This document discusses memory efficiency with closures in Node.js. It defines closures and describes three common use cases: 1) completion handlers where memory is retained until the handler returns; 2) intermediary functions where memory is retained until references are cleared; and 3) listener functions where memory is retained until listeners are removed. It provides examples of each use case and describes how understanding closure semantics is important for developing efficient Node.js code. The document warns that closures can lead to memory leaks if not properly managed and cleared.