Presenting a mental framework for strategic analysis of project portfolios in an organization. The example used is IT-Business alignment, but many components of this framework may be used in other applications.

1. Project Portfolio Management and Strategic Planning Vladimir Makarov, PhD, MBA

16. Sample capabilities for KM - 1 Training Collaboration – internal Collaboration – across sites or acquired units Collaboration – across business functions Collaboration with external industry partners Users Platform definition Process simplification Deployment of standards Characterization of compounds and process engineering Compound life cycle management Technology transfer Processes Capabilities Category or Group

17. Sample capabilities for KM - 2 Usability Systems integration Enables strategic decision making Enable tactical (in process) decision making Enable work flow Create IT platform standards Tools and Systems Timeliness Accessibility Information integrity Extraction of structured information from unstructured data Ability to maintain context Complete traceability Data acquisition Data retention Integration of GxP and non-GxP Data and Information Capabilities Category or Group

22. Example of capability - project matrix Disclaimer: All data is fictitious Large Large Med Small Gap 1 1 2 1 0 Lifecycle management 1 0 0 0 1 Extract structured from unstructured 0 2 1 0 3 Charact. & PE 0 1 1 0 3 Collaboration Prj 5 Prj 4 Prj 3 Prj 2 Prj 1 Capability

23. Example of capability - project matrix Project that addresses multiple capability gaps Large Large Med Small Gap 1 1 2 1 0 Lifecycle management 1 0 0 0 1 Extract structured from unstructured 0 2 1 0 3 Charact. & PE 0 1 1 0 3 Collaboration Prj 5 Prj 4 Prj 3 Prj 2 Prj 1 Capability

24. Example of capability - project matrix Project that addresses only one capability gap, and even that poorly Large Large Med Small Gap 1 1 2 1 0 Lifecycle management 1 0 0 0 1 Extract structured from unstructured 0 2 1 0 3 Charact. & PE 0 1 1 0 3 Collaboration Prj 5 Prj 4 Prj 3 Prj 2 Prj 1 Capability

25. Example of capability - project matrix Small capability gap addressed by many projects Large Large Med Small Gap 1 1 2 1 0 Lifecycle management 1 0 0 0 1 Extract structured from unstructured 0 2 1 0 3 Charact. & PE 0 1 1 0 3 Collaboration Prj 5 Prj 4 Prj 3 Prj 2 Prj 1 Capability

26. Example of capability - project matrix Large capability gap poorly addressed by projects in current portfolio Large Large Med Small Gap 1 1 2 1 0 Lifecycle management 1 0 0 0 1 Extract structured from unstructured 0 2 1 0 3 Charact. & PE 0 1 1 0 3 Collaboration Prj 5 Prj 4 Prj 3 Prj 2 Prj 1 Capability