The document outlines the smart specialization strategy (S3) and cluster policy in the Basque Country, detailing the importance of innovation and collaboration in enhancing regional competitiveness. It highlights the evolution of cluster policies since the 1990s, emphasizing the need for a participative process and effective governance in developing specialized industries while addressing the challenges of local agent capabilities. Conclusions drawn stress the intertwined nature of cluster policies and S3, advocating for synergy between existing frameworks and the importance of patience and long-term commitment in fostering successful innovation strategies.