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Do sulphur-containing compounds interfere with beta-cell glucose metabolising enzyme function? M. S. S. Raja Sivanantham (B00535767) Supervisor: Professor Neville H McClenaghan  April 2010
Introduction ,[object Object],[object Object],[object Object],[object Object],[object Object]
Aims and Objectives ,[object Object],[object Object],[object Object],[object Object],[object Object]
Methods ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Results
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Results
Figure 1: Effects of prolonged (18 hour) exposure to homocysteine without or with alloxan and taurine on glucose phosphorylation Values are mean ± S.E.M. (n = 8). **P<0.01, ***P<0.001 compared to 100 mM glucose (GK activity) of control (None).  ΔΔ P<0.01 compared to HC + Ax. Abbreviations: HC, homocysteine; Ax, alloxan, Tau, taurine.
Figure 2: Effects of prolonged (18 hour) exposure to homocysteine thiolactone without or with alloxan and taurine on glucose phosphorylation Values are mean ± S.E.M. (n = 8). ***P<0.001 compared to 100 mM glucose (GK activity) of control (None).  ΔΔ P<0.01 compared to HCTL + Ax. Abbreviations: HCTL, homocysteine thiolactone; Ax, alloxan, Tau, taurine.
Figure 3: Effect of prolonged (18 hour) exposure to  cysteine  without or with alloxan and taurine on glucose phosphorylation Values are mean ± S.E.M. (n = 8). ***P<0.001 compared to 100 mM glucose (GK activity) of control (None).  ΔΔΔ P<0.01 compared to Cys + Ax. Abbreviations: Cys, cysteine; Ax, alloxan, Tau, taurine.
Figure 4: Effects of prolonged (18 hour) exposure to  cysteic acid  without or with alloxan and taurine on glucose phosphorylation Values are mean ± S.E.M. (n = 8). **P<0.01, ***P<0.001 compared to 100 mM glucose (GK activity) of control (None).  ΔΔ P<0.01 compared to CysA + Ax. Abbreviations: CysA, cysteic acid; Ax, alloxan, Tau, taurine.
Discussion and Conclusions ,[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],References

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Raja Sivanantham Ulster Uni Coleraine B Sc Research Slides

  • 1. Do sulphur-containing compounds interfere with beta-cell glucose metabolising enzyme function? M. S. S. Raja Sivanantham (B00535767) Supervisor: Professor Neville H McClenaghan April 2010
  • 2.
  • 3.
  • 4.
  • 5.
  • 6.
  • 7. Figure 1: Effects of prolonged (18 hour) exposure to homocysteine without or with alloxan and taurine on glucose phosphorylation Values are mean ± S.E.M. (n = 8). **P<0.01, ***P<0.001 compared to 100 mM glucose (GK activity) of control (None). ΔΔ P<0.01 compared to HC + Ax. Abbreviations: HC, homocysteine; Ax, alloxan, Tau, taurine.
  • 8. Figure 2: Effects of prolonged (18 hour) exposure to homocysteine thiolactone without or with alloxan and taurine on glucose phosphorylation Values are mean ± S.E.M. (n = 8). ***P<0.001 compared to 100 mM glucose (GK activity) of control (None). ΔΔ P<0.01 compared to HCTL + Ax. Abbreviations: HCTL, homocysteine thiolactone; Ax, alloxan, Tau, taurine.
  • 9. Figure 3: Effect of prolonged (18 hour) exposure to cysteine without or with alloxan and taurine on glucose phosphorylation Values are mean ± S.E.M. (n = 8). ***P<0.001 compared to 100 mM glucose (GK activity) of control (None). ΔΔΔ P<0.01 compared to Cys + Ax. Abbreviations: Cys, cysteine; Ax, alloxan, Tau, taurine.
  • 10. Figure 4: Effects of prolonged (18 hour) exposure to cysteic acid without or with alloxan and taurine on glucose phosphorylation Values are mean ± S.E.M. (n = 8). **P<0.01, ***P<0.001 compared to 100 mM glucose (GK activity) of control (None). ΔΔ P<0.01 compared to CysA + Ax. Abbreviations: CysA, cysteic acid; Ax, alloxan, Tau, taurine.
  • 11.
  • 12.