Prejudice is significant in 'To Kill a Mockingbird' in several ways. Racism against black characters like Tom Robinson and the Finch's black housekeeper Calpurnia is prominent. Gender prejudice is also shown through the treatment of Scout and other female characters. Poverty adds further challenges, as the Ewell family faces due to their socioeconomic status. Overall, the novel illuminates the prejudices that existed in 1930s Alabama through the experiences of its characters.