This document provides a study guide for a psychology midterm exam covering topics in cognitive neuroscience and fMRI research.
Key points covered include: how cognitive neuroscience focuses on neuronal mechanisms of mental processes; conducting fMRI studies by designing behavioral tasks, modifying tasks for fMRI, and analyzing data; experimental design principles of describing, predicting, determining causes, and explaining; types of experimental designs including controlled, correlational, and descriptive; and analyzing fMRI data.
Lab readings summarize research on conflict adaptation and the role of the anterior cingulate cortex in monitoring conflicts versus selecting actions. Studies aim to distinguish these accounts by varying temporal intervals between distractors and targets.
Later sections cover basic statistics for comparing means
severe combined immunodeficiency syndromeFatima Sayeed
Severe combined immunodeficiency syndrome (SCID) is a rare genetic disorder characterized by the absence of both T cells and B cells. This leaves the body unable to fight infections and affected infants often develop severe, life-threatening infections within the first year of life if untreated. There are 13 known genetic causes of SCID. The main treatment is a bone marrow transplant from a matched donor, which can cure the condition if performed early in life. Gene therapy is also being explored as a potential treatment.
Chédiak-Higashi syndrome is a rare autosomal recessive disorder caused by mutations in the LYST gene. This results in abnormal granules in skin and immune cells, leading to partial albinism, infections, and neuropathy. Without treatment, an accelerated phase can develop with fever, bleeding, infections and organ failure. Diagnosis involves observing giant granules in leukocytes. There is no cure, but bone marrow transplants have been successful in some cases.
El ciclo celular consta de dos procesos clave: la interfase donde la célula crece y duplica su ADN, y la división celular donde se dividen el núcleo y el citoplasma para formar dos células hijas. La interfase incluye las fases G1, S, G2 y G0. La división celular comprende las fases de la mitosis: profase, metafase, anafase y telofase, seguida de la citocinesis para separar el citoplasma. Este ciclo permite el crecimiento, regeneración de
El documento describe las características y tipos de esponjas, así como su reproducción asexual y sexual. Las esponjas habitan en medios acuáticos, carecen de sistema de órganos y son asimétricas y filtradoras. Se reproducen asexualmente por gemación y sexualmente cuando los espermatozoides fecundan los óvulos dentro de la misma esponja. Existen tres tipos principales de esponjas: asconoide, siconoide y leuconoide.
Las esponjas son animales inferiores acelulares que viven en agua dulce o marina. Carecen de órganos y partes móviles, y se reproducen asexualmente por yemas. Existen cuatro clases principales de esponjas que se diferencian por la composición de su esqueleto interno.
Este documento describe los sistemas reproductivos de varios grupos animales. Explica que la reproducción puede ser asexual o sexual, y proporciona ejemplos de cada tipo para poríferos, cnidarios, platelmintos, nemátodos, anélidos, arácnidos, insectos, crustáceos, moluscos, equinodermos, peces, anfibios, reptiles, aves y mamíferos. También describe los procesos de fecundación, larvas y modos de desarrollo para muchos de estos grupos.
severe combined immunodeficiency syndromeFatima Sayeed
Severe combined immunodeficiency syndrome (SCID) is a rare genetic disorder characterized by the absence of both T cells and B cells. This leaves the body unable to fight infections and affected infants often develop severe, life-threatening infections within the first year of life if untreated. There are 13 known genetic causes of SCID. The main treatment is a bone marrow transplant from a matched donor, which can cure the condition if performed early in life. Gene therapy is also being explored as a potential treatment.
Chédiak-Higashi syndrome is a rare autosomal recessive disorder caused by mutations in the LYST gene. This results in abnormal granules in skin and immune cells, leading to partial albinism, infections, and neuropathy. Without treatment, an accelerated phase can develop with fever, bleeding, infections and organ failure. Diagnosis involves observing giant granules in leukocytes. There is no cure, but bone marrow transplants have been successful in some cases.
El ciclo celular consta de dos procesos clave: la interfase donde la célula crece y duplica su ADN, y la división celular donde se dividen el núcleo y el citoplasma para formar dos células hijas. La interfase incluye las fases G1, S, G2 y G0. La división celular comprende las fases de la mitosis: profase, metafase, anafase y telofase, seguida de la citocinesis para separar el citoplasma. Este ciclo permite el crecimiento, regeneración de
El documento describe las características y tipos de esponjas, así como su reproducción asexual y sexual. Las esponjas habitan en medios acuáticos, carecen de sistema de órganos y son asimétricas y filtradoras. Se reproducen asexualmente por gemación y sexualmente cuando los espermatozoides fecundan los óvulos dentro de la misma esponja. Existen tres tipos principales de esponjas: asconoide, siconoide y leuconoide.
Las esponjas son animales inferiores acelulares que viven en agua dulce o marina. Carecen de órganos y partes móviles, y se reproducen asexualmente por yemas. Existen cuatro clases principales de esponjas que se diferencian por la composición de su esqueleto interno.
Este documento describe los sistemas reproductivos de varios grupos animales. Explica que la reproducción puede ser asexual o sexual, y proporciona ejemplos de cada tipo para poríferos, cnidarios, platelmintos, nemátodos, anélidos, arácnidos, insectos, crustáceos, moluscos, equinodermos, peces, anfibios, reptiles, aves y mamíferos. También describe los procesos de fecundación, larvas y modos de desarrollo para muchos de estos grupos.
This document provides an overview of how to design experiments. It discusses key elements like defining research questions and hypotheses, choosing subjects randomly, controlling for different types of noise, and ensuring internal and external validity. It emphasizes randomization and controlling independent variables to properly demonstrate causal relationships. The document also covers organizing and analyzing data, including keeping configuration files and scripts to check for technical issues during experiments.
This document discusses various research designs used in nursing research. It defines research design as the plan or blueprint for conducting a study. Experimental designs aim to identify cause-effect relationships through manipulation of independent variables and use of control groups. True experiments allow the highest level of control but quasi-experiments and pre-experimental designs are also used when true experiments are not possible. Non-experimental designs observe variables without manipulation and are used when variables cannot be manipulated or experiments would be unethical.
This document provides an overview of quantitative research methods. It begins by defining quantitative research as objective and empirical, utilizing numerical data and analysis. It then describes key characteristics of quantitative research like clearly defined research questions, structured instruments, and large sample sizes. Strengths are listed as being objective, replicable, and allowing for statistical analysis, while weaknesses include high costs and potential inaccuracy. Different types of quantitative research are defined, including descriptive, correlational, experimental, and survey research. The document concludes by explaining key concepts in quantitative research like variables, and distinguishing between independent, dependent, intervening, and confounding variables.
Methods of Psychology Class XI PsychologyAngelinemaryb
Scientific Methods in Psychology -
observation, case study, surveys,
psychological tests, experimentation – steps.
Psychological tests and their uses.
The application of scientific methods in the
study of behaviour. What is meant by
scientific observation? Field study;
controlled and uncontrolled observation;
longitudinal and cross-sectional studies; the
case history method; the experimental method
- variables and controls - steps in an
experiment; surveys and use of
questionnaires/self-reports. One advantage
and one disadvantage for each method of
Psychology. Meaning of samples (random,
biased, representative); meaning of
population. Psychological tests –
characteristics, definition, uses and types.
(ii) Interpretation of research results – use of
statistics in interpretation of data understanding of why statistics is used
(descriptive & inferential). Basic statistical
concepts – statistics, sample, population
This tutorial corresponds with Module A Lesson 2 and should be completed by students enrolled in Professor Hokerson's Psychology 300 online class at American River College.
Introduction To Psychological Science Canadian 2nd Edition Krause Test BankStaceyDays
Full download : http://alibabadownload.com/product/introduction-to-psychological-science-canadian-2nd-edition-krause-test-bank/ Introduction To Psychological Science Canadian 2nd Edition Krause Test Bank
Final_Huntington_s Disease_Voluntary Movement and the Mechanisms for Failure_...Jaime Knoch
This document provides an instructor's manual for teaching a unit on Huntington's Disease. It includes an overview of the unit content, which covers brain anatomy, movement pathways in the basal ganglia, neurotransmitters involved in movement, genetics of HD, and cognitive/psychological effects of HD. The unit utilizes activities to reinforce learning. Students will be assessed through a unit test, activities, class participation, take-home research questions, and homework assignments. The unit is designed for a grade 12 university biology class and can be taught over 5 lecture periods, with accompanying activities for each topic.
This document provides information about the Bhatia Battery of Performance Test of Intelligence, which is one of the practicals to be conducted by MA Psychology students. It discusses the origins and early developments of intelligence testing, defining intelligence and noting it is a difficult concept to measure. It describes Binet and Simon's early intelligence tests from 1905 and the subsequent revisions by Terman. Students will conduct the Bhatia Battery practical, which involves administering the test, scoring it, and interpreting the results.
The document provides an overview of research methods and objectives for an AP Psychology class. It defines different types of research such as experiments, correlational studies, surveys, naturalistic observations, and case studies. It explains that research design determines reasonable conclusions that can be drawn from studies. Experiments are useful for determining cause and effect, while controls reduce alternative explanations. The document outlines chapter objectives, including describing experimentation and research methods, identifying variables, distinguishing random assignment from selection, and applying statistics. It provides a schedule of lesson topics such as the controlled experiment, research validity and reliability, and ethics.
This document provides an overview and instructions for assignments in PSY 335 Research Methods. It includes instructions for completing an APA Code of Ethics activity in Week 1. In Week 2, students watch a video on nonexperimental research methods and complete a descriptive methods worksheet listing research methods and their advantages and disadvantages. They also complete a proposal worksheet developing a research topic as a team. Week 3 includes a quiz on experimental design and writing a methods paper discussing their proposal. Week 4 includes an experimental designs worksheet and developing an IRB application for their proposed study.
The document discusses the different types of quantitative research, including survey research and experimental research. It defines survey research as using questionnaires to collect data from a sample at one or more points in time, while experimental research examines causal relationships by applying treatments to experimental and control groups. The key components of each type are described, such as survey design, variables, and data analysis techniques. Examples are provided of how quantitative research is applied across various fields like medicine, psychology, business, and more.
This document discusses research design and different types of research designs. It begins by defining research design as the conceptual framework for a research study that determines what data needs to be collected and how it will be analyzed. It then lists factors that should be considered in research design such as the study topic, objectives, data collection methods, and analysis. The document outlines different types of research designs including exploratory, descriptive, diagnostic, and experimental designs. It provides examples of designs within each type and principles that govern experimental designs such as replication and randomization.
This document provides an overview of different research designs including randomized controlled trials (RCTs), quasi-experimental designs, and observational studies. It discusses the key aspects of RCTs such as random assignment to experimental and control groups to prevent bias. Quasi-experimental designs are described as not using random assignment but comparing an intervention group to a control group. Observational studies simply observe behaviors without any intervention. The advantages and disadvantages of these designs are presented along with examples of threats to internal validity.
This chapter discusses quantitative research methodology. It outlines two major quantitative research designs: experimental and non-experimental. Experimental designs manipulate independent variables and include true experiments, quasi-experiments, and pre-experiments. Non-experimental designs do not manipulate variables and include survey studies, correlational studies, and evaluation studies. The chapter also describes threats to internal and external validity in experimental research and provides examples of different quantitative research methods.
This document outlines an experimental research methods assignment for a group of students at Addis Ababa University College of Veterinary Medicine and Agriculture. It discusses key aspects of experimental design including objectives, variables, validity, types of designs, and potential sources of invalidity. The group's assignment is to design an experiment and address factors such as controls, randomization, measurements, and data analysis. Attention to these elements in the planning stage can help produce reliable and valid experimental results.
Group 1 -topic learning theory and researchjenychu1703
The document discusses theories of learning and assessment. It covers three main topics: learning theory, research, and assessment of learning. For learning theory, it describes definitions of learning theory and different types of learning theories including behaviorism, cognitivism, and constructivism. For research, it discusses the significance of research in relation to theory and teaching as well as different research models. For assessment of learning, it defines assessment and describes traditional and alternative assessment methods.
Chapter 8 Quantitative Research Methodologies.pptPatrickLlamas2
Variables are concepts that can be measured and used in quantitative research. They can be dependent or independent, and can also be mediating, moderating, or confounding. There are several types of quantitative research methods, including survey research, experimental research, and correlational research. Survey research involves administering standardized questionnaires to a sample. Experimental research manipulates an independent variable and measures its effect on a dependent variable using experimental and control groups. Correlational research examines relationships between variables without manipulation.
Please Subscribe to this Channel for more solutions and lectures
http://www.youtube.com/onlineteaching
Chapter 1: Introduction to Statistics
Section 1.3: Collecting Sample Data
The document describes the scientific method, which consists of 7 steps: 1) make observations, 2) state the problem, 3) collect preliminary data, 4) formulate a hypothesis, 5) test the hypothesis through experiments that have independent and dependent variables as well as control and experimental groups, 6) collect and analyze data, and 7) draw a conclusion. It provides examples of applying these steps, such as designing an experiment to test the hypothesis that plants can grow without direct sunlight.
This document provides an overview of how to design experiments. It discusses key elements like defining research questions and hypotheses, choosing subjects randomly, controlling for different types of noise, and ensuring internal and external validity. It emphasizes randomization and controlling independent variables to properly demonstrate causal relationships. The document also covers organizing and analyzing data, including keeping configuration files and scripts to check for technical issues during experiments.
This document discusses various research designs used in nursing research. It defines research design as the plan or blueprint for conducting a study. Experimental designs aim to identify cause-effect relationships through manipulation of independent variables and use of control groups. True experiments allow the highest level of control but quasi-experiments and pre-experimental designs are also used when true experiments are not possible. Non-experimental designs observe variables without manipulation and are used when variables cannot be manipulated or experiments would be unethical.
This document provides an overview of quantitative research methods. It begins by defining quantitative research as objective and empirical, utilizing numerical data and analysis. It then describes key characteristics of quantitative research like clearly defined research questions, structured instruments, and large sample sizes. Strengths are listed as being objective, replicable, and allowing for statistical analysis, while weaknesses include high costs and potential inaccuracy. Different types of quantitative research are defined, including descriptive, correlational, experimental, and survey research. The document concludes by explaining key concepts in quantitative research like variables, and distinguishing between independent, dependent, intervening, and confounding variables.
Methods of Psychology Class XI PsychologyAngelinemaryb
Scientific Methods in Psychology -
observation, case study, surveys,
psychological tests, experimentation – steps.
Psychological tests and their uses.
The application of scientific methods in the
study of behaviour. What is meant by
scientific observation? Field study;
controlled and uncontrolled observation;
longitudinal and cross-sectional studies; the
case history method; the experimental method
- variables and controls - steps in an
experiment; surveys and use of
questionnaires/self-reports. One advantage
and one disadvantage for each method of
Psychology. Meaning of samples (random,
biased, representative); meaning of
population. Psychological tests –
characteristics, definition, uses and types.
(ii) Interpretation of research results – use of
statistics in interpretation of data understanding of why statistics is used
(descriptive & inferential). Basic statistical
concepts – statistics, sample, population
This tutorial corresponds with Module A Lesson 2 and should be completed by students enrolled in Professor Hokerson's Psychology 300 online class at American River College.
Introduction To Psychological Science Canadian 2nd Edition Krause Test BankStaceyDays
Full download : http://alibabadownload.com/product/introduction-to-psychological-science-canadian-2nd-edition-krause-test-bank/ Introduction To Psychological Science Canadian 2nd Edition Krause Test Bank
Final_Huntington_s Disease_Voluntary Movement and the Mechanisms for Failure_...Jaime Knoch
This document provides an instructor's manual for teaching a unit on Huntington's Disease. It includes an overview of the unit content, which covers brain anatomy, movement pathways in the basal ganglia, neurotransmitters involved in movement, genetics of HD, and cognitive/psychological effects of HD. The unit utilizes activities to reinforce learning. Students will be assessed through a unit test, activities, class participation, take-home research questions, and homework assignments. The unit is designed for a grade 12 university biology class and can be taught over 5 lecture periods, with accompanying activities for each topic.
This document provides information about the Bhatia Battery of Performance Test of Intelligence, which is one of the practicals to be conducted by MA Psychology students. It discusses the origins and early developments of intelligence testing, defining intelligence and noting it is a difficult concept to measure. It describes Binet and Simon's early intelligence tests from 1905 and the subsequent revisions by Terman. Students will conduct the Bhatia Battery practical, which involves administering the test, scoring it, and interpreting the results.
The document provides an overview of research methods and objectives for an AP Psychology class. It defines different types of research such as experiments, correlational studies, surveys, naturalistic observations, and case studies. It explains that research design determines reasonable conclusions that can be drawn from studies. Experiments are useful for determining cause and effect, while controls reduce alternative explanations. The document outlines chapter objectives, including describing experimentation and research methods, identifying variables, distinguishing random assignment from selection, and applying statistics. It provides a schedule of lesson topics such as the controlled experiment, research validity and reliability, and ethics.
This document provides an overview and instructions for assignments in PSY 335 Research Methods. It includes instructions for completing an APA Code of Ethics activity in Week 1. In Week 2, students watch a video on nonexperimental research methods and complete a descriptive methods worksheet listing research methods and their advantages and disadvantages. They also complete a proposal worksheet developing a research topic as a team. Week 3 includes a quiz on experimental design and writing a methods paper discussing their proposal. Week 4 includes an experimental designs worksheet and developing an IRB application for their proposed study.
The document discusses the different types of quantitative research, including survey research and experimental research. It defines survey research as using questionnaires to collect data from a sample at one or more points in time, while experimental research examines causal relationships by applying treatments to experimental and control groups. The key components of each type are described, such as survey design, variables, and data analysis techniques. Examples are provided of how quantitative research is applied across various fields like medicine, psychology, business, and more.
This document discusses research design and different types of research designs. It begins by defining research design as the conceptual framework for a research study that determines what data needs to be collected and how it will be analyzed. It then lists factors that should be considered in research design such as the study topic, objectives, data collection methods, and analysis. The document outlines different types of research designs including exploratory, descriptive, diagnostic, and experimental designs. It provides examples of designs within each type and principles that govern experimental designs such as replication and randomization.
This document provides an overview of different research designs including randomized controlled trials (RCTs), quasi-experimental designs, and observational studies. It discusses the key aspects of RCTs such as random assignment to experimental and control groups to prevent bias. Quasi-experimental designs are described as not using random assignment but comparing an intervention group to a control group. Observational studies simply observe behaviors without any intervention. The advantages and disadvantages of these designs are presented along with examples of threats to internal validity.
This chapter discusses quantitative research methodology. It outlines two major quantitative research designs: experimental and non-experimental. Experimental designs manipulate independent variables and include true experiments, quasi-experiments, and pre-experiments. Non-experimental designs do not manipulate variables and include survey studies, correlational studies, and evaluation studies. The chapter also describes threats to internal and external validity in experimental research and provides examples of different quantitative research methods.
This document outlines an experimental research methods assignment for a group of students at Addis Ababa University College of Veterinary Medicine and Agriculture. It discusses key aspects of experimental design including objectives, variables, validity, types of designs, and potential sources of invalidity. The group's assignment is to design an experiment and address factors such as controls, randomization, measurements, and data analysis. Attention to these elements in the planning stage can help produce reliable and valid experimental results.
Group 1 -topic learning theory and researchjenychu1703
The document discusses theories of learning and assessment. It covers three main topics: learning theory, research, and assessment of learning. For learning theory, it describes definitions of learning theory and different types of learning theories including behaviorism, cognitivism, and constructivism. For research, it discusses the significance of research in relation to theory and teaching as well as different research models. For assessment of learning, it defines assessment and describes traditional and alternative assessment methods.
Chapter 8 Quantitative Research Methodologies.pptPatrickLlamas2
Variables are concepts that can be measured and used in quantitative research. They can be dependent or independent, and can also be mediating, moderating, or confounding. There are several types of quantitative research methods, including survey research, experimental research, and correlational research. Survey research involves administering standardized questionnaires to a sample. Experimental research manipulates an independent variable and measures its effect on a dependent variable using experimental and control groups. Correlational research examines relationships between variables without manipulation.
Please Subscribe to this Channel for more solutions and lectures
http://www.youtube.com/onlineteaching
Chapter 1: Introduction to Statistics
Section 1.3: Collecting Sample Data
The document describes the scientific method, which consists of 7 steps: 1) make observations, 2) state the problem, 3) collect preliminary data, 4) formulate a hypothesis, 5) test the hypothesis through experiments that have independent and dependent variables as well as control and experimental groups, 6) collect and analyze data, and 7) draw a conclusion. It provides examples of applying these steps, such as designing an experiment to test the hypothesis that plants can grow without direct sunlight.
Phenomics assisted breeding in crop improvementIshaGoswami9
As the population is increasing and will reach about 9 billion upto 2050. Also due to climate change, it is difficult to meet the food requirement of such a large population. Facing the challenges presented by resource shortages, climate
change, and increasing global population, crop yield and quality need to be improved in a sustainable way over the coming decades. Genetic improvement by breeding is the best way to increase crop productivity. With the rapid progression of functional
genomics, an increasing number of crop genomes have been sequenced and dozens of genes influencing key agronomic traits have been identified. However, current genome sequence information has not been adequately exploited for understanding
the complex characteristics of multiple gene, owing to a lack of crop phenotypic data. Efficient, automatic, and accurate technologies and platforms that can capture phenotypic data that can
be linked to genomics information for crop improvement at all growth stages have become as important as genotyping. Thus,
high-throughput phenotyping has become the major bottleneck restricting crop breeding. Plant phenomics has been defined as the high-throughput, accurate acquisition and analysis of multi-dimensional phenotypes
during crop growing stages at the organism level, including the cell, tissue, organ, individual plant, plot, and field levels. With the rapid development of novel sensors, imaging technology,
and analysis methods, numerous infrastructure platforms have been developed for phenotyping.
Or: Beyond linear.
Abstract: Equivariant neural networks are neural networks that incorporate symmetries. The nonlinear activation functions in these networks result in interesting nonlinear equivariant maps between simple representations, and motivate the key player of this talk: piecewise linear representation theory.
Disclaimer: No one is perfect, so please mind that there might be mistakes and typos.
dtubbenhauer@gmail.com
Corrected slides: dtubbenhauer.com/talks.html
Describing and Interpreting an Immersive Learning Case with the Immersion Cub...Leonel Morgado
Current descriptions of immersive learning cases are often difficult or impossible to compare. This is due to a myriad of different options on what details to include, which aspects are relevant, and on the descriptive approaches employed. Also, these aspects often combine very specific details with more general guidelines or indicate intents and rationales without clarifying their implementation. In this paper we provide a method to describe immersive learning cases that is structured to enable comparisons, yet flexible enough to allow researchers and practitioners to decide which aspects to include. This method leverages a taxonomy that classifies educational aspects at three levels (uses, practices, and strategies) and then utilizes two frameworks, the Immersive Learning Brain and the Immersion Cube, to enable a structured description and interpretation of immersive learning cases. The method is then demonstrated on a published immersive learning case on training for wind turbine maintenance using virtual reality. Applying the method results in a structured artifact, the Immersive Learning Case Sheet, that tags the case with its proximal uses, practices, and strategies, and refines the free text case description to ensure that matching details are included. This contribution is thus a case description method in support of future comparative research of immersive learning cases. We then discuss how the resulting description and interpretation can be leveraged to change immersion learning cases, by enriching them (considering low-effort changes or additions) or innovating (exploring more challenging avenues of transformation). The method holds significant promise to support better-grounded research in immersive learning.
Current Ms word generated power point presentation covers major details about the micronuclei test. It's significance and assays to conduct it. It is used to detect the micronuclei formation inside the cells of nearly every multicellular organism. It's formation takes place during chromosomal sepration at metaphase.
hematic appreciation test is a psychological assessment tool used to measure an individual's appreciation and understanding of specific themes or topics. This test helps to evaluate an individual's ability to connect different ideas and concepts within a given theme, as well as their overall comprehension and interpretation skills. The results of the test can provide valuable insights into an individual's cognitive abilities, creativity, and critical thinking skills
PPT on Direct Seeded Rice presented at the three-day 'Training and Validation Workshop on Modules of Climate Smart Agriculture (CSA) Technologies in South Asia' workshop on April 22, 2024.
The technology uses reclaimed CO₂ as the dyeing medium in a closed loop process. When pressurized, CO₂ becomes supercritical (SC-CO₂). In this state CO₂ has a very high solvent power, allowing the dye to dissolve easily.
Basics of crystallography, crystal systems, classes and different forms
Psych 302 Midterm Study Guide
1. Ibtihal Makki
Section 007
Psych 302 Midterm Study Guide
Week 1- Introduction
Lecture/ Lecture reading:
● Cognitive Neuroscience focuses on the neuronal mechanisms by which various
mental processes occur.
● Keys to Conducting an fMRI study
a. Design behavioral task: Isolate psychological process that you are interested
in
b. Modify the behavioral task to make it appropriate for an fMRI study
c. Analyze behavioral and fMRI data
● Experimental Design (Ch. 6, “Experimental Design in Psychological Research)
a. Variables are carefully controlled
b. 4 Goals
i. Describe
i.e. early astronomers describing the positions and motions of stars
ii. Predict
i.e. through careful observations and documentation, later astronomers
because skillful at predicting planetary stellar motion
iii. Determine causes
i.e. Newton’s laws of motion and Einstein’s special and general theories of
relatively thereby explaining the causes of stellar motion
iv. Explain
i.e. A full explanation is not yet elusive because using gravity as an explanation
is merely a label for the phenomenon and doesn’t explain how gravity works.
c. 3 major types
i. Controlled (“true”)
● RANDOM ASSIGNMENT, identical experimental conditions,
independent variable, dependent variable.
ii. Correlational
● Relies on patterns of co-occurrence or correlations between
events
● Classical ex- cigarette smoking and cancer; problem: “factor x”
iii. Descriptive
● Seek to describe an aspect of the world as it is
● I.e- which part of the brain is activated when a person
performs a mental calculation
d. Study designs
i. Between-subjects
● Each group is in ONE condition ONLY= independent group
design
2. ii. Within-subjects
● Every subject is tested in EVERY condition= repeated measures
design
● Advantage: smaller number of subjects required
● Disadvantage: demand characteristics- subjects are not as
naive about the experimental manipulation, carryover effects,
order effects
e. Confounds
i. Clever Hans
● Horse- became famous following demonstrations in which he
performed simple addition and subtraction by tapping his hoof
on the ground
● Problem: it was discovered that Hans became adept at picking
up subtle movements on the part of the questioner that cued
him to stop tapping his hoof
f. Ethical Considerations
i. Informed consent
● Subjects given an accurate description of their task, risks,
allowed to leave experiment
ii. Debriefing
● Following experiment, subject given an explanation of the
hypothesis and methods
iii. Privacy/Confidentiality
● Subject information that is collected is coded and stored in a
way that leaves identities confidential
iv. Fraud
● Data should not be fabricated and false
data/analyses/conclusions should never be knowingly
published.
g. Analyzing Data
i. Measurement error
ii. Significance testing
● Reproducibility of experiments in psychological science
● Distraction slides included in notes under “Week 2”
Lab Readings
Botvinick et al. (1999). “Conflict monitoring versus selection-for-action in anterior
cingulate cortex
● Hypothesis: 2 Possible function of ACC:
1. Conflict Monitoring
3. 2. Selection for action
The ACC is involved in regulating attention and functions via conflict monitoring
● Basic Procedure: Used fMRI and flanker test (arrows) to measure brain activation in
the ACC
● Main Result: ACC had increased activation during the CI trails high levels of conflict;
weak selection for action→ evidence supports conflict-monitoring theory.
Conclusion: The role of the ACC is conflict detection
● Limitations: Feature repetitions only occur on cC and iI trials: Maybe CSE is really
just a learning effect. Mental rotation confounds.
Mayr et al. (2003). “Conflict adaptation effects in the absence of executive control”
● Hypothesis: The conflict adaptation effect is due to repetition priming and will be:
○ present when the target and flanker are repeated
○ absent when either the target or flanker change
● Basic Procedure:
Study 1: Which direction does the central arrow point? Measure cC, cI, iI, and iC
trials: Determine if (cI-cC)>(iI-iC) as a function of repetition
Study 2: Same question; to prevent stimulus repetitions, alternated between L/R
and U/D arrows
● Main Results:
Study 1: Conflict adaption only in repetition trials: consistent with hypothesis;
contradicts conflict monitoring model
Study 1: No observed conflict adaption: consistent with hypothesis; contradicts
conflict monitoring model
● Limitations: mental rotation confounds
Week 2- Conflict Adaptation
Lecture/ Lecture reading:
● Coping with Distractions: we are constantly inundated with stimuli and need to
selectively attend to certain tasks while ignoring to “distractors”
● Laboratory tasks for investigating distraction
○ Stroop-like task (green/red)
■ Often have many trials
○ Flanker task (arrows)
○ Simon task (left/right)
● Congruency effect: reaction times (RT) for subjects is faster during congruent trials
when compared to incongruent trials in selective attention tasks.
● Congruency sequence effect: the congruency effect is smaller in trials following
incongruent trials when compared to congruent trials
4. ● Mechanisms underlying CSE:
○ Selection for Action: -shifting attention to something
■ Perceptual expectation
■ Conflict monitoring
● ACC/conflict monitoring
Botvinick et al 1999 investigated if the ACC underlies selection for
action or whether it triggers it through conflict monitoring
**Explained above in Week 1 Lab readings**
■ Negative effect
○ Response Inhibition: inhibit response primed by distractor
● Influences on the CSE: Learning/memory processes
○ Feature repetitions: (Mayr 2-AFC flanker task) only occur on cC and iI trials:
Maybe CSE is really just a learning effect.
○ Contingency learning biases- participant learn to prepare the congruent
response signaled by the distracted (i.e. in Ullsperger’s 9-AFC digit flanker
task) because it is more likely to be correct and so can lead to a confound
driven CSE
● Mental rotation confounds
○ In experiments that utilize arrows as stimuli, it is important to realize that
each arrow stimulus is a mental rotation of the other arrow stimuli.
● CSE without confounds
Reading: Schmidt & Weissman (2014). “Congruency sequence effects without feature
integration or contingency learning confounds”
● Hypothesis: A CSE can be observed without feature repetition, contingency learning,
or mental rotation confounds
● Basic procedure:
4-AFC task → a pair of 2-AFC tasks
○ Example: “left-right” versus “up-down”
Alternated between these 2 tasks on every trial
○ Each task performed with a different hand (index & middle fingers)
Presented congruent/incongruent stimuli equally often in each task
Counterbalanced congruent/incongruent trials in every block
○ Ensured equal numbers of cC, cI, iC, & iI trials
● Main result: A CSE can be observed independent of feature repetitions and
contingency learning confounds
● Limitations: This suggests that a control process influences the CSE, but does not
reveal which one: (Selection for Action or Response inhibition)
Class experiment:
Goal- Distinguish between Selection for Action and Response inhibition accounts
5. Method: vary the temporal interval separating the distractor from the target
Task: indicate the direction of the word specified by the large target word left, right, up,
down) and not the preceding distractor.
● If the selection for action account is correct, there should be no congruency effect
after incongruent trials because with long intervals separating the distractor and
target, it should be the case that subjects are able to shift their attention to the
target, entirely.
● If the response inhibition account is correct, there should be an observed negative
or reverse congruency effect after incongruent trials because with long intervals
separating the distractor and target, it should be the case that subjects are able to
inhibit the response signaled by the distractor, fully.
Week 3-Basic Statistics
Lecture/ Lecture reading:
Reading- Statistics Review 5: Comparison of Means
The following notes integrate the lecture slides with the reading
● Stats describes how likely a particular sample mean is to come from the distribution
associated with the null hypothesis
● P-value is the probably that the sample mean came from that null distribution (one-
or two-tailed tests)
● Comparison of a single mean with a hypothesized value
○ To compare a mean value from a sample mean to an external standard (i.e
hemoglobin concentrations in UK males to the standard).
● Comparison of two means arising from paired data
○ Paired data arise in matched case-control studies or repeated measures
studies
● Comparison of two means arising from unpaired data
○ Comparison of two means arising from unpaired data (i.e. comparison of data
from two independent groups)
● Assumptions and limitations
○ Unpaired t-test relies on the assumption that the data from the two samples
are both normally distributed
● Main effects and Interactions
○ Main effect: effect of a single independent variable on a dependent variable;
all other independent variables are ignored
○ Interaction: the different conditions for an independent variable produce
different results depending on which condition you consider for a second
independent variable (difference of differences).
6. ○ The Youtube video posted by professor weissman on the canvas site is very
helpful (https://www.youtube.com/watch?v=OE46w0RqmQA)
Lab Readings
Ullsperger et al. (2005, skip Experiment 1). “The conflict adaptation effect: It’s not just
priming”
● Hypothesis: Their experiment would reveal a CSE on trial sequences not involving
stimulus repetitions
● Basic procedure: Indicate the underscored target digit (1-9), which was surrounded
by two identical flanker digits on either side (presented at the same time)
● Results: CSEs were demonstrated by the experimentation
● Limitations: Contingency learning bias multiplied # of compatible trials by 8,
made it possible for subjects to guess that 50% of the trial would be compatible
Kunde & Wuhr (2006, skip Experiment 2). “Sequential modulations of correspondence
effects across spatial dimensions and tasks
● Hypothesis: Repetition/alternation account exists if sequential modulation of SR
compatibility effects are absent and response conflict account exists if sequential
modulations of SR compatibility effects persist.
● Basic procedure: 4-AFC prime-probe task with left, right, up, and down arrows
● Results: Observed a CSE even in trials without exact feature repetitions or
contingency learning biases
● Limitation: Arrow stimuli = mental rotations of the same arrow stimulus
Week 4-Scientific Writing
Lecture(no lecture slides)
Lecture reading: Commentary, the art of writing science
The elements of Scientific Style:
● Word choice
○ Do not invent new words or phrases, use words already in the literature.
○ Avoid abbreviations (i.e. use ‘‘the forward rate constant’’ rather than ‘kf’)
○ Avoid arbitrary names (i.e. use ‘‘protein dilution buffer’’ instead of “buffer A”)
○ Use formal, precise words rather than colloquial, ambiguous ones (i.e. ‘‘these
data show’’ is less precise than ‘‘these data indicate)
○ Use present tense when possible
● Sentences
○ Don’t use passive voice
○ Vary sentence length across a paragraph
○ Symmetrical language, parallel structures within and between sentences
● Paragraphs
7. ○ First sentence: tell reader what they will expect
○ Discuss a single idea per paragraph
○ Transition logically between sentences and between paragraphs
The elements of a scientific paper
● Title: highlight the main result of the study, not the main effort
● Introduction
○ One purpose: convince readers to read the paper
○ Convince readers the question is important and give a reason for them to
care
○ Prime readers to expect an answer
○ Keep the intro short
○ Start broad and progress into specific details
● Results
○ Provide conceptual tools to understand the results
○ Minimal discussion
● Discussion
○ Reiterate point blatantly
○ Speculate on implications
○ Start specific and give wider ideas
● Methods
○ Every necessary detail were someone to attempt to reproduce your work
○ Watch tenses here too
● Figures/captions
○ Clearly and concisely tell the reader what you expect them to learn from
figures in the caption
● Abstract
○ The entire paper in brief
○ Should start with a blunt sentence describing the broad field
○ Followed by as sentence describing the specific problem at hand
○ Next sentence states what the reader should expect to learn
○ Briefly describe results and conclusion
Most important rule: ignore any and all rules if doing so makes the paper easier to read
● Purdue reading, main points:
○ Use plain, concise and clear language
○ Psychology bases arguments on evidence based reasoning
○ Use APA format
No Lab readings
Week 5- What is fMRI?
8. Lecture/ Lecture reading:
The following notes integrate the lecture slides with the reading
“What is fMRI?”
● fMRI is a technique used to measure brain activity
● When a brain area is more active, it consumes more oxygen and to meet this
increased demand, blood flow increases to that area
● Advantages:
1. Non-invasive and doesn’t use radiation (safe)
2. Excellent spatial and good temporal resolution
3. Easy for experimentation to use
● Key: the signal from hydrogen nuclei varies in strength depending on surroundings
○ Provides a means of discriminating between gray matter, white matter and
cerebrospinal fluid in structural images of the brain
● BOLD signal
○ An indirect measure of neural activity
○ Since blood oxygenation varies according to the levels of neural activity,
differences in magnetic properties of hemoglobin (diamagnetic when
oxygenated and paramagnetic when deoxygenated) can be used to detect
brain activity
Ch. 4 “The imaged brain” from the “Student’s Guide to Cognitive Neuroscience” by Ward
● Structural vs functional imaging methods
● Computerized tomography (CT)
○ Construed according to x0ray absorption in different types of tissue
■ Typically used only in clinical settings (diagnosing tumors, identifying
hemorrhaging, etc.)
● Advantages of MRI (some of this is similar to the information from the reading
above):
○ Does not use ionizing radiation, is safe
○ Provides better spatial resolution (individual gyri discrete)
○ Provides better discrimination between white and gray matter
○ Can be adapted for use in detecting blood oxygenation changes associated
with neural activity (fMRI)
● Structural MRI is used to study brain anatomy while Functional MRI is used to study
brain function
● Diffusion tensor imaging (DTI)
○ MRI based methods for imaging the axon tracts that form the white matter of
the brain
○ Measures density and motion of water traveling along myelin-covered axons
○ Water normally diffused in all directions but since myelin has a lipid
boundary, that biases water to move along the length of the axon
9. ○ Measuring this movement can create images of white matter tracts in brain
● Basic physiology underpinning functional imaging
○ Brain consumes a fifth of the body’s oxygen uptake, does not store oxygen
and little glucose
○ Blood supply to an activated region must increase to meet the demand
○ Brain is always physiologically active
● PET
○ Uses a radioactive tracer injected into the bloodstream
○ Greater blood flow i a region indicated by a greater signal being emitted by
the racer in that region
○ Usually oxygen-15 or fluorine-18
● More fMRI information
○ The way the BOLD signal evolves over time in response to an increase in
neural activity is called the hemodynamic response function (HRF)
○ HRF has 3 phases:
1. Initial dip
2. Overcompensation
3. Undershoot
● Cognitive theory
○ Cognitive subtraction: by comparing the activity of the brain in a task that
utilizes a particular cognitive component to the activity of the brain in a
baseline task that does not, it is possible to infer which regions are
specialized for that particular cognitive component
○ Problems: assumption of pure insertions and interactions make imaging data
ambiguous
● Parametric vs categorical design
○ Continuous vs categorical variables
● Functional integration: refers to the way in which different regions communicate
with each other
○ It is likely to be essential for a full understanding of how cognition is linked
to the brain
The rest of this reading is described in week 6 material since it relates to the lecture
notes from that week!
● Sports and head injury
○ Concussions and subconcussive hits in many sports are suggested to be
associated with chronic traumatic encephalopathy (CTE)
■ Buildup of tau protein, problems with memory, concentration,
depression, anger
■ Stricter policies implemented in some sports
10. Lab readings:
Parvizi et al. (2013). “The will to persevere induced by electrical stimulation of the human
cingulate gyrus”
● Hypothesis: (1) Activation of the ACC will induce autonomic, emotional, and
cognitive experiences defined as the “will to preserve” and (2) activity in the ACC
will modulate activity in a larger network of connected regions
● Methods: multimodal data acquisition: electrical stimulation and prompting
question, resting fMRI, intracranial implementation, electrical brain stimulation,
heart rate analysis, and patient reports
● Results: Emotional salience network seeded from location of stimulation in both
patients.
● Implications: structural brain anatomy and environmental influences on plasticity
for differences in coping
Coleshill et al. (2004). “Material-specific recognition deficits elicited by Unilateral
Hippocampal Stimulation.”
● Hypothesis: unilateral stimulation-induced hippocampal disruption produces
impairments on delayed RM tasks which supports the material-specific laterality of
hippocampal function with respect to RM.
● Methods: electrode implantation, stimulation, recognition tests (faces, objects,
words)
● Results: double disassociation for the hippocampus’ role in delayed RM: left side,
word RM and right side: face RM deficits.
● Limitations: Small and specific sample size; generalization to a larger population?
Oliver Sacks (1970). “The Man who mistook his wife for a hat”, pages 7-15.
● Dr. P: musician of distinction (teacher)
● Perfectly healthy except problems identifying visual images: faces particularly
● Recognized distinctive features (i.e. jaw/teeth)
● Dr. Sacks examined him: tests with shapes and pictures--couldn’t tell the difference
between his shoe and foot
● Visualization was actually fine but his interpretation of faces/scenes: impaired
● “I think that music, for him, had taken the place of image” -Dr. Sacks
Week 6- How to design fMRI studies
Lecture/ Lecture reading:
The following notes integrate the lecture slides with the reading
Ch. 9, “Experimental Design for fMRI”, Huettel et al. (2009). Functional MRI.
● Experimental design/ Basic principles
11. ○ Functional connectivity: pattern of functional relationships among regions,
inferred from common changes in activation over time; may reflect direct or
indirect links
○ Other terms: research hypothesis, experiment, experimental design,
efficiency, variable, independent variables, conditions, dependent variables
○ Categorical variables: discrete
○ between/within-subject manipulation (explained in week 1)
● Hypothesis:
○ 3 distinct levels:
■ most specific level are about hemodynamic activation
■ second class are about neuronal activity
■ Third is the psychological hypothesis (most difficult to construct)
● Terms to be familiar with: theory, experimental condition, control condition,
epiphenomenal(as it related to correlational interpretations)
● Confounding factors: property that covaries with the independent variable within
the experiment but could be distinguished from the independent variable using a
different design.
○ if an experiment has two conditions (experimental and control; they should
be as similar as possible
○ Terms to be familiar with: Subtraction, randomization, counterbalancing
● Good practices in fMRI design:
1. Evoke cognitive processes of interest
2. Collect as much data as possible from each subject
3. Collect data from as many subjects as possible
4. Choose stimulus condition and the timing to evoke maximal changes in the cognitive
process of interest
5. Organize timing of stimuli so that successively elicited processes of interest are
minimally correlated with each other
6. Obtain measurements of subjects’ behavior if possible
Event-Related vs. Blocked designs
● Blocked design: separation of experimental conditions into two distinct blocks so
that each condition is presented for an extended period of time
○ Consider the length of task blocks for the research question you are
exploring
○ Alternating design: block design in which two conditions are presented one
after another for the duration of the experimental run
○ Control block: contains trials of control conditions
○ null task block: control block in which there is no task requirements for the
subject (baseline)
○ Pros/cons:
12. ■ Pro: Blocked design very good for detecting significant fMRI
activation, the signal to noise ratio should be maximized to the task
frequency
■ Con: Relatively insensitive to the shape of the hemodynamic response
○ Having two block types: counterbalance the order across runs or subjects
■ Resulting signals mainly reveal differences in activity between the
block types
■ Poor estimate of baseline
■ But maximizes our ability to detect differences in activity at the
expense of detecting absolute activity
■ If include low-level baseline condition between blocks, signals reveal:
activity for each block type and differences between blocks
● More efficient at detecting absolute activation but less efficient
at detecting differences
● Event related: presentation of discrete, short-duration events whose timing and
order may be randomized
○ Central assumption: neuronal activity of interest will occur for short and
discrete intervals
○ Terms to understand: event, interstimulus interval, EEG, time-locking, signal
averaging, ERPs
○ Epoch: time segment extracted from the larger series of images, usually
corresponding to the period of time surrounding an event of interest
○ Averaged epch: result of averaging a large number of epochs that are time
locked to similar events
○ Example used in class: cued stroop task, revealed a double dissociation
○ Linearity assumption: do things add up?
■ Sync each trial response to start of trial; not quite linear but good
enough
Design Types:
● Rapid unjittered event-related design (randomized trial order)
○ Examples: Kerns et al. 2004 (short, constant ITI needed to study conflict
adaptation
● Rapid, jittered ER design
○ Example: Recognition memory, wagner et al. 1998
● Communication between brain regions: Functional connectivity-
○ If activity in two regions is correlated across time, these regions may be
communicating
○ Uses: flanker and stroop tasks
13. Week 7- fMRI processing
Lecture/ Lecture reading:
The following notes integrate the lecture slides with the reading
Chapter 4, Preprocessing section (“Analyzing Data from Functional Imaging”, pp. 65-68).
Student’s Guide to Cog Neuroscience
Preprocessing: eliminates variability in the BOLD signal that is not due to the task
1. Slice Timing
Can be interleaved, ascending, or descending
SPM assumes each scan is instantaneous
● Data not collected at the same time but want to make it seem like we did so we
correct for this
● Only needed when temporal dynamics of BOLD responses are important and TR is
small enough to permit interpolation (TR< 3 second)
2. Realignment
● People move around in scanner (pitch, roll, yawn)
● Realignment adjusts for this
● There are ways to prevent movement of subjects, including reminding them!
3. Coregistration
● Brain activation (fMRI) data is aligned with a structural image
4. Normalization
● Wrap each subject’s brain to a template (average) brain
○ Basically nonlinear transformations to get all brains to “fit” in a standard
brain
5. Smoothing
● Still some variability left before doing this step
● Replace intensity value of a voxel with a weighted average of its original value plus
the value of neighboring voxels
○ [voxel: volume-based unit--in imaging research the brain is divided into may
thousands of these]
● Smoothing spreads the activity across voxels: some voxels may be enhanced
whereas others may be reduced
● Comes with the cost of spatial precision
○ Do not use if brain region is very small (1-2 voxels)!