PSL has provided over 1,300 powder processing installations worldwide since being founded in 1989. They offer a range of products including filter dryers, tray dryers, containment isolators, and complete turn-key processing solutions. PSL prides itself on quality, compliance with cGMP guidelines, and supporting customers from research to large-scale production.

2. Business growth over the past 26 years has
allowed over 1,300 PSL installations worldwide.
1989 PSL founded in Liverpool, UK
1991 PSL achieved extreme containment
1992
PSL project leaders (acting on behalf of UNICEF) developed a solution to
eliminate goitre in children in Bangladesh.
1999 Duke of Westminster Award & Queen’s Award for Export Achievement
2001 HRH Prince Andrew visited PSL UK
2004 PSL Filter Dryer redesigned to achieve 2.5ppm reflux cleaning
2009 PSL pioneering CakeStand Tray Dryer design launched
2010 Launch of the Glass Filter Dryer (GFD®)
2013 Pioneering MicroSphere RefinerTM design launched
2013 Best Pharma Technology Provider @ Asia Manufacturing Awards
2014 New addition to GFD range with Stainless Steel Vessel
2014 Best Pharma Technology Provider @ Asia Manufacturing Awards
2014 Best Manufacturing Business @ E3 Business Awards
2015 Best International Business @ NW Entrepreneur Awards
2015 Liverpool Lord Mayor visited PSL UK
2015 Nominated for Exported by Britain by constituency’s MP
2015 Winner of the ACHEMA Innovation Award, Mechanical Processes
2016 Export Champion from the UK Trade & Investment

3. Worldwide
PSL continues to increase its number of global offices, agents and distributors to aid the smooth distribution
of its equipment to any part of the world.

4. Supporting global pharmaceutical, biopharmaceutical, chemical and laboratory
industries since 1989.
See PSL’s Customers Testimonials: http://www.powdersystems.com/testimonials.html

5. Full Scale Ergonomic Mock-upDetailed 3D Modeling …Up to Complete Installation
PSL’s Approach: ‘Solution Efficiency’
PSL takes client’s vision and translates it into their project, providing complete solution efficiency.

6. From lab and R&D to production and complex full process systems.
• Agitated Nutsche Filter Dryers
• Nano-Containment Isolators
Products
• Vacuum Tray Dryers
• Microsphere Formulation

7. Quality Insurance
PSL operates to the highest level of Good Manufacturing Practice (cGMP) and complies with
global regulatory bodies:
ISO 9001:2008 | cGMP | GAMP | CE | ATEX | ASME| PED | UL

8. Full Process Solutions
1) Raw Materials
(Dispensing/Sampling/Charging)
2) Reaction/
Fermentation
3) Filtration/
Drying4) Conditioning
5) Formulation

9. Dispensing and Sampling
Nano-Containment
PSL’s isolators are designed for Laboratories, Clinical Trials
and Production facilities.
• Accommodate all sizes of pharmaceutical
containers
• Achieve high containment levels
• Versatile Solutions
• Powder handling through split valves,
airlocks, rapid transfer ports (RTPs) and
bag out ports
• Completely integrated design: including
hoists, weigh systems, transfer devices,
CIP and safety

10. Containment
Charging
• FIBC reactor direct charging
• Compact small-scale charging isolator
• Slurry vessel charging
• Reactor charging with pressure rated plug

11. Filter Dryers
PSL’s filter dryers are designed for washing and isolating solids with or without integrated
containment systems.
Laboratory (GFD®) Kilo Laboratory Pilot Plant Commercial Production
0.002m2 to 0.05m2 0.03m2 to 0.125m2 0.3m2 to 0.6m2 1m2 to 4m2

12. • Highly efficient drying including direct underplate heating
with no air gap between the base and filtration media
• Minimum gap design
• Reflux cleaning at 2.5ppm to none detectable
• Special agitator design
• Minimum solvent volumes beneath mesh
• Pioneers of direct heal recovery system
Filter Dryers

13. Laboratory Glass Filter Dryers
is a miniature version of a PSL production filter dryer for easy lab-scale filtration and drying.
0.002m2 0.01m2 0.05m2

14. Laboratory Glass Filter Dryers
Lab scale filtration and drying with the same reliability and
benefits as full size PSL filter dryer products:
• Batch homogeneity
• Improved yield
• Reduced product exposure
• Minimum process disruption
• Easy cleaning
• Process visibility
• Removable filter basket

15. Lab scale filtration and drying with metallic vessel for higher pressure requirement and
direct scale up.
Laboratory Filter Dryers

16. Pilot Plant Simple Filter Dryer
• Heated jacket for drying
• Different filtration media
• Vessel discharge hatch
• Nitrogen purged GloveBag with airlock
• Contained sampling

17. Kilo Laboratory Filter Dryers
• Contained discharge, heel removal and sampling
• Available as mobile solution
• Contained discharge
• Fully scalable solution
• Maximum product yield
0.05m² - 0.125m²
Small Scale Production Filter Dryers
0.3m² to 0.6m²

18. Large Scale Production Filter Dryers
• High containment heel and product recovery system available
1m² to 5m²

19. Laboratory (GFD® FilterBox) Kilo Laboratory FilterBox Pilot Plant FilterBox
0.002m2 & 0.01m2 0.05m2 0.125m2 to 0.4m2
High Containment Filter Dryers
Contained filtration and drying through a fully integrated lab to production filter dryer inside a
high containment glove box.

20. Tray Dryer
Tray Dryers
PSL tray dryers can operate in
down flow booths, clean rooms or
in conjunction with PSL
containment isolators.
• Uniform direct tray heating
• Total ease of cleaning
• Enhanced ergonomics

21. MicroSphere Refiner
PSL developed the unique Refiner technology for microsphere formulation from small scale
processes up to production.

22. Microsphere Scalping & Refiner Range
R&D Scale Production Scale
0.002m2 to 0.01m2 0.03m² & 0.05m² 0.125m2 to 0.3m2 Filtration Area
10 to 100 grams 100g to 4.5Kgs > 4.5Kgs Quantity
Non – Sterile Sterile & Non-Sterile Sterile Sterility

23. R&D and Small Scale Microsphere Refiners
0.03m² and 0.05m²
CIP and SIP capabilities
Tiltable discharge

24. Large Scale Microsphere Refiner
0.125m² and 0.3m²
• Gas lift-off mechanical seals
• Unique off-loading designs
• CIP and SIP capabilities

25. Containment
Offloading
PSL’s FlowBox is a single drum filling glovebox
with single/multiple contained glovebox levels for
handling powders of varying potency.
PSL analyse accuracy requirements - delivering
precise weights and catch weights or volumetric
• Fully contained product discharge
• Contained sampling & Heel Recovery system
• Continuous Liner Systems

26. Containment
Milling and Micronizing
Our contained micronizer mill/air jet mill glovebox
are innovatively designed by expert process
engineers for size reduction of active ingredients.
• Milling process assessment including types of mill,
feeders and product collection
• Full safety review including nitrogen protection
system for dust explosion risks
• Sampling method evaluation including integration
of online particle size analysers

27. Containment
Sieving & Blending
PSL’s sieving isolators are designed and manufactured to maximum containment standards down to
nanogram level.
• Material flows analysis including drum sizes, weights and transfers
• Half suit design available providing ergonomic advantage
• Can be engineered alone or with integrated process equipment: mills and micronizers, blenders and weighing scales

28. Containment
Tablets and Capsules
Bespoke high containment retrofit systems for existing capsule filling
machines and tablet presses.
• Swing-out doors with safety interlocks
• Special gloveport retainers
• Contained de-dusting and internal vacuum cleaning system
High Containment Micro Dosing Xcelodose® (from Capsugel):
the Xceloprotect™

29. Small Scale Acrylic Isolator
Laboratory or QA process steps can be contained within a simple
acrylic glovebox for enhanced visibility and cost-effectiveness

30. Total Process Solutions
Multiple process steps can be contained
within a single isolator providing a complete
synthesis or formulation suite.

31. Complete Turn-Key Solution
Containment Testing and Validation
PSL uses a third party industrial hygienist to monitor testing and generate a final OEL test report.
In conjunction with our clients, PSL defines OEL parameters and generate an OEL test protocol
following industry best practice guidelines such as ISPE.

32. Complete Turn-Key Solution
Glove Integrety Testing System
PSL offers solutions to test and validate the glove integrity of high containment isolators and
gloveboxes.
The new PSL Glove Testing System provides a quick, safe and easy method to test fitted pharma
gloves.
• Easy to use, just unpack, insert and start
the automated measurement
• Superior hole detection
• Manual to fully automated measurement,
with WiFi remote control and RFiD built-in
technology
• Customizable in size and shape, tailored
to any glove type and detection
requirements

33. PSL Serve
• Aftercare Service
• Preventative maintenance contracts
• Worldwide emergency call out
• Spare parts including standard consumables and recommended spares
Our reputation for reliability is synonymous with the quality of service that we offer.

34. FILTRATION, DRYING & HIGH CONTAINMENT
POWDER HANDLING SOLUTIONS