Cigarettes contain over 4,000 chemicals including nicotine, acetone, benzene, arsenic, and formaldehyde. Smoking causes over 440,000 deaths per year in the United States, with 1 in 5 deaths related to smoking. Cigarette smoking is responsible for 30% of cancer deaths and causes various types of cancer as well as diseases like heart disease and emphysema. Major cigarette companies that produce and advertise cigarettes include American Cigarette Company and R.J. Reynolds Tobacco Company.