The document outlines an organized clinical problem solving approach to precision ventilator management consisting of the following elements: 1. Identifying the problems to target in multiple body systems including pulmonary, thoracic, hemodynamic, metabolic, and neurologic factors. 2. Determining appropriate strategies and targets to address each problem, such as optimizing PEEP, minute ventilation, and I:E ratio while balancing oxygenation, CO2, pH, lung protection and mental status. 3. Employing an iterative hypothesis testing approach of gathering data, revising hypotheses, and adjusting management on a continuous basis to refine ventilator settings.