoking diary to find out. Keep track of when you
smoke each cigarette, what you're doing (the activity),
how you're
Benefits of Quitting: Remember… former smokers
live longer than people who keep smoking. Fight the
urge to smoke today for better health tomorrow.
Encouragement: Have you been rewarding yourself
everyday that you are not smoking? What are you
going to do special for your self today for not smoking
6. SMS TURKEY (CEBINZ BIRYAKIN DIYOR):
MESSAGE TYPES
Pharmacotherapy: Put your reasons for quitting on
the fridge, or somewhere else where you will see
them. Talk to your doctor about pharmacotherapy, or
buy some nicotine gum at the store.
Coping strategies: Here are some coping strategies.
Practice the 4 D's as you work on cutting down:
Delay, Distract, Deep breathe, and Drink water.
(Dealing with) Discomfort: Many smokers do gain
some weight when they quit but it's because they eat
to compensate for not smoking. A healthy diet and
exercise can keep the weight off.
7. SMS TURKEY (CEBINZ BIRYAKIN DIYOR):
RCT METHODOLOGY
Eligibility criteria:
18 years of age or older
Owning a mobile phone and having used text
messaging in the past year
Smoking daily
Seriously thinking about quitting in the next 15 days
Living in Ankara
Not having a chronic disease
9. SMS TURKEY (CEBINZ BIRYAKIN DIYOR):
SAMPLE CHARACTERISTICS (N=151*)
Personal characteristics Control
(n=75)
Intervention
(n=76)
P-
value
Demographic characteristics
Age (Range: 19-62) 35.6 (10.3) 36.1 (9.5) 0.76
Female 32.0% (24) 46.1% (35) 0.08
Lower income (<2000 ytl / mo) 49.3% (37) 30.3% (23) 0.02
Married 65.3% (49) 55.3% (42) 0.21
HH education or lower 50.7% (38) 36.8% (28) 0.09
Smoking characteristics
Average number of cigarettes
smoked per day (Range: 7-40) 20.4 (9.2) 18.7 (7.2) 0.21
Age at first cigarette (Range: 6-29) 17.1 (3.6) 17.5 (3.7) 0.48
Fagerström score (Range: 0-10) 4.9 (2.5) 4.8 (2.3) 0.79
*The submitted abstract included 134 participants. Results reported here include the full sample (n=151)
10. PRIMARY OUTCOME: CO-VERIFIED
CONTINUOUS ABSTINENCE AT 12 WEEKS
15%
5%
24%
11%
0%
5%
10%
15%
20%
25%
30%
35%
Among respondents at 12-
weeks
ITT (non-respondents are
smoking)
Control
Intervention
aRR = 2.0; 95% CI: 0.42, 9.9
aRR = 2.3, 95% CI: 0.57, 9.0
n=34
n=27
n=75
n=76
Relative Risk adjusted for: biological sex, income, education, smoking triggers, appraisal of good things about
smoking, appraisal of good things about quitting; and social support from family, friends, and a special person
13. SMS TURKEY (CEBINZ BIRYAKIN DIYOR):
CONCLUSION
Results provide optimism for future research on SMS
Turkey and other text messaging-based smoking
cessation programs in Turkey.
The SMS Turkey program seems to be especially
helpful for females and light smokers.
Based upon these findings, the next step should be a
sufficiently powered randomized controlled trial to
examine the efficacy of SMS Turkey at the national
level.
Editor's Notes
Compared to the United States where 23% of men and 18% of women are current smokers (Pleis JR, Ward BW, Lucas JW. Summary health statistics for U.S. adults: National Health Interview Survey, 2009. Vital Health Stat 10. 2010(249):1-207)Text messaging may be a way to increase the availability of cessation services because it is both scalable and cost effective.
This 6-week program begins two weeks prior to one’s quit day and continues through 4-weeks post-quit. Daily text messaging content is based upon cognitive behavioral therapy (e.g., self-efficacy, replacement of old behaviors with new, relapse prevention).
Similar in terms of smoking characteristicsDifferent in terms of demographic characteristics: intervention was less likely to be lower income and lower education; and more likely to be female