SlideShare a Scribd company logo
1 of 36
PNEUMOCOCCAL INFECTION AND
NASOPHARYNGYTIS
MITTAL PULKIT
PNEUMOCOCCAL
INFECTION
This Photo by Unknown Author is licensed under CC BY
Description
Gram-positive diplococci (in pairs)
Encapsulated ovoid or lanceolate coccus
Non-motile
Fastidious (enriched media)
Blood or chocolate agar
5-10 % CO2
Alpha haemolysis + draughtsman appearance
Some strains are mucoid
Soluble in bile
Optochin sensitive
Pathogenesis
Virulence factors
Capsular polysaccharide
The major factor
84 serotypes
Both antigenic and type specific
Antiphagocytic
Serotype 3 , 7 are most virulent
90% of cases of bacteraemic pneumococcal pneumonia and meningitis are
caused by 23 serotypes
Quellung reaction , india ink
Pneumolysin
Membrane damaging toxin
Carrier rate
Oropharyngeal flora of 5 – 70% of the
population
Significance in respiratory infection
Predisposing factors
Aspiration of upper airway secretions ( endogenous )
No person-person spread
Disturbed consciousness , general anaesthesia , convulsions ,
CVA , epilepsy , head trauma
Prior LRT. VIRAL infection
Preexisting respiratory diseases , smoking
Chronic bronchitis , bronchogenic malignancy
Chronic heart disease
Chronic renal disease ( nephrotic syndrome )
Chronic liver disease ( cirrhosis)
Diabetes mellitus
Old age , (extreme of age )
Malnutrition , alcoholism
Specific deficiencies in host defence
Hypogamaglobulinaemia
Asplenia , hypospenism ( tuftsin )
Homozygous sickle cell disease
Coeliac disease
Multiple myeloma , leukaemia , lymphomas
Neutropenia
HIV
Relative or absolute deficiency of opsonic antibody or inadequate manufacture
of type specific antibody
Diseases
Respiratory tract infections
Lobar pneumonia ( commonest cause of CAP )
Empyema
Otitis media (6 months – 3 yrs )
Mastoiditis
Sinusitis
Acute exacerbation of chronic bronchitis
Meningitis
Conjunctivitis
Peritonitis ( primary )
Bacteraemia ( 15 % of pneumonia )
septicaemia
Clinical feature
Lobar pneumonia
Sudden onset
Fever
rigor
Cough , rusty sputum
Pleural pain
Signs of lobar consolidation
Polymorphonuclear leucocytosis
Empyema , pericarditis
Meningitis
The most virulent pathogen of meningitis
Mortality ( 20% )
Primary
Complicate infections at other site ( lung )
Bacteraemia usually coexists
Bimodal incidence ( < 3 yr - > 45 yr )
Mortality
Age (> 65 yr )
Preexisting disease
Bacteraemia
Serotype 3 , 7
Laboratory
diagnosis
Specimen
Sputum
CSF
Swabs
Pus
Blood culture
Aspirate
Microscopy
Gram stained smear
Gram-positive diplococci + pus cells
culture
Blood agar , chocolate agar + 10 % CO2
identification
Alph-haemolytic colonies
Optochin sensitive
Bile soluble
Sensitivity testing
Penicillin
susceptible
Sensitive
Nonsusceptible
Intermediate
Resistant
Ampicillin , amoxicillin
Erythromycin
Ceftriaxone , cefuroxime
Clindamycin
Fluroquinolones
tetracyclines
Vancomycin
Treatment
Meningitis
Parenteral ceftriaxone + vancomycin
pneumonia
Outpatients
Erythromycin
Amoxacillin – clavulanic acid
Cefuroxime or ceftriaxone (IV) + oral b- lactam
Inpatients
Parenteral cefuroxime or ceftriaxone
Prevention
23 polysaccharide vaccine
Not effective in children < 2 yrs
>65 yrs
Functional or anatomical asplenia
SCD
7-valent – protein- conjugated vaccine
Children < 3 yrs
NSOPHARYNGITIS
DESCRIPTION
• Is commonly known as common cold.
• Nasopharyngitis refers to the swelling of the nasal passages and
the back of the throat.
• Usually last about 7 days or less
• It can cause a blocked nose followed by a runny nose, sneezing, a
sore throat and a cough
• Can be contagious
The etiology:
•
• Rhinovirus is the most common cold-causing virus and
it’s highly contagious.
A virus or bacteria can cause nasopharyngitis. It can
spread through tiny air droplets that are expelled when a
person infected with the virus: sneezes, coughs, blows
their nose, talks.
PATHOPHYSIOLOGY
• The mechanism of this immune response is virus specific. For
example, the rhinovirus is typically acquired by direct contact it
binds to human ICAM-1 receptors(Inter-Cellular Adhesion
Molecule 2)
• This receptors present on respiratory epithelial cells. As the
virus replicates and spreads, infected cells release distress
signals known as chemokines and cytokines(which in turn
activate inflammatory mediators).
• These inflammatory mediators then produce the symptoms.
A cold can be spread through:
• direct contact – sneeze or cough, tiny droplets
of fluid containing the cold virus are launched
into the air and can be breathed in by others.
• indirect contact – sneeze onto a door handle
and someone else touches the handle a few
minutes later, they may catch the cold virus if
they can touch their mouth or nose
Signs and symptoms
• Dry or sore throat.
• Runny nose .
• Sneezing.
• Headache .
• Earaches, also brought on by the
congestion (especially in children).
• Slight fever and chills .
• Coughing.
• Feeling tired.
• Watery or itchy eyes
• Body aches
• Post nasal drip
DIAGNOSIS
• Symptoms and a physical examination are all
the doctor needs to diagnose the common cold.
• Usually, no blood tests or X-ray are necessary.
• During the physical examination, the doctor
will pay careful attention to the head, neck, and
chest.
• Examine the eyes, ears, throat, and chest to
help determine if a bacterial source is causing
the illness.
MEDICAL MANAGEMENT
• Antipyretics or analgesics- may be indicated
for mild fever and discomfort, and pain and the
cold itself.
• Cough Suppressants- containing
dextromethorphan may be prescribed for a dry,
hacking cough, especially at night
• Rest is recommended
• Antihistamines – for runny nose, sneezing,
itching and to induce sleep.
• Decongestants- may be prescribed for children
and infants older than 12 months of age to
shrink swollen nasal passages
COMPLICATIONS
Colds may aggravate the symptoms of other
conditions, such as asthma and chronic
obstructive pulmonary disease (COPD).
Cold can also lead to:
• acute bacterial bronchitis – inflammation of
the windpipe (trachea)
• strep throat -bacterial infection that causes
inflammation and pain in the throat
• Pneumonia – lung infection
• Otitis media – any inflammation in the
middle ear due to nasopharyngeal secretions
PREVENTIONS
1. GOOD HANDWASHING!
2.Cough and sneeze into arm or
tissue, not into your hand.
3. Sanitize your hands if you have
hand sanitizer.
4. Use tissues
5. Disinfect stuff
6. Don’t share
Assessment diagnosis planning intervention rationale evaluation
v/s T-100.4 F (38 C)
• complaint of nasal
congestion
• headache
• burning eyes
• slight fever
• runny nose
• watery eyes
• chills (feeling cold)
• dry or sore throat
• hoarseness
• sneezing
• coughing
• irritability,
restlessness
Impaired sleeping
pattern related to
excess mucus
evidence by patient
stating “I have
trouble sleeping at
night because of my
stuffy nose” and
signs of nasal flaring.
After 3 days
child should feel
relieved of
production in nose as stuffy nose and
have no fever
1. Monitor vitals
2. Put patient in a
semi- fowlers position
3. Administer
analgesic
4. Give antihistamine
(Benadryl)
5. Give fluids
6. Adequate rest
7. Educate patient on
washing hands,
covering nose when
coughing and
sneezing.
8. Educate parents on
this condition…
1. Monitor for fever
2. To facilitate lung expansion
3. For fever, pain and cold
itself,
4. For runny nose, sneezing,
itching. induce sleep
5. Hydration is good to cough
out the mucous
6. Its important for the body
to get rest as the body’s
immune system is fighting off
the virus.
7. To prevent illness and
spread of infection.
8. Reassure parents that
common colds are normal and
can be frequent in children
and by age 5 they will develop
immunity to viruses
After 3 days child
states he feels
relieved of stuffy
nose and feels relief
of fever.
Assessment
8. dry or sore throat.
9. hoarsness
10. sneezing
11. coughing
12. irritability, restlessness
v/s T-100.4 F (38 C)
1. complaint of nasal congestion
2. headache
3. burning eyes
4. fever
5. runny nose
6. watery eyes
7. chills (feeling cold)
dry or sore thoat
DIAGNOSIS
1. Impaired sleeping pattern related to excess mucus production in nose
as evidence by patient stating “I have trouble sleeping at night because of
my stuffy nose” and signs of nasal flaring.
PLANNING
- After 3 days child should feel relieved of stuffy nose and
have no fever
1. Do a physical examination
2. Monitor and record vital
signs
3.Put patient in a semi
fowlers position.
4. Administer analgesics
5. Give antihistamine
6. Give fluids.
7. Educate parent that child
needs adequate rest
intervention rationale
1. Check for signs and symptoms on
child
2. Monitor temperature for any
fever.
3. To facilitate lung expansion
4. For pain, reduce fever
5. For runny nose, sneezing, itching,
induce sleep
6. Hydration is good to cough out the
mucous
7. The body needs to rest as the
body’s immune system is fighting
off the virus.
8.To prevent illness and spread of
infection.
9.Reassure parents that common
colds are normal and can be frequent
in children and by age 5 they will
develop immunity to viruses
8. Educate patient on washing
hands, covering nose when
coughing and sneezing.
9. Educate parents on this
condition…
EVALUATION
- After 3 days child states he feels relieved
of stuffy nose and feels relief of fever.
PNEUMOCOCCAL INFECTION AND  NASOPHARYNGITIS 13032024 WENESDAY .pptx

More Related Content

Similar to PNEUMOCOCCAL INFECTION AND NASOPHARYNGITIS 13032024 WENESDAY .pptx

Lower respiratory tract infection (LRTI) in
Lower respiratory tract infection (LRTI) inLower respiratory tract infection (LRTI) in
Lower respiratory tract infection (LRTI) in
Osama Felemban
 

Similar to PNEUMOCOCCAL INFECTION AND NASOPHARYNGITIS 13032024 WENESDAY .pptx (20)

BRONCHIOLITIS.pptx
BRONCHIOLITIS.pptxBRONCHIOLITIS.pptx
BRONCHIOLITIS.pptx
 
Acute respiratory Infection & IMNCI
Acute respiratory Infection & IMNCIAcute respiratory Infection & IMNCI
Acute respiratory Infection & IMNCI
 
Pneumonia
PneumoniaPneumonia
Pneumonia
 
PNEUMONIA.pptx
PNEUMONIA.pptxPNEUMONIA.pptx
PNEUMONIA.pptx
 
Pneumonia
PneumoniaPneumonia
Pneumonia
 
Pneumonia
PneumoniaPneumonia
Pneumonia
 
Approach to patient with uper and lower airway diseases
Approach to patient with uper and lower airway diseasesApproach to patient with uper and lower airway diseases
Approach to patient with uper and lower airway diseases
 
Laryngeal infections
Laryngeal infectionsLaryngeal infections
Laryngeal infections
 
Introduction to Respiratory Peds.ppt
Introduction to Respiratory Peds.pptIntroduction to Respiratory Peds.ppt
Introduction to Respiratory Peds.ppt
 
Denguepowerpoint2 090308093035-phpapp01
Denguepowerpoint2 090308093035-phpapp01Denguepowerpoint2 090308093035-phpapp01
Denguepowerpoint2 090308093035-phpapp01
 
Diptheria & pertussis
Diptheria & pertussisDiptheria & pertussis
Diptheria & pertussis
 
Lower respiratory tract infection (LRTI) in
Lower respiratory tract infection (LRTI) inLower respiratory tract infection (LRTI) in
Lower respiratory tract infection (LRTI) in
 
Respiratory system diseases
Respiratory system diseases Respiratory system diseases
Respiratory system diseases
 
Pediatric Pneumonia.pptx
Pediatric Pneumonia.pptxPediatric Pneumonia.pptx
Pediatric Pneumonia.pptx
 
Pneumonia in peadiatrics
Pneumonia in peadiatricsPneumonia in peadiatrics
Pneumonia in peadiatrics
 
13. Pneumonia and Childhood TB.pptx
13. Pneumonia and Childhood TB.pptx13. Pneumonia and Childhood TB.pptx
13. Pneumonia and Childhood TB.pptx
 
Wheezing and noisy breathing seminar
Wheezing and noisy breathing seminarWheezing and noisy breathing seminar
Wheezing and noisy breathing seminar
 
Dry cough
Dry coughDry cough
Dry cough
 
Airborne Diseases
Airborne  DiseasesAirborne  Diseases
Airborne Diseases
 
Childhood Asthma.pptx
Childhood Asthma.pptxChildhood Asthma.pptx
Childhood Asthma.pptx
 

More from PulkitMittal54 (8)

PREECLAMPSIA TOPIC 4 MITTAL PULKIT PPT
PREECLAMPSIA TOPIC 4 MITTAL PULKIT   PPTPREECLAMPSIA TOPIC 4 MITTAL PULKIT   PPT
PREECLAMPSIA TOPIC 4 MITTAL PULKIT PPT
 
PLACENTAL DYSFUNCTION MITTAL PULKIT 10042024 WEDNESDAY
PLACENTAL DYSFUNCTION MITTAL PULKIT 10042024 WEDNESDAYPLACENTAL DYSFUNCTION MITTAL PULKIT 10042024 WEDNESDAY
PLACENTAL DYSFUNCTION MITTAL PULKIT 10042024 WEDNESDAY
 
Meningococcal Infection 13032024 WEDNESDAY.pptx
Meningococcal Infection 13032024 WEDNESDAY.pptxMeningococcal Infection 13032024 WEDNESDAY.pptx
Meningococcal Infection 13032024 WEDNESDAY.pptx
 
HERPES SIMPLEX VIRUS 12032019 TUESDAY pptx
HERPES SIMPLEX VIRUS 12032019 TUESDAY  pptxHERPES SIMPLEX VIRUS 12032019 TUESDAY  pptx
HERPES SIMPLEX VIRUS 12032019 TUESDAY pptx
 
DIPHTHERIA 12032024. TUESDAY.pptx
DIPHTHERIA     12032024.    TUESDAY.pptxDIPHTHERIA     12032024.    TUESDAY.pptx
DIPHTHERIA 12032024. TUESDAY.pptx
 
ACUTE RHEUMATIC FEVER PEDIATRICS TOPIC .28092023. THRUSDAYpptx
ACUTE RHEUMATIC FEVER PEDIATRICS TOPIC .28092023. THRUSDAYpptxACUTE RHEUMATIC FEVER PEDIATRICS TOPIC .28092023. THRUSDAYpptx
ACUTE RHEUMATIC FEVER PEDIATRICS TOPIC .28092023. THRUSDAYpptx
 
HEMORRHAGIC STROKE TOPIC 18092023 MONDAY.ppt.
HEMORRHAGIC STROKE TOPIC 18092023 MONDAY.ppt.HEMORRHAGIC STROKE TOPIC 18092023 MONDAY.ppt.
HEMORRHAGIC STROKE TOPIC 18092023 MONDAY.ppt.
 
CHOLERA TOPIC PPT 07032024 THRUSDAY pptx
CHOLERA TOPIC PPT 07032024 THRUSDAY pptxCHOLERA TOPIC PPT 07032024 THRUSDAY pptx
CHOLERA TOPIC PPT 07032024 THRUSDAY pptx
 

Recently uploaded

Call Girl in Indore 8827247818 {LowPrice} ❤️ (ahana) Indore Call Girls * UPA...
Call Girl in Indore 8827247818 {LowPrice} ❤️ (ahana) Indore Call Girls  * UPA...Call Girl in Indore 8827247818 {LowPrice} ❤️ (ahana) Indore Call Girls  * UPA...
Call Girl in Indore 8827247818 {LowPrice} ❤️ (ahana) Indore Call Girls * UPA...
mahaiklolahd
 

Recently uploaded (20)

Call Girls Rishikesh Just Call 9667172968 Top Class Call Girl Service Available
Call Girls Rishikesh Just Call 9667172968 Top Class Call Girl Service AvailableCall Girls Rishikesh Just Call 9667172968 Top Class Call Girl Service Available
Call Girls Rishikesh Just Call 9667172968 Top Class Call Girl Service Available
 
Low Rate Call Girls Bangalore {7304373326} ❤️VVIP NISHA Call Girls in Bangalo...
Low Rate Call Girls Bangalore {7304373326} ❤️VVIP NISHA Call Girls in Bangalo...Low Rate Call Girls Bangalore {7304373326} ❤️VVIP NISHA Call Girls in Bangalo...
Low Rate Call Girls Bangalore {7304373326} ❤️VVIP NISHA Call Girls in Bangalo...
 
8980367676 Call Girls In Ahmedabad Escort Service Available 24×7 In Ahmedabad
8980367676 Call Girls In Ahmedabad Escort Service Available 24×7 In Ahmedabad8980367676 Call Girls In Ahmedabad Escort Service Available 24×7 In Ahmedabad
8980367676 Call Girls In Ahmedabad Escort Service Available 24×7 In Ahmedabad
 
Pondicherry Call Girls Book Now 9630942363 Top Class Pondicherry Escort Servi...
Pondicherry Call Girls Book Now 9630942363 Top Class Pondicherry Escort Servi...Pondicherry Call Girls Book Now 9630942363 Top Class Pondicherry Escort Servi...
Pondicherry Call Girls Book Now 9630942363 Top Class Pondicherry Escort Servi...
 
Russian Call Girls Service Jaipur {8445551418} ❤️PALLAVI VIP Jaipur Call Gir...
Russian Call Girls Service  Jaipur {8445551418} ❤️PALLAVI VIP Jaipur Call Gir...Russian Call Girls Service  Jaipur {8445551418} ❤️PALLAVI VIP Jaipur Call Gir...
Russian Call Girls Service Jaipur {8445551418} ❤️PALLAVI VIP Jaipur Call Gir...
 
Call Girls Hyderabad Just Call 8250077686 Top Class Call Girl Service Available
Call Girls Hyderabad Just Call 8250077686 Top Class Call Girl Service AvailableCall Girls Hyderabad Just Call 8250077686 Top Class Call Girl Service Available
Call Girls Hyderabad Just Call 8250077686 Top Class Call Girl Service Available
 
Call Girls Madurai Just Call 9630942363 Top Class Call Girl Service Available
Call Girls Madurai Just Call 9630942363 Top Class Call Girl Service AvailableCall Girls Madurai Just Call 9630942363 Top Class Call Girl Service Available
Call Girls Madurai Just Call 9630942363 Top Class Call Girl Service Available
 
Coimbatore Call Girls in Thudiyalur : 7427069034 High Profile Model Escorts |...
Coimbatore Call Girls in Thudiyalur : 7427069034 High Profile Model Escorts |...Coimbatore Call Girls in Thudiyalur : 7427069034 High Profile Model Escorts |...
Coimbatore Call Girls in Thudiyalur : 7427069034 High Profile Model Escorts |...
 
The Most Attractive Hyderabad Call Girls Kothapet 𖠋 9332606886 𖠋 Will You Mis...
The Most Attractive Hyderabad Call Girls Kothapet 𖠋 9332606886 𖠋 Will You Mis...The Most Attractive Hyderabad Call Girls Kothapet 𖠋 9332606886 𖠋 Will You Mis...
The Most Attractive Hyderabad Call Girls Kothapet 𖠋 9332606886 𖠋 Will You Mis...
 
Call Girls Ahmedabad Just Call 9630942363 Top Class Call Girl Service Available
Call Girls Ahmedabad Just Call 9630942363 Top Class Call Girl Service AvailableCall Girls Ahmedabad Just Call 9630942363 Top Class Call Girl Service Available
Call Girls Ahmedabad Just Call 9630942363 Top Class Call Girl Service Available
 
Call Girls in Delhi Triveni Complex Escort Service(🔝))/WhatsApp 97111⇛47426
Call Girls in Delhi Triveni Complex Escort Service(🔝))/WhatsApp 97111⇛47426Call Girls in Delhi Triveni Complex Escort Service(🔝))/WhatsApp 97111⇛47426
Call Girls in Delhi Triveni Complex Escort Service(🔝))/WhatsApp 97111⇛47426
 
Andheri East ) Call Girls in Mumbai Phone No 9004268417 Elite Escort Service ...
Andheri East ) Call Girls in Mumbai Phone No 9004268417 Elite Escort Service ...Andheri East ) Call Girls in Mumbai Phone No 9004268417 Elite Escort Service ...
Andheri East ) Call Girls in Mumbai Phone No 9004268417 Elite Escort Service ...
 
Call Girls Kolkata Kalikapur 💯Call Us 🔝 8005736733 🔝 💃 Top Class Call Girl Se...
Call Girls Kolkata Kalikapur 💯Call Us 🔝 8005736733 🔝 💃 Top Class Call Girl Se...Call Girls Kolkata Kalikapur 💯Call Us 🔝 8005736733 🔝 💃 Top Class Call Girl Se...
Call Girls Kolkata Kalikapur 💯Call Us 🔝 8005736733 🔝 💃 Top Class Call Girl Se...
 
Premium Bangalore Call Girls Jigani Dail 6378878445 Escort Service For Hot Ma...
Premium Bangalore Call Girls Jigani Dail 6378878445 Escort Service For Hot Ma...Premium Bangalore Call Girls Jigani Dail 6378878445 Escort Service For Hot Ma...
Premium Bangalore Call Girls Jigani Dail 6378878445 Escort Service For Hot Ma...
 
9630942363 Genuine Call Girls In Ahmedabad Gujarat Call Girls Service
9630942363 Genuine Call Girls In Ahmedabad Gujarat Call Girls Service9630942363 Genuine Call Girls In Ahmedabad Gujarat Call Girls Service
9630942363 Genuine Call Girls In Ahmedabad Gujarat Call Girls Service
 
Call Girls Raipur Just Call 9630942363 Top Class Call Girl Service Available
Call Girls Raipur Just Call 9630942363 Top Class Call Girl Service AvailableCall Girls Raipur Just Call 9630942363 Top Class Call Girl Service Available
Call Girls Raipur Just Call 9630942363 Top Class Call Girl Service Available
 
Call Girls Service Jaipur {9521753030} ❤️VVIP RIDDHI Call Girl in Jaipur Raja...
Call Girls Service Jaipur {9521753030} ❤️VVIP RIDDHI Call Girl in Jaipur Raja...Call Girls Service Jaipur {9521753030} ❤️VVIP RIDDHI Call Girl in Jaipur Raja...
Call Girls Service Jaipur {9521753030} ❤️VVIP RIDDHI Call Girl in Jaipur Raja...
 
Coimbatore Call Girls in Coimbatore 7427069034 genuine Escort Service Girl 10...
Coimbatore Call Girls in Coimbatore 7427069034 genuine Escort Service Girl 10...Coimbatore Call Girls in Coimbatore 7427069034 genuine Escort Service Girl 10...
Coimbatore Call Girls in Coimbatore 7427069034 genuine Escort Service Girl 10...
 
Jogeshwari ! Call Girls Service Mumbai - 450+ Call Girl Cash Payment 90042684...
Jogeshwari ! Call Girls Service Mumbai - 450+ Call Girl Cash Payment 90042684...Jogeshwari ! Call Girls Service Mumbai - 450+ Call Girl Cash Payment 90042684...
Jogeshwari ! Call Girls Service Mumbai - 450+ Call Girl Cash Payment 90042684...
 
Call Girl in Indore 8827247818 {LowPrice} ❤️ (ahana) Indore Call Girls * UPA...
Call Girl in Indore 8827247818 {LowPrice} ❤️ (ahana) Indore Call Girls  * UPA...Call Girl in Indore 8827247818 {LowPrice} ❤️ (ahana) Indore Call Girls  * UPA...
Call Girl in Indore 8827247818 {LowPrice} ❤️ (ahana) Indore Call Girls * UPA...
 

PNEUMOCOCCAL INFECTION AND NASOPHARYNGITIS 13032024 WENESDAY .pptx

  • 2. PNEUMOCOCCAL INFECTION This Photo by Unknown Author is licensed under CC BY
  • 3. Description Gram-positive diplococci (in pairs) Encapsulated ovoid or lanceolate coccus Non-motile Fastidious (enriched media) Blood or chocolate agar 5-10 % CO2 Alpha haemolysis + draughtsman appearance Some strains are mucoid Soluble in bile Optochin sensitive
  • 4. Pathogenesis Virulence factors Capsular polysaccharide The major factor 84 serotypes Both antigenic and type specific Antiphagocytic Serotype 3 , 7 are most virulent 90% of cases of bacteraemic pneumococcal pneumonia and meningitis are caused by 23 serotypes Quellung reaction , india ink Pneumolysin Membrane damaging toxin
  • 5. Carrier rate Oropharyngeal flora of 5 – 70% of the population Significance in respiratory infection
  • 6. Predisposing factors Aspiration of upper airway secretions ( endogenous ) No person-person spread Disturbed consciousness , general anaesthesia , convulsions , CVA , epilepsy , head trauma Prior LRT. VIRAL infection Preexisting respiratory diseases , smoking Chronic bronchitis , bronchogenic malignancy Chronic heart disease Chronic renal disease ( nephrotic syndrome ) Chronic liver disease ( cirrhosis) Diabetes mellitus Old age , (extreme of age ) Malnutrition , alcoholism
  • 7. Specific deficiencies in host defence Hypogamaglobulinaemia Asplenia , hypospenism ( tuftsin ) Homozygous sickle cell disease Coeliac disease Multiple myeloma , leukaemia , lymphomas Neutropenia HIV Relative or absolute deficiency of opsonic antibody or inadequate manufacture of type specific antibody
  • 8. Diseases Respiratory tract infections Lobar pneumonia ( commonest cause of CAP ) Empyema Otitis media (6 months – 3 yrs ) Mastoiditis Sinusitis Acute exacerbation of chronic bronchitis Meningitis Conjunctivitis Peritonitis ( primary ) Bacteraemia ( 15 % of pneumonia ) septicaemia
  • 9. Clinical feature Lobar pneumonia Sudden onset Fever rigor Cough , rusty sputum Pleural pain Signs of lobar consolidation Polymorphonuclear leucocytosis Empyema , pericarditis
  • 10. Meningitis The most virulent pathogen of meningitis Mortality ( 20% ) Primary Complicate infections at other site ( lung ) Bacteraemia usually coexists Bimodal incidence ( < 3 yr - > 45 yr )
  • 11. Mortality Age (> 65 yr ) Preexisting disease Bacteraemia Serotype 3 , 7
  • 13. Microscopy Gram stained smear Gram-positive diplococci + pus cells culture Blood agar , chocolate agar + 10 % CO2 identification Alph-haemolytic colonies Optochin sensitive Bile soluble
  • 14. Sensitivity testing Penicillin susceptible Sensitive Nonsusceptible Intermediate Resistant Ampicillin , amoxicillin Erythromycin Ceftriaxone , cefuroxime Clindamycin Fluroquinolones tetracyclines Vancomycin
  • 15. Treatment Meningitis Parenteral ceftriaxone + vancomycin pneumonia Outpatients Erythromycin Amoxacillin – clavulanic acid Cefuroxime or ceftriaxone (IV) + oral b- lactam Inpatients Parenteral cefuroxime or ceftriaxone
  • 16. Prevention 23 polysaccharide vaccine Not effective in children < 2 yrs >65 yrs Functional or anatomical asplenia SCD 7-valent – protein- conjugated vaccine Children < 3 yrs
  • 17.
  • 18.
  • 19.
  • 21. DESCRIPTION • Is commonly known as common cold. • Nasopharyngitis refers to the swelling of the nasal passages and the back of the throat. • Usually last about 7 days or less • It can cause a blocked nose followed by a runny nose, sneezing, a sore throat and a cough • Can be contagious
  • 22. The etiology: • • Rhinovirus is the most common cold-causing virus and it’s highly contagious. A virus or bacteria can cause nasopharyngitis. It can spread through tiny air droplets that are expelled when a person infected with the virus: sneezes, coughs, blows their nose, talks.
  • 23. PATHOPHYSIOLOGY • The mechanism of this immune response is virus specific. For example, the rhinovirus is typically acquired by direct contact it binds to human ICAM-1 receptors(Inter-Cellular Adhesion Molecule 2) • This receptors present on respiratory epithelial cells. As the virus replicates and spreads, infected cells release distress signals known as chemokines and cytokines(which in turn activate inflammatory mediators). • These inflammatory mediators then produce the symptoms.
  • 24. A cold can be spread through: • direct contact – sneeze or cough, tiny droplets of fluid containing the cold virus are launched into the air and can be breathed in by others. • indirect contact – sneeze onto a door handle and someone else touches the handle a few minutes later, they may catch the cold virus if they can touch their mouth or nose
  • 25. Signs and symptoms • Dry or sore throat. • Runny nose . • Sneezing. • Headache . • Earaches, also brought on by the congestion (especially in children). • Slight fever and chills . • Coughing. • Feeling tired. • Watery or itchy eyes • Body aches • Post nasal drip
  • 26. DIAGNOSIS • Symptoms and a physical examination are all the doctor needs to diagnose the common cold. • Usually, no blood tests or X-ray are necessary. • During the physical examination, the doctor will pay careful attention to the head, neck, and chest. • Examine the eyes, ears, throat, and chest to help determine if a bacterial source is causing the illness.
  • 27. MEDICAL MANAGEMENT • Antipyretics or analgesics- may be indicated for mild fever and discomfort, and pain and the cold itself. • Cough Suppressants- containing dextromethorphan may be prescribed for a dry, hacking cough, especially at night • Rest is recommended • Antihistamines – for runny nose, sneezing, itching and to induce sleep. • Decongestants- may be prescribed for children and infants older than 12 months of age to shrink swollen nasal passages
  • 28. COMPLICATIONS Colds may aggravate the symptoms of other conditions, such as asthma and chronic obstructive pulmonary disease (COPD). Cold can also lead to: • acute bacterial bronchitis – inflammation of the windpipe (trachea) • strep throat -bacterial infection that causes inflammation and pain in the throat • Pneumonia – lung infection • Otitis media – any inflammation in the middle ear due to nasopharyngeal secretions
  • 29. PREVENTIONS 1. GOOD HANDWASHING! 2.Cough and sneeze into arm or tissue, not into your hand. 3. Sanitize your hands if you have hand sanitizer. 4. Use tissues 5. Disinfect stuff 6. Don’t share
  • 30. Assessment diagnosis planning intervention rationale evaluation v/s T-100.4 F (38 C) • complaint of nasal congestion • headache • burning eyes • slight fever • runny nose • watery eyes • chills (feeling cold) • dry or sore throat • hoarseness • sneezing • coughing • irritability, restlessness Impaired sleeping pattern related to excess mucus evidence by patient stating “I have trouble sleeping at night because of my stuffy nose” and signs of nasal flaring. After 3 days child should feel relieved of production in nose as stuffy nose and have no fever 1. Monitor vitals 2. Put patient in a semi- fowlers position 3. Administer analgesic 4. Give antihistamine (Benadryl) 5. Give fluids 6. Adequate rest 7. Educate patient on washing hands, covering nose when coughing and sneezing. 8. Educate parents on this condition… 1. Monitor for fever 2. To facilitate lung expansion 3. For fever, pain and cold itself, 4. For runny nose, sneezing, itching. induce sleep 5. Hydration is good to cough out the mucous 6. Its important for the body to get rest as the body’s immune system is fighting off the virus. 7. To prevent illness and spread of infection. 8. Reassure parents that common colds are normal and can be frequent in children and by age 5 they will develop immunity to viruses After 3 days child states he feels relieved of stuffy nose and feels relief of fever.
  • 31. Assessment 8. dry or sore throat. 9. hoarsness 10. sneezing 11. coughing 12. irritability, restlessness v/s T-100.4 F (38 C) 1. complaint of nasal congestion 2. headache 3. burning eyes 4. fever 5. runny nose 6. watery eyes 7. chills (feeling cold) dry or sore thoat
  • 32. DIAGNOSIS 1. Impaired sleeping pattern related to excess mucus production in nose as evidence by patient stating “I have trouble sleeping at night because of my stuffy nose” and signs of nasal flaring. PLANNING - After 3 days child should feel relieved of stuffy nose and have no fever
  • 33. 1. Do a physical examination 2. Monitor and record vital signs 3.Put patient in a semi fowlers position. 4. Administer analgesics 5. Give antihistamine 6. Give fluids. 7. Educate parent that child needs adequate rest intervention rationale 1. Check for signs and symptoms on child 2. Monitor temperature for any fever. 3. To facilitate lung expansion 4. For pain, reduce fever 5. For runny nose, sneezing, itching, induce sleep 6. Hydration is good to cough out the mucous 7. The body needs to rest as the body’s immune system is fighting off the virus.
  • 34. 8.To prevent illness and spread of infection. 9.Reassure parents that common colds are normal and can be frequent in children and by age 5 they will develop immunity to viruses 8. Educate patient on washing hands, covering nose when coughing and sneezing. 9. Educate parents on this condition…
  • 35. EVALUATION - After 3 days child states he feels relieved of stuffy nose and feels relief of fever.