Analgesics aka Pain killer not only relieving from pain but they also have bad effects on overdose. Intentionally or unknowingly, it affects both. NSAIDS and Opiods both affects systemically. Opioids interacts its receptor in brain and prevents a chemical GABA from release, these controls Dopamine. Increase in Dopamine concentration causes feeling of euphoria, constipation, itching, ineffective ventilation respiratory effects during sleep or sleep apnea. NSAIDs affects Liver, kidney, pregnant, breastfeeding, Peptic ulcer, Asthma, Allergies, Chron's disease. Pain killer along with alcohol is more harmfull as it depresses brain synergistically. Call us regarding Dental Treatment:- Dr. Rajat Sachdeva +919818894041,01142464041 drrajatsachdeva@gmail.com Follow us here:- • Google+ link: https://goo.gl/vqAmvr • Facebook link: https://goo.gl/tui98A • Youtube link: https://goo.gl/mk7jfm • Linkedin link: https://goo.gl/PrPgpB • Slideshare link : http://goo.gl/0HY6ep • Twitter Page : https://goo.gl/tohkcI • Instagram page : https://goo.gl/OOGVig Learn more:- • www.sachdevadentalcare.com • www.dentalclinicindelhi.com • www.dentalimplantindia.co.in • www.dentalcoursesdelhi.com • www.facialaestheticsdelhi.com

1. EFFECTS OF OVER THE
COUNTER ANALGESICS

2. • ANALGESICS / PAIN KILLERS
• The drugs that are used for
relieving pain selectively without blocking the
conduction of nerve impulses or affecting
consciousness.
• Although NSAIDs (non-steroidal anti- inflammatory
drugs) and Opioids are frequently used, but there
widespread use has caused significant health
issues.

3. REFERENCE BY WHICH PEOPLE
CONSUME ANALGESICS?

4. LONG TERM ADVERSE EFFECTS
OF PAINKILLERS

5. • There are a number of unpleasant side effects
associated with painkiller abuse. Mild side effects
include nausea, vomiting and diarrhea, usually caused
by the way the drug interacts with opioid receptors
along the digestive tract.
• As the opiate in the body breaks down at the opioid
receptor, GABA starts going back into full swing, but
this also causes a sudden cessation of dopamine,
which causes random muscular twitches.

6. • Crushing and injecting the tablet into the
bloodstream can cause long-term heart
damage and other cardiovascular issues.
• Injecting painkillers or any type of drug,
especially if done under non-sterile conditions
or in association with shared needles
elevates one's risk of contracting blood-borne
diseases.

7. What Can Overdose Of Painkillers
Cause?

8. • Whether it occurs accidentally or intentionally, an
overdose can often be fatal.
• Amongst analgesics, Opioids is amongst the common
drug consumed intentionally as user have a sensation of
euphoria when the drug first hits their brains.
• This is why people become addicted to it. Eventually, the
brain will develop a tolerance to painkillers, and you’ll
need to take larger doses of the drug to achieve the
same high – and that put you at the risk of overdose.

9. What happens to your body during
an overdose?

10. • During an overdose, the drug over counters the parts of your
brain that control respiratory and circulatory functions.
Breathing and heart rate become slow.
• Sometimes, people who overdose may experience abnormal
heart rhythms. They might suffer cardiac arrest.
• As heart and lung function ceases, organs become deprived
of oxygen and the longer your brain goes without oxygen-rich
blood, the higher your chances are of developing severe
seizures and irreversible brain damage.

11. Signs of an overdose of painkillers includes:
Cold, clammy skin /
Blue or grey lips
and nails
Slow or absent
breathing
Gurgling
sounds
Confusion /
Disorientation
Vomiting
Tiny pupils
Unresponsiveness
Constipation /
Itchiness

12. ANALGESIC
EFFECTS
ON
PREGNANCY

13. • Pregnancy care is one of the greatest
challenges in medicine as it demands
a special care in the use of drugs
because of altered physiology.
• At least 10 percent of birth defects are
thought to result from maternal drug
exposures.
• NSAIDS are one of the most
commonly used medications during
pregnancy to treat painful events.

14. • Paracetamol – low birth weight and pre-term deliveries
have been observed with chronic usage.
• Salicylates - associated with increased perinatal
mortality, neonatal hemorrhage, decreased birth weight,
prolonged gestation and labor, and possible birth
defects.
• Indomethacin - it may result in premature closure of the
fetal ductus arteriosus with subsequent persistent
pulmonary hypertension of the newborn, fetal
nephrotoxicity, and periventricular hemorrhage.

15. PAIN KILLERS AND ALCOHOL
• Both pain killers and Alcohol
depresses the Cental
nervous system.
• Consuming both together
can result in a more severe
depressive effect.

16. The combination of alcohol with drug can develop –
 Brain damage
 Liver damage
 Damage to CVS / GIT
 Plus, there is an increased potential to develop
addiction / physical dependence.

17. CERTAIN COMMON DRUGS AND
THEIR ADVERSE EFFECTS

18. OPIATES
 As opiates interact at the various receptors in
the brain, they have a wide range of side effects.
 It is a frequently abused drug. The reason for
their abuse is that they interact at various opioid
receptors in the brain, preventing a chemical
known as GABA from being released.

19. • This chemical normally controls the release of
dopamine, along with a couple of other
neurotransmitters, which causes dopamine to
flood the brain, creating the feeling of euphoria.

20. Adverse effects may include :
• Constipation and itching which may require long-term
treatment.
• Decreased central respiratory drive, respiratory rate
which may lead to ineffective ventilation.

21. • The respiratory effects of opioids are more
pronounced during sleep.
• Fatalities have been reported in patients
with obstructive sleep apnea who are
prescribed opioids and sleep apnea may
be a relative contraindication to opioid
therapy.

22. PARACETAMOL
• Non-opioid painkillers are the most common
type of painkiller.
• Adverse effects of paracetamol
• Paracetamol can damage your liver if taken at
high doses. You should only drink alcohol in
moderation when taking paracetamol.
• It is used in lower doses than usual if you have
kidney problems.

23. ASPIRIN
• If you possess following characteristics, then you have to
consult doctor for taking pain killers :
 asthma
 Peptic ulcers
 Liver or kidney problems
 Bleeding disorder such as haemophilia
 High blood pressure that is not being controlled
 Are pregnant, breastfeeding or trying to get pregnant
 Had an allergic reaction to aspirin or NSAIDs

24. • If any of these apply to you, ask a doctor or
pharmacist for advice before taking NSAIDs.
• This drug is contra-indicated for children below
16 years.

25. IBUPROFEN
Not recommended in
following patients
pregnancy / lactating
Past allergic reaction to
aspirin or NSAIDs
Stomach ulcers
Crohn's disease or
ulcerative colitis

26. Having severe heart
failure or liver /kidney
disease
Asthmatic Patients
Lupus erythematosus
Ever had any bleeding
in your stomach
High blood pressure /
stroke

27. TOPICAL ANALGESICS
• Topical analgesics are commonly used for minor
strains and sprains and include camphor, menthol,
methyl salicylate, methyl nicotinate and capsacin.
• Patients on anticoagulation therapy should be not
be advised to use this as it may relate to prolonged
prothrombin time.

28. • Products should be
discontinued if the
patient experiences
excessive redness or
blistering of the skin.
• Patients should also be
advised not to use
heating devices in
conjunction with topical
analgesics.

29. HOW TO AVOID PAINKILLER ADDICTION

30. • There is an alarming prevalence of analgesics use
among patients. This high usage rate is combined
with inadequate level of awareness about the
associated health risks, which raises several
concerns about patients safety.

31. @dentalcoursesdelhi
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drrajatsachdeva@surgicalmasterrajat
www.facialaestheticsdelhi.com

32. To book an appmt. contact
Dr.Rajat Sachdeva
Dr Sachdeva’s Dental
Aesthetic & Implant
Institute
I 101, Ashok Vihar Phase 1,
Delhi- 110052
Contact us at
Phone : +919818894041
01142464041