- Optometrists should recognize themselves as primary eye care providers and feel confident prescribing oral medications for eye conditions when appropriate.
- Oral medications are underutilized by doctors for treating eye conditions.
- The lecture aims to instill confidence in optometrists to prescribe in the best interests of their patients.
Re-lab project. Formats reverse engineering: tools and resultslgworld
Insight on re-lab's reverse engineering tools and their usage to implement/improve support for proprietary file formats in your program. Progress report on latest achievements.
Konstantin Dmitriev introduces Remake — an open source build system for animation projects, created for Morevna project.
Remake supports a variety of free software, including Blender, Synfig and Pencil.
The talk was delivered at Libre Graphics Meeting 2012.
Implementing OpenCL support in GEGL and GIMPlgworld
"In this session I'm going to describe some efforts to bring OpenCL acceleration to the General Graphics Library (GEGL) and the GNU Image Manipulation Program (GIMP). I intend to show the current state of the project, some implementations techniques used and performance comparisons among common GPUs."
Re-lab project. Formats reverse engineering: tools and resultslgworld
Insight on re-lab's reverse engineering tools and their usage to implement/improve support for proprietary file formats in your program. Progress report on latest achievements.
Konstantin Dmitriev introduces Remake — an open source build system for animation projects, created for Morevna project.
Remake supports a variety of free software, including Blender, Synfig and Pencil.
The talk was delivered at Libre Graphics Meeting 2012.
Implementing OpenCL support in GEGL and GIMPlgworld
"In this session I'm going to describe some efforts to bring OpenCL acceleration to the General Graphics Library (GEGL) and the GNU Image Manipulation Program (GIMP). I intend to show the current state of the project, some implementations techniques used and performance comparisons among common GPUs."
5-hydroxytryptamine or 5-HT or Serotonin is a neurotransmitter that serves a range of roles in the human body. It is sometimes referred to as the happy chemical since it promotes overall well-being and happiness.
It is mostly found in the brain, intestines, and blood platelets.
5-HT is utilised to transport messages between nerve cells, is known to be involved in smooth muscle contraction, and adds to overall well-being and pleasure, among other benefits. 5-HT regulates the body's sleep-wake cycles and internal clock by acting as a precursor to melatonin.
It is hypothesised to regulate hunger, emotions, motor, cognitive, and autonomic processes.
PGx Analysis in VarSeq: A User’s PerspectiveGolden Helix
Since our release of the PGx capabilities in VarSeq, we’ve had a few months to gather some insights from various use cases. Some users approach PGx workflows by means of array genotyping or what seems to be a growing trend of adding the star allele calling to the existing NGS pipeline for whole genome data. Luckily, both approaches are supported with the VarSeq software platform. The genotyping method being used will also dictate what the scope of the tertiary analysis will be. For example, are your PGx reports a standalone pipeline or would your lab’s goal be to handle a dual-purpose workflow and report on PGx + Diagnostic findings.
The purpose of this webcast is to:
Discuss and demonstrate the approaches with array and NGS genotyping methods for star allele calling to prep for downstream analysis.
Following genotyping, explore alternative tertiary workflow concepts in VarSeq to handle PGx reporting.
Moreover, we will include insights users will need to consider when validating their PGx workflow for all possible star alleles and options you have for automating your PGx analysis for large number of samples. Please join us for a session dedicated to the application of star allele genotyping and subsequent PGx workflows in our VarSeq software.
The skin is the largest organ and its health plays a vital role among the other sense organs. The skin concerns like acne breakout, psoriasis, or anything similar along the lines, finding a qualified and experienced dermatologist becomes paramount.
NAVIGATING THE HORIZONS OF TIME LAPSE EMBRYO MONITORING.pdfRahul Sen
Time-lapse embryo monitoring is an advanced imaging technique used in IVF to continuously observe embryo development. It captures high-resolution images at regular intervals, allowing embryologists to select the most viable embryos for transfer based on detailed growth patterns. This technology enhances embryo selection, potentially increasing pregnancy success rates.
STUDIES IN SUPPORT OF SPECIAL POPULATIONS: GERIATRICS E7shruti jagirdar
Unit 4: MRA 103T Regulatory affairs
This guideline is directed principally toward new Molecular Entities that are
likely to have significant use in the elderly, either because the disease intended
to be treated is characteristically a disease of aging ( e.g., Alzheimer's disease) or
because the population to be treated is known to include substantial numbers of
geriatric patients (e.g., hypertension).
- Video recording of this lecture in English language: https://youtu.be/Pt1nA32sdHQ
- Video recording of this lecture in Arabic language: https://youtu.be/uFdc9F0rlP0
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Histololgy of Female Reproductive System.pptxAyeshaZaid1
Dive into an in-depth exploration of the histological structure of female reproductive system with this comprehensive lecture. Presented by Dr. Ayesha Irfan, Assistant Professor of Anatomy, this presentation covers the Gross anatomy and functional histology of the female reproductive organs. Ideal for students, educators, and anyone interested in medical science, this lecture provides clear explanations, detailed diagrams, and valuable insights into female reproductive system. Enhance your knowledge and understanding of this essential aspect of human biology.
These lecture slides, by Dr Sidra Arshad, offer a simplified look into the mechanisms involved in the regulation of respiration:
Learning objectives:
1. Describe the organisation of respiratory center
2. Describe the nervous control of inspiration and respiratory rhythm
3. Describe the functions of the dorsal and respiratory groups of neurons
4. Describe the influences of the Pneumotaxic and Apneustic centers
5. Explain the role of Hering-Breur inflation reflex in regulation of inspiration
6. Explain the role of central chemoreceptors in regulation of respiration
7. Explain the role of peripheral chemoreceptors in regulation of respiration
8. Explain the regulation of respiration during exercise
9. Integrate the respiratory regulatory mechanisms
10. Describe the Cheyne-Stokes breathing
Study Resources:
1. Chapter 42, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 36, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 13, Human Physiology by Lauralee Sherwood, 9th edition
The biomechanics of running involves the study of the mechanical principles underlying running movements. It includes the analysis of the running gait cycle, which consists of the stance phase (foot contact to push-off) and the swing phase (foot lift-off to next contact). Key aspects include kinematics (joint angles and movements, stride length and frequency) and kinetics (forces involved in running, including ground reaction and muscle forces). Understanding these factors helps in improving running performance, optimizing technique, and preventing injuries.
Know the difference between Endodontics and Orthodontics.Gokuldas Hospital
Your smile is beautiful.
Let’s be honest. Maintaining that beautiful smile is not an easy task. It is more than brushing and flossing. Sometimes, you might encounter dental issues that need special dental care. These issues can range anywhere from misalignment of the jaw to pain in the root of teeth.
2024 State of Marketing Report – by HubspotMarius Sescu
https://www.hubspot.com/state-of-marketing
· Scaling relationships and proving ROI
· Social media is the place for search, sales, and service
· Authentic influencer partnerships fuel brand growth
· The strongest connections happen via call, click, chat, and camera.
· Time saved with AI leads to more creative work
· Seeking: A single source of truth
· TLDR; Get on social, try AI, and align your systems.
· More human marketing, powered by robots
ChatGPT is a revolutionary addition to the world since its introduction in 2022. A big shift in the sector of information gathering and processing happened because of this chatbot. What is the story of ChatGPT? How is the bot responding to prompts and generating contents? Swipe through these slides prepared by Expeed Software, a web development company regarding the development and technical intricacies of ChatGPT!
5-hydroxytryptamine or 5-HT or Serotonin is a neurotransmitter that serves a range of roles in the human body. It is sometimes referred to as the happy chemical since it promotes overall well-being and happiness.
It is mostly found in the brain, intestines, and blood platelets.
5-HT is utilised to transport messages between nerve cells, is known to be involved in smooth muscle contraction, and adds to overall well-being and pleasure, among other benefits. 5-HT regulates the body's sleep-wake cycles and internal clock by acting as a precursor to melatonin.
It is hypothesised to regulate hunger, emotions, motor, cognitive, and autonomic processes.
PGx Analysis in VarSeq: A User’s PerspectiveGolden Helix
Since our release of the PGx capabilities in VarSeq, we’ve had a few months to gather some insights from various use cases. Some users approach PGx workflows by means of array genotyping or what seems to be a growing trend of adding the star allele calling to the existing NGS pipeline for whole genome data. Luckily, both approaches are supported with the VarSeq software platform. The genotyping method being used will also dictate what the scope of the tertiary analysis will be. For example, are your PGx reports a standalone pipeline or would your lab’s goal be to handle a dual-purpose workflow and report on PGx + Diagnostic findings.
The purpose of this webcast is to:
Discuss and demonstrate the approaches with array and NGS genotyping methods for star allele calling to prep for downstream analysis.
Following genotyping, explore alternative tertiary workflow concepts in VarSeq to handle PGx reporting.
Moreover, we will include insights users will need to consider when validating their PGx workflow for all possible star alleles and options you have for automating your PGx analysis for large number of samples. Please join us for a session dedicated to the application of star allele genotyping and subsequent PGx workflows in our VarSeq software.
The skin is the largest organ and its health plays a vital role among the other sense organs. The skin concerns like acne breakout, psoriasis, or anything similar along the lines, finding a qualified and experienced dermatologist becomes paramount.
NAVIGATING THE HORIZONS OF TIME LAPSE EMBRYO MONITORING.pdfRahul Sen
Time-lapse embryo monitoring is an advanced imaging technique used in IVF to continuously observe embryo development. It captures high-resolution images at regular intervals, allowing embryologists to select the most viable embryos for transfer based on detailed growth patterns. This technology enhances embryo selection, potentially increasing pregnancy success rates.
STUDIES IN SUPPORT OF SPECIAL POPULATIONS: GERIATRICS E7shruti jagirdar
Unit 4: MRA 103T Regulatory affairs
This guideline is directed principally toward new Molecular Entities that are
likely to have significant use in the elderly, either because the disease intended
to be treated is characteristically a disease of aging ( e.g., Alzheimer's disease) or
because the population to be treated is known to include substantial numbers of
geriatric patients (e.g., hypertension).
- Video recording of this lecture in English language: https://youtu.be/Pt1nA32sdHQ
- Video recording of this lecture in Arabic language: https://youtu.be/uFdc9F0rlP0
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Histololgy of Female Reproductive System.pptxAyeshaZaid1
Dive into an in-depth exploration of the histological structure of female reproductive system with this comprehensive lecture. Presented by Dr. Ayesha Irfan, Assistant Professor of Anatomy, this presentation covers the Gross anatomy and functional histology of the female reproductive organs. Ideal for students, educators, and anyone interested in medical science, this lecture provides clear explanations, detailed diagrams, and valuable insights into female reproductive system. Enhance your knowledge and understanding of this essential aspect of human biology.
These lecture slides, by Dr Sidra Arshad, offer a simplified look into the mechanisms involved in the regulation of respiration:
Learning objectives:
1. Describe the organisation of respiratory center
2. Describe the nervous control of inspiration and respiratory rhythm
3. Describe the functions of the dorsal and respiratory groups of neurons
4. Describe the influences of the Pneumotaxic and Apneustic centers
5. Explain the role of Hering-Breur inflation reflex in regulation of inspiration
6. Explain the role of central chemoreceptors in regulation of respiration
7. Explain the role of peripheral chemoreceptors in regulation of respiration
8. Explain the regulation of respiration during exercise
9. Integrate the respiratory regulatory mechanisms
10. Describe the Cheyne-Stokes breathing
Study Resources:
1. Chapter 42, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 36, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 13, Human Physiology by Lauralee Sherwood, 9th edition
The biomechanics of running involves the study of the mechanical principles underlying running movements. It includes the analysis of the running gait cycle, which consists of the stance phase (foot contact to push-off) and the swing phase (foot lift-off to next contact). Key aspects include kinematics (joint angles and movements, stride length and frequency) and kinetics (forces involved in running, including ground reaction and muscle forces). Understanding these factors helps in improving running performance, optimizing technique, and preventing injuries.
Know the difference between Endodontics and Orthodontics.Gokuldas Hospital
Your smile is beautiful.
Let’s be honest. Maintaining that beautiful smile is not an easy task. It is more than brushing and flossing. Sometimes, you might encounter dental issues that need special dental care. These issues can range anywhere from misalignment of the jaw to pain in the root of teeth.
2024 State of Marketing Report – by HubspotMarius Sescu
https://www.hubspot.com/state-of-marketing
· Scaling relationships and proving ROI
· Social media is the place for search, sales, and service
· Authentic influencer partnerships fuel brand growth
· The strongest connections happen via call, click, chat, and camera.
· Time saved with AI leads to more creative work
· Seeking: A single source of truth
· TLDR; Get on social, try AI, and align your systems.
· More human marketing, powered by robots
ChatGPT is a revolutionary addition to the world since its introduction in 2022. A big shift in the sector of information gathering and processing happened because of this chatbot. What is the story of ChatGPT? How is the bot responding to prompts and generating contents? Swipe through these slides prepared by Expeed Software, a web development company regarding the development and technical intricacies of ChatGPT!
Product Design Trends in 2024 | Teenage EngineeringsPixeldarts
The realm of product design is a constantly changing environment where technology and style intersect. Every year introduces fresh challenges and exciting trends that mold the future of this captivating art form. In this piece, we delve into the significant trends set to influence the look and functionality of product design in the year 2024.
How Race, Age and Gender Shape Attitudes Towards Mental HealthThinkNow
Mental health has been in the news quite a bit lately. Dozens of U.S. states are currently suing Meta for contributing to the youth mental health crisis by inserting addictive features into their products, while the U.S. Surgeon General is touring the nation to bring awareness to the growing epidemic of loneliness and isolation. The country has endured periods of low national morale, such as in the 1970s when high inflation and the energy crisis worsened public sentiment following the Vietnam War. The current mood, however, feels different. Gallup recently reported that national mental health is at an all-time low, with few bright spots to lift spirits.
To better understand how Americans are feeling and their attitudes towards mental health in general, ThinkNow conducted a nationally representative quantitative survey of 1,500 respondents and found some interesting differences among ethnic, age and gender groups.
Technology
For example, 52% agree that technology and social media have a negative impact on mental health, but when broken out by race, 61% of Whites felt technology had a negative effect, and only 48% of Hispanics thought it did.
While technology has helped us keep in touch with friends and family in faraway places, it appears to have degraded our ability to connect in person. Staying connected online is a double-edged sword since the same news feed that brings us pictures of the grandkids and fluffy kittens also feeds us news about the wars in Israel and Ukraine, the dysfunction in Washington, the latest mass shooting and the climate crisis.
Hispanics may have a built-in defense against the isolation technology breeds, owing to their large, multigenerational households, strong social support systems, and tendency to use social media to stay connected with relatives abroad.
Age and Gender
When asked how individuals rate their mental health, men rate it higher than women by 11 percentage points, and Baby Boomers rank it highest at 83%, saying it’s good or excellent vs. 57% of Gen Z saying the same.
Gen Z spends the most amount of time on social media, so the notion that social media negatively affects mental health appears to be correlated. Unfortunately, Gen Z is also the generation that’s least comfortable discussing mental health concerns with healthcare professionals. Only 40% of them state they’re comfortable discussing their issues with a professional compared to 60% of Millennials and 65% of Boomers.
Race Affects Attitudes
As seen in previous research conducted by ThinkNow, Asian Americans lag other groups when it comes to awareness of mental health issues. Twenty-four percent of Asian Americans believe that having a mental health issue is a sign of weakness compared to the 16% average for all groups. Asians are also considerably less likely to be aware of mental health services in their communities (42% vs. 55%) and most likely to seek out information on social media (51% vs. 35%).
AI Trends in Creative Operations 2024 by Artwork Flow.pdfmarketingartwork
Creative operations teams expect increased AI use in 2024. Currently, over half of tasks are not AI-enabled, but this is expected to decrease in the coming year. ChatGPT is the most popular AI tool currently. Business leaders are more actively exploring AI benefits than individual contributors. Most respondents do not believe AI will impact workforce size in 2024. However, some inhibitions still exist around AI accuracy and lack of understanding. Creatives primarily want to use AI to save time on mundane tasks and boost productivity.
Organizational culture includes values, norms, systems, symbols, language, assumptions, beliefs, and habits that influence employee behaviors and how people interpret those behaviors. It is important because culture can help or hinder a company's success. Some key aspects of Netflix's culture that help it achieve results include hiring smartly so every position has stars, focusing on attitude over just aptitude, and having a strict policy against peacocks, whiners, and jerks.
PEPSICO Presentation to CAGNY Conference Feb 2024Neil Kimberley
PepsiCo provided a safe harbor statement noting that any forward-looking statements are based on currently available information and are subject to risks and uncertainties. It also provided information on non-GAAP measures and directing readers to its website for disclosure and reconciliation. The document then discussed PepsiCo's business overview, including that it is a global beverage and convenient food company with iconic brands, $91 billion in net revenue in 2023, and nearly $14 billion in core operating profit. It operates through a divisional structure with a focus on local consumers.
Content Methodology: A Best Practices Report (Webinar)contently
This document provides an overview of content methodology best practices. It defines content methodology as establishing objectives, KPIs, and a culture of continuous learning and iteration. An effective methodology focuses on connecting with audiences, creating optimal content, and optimizing processes. It also discusses why a methodology is needed due to the competitive landscape, proliferation of channels, and opportunities for improvement. Components of an effective methodology include defining objectives and KPIs, audience analysis, identifying opportunities, and evaluating resources. The document concludes with recommendations around creating a content plan, testing and optimizing content over 90 days.
How to Prepare For a Successful Job Search for 2024Albert Qian
The document provides guidance on preparing a job search for 2024. It discusses the state of the job market, focusing on growth in AI and healthcare but also continued layoffs. It recommends figuring out what you want to do by researching interests and skills, then conducting informational interviews. The job search should involve building a personal brand on LinkedIn, actively applying to jobs, tailoring resumes and interviews, maintaining job hunting as a habit, and continuing self-improvement. Once hired, the document advises setting new goals and keeping skills and networking active in case of future opportunities.
A report by thenetworkone and Kurio.
The contributing experts and agencies are (in an alphabetical order): Sylwia Rytel, Social Media Supervisor, 180heartbeats + JUNG v MATT (PL), Sharlene Jenner, Vice President - Director of Engagement Strategy, Abelson Taylor (USA), Alex Casanovas, Digital Director, Atrevia (ES), Dora Beilin, Senior Social Strategist, Barrett Hoffher (USA), Min Seo, Campaign Director, Brand New Agency (KR), Deshé M. Gully, Associate Strategist, Day One Agency (USA), Francesca Trevisan, Strategist, Different (IT), Trevor Crossman, CX and Digital Transformation Director; Olivia Hussey, Strategic Planner; Simi Srinarula, Social Media Manager, The Hallway (AUS), James Hebbert, Managing Director, Hylink (CN / UK), Mundy Álvarez, Planning Director; Pedro Rojas, Social Media Manager; Pancho González, CCO, Inbrax (CH), Oana Oprea, Head of Digital Planning, Jam Session Agency (RO), Amy Bottrill, Social Account Director, Launch (UK), Gaby Arriaga, Founder, Leonardo1452 (MX), Shantesh S Row, Creative Director, Liwa (UAE), Rajesh Mehta, Chief Strategy Officer; Dhruv Gaur, Digital Planning Lead; Leonie Mergulhao, Account Supervisor - Social Media & PR, Medulla (IN), Aurelija Plioplytė, Head of Digital & Social, Not Perfect (LI), Daiana Khaidargaliyeva, Account Manager, Osaka Labs (UK / USA), Stefanie Söhnchen, Vice President Digital, PIABO Communications (DE), Elisabeth Winiartati, Managing Consultant, Head of Global Integrated Communications; Lydia Aprina, Account Manager, Integrated Marketing and Communications; Nita Prabowo, Account Manager, Integrated Marketing and Communications; Okhi, Web Developer, PNTR Group (ID), Kei Obusan, Insights Director; Daffi Ranandi, Insights Manager, Radarr (SG), Gautam Reghunath, Co-founder & CEO, Talented (IN), Donagh Humphreys, Head of Social and Digital Innovation, THINKHOUSE (IRE), Sarah Yim, Strategy Director, Zulu Alpha Kilo (CA).
Trends In Paid Search: Navigating The Digital Landscape In 2024Search Engine Journal
The search marketing landscape is evolving rapidly with new technologies, and professionals, like you, rely on innovative paid search strategies to meet changing demands.
It’s important that you’re ready to implement new strategies in 2024.
Check this out and learn the top trends in paid search advertising that are expected to gain traction, so you can drive higher ROI more efficiently in 2024.
You’ll learn:
- The latest trends in AI and automation, and what this means for an evolving paid search ecosystem.
- New developments in privacy and data regulation.
- Emerging ad formats that are expected to make an impact next year.
Watch Sreekant Lanka from iQuanti and Irina Klein from OneMain Financial as they dive into the future of paid search and explore the trends, strategies, and technologies that will shape the search marketing landscape.
If you’re looking to assess your paid search strategy and design an industry-aligned plan for 2024, then this webinar is for you.
5 Public speaking tips from TED - Visualized summarySpeakerHub
From their humble beginnings in 1984, TED has grown into the world’s most powerful amplifier for speakers and thought-leaders to share their ideas. They have over 2,400 filmed talks (not including the 30,000+ TEDx videos) freely available online, and have hosted over 17,500 events around the world.
With over one billion views in a year, it’s no wonder that so many speakers are looking to TED for ideas on how to share their message more effectively.
The article “5 Public-Speaking Tips TED Gives Its Speakers”, by Carmine Gallo for Forbes, gives speakers five practical ways to connect with their audience, and effectively share their ideas on stage.
Whether you are gearing up to get on a TED stage yourself, or just want to master the skills that so many of their speakers possess, these tips and quotes from Chris Anderson, the TED Talks Curator, will encourage you to make the most impactful impression on your audience.
See the full article and more summaries like this on SpeakerHub here: https://speakerhub.com/blog/5-presentation-tips-ted-gives-its-speakers
See the original article on Forbes here:
http://www.forbes.com/forbes/welcome/?toURL=http://www.forbes.com/sites/carminegallo/2016/05/06/5-public-speaking-tips-ted-gives-its-speakers/&refURL=&referrer=#5c07a8221d9b
ChatGPT and the Future of Work - Clark Boyd Clark Boyd
Everyone is in agreement that ChatGPT (and other generative AI tools) will shape the future of work. Yet there is little consensus on exactly how, when, and to what extent this technology will change our world.
Businesses that extract maximum value from ChatGPT will use it as a collaborative tool for everything from brainstorming to technical maintenance.
For individuals, now is the time to pinpoint the skills the future professional will need to thrive in the AI age.
Check out this presentation to understand what ChatGPT is, how it will shape the future of work, and how you can prepare to take advantage.
The document provides career advice for getting into the tech field, including:
- Doing projects and internships in college to build a portfolio.
- Learning about different roles and technologies through industry research.
- Contributing to open source projects to build experience and network.
- Developing a personal brand through a website and social media presence.
- Networking through events, communities, and finding a mentor.
- Practicing interviews through mock interviews and whiteboarding coding questions.
Google's Just Not That Into You: Understanding Core Updates & Search IntentLily Ray
1. Core updates from Google periodically change how its algorithms assess and rank websites and pages. This can impact rankings through shifts in user intent, site quality issues being caught up to, world events influencing queries, and overhauls to search like the E-A-T framework.
2. There are many possible user intents beyond just transactional, navigational and informational. Identifying intent shifts is important during core updates. Sites may need to optimize for new intents through different content types and sections.
3. Responding effectively to core updates requires analyzing "before and after" data to understand changes, identifying new intents or page types, and ensuring content matches appropriate intents across video, images, knowledge graphs and more.
A brief introduction to DataScience with explaining of the concepts, algorithms, machine learning, supervised and unsupervised learning, clustering, statistics, data preprocessing, real-world applications etc.
It's part of a Data Science Corner Campaign where I will be discussing the fundamentals of DataScience, AIML, Statistics etc.
Time Management & Productivity - Best PracticesVit Horky
Here's my presentation on by proven best practices how to manage your work time effectively and how to improve your productivity. It includes practical tips and how to use tools such as Slack, Google Apps, Hubspot, Google Calendar, Gmail and others.
The six step guide to practical project managementMindGenius
The six step guide to practical project management
If you think managing projects is too difficult, think again.
We’ve stripped back project management processes to the
basics – to make it quicker and easier, without sacrificing
the vital ingredients for success.
“If you’re looking for some real-world guidance, then The Six Step Guide to Practical Project Management will help.”
Dr Andrew Makar, Tactical Project Management
Beginners Guide to TikTok for Search - Rachel Pearson - We are Tilt __ Bright...
April 5, 2012 - Oral Meds and the Eye
1. 4/10/2012
Optometrists need to recognize ourselves as
primary care health providers
Oral meds are under utilized by doctors for eye
conditions
This lecture should instill confidence in us to
prescribe in the best interests of our patients
Jill Autry, OD, RPh
SPECIAL THANKS TO JILL AUTRY OD RPh Eye Center of Texas, Houston
from the Eye Center of Texas drjillautry@tropicalce.com
Optometric Glaucoma Specialist
One 10-day supply of oral antibiotics Internal/External hordeola
One 72-hour supply of oral antihistamines Preseptal cellulitis
Dacryocystitis
One 7-day supply of oral NSAIDs
Dacryoadenitis
One 3-day supply of analgesics in
Canaliculitis
Schedules III, IV, and V
Chlamydia
Antiglaucoma drugs
Dry eye/posterior blepharitis/ocular rosacea
Appropriate medications to treat anaphylaxis
1
3. 4/10/2012
Penicillin antibiotic (aminopenicillin)
Extended coverage over standard PCN
Good for staph infections because resistant
to beta lactamases
Also has some gram negative coverage
Gram negative resistance increasing
Inexpensive
3
4. 4/10/2012
Skin and soft tissue infections
Adults
875mg q12h
Children
20-40mg/kg/day divided q8h
Edward Wade, M.D. Ting Fang-Suarez, M.D. Mark Mayo, M.D.
Chris Allee, O.D. Jill Autry, O.D. Randy Reichle, O.D.
6565 West Loop South 4415 Crenshaw Rd. 15400 SW Frwy
Bellaire, TX 77401 Pasadena, TX 77504 Sugar Land, TX 77478
Phone (713)797-1010 Phone (281)998-3333 (281)277-1010 Augmentin = Amoxicillin + Clavulanic acid
450 Medical Ctr Blvd, #305
Webster, TX 77598
11914 Astoria Boulevard, #325
Houston, TX 77089
21700 Kingsland Blvd.
Katy, TX 77450
Cannot use if penicillin allergic
(281) 332-1397 (281) 484-2030 (281) 578-4815
Clavulanic acid is a “suicide inhibitor”
Protects amoxicillin from beta-lactamases
NAME Jack Cooper AGE ________
Does not have antibiotic action itself
ADDRESS_____________________________________________________DATE 3-3-12 Allows increased coverage with less
destruction by beta-lactamases
Rx Amoxicillin 875mg
1 po bid x 10 days #20 Also covers anaerobes
Good for human and animal bites
REFILLS-- 0 Jill Autry, O.D.
4
5. 4/10/2012
Edward Wade, M.D. Ting Fang-Suarez, M.D. Mark Mayo, M.D.
Chris Allee, O.D. Jill Autry, O.D. Randy Reichle, O.D.
6565 West Loop South 4415 Crenshaw Rd. 15400 SW Frwy
Bellaire, TX 77401 Pasadena, TX 77504 Sugar Land, TX 77478
Phone (713)797-1010 Phone (281)998-3333 (281)277-1010
Can use in pregnancy (category B) 450 Medical Ctr Blvd, #305
Webster, TX 77598
11914 Astoria Boulevard, #325
Houston, TX 77089
21700 Kingsland Blvd.
Katy, TX 77450
Can use in children (281) 332-1397 (281) 484-2030 (281) 578-4815
Can cause nausea/vomiting/diarrhea NAME Jack Cooper AGE ________
Take with food/yogurt
ADDRESS_____________________________________________________DATE 3-3-12
Few drug interactions
Allopurinol/probenecid (both for gout) Rx Augmentin 875mg
1 po bid x 10 days #20
875mg bid
Generic available but still expensive ($60.54)
REFILLS-- 0 Jill Autry, O.D.
Small percentage of patients will also be Beta-lactam antibiotic class
allergic to cephalosporins Increased coverage over penicillin class
Literature suggests anywhere from 3-10% 3-10% cross-sensitivity to penicillin class in
cross-sensitivity regards to allergic reactions
Could use a –mycin, –cycline, -quinolone Four generations of cephalosporins
Could use Septra if not sulfa allergic Increasing gram negative activity from 1 to 4
First and second generations better for ocular
conditions (more likely gram positive)
5
6. 4/10/2012
82% of patients who report a PCN allergy do
not react to skin testing
Risk is much lower with second (0.2%) and
third (0.2%) gen vs. first gen (0.5%)
American Academy of Pediatrics ok with
certain meds even in the face of PCN allergy as
long as not severe, i.e. anaphylaxis
Edward Wade, M.D. Ting Fang-Suarez, M.D. Mark Mayo, M.D.
Chris Allee, O.D. Jill Autry, O.D. Randy Reichle, O.D.
6565 West Loop South 4415 Crenshaw Rd. 15400 SW Frwy
Bellaire, TX 77401 Pasadena, TX 77504 Sugar Land, TX 77478
Phone (713)797-1010 Phone (281)998-3333 (281)277-1010
According to the Academy of Pediatrics… 450 Medical Ctr Blvd, #305 11914 Astoria Boulevard, #325 21700 Kingsland Blvd.
If allergic to PCN… Webster, TX 77598
(281) 332-1397
Houston, TX 77089
(281) 484-2030
Katy, TX 77450
(281) 578-4815
OK to use cefdinir (Omnicef™) or
cefuroxime(Ceftin™) if: NAME Jack Cooper AGE ________
No history of cephalosporin allergy ADDRESS_____________________________________________________DATE 3-3-12
No history of multiple other allergic reactions
Rx Ceftin 500mg #14
No history of atopic conditions
1 po bid UAT
No history of severe allergic reaction
REFILLS-- 0 Jill Autry, O.D.
6
7. 4/10/2012
Edward Wade, M.D. Ting Fang-Suarez, M.D. Mark Mayo, M.D.
Chris Allee, O.D. Jill Autry, O.D. Randy Reichle, O.D.
6565 West Loop South 4415 Crenshaw Rd. 15400 SW Frwy
Bellaire, TX 77401 Pasadena, TX 77504 Sugar Land, TX 77478
Phone (713)797-1010 Phone (281)998-3333 (281)277-1010
450 Medical Ctr Blvd, #305 11914 Astoria Boulevard, #325 21700 Kingsland Blvd. Inhibit bacterial protein synthesis
Webster, TX 77598 Houston, TX 77089 Katy, TX 77450
(281) 332-1397 (281) 484-2030 (281) 578-4815 Erythromycin, clarithromycin, azithromycin
Use with caution in liver disease
NAME Jack Cooper AGE ________
Drug interactions increased
ADDRESS_____________________________________________________DATE 3-3-12 Great for penicillin allergic patients
Rx Omnicef 300mg #14
1 po bid UAT
REFILLS-- 0 Jill Autry, O.D.
Macrolide antibiotic Z-pack
Dosing regimen increases compliance 500mg day one; 250mg days 2-5
OK in pregnancy and children Great for compliance
For milder infections
Less GI effects than erythromycin
Less drug interactions than other macrolides Treatment of chlamydia with 1 g dose
Prescribe four 250mg tablets
Drug of choice for chlamydial conjunctivitis
Take all at once
7
8. 4/10/2012
Edward Wade, M.D. Ting Fang-Suarez, M.D. Mark Mayo, M.D. Edward Wade, M.D. Ting Fang-Suarez, M.D. Mark Mayo, M.D.
Chris Allee, O.D. Jill Autry, O.D. Randy Reichle, O.D. Chris Allee, O.D. Jill Autry, O.D. Randy Reichle, O.D.
6565 West Loop South 4415 Crenshaw Rd. 15400 SW Frwy 6565 West Loop South 4415 Crenshaw Rd. 15400 SW Frwy
Bellaire, TX 77401 Pasadena, TX 77504 Sugar Land, TX 77478 Bellaire, TX 77401 Pasadena, TX 77504 Sugar Land, TX 77478
Phone (713)797-1010 Phone (281)998-3333 (281)277-1010 Phone (713)797-1010 Phone (281)998-3333 (281)277-1010
450 Medical Ctr Blvd, #305 11914 Astoria Boulevard, #325 21700 Kingsland Blvd. 450 Medical Ctr Blvd, #305 11914 Astoria Boulevard, #325 21700 Kingsland Blvd.
Webster, TX 77598 Houston, TX 77089 Katy, TX 77450 Webster, TX 77598 Houston, TX 77089 Katy, TX 77450
(281) 332-1397 (281) 484-2030 (281) 578-4815 (281) 332-1397 (281) 484-2030 (281) 578-4815
NAME Jack Cooper AGE ________ NAME Jack Cooper AGE ________
ADDRESS_____________________________________________________DATE 3-3-12 ADDRESS_____________________________________________________DATE 3-3-12
Rx Zpak Rx Zithromax 250mg #4
Take 4 pills all at once
REFILLS-- 0 Jill Autry, O.D.
REFILLS-- 0 Jill Autry, O.D.
Sulfamethoxazole/Trimethoprim Sulfa allergy not sulfur allergy
Septra DS, Bactrim DS Rash is common sign; usually seen in the
Can use in PCN allergic patients antibiotic class of sulfonamides (like Septra®
or sulfacetamide ointment)
CANNOT use if Sulfa allergic
Less likely to see in non-antibiotic meds
Great gram positive and gram negative
Diamox®, Neptazane®, Azopt®, Trusopt®,
coverage
Cosopt®
Covers MRSA Even less likely to see with topical
Consider if cellulitis plus abscess and severe pain medications
Sulfites and sulfates are chemically different-
no cross reactivity with sulfa allergies
8
9. 4/10/2012
Inhibits bacterial protein synthesis
Tetracycline, Doxycyline, Minocycline Good broad spectrum activity
Cannot use in children younger than 8 qd to bid dosing
Cannot use in pregnancy/nursing Can take with food
Causes photosensitivity and photophobia Can take with dairy products
Long-term therapy associated with Cannot take with antacids
pseudotumor cerebri (rare) Cannot take before lying down
Minocycline more than other forms Must wait 2 hours
Esophageal ulceration
Edward Wade, M.D. Ting Fang-Suarez, M.D. Mark Mayo, M.D.
Chris Allee, O.D. Jill Autry, O.D. Randy Reichle, O.D.
6565 West Loop South 4415 Crenshaw Rd. 15400 SW Frwy
Bellaire, TX 77401 Pasadena, TX 77504 Sugar Land, TX 77478
Phone (713)797-1010 Phone (281)998-3333 (281)277-1010
450 Medical Ctr Blvd, #305 11914 Astoria Boulevard, #325 21700 Kingsland Blvd.
Webster, TX 77598
(281) 332-1397
Houston, TX 77089
(281) 484-2030
Katy, TX 77450
(281) 578-4815
Antibiotic use
100mg bid x 10 days
NAME Jack Cooper AGE ________ Posterior blepharitis and Dry eye
50mg bid x 4-6 weeks then
ADDRESS_____________________________________________________DATE 3-3-12
50mg qd x 3-6 months or indefinitely
Rx Doxycycline 100mg Dermatologist to prescribe
1 po bid #20
Take with food
REFILLS-- 0 Jill Autry, O.D.
9
10. 4/10/2012
Cannot use in patients less than 18 years
Ciprofloxacin (CIPRO®) is prototype old
May decrease cartilage and bone formation
Blocks bacterial DNA synthesis
Heavily prescribed for urinary tract Cannot use in pregnancy/nursing
infections Cannot use in renal disease
Overprescribed in the 1990s Multiple drug and vitamin interactions
Little staph coverage now Musculoskeletal side effects
Mainly used for gram negative urinary tract Arthralgia, tendonitis, tendon rupture
infections
A fluoroquinolone
Can be used for patients allergic to PCN None are controlled substances
and/or cephalosporin Little to no abuse potential
OK for hordeolum/preseptal cellulitis Many available in OTC strength
Has some coverage against MRSA Patients vary in response to various products
NSAID ACTIONS
500mg qd x 7-10 days Inhibit cyclo-oxygenase pathway
No in children/pregnancy/breast feeding Results in decreased prostaglandin formation
Reduces pain
Reduces inflammation
Reduces edema
10
11. 4/10/2012
OTC
Ibuprofen 200mg
Schedule III and IV analgesics
Motrin®, Advil®, Nuprin® Non-scheduled pain meds
Naproxen 200mg
Alleve® Corneal abrasions, post-op PRK, post-op
Rx pterygium surgery, etc.
Ibuprofen 400mg, 600mg, 800mg
Naproxen (Naprosyn®)
Do not use in infectious processes, will mask
Ketorolac (Toradol®) 10mg pain of worsening infection
Celebrex® 100mg, 200mg
Others
Short term therapy only recommended
Need DEA # to prescribe scheduled meds
11
12. 4/10/2012
Edward Wade, M.D. Ting Fang-Suarez, M.D. Mark Mayo, M.D.
Chris Allee, O.D. Jill Autry, O.D. Randy Reichle, O.D.
6565 West Loop South 4415 Crenshaw Rd. 15400 SW Frwy
Bellaire, TX 77401 Pasadena, TX 77504 Sugar Land, TX 77478
Phone (713)797-1010 Phone (281)998-3333 (281)277-1010
450 Medical Ctr Blvd, #305 11914 Astoria Boulevard, #325 21700 Kingsland Blvd.
Schedule III Webster, TX 77598 Houston, TX 77089 Katy, TX 77450
(281) 332-1397 (281) 484-2030 (281) 578-4815
Central acting narcotic analgesic
325mg acetaminophen + 30mg codeine NAME Jack Cooper AGE ________
Tylenol with codeine® elixir is APAP
120mg/5cc with 12mg codeine/5cc ADDRESS 6565 Golden River Drive, Houston, TX 77082 DATE 3-3-11
Avoid in liver/renal disease/alcoholism Rx Tylenol #3 #20 (twenty)
No extra Tylenol® in addition 1-2 po q4-6h prn pain
No alcohol
GI distress and sedation are main side effects
REFILLS-- zero Jill Autry, O.D.
MA0123456
12
13. 4/10/2012
Most codeine “allergies” are GI side effects or Significantly more pain relief and duration
of action compared to codeine
codeine initiated histamine release More addictive
“Stomach upset” Vicodin® (APAP w/hydrocodone)
Flushing 500mg APAP + 5mg hydrocodone
Itching Schedule III
True IgE mediated allergic reaction low Vicodin® ES (APAP w/hydrocodone)
750mg APAP + 7.5mg hydrocodone
Can use hydrocodone because it is a semi- Schedule III
synthetic form of codeine Vicoprofen®
200mg ibuprofen + 7.5mg hydrocodone
When Tylenol® is contraindicated/liver disease
Schedule III
Edward Wade, M.D. Ting Fang-Suarez, M.D. Mark Mayo, M.D.
Chris Allee, O.D. Jill Autry, O.D. Randy Reichle, O.D.
6565 West Loop South 4415 Crenshaw Rd. 15400 SW Frwy
Bellaire, TX 77401 Pasadena, TX 77504 Sugar Land, TX 77478
Phone (713)797-1010 Phone (281)998-3333 (281)277-1010
450 Medical Ctr Blvd, #305
Webster, TX 77598
11914 Astoria Boulevard, #325
Houston, TX 77089
21700 Kingsland Blvd.
Katy, TX 77450
Nonbacteriostatic sulfonamide
(281) 332-1397 (281) 484-2030 (281) 578-4815
Decreases carbonic anhydrase
Decreases hydrogen and bicarb ion formation
NAME Jack Cooper AGE ________
Results in decreased aqueous production in
ADDRESS 6565 Golden River Drive, Houston, TX 77082 DATE 3-3-12 the ciliary body
Rx Vicodin 5/500 #20 (twenty)
Results in alkaline diuresis in the kidney but
1-2 po q4-6h prn pain
tolerance develops quickly
Contraindicated in renal, hepatic, or
respiratory disease
REFILLS-- zero Jill Autry, O.D.
MA0123456
13
14. 4/10/2012
Treatment of acute angle closure glaucoma
Treatment of less acute increased IOP
Treatment of post-surgical IOP spikes
Treatment of pseudotumor cerebri
Controversial treatment of serous retinal
detachments
Also used to prevent “altitude sickness”
Decreases carbonic anhydrase in the ciliary body
which decreases aqueous humor formation
Decreases IOP by 40-60%
Starts to work in 1 hour, peak effect at 4 hours
Comes in 125mg, 250mg, 500mg sequels
Angle closure dose: (2) 250mg tablets initially—
needs PI
14
15. 4/10/2012
Severe symptoms
Swelling of lips, tongue, throat
Difficulty breathing or swallowing
Call 911
Epi-pen if available
For treatment of anaphylactic reactions
Direct someone to call 911
Subcutaneous auto-injector
Works immediately but lasts only 10-15
minutes
Can write a prescription to keep in office
But only 18 month shelf life
15
16. 4/10/2012
1. PULL OFF GREY CAP
Found in tears
Can use for epithelial disease if patient can’t
2. HOLD FLUSH TO MID-THIGH.
use Viroptic®/Zirgan® secondary to
toxicity/severe dry eye/availability
Does not help in the treatment of stromal
3. PRESS HARD; WILL HEAR CLICK.
disease
Treat stromal disease with topical steroid
4. LEAVE FOR 10-15 SECONDS. Cover steroid with Viroptic®/Zirgan® or
oral antiviral
Herpes simplex keratitis
For Herpes Zoster (shingles) treatment
In place of topical treatment
For Bell’s Palsy treatment Acyclovir 400mg 5x day x 10 days
Must start within 72 hrs for best effect; Famvir® 250mg tid x 7 days
preferably within 24 hrs Valtrex® 500mg tid x 7 days
Acyclovir 800mg 5X day For prevention of recurrences
Acyclovir 400mg qd-bid
Famvir 500mg tid
Famvir® 250mg qd
Valtrex 1 gram tid Valtrex® 500 qd
16
17. 4/10/2012
Allergic reaction
Anterior uveitis
Posterior uveitis
Scleritis
Arteritic ischemic optic neuropathy
“Giant Cell”
Optic neuritis
Orbital pseudotumor
Herpes zoster
Other optic neuropathies
Increased intraocular pressure
Topical will increase in 2-4 weeks
Oral/IV can increase within 3-4 days
Cataract
Usually posterior subcapsular/ seen with oral steroids
Steroid induced diabetes/decrease control
Osteoporosis
Gastrointestinal ulceration
Adrenal suppression
Reduced immunity/infections
Mood swings/erratic behavior
17
18. 4/10/2012
Edward Wade, M.D. Ting Fang-Suarez, M.D. Mark Mayo, M.D.
Chris Allee, O.D. Jill Autry, O.D. Randy Reichle, O.D.
6565 West Loop South 4415 Crenshaw Rd. 15400 SW Frwy
Bellaire, TX 77401 Pasadena, TX 77504 Sugar Land, TX 77478
Phone (713)797-1010 Phone (281)998-3333 (281)277-1010
Take with food or milk
Generally start 60-80 mg/day
450 Medical Ctr Blvd, #305 11914 Astoria Boulevard, #325 21700 Kingsland Blvd.
Webster, TX 77598 Houston, TX 77089 Katy, TX 77450
For posterior uveitis, Giant cell, after IV steroids (281) 332-1397 (281) 484-2030 (281) 578-4815
for optic neuritis, pseudotumor, scleritis
Must taper dosage over 1-2 weeks depending on
response NAME Joe Johnson AGE ______________
40-60 mg x 2-3 days does not need taper
ADDRESS_____________________________________________________DATE 3-3-12
Otherwise taper by 20% every few days unless on
steroids for months (then taper more slowly)
Rx Prednisone 20mg #30
Consider Medrol Dosepak 3 tabs (60mg) qd with food/milk
For allergic reactions, zoster, anterior uveitis
Less serious inflammations
REFILLS-- 0 _____________
Edward Wade, M.D. Ting Fang-Suarez, M.D. Mark Mayo, M.D.
Chris Allee, O.D. Jill Autry, O.D. Randy Reichle, O.D.
6565 West Loop South 4415 Crenshaw Rd. 15400 SW Frwy
Bellaire, TX 77401 Pasadena, TX 77504 Sugar Land, TX 77478
Phone (713)797-1010 Phone (281)998-3333 (281)277-1010
450 Medical Ctr Blvd, #305 11914 Astoria Boulevard, #325 21700 Kingsland Blvd.
Webster, TX 77598 Houston, TX 77089 Katy, TX 77450
(281) 332-1397 (281) 484-2030 (281) 578-4815
NAME Joe Johnson AGE ______________
ADDRESS_____________________________________________________DATE 3-3-11
Rx Medrol Dose Pack
TUD
REFILLS-- 0 _____________
18
19. 4/10/2012
Tamoxifen
Most commonly after one year of therapy
Macular refractile bodies and RPE changes
Does not warrant discontinuation
Stop med if color vision decreases or CME
develops
Up to 6-8 diopters of acute myopia
Most cases within one month initiation
Choroidal effusion and ciliary body edema
Can lead to anterior displacement of lens and acute
angle closure with increased IOP
Not related to pupillary block
Not relieved by peripheral iridotomy (PI)
19
20. 4/10/2012
Increased risk of retinopathy:
Patients should discontinue the medication > 5 years use
as quickly as possible Cumulative dose > 1000 g
Must be tapered-cannot stop abruptly Daily dose > 400 mg/day
Hyperosmotic therapy Elderly
Kidney or liver disease
Cycloplegic
Concurrent retinal/macular disease
Topical antiglaucoma agents
Reported more with hyperopes
20
21. 4/10/2012
Revised recommendations on screening for
chloroquine and hydroxychloroquine
retinopathy
Ophthalmology. 2011 Feb;118(2):415-22
Screening:
10-2 VF (white-on-white)
Repeat promptly if changes
Fundus examination
Fundus photography
Not for screening; may be useful for documentation
No longer: Amsler grid, color vision, FA, etc.
http://www.alberta-
retina.com/Alberta%20Retina%20Consultants/Patient%20Info/Eye%20Diseases/Images/Plaq%20toxicity.jpg
Baseline examination
Within 1st year of therapy Optic neuropathy
Counsel patient about risk
Optic neuropathy secondary to decreased
Annual screening
axoplasmic flow
MINIMAL guidelines
Begin immediately if high risk Resulting optic nerve edema
Begin after 5 years of use Seen within weeks of initiation of drug
All patients
Visual acuity less affected than AION
If toxicity
Consider discontinuing medication Discontinue use
Slow clearing Disc edema will resolve over months
Visual function may continue to deteriorate
21
22. 4/10/2012
See the TOA Website for more
details about any of
our programs and issues
http:/texas.aoa.org
22