This document examines the need for a systemic transformation in how cities are developed to make them more sustainable and beneficial to human development and the environment. It discusses how cities have evolved over time from centers of trade, production and social organization to places that now threaten biodiversity and natural resources through pollution, waste and unsustainable growth patterns. The document proposes a vision of "rejuvenative cities" that would take a holistic approach to city planning and development focused on positively contributing to both human well-being and planetary health.