This document summarizes Andalusia's regional economic context and strategy for smart specialization. Andalusia has a population of 8.3 million with a GDP dominated by services (70%). The region aims to promote knowledge industry and innovation through 7 strategic sectors: aeronautics, ICT, agroindustry, biotechnology, metalworking, entertainment, and energy/environment. Andalusia's smart specialization strategy (RIS3) involves identifying regional specializations through an entrepreneurial discovery process involving companies, universities, and other stakeholders to establish priorities and policy actions. Progress will be monitored using indicators through the Andalusian Agency for Knowledge and the Smart Specialization Platform.