Pi Health Inc. (PiVOT) is a clinical research organization incorporated in 2018 that is 100% owned by First Philippine Holdings, a Lopez family-owned conglomerate. PiVOT obtained regulatory approval from the Philippine FDA and aims to support the growing clinical trials landscape in the Philippines. It currently has 96 employees and 4 staff seconded from its parent company, and focuses on oncology, vaccines, and infectious disease trials through partnerships with hospitals and medical institutions.
Terra Prima Partners - Investing in Sustainable Solutions that WILL change th...Anric Blatt
Terra Prima is a venture capital and private equity firm that helps entrepreneurs turn breakthroughs within emerging Renewable and Sustainable Life and Physical Science Technologies into world-changing businesses.
An overview of Food Machinery and Chemicals Corporation (FMC)’s Managerial hi...Ayesha Majid
FMC Corporation is an American chemical manufacturing company headquartered in Philadelphia, Pennsylvania. As a global leader utilizing advanced technologies and customer-focused research and development, FMC provides innovative and cost-effective solutions to enhance crop yield and quality by controlling a broad spectrum of insects, weeds and disease, as well as in non-agricultural markets for pest control.
Terra Prima Partners - Investing in Sustainable Solutions that WILL change th...Anric Blatt
Terra Prima is a venture capital and private equity firm that helps entrepreneurs turn breakthroughs within emerging Renewable and Sustainable Life and Physical Science Technologies into world-changing businesses.
An overview of Food Machinery and Chemicals Corporation (FMC)’s Managerial hi...Ayesha Majid
FMC Corporation is an American chemical manufacturing company headquartered in Philadelphia, Pennsylvania. As a global leader utilizing advanced technologies and customer-focused research and development, FMC provides innovative and cost-effective solutions to enhance crop yield and quality by controlling a broad spectrum of insects, weeds and disease, as well as in non-agricultural markets for pest control.
TPI Polene Public Company Limited, graced the cover of World’s Leaders Magazine as one of the Worlds Best Companies to Work for 2024. Prachai Leophairatana serves as the CEO of TPI Polene Public.
Ricoh Uk Products Ltd Corporate Biodiversity report, showing how the Telford manufacturing site has taken Ricoh's corporate strategy and applied it to both comminuty and on-site biodiversity projects, working closely with Shropshire Wildlfe Trust.
A corporate Biodiversity report for Ricoh's Telford site outlining how working with stakeholders such as the Wildlife Trust has improved the natural capital of site making it a haven for wildlife as well as a functional industrial factory.
UN SDG SDGs Sustainability Impacts KPIs are for the assessment of actual impacts on sustainable development through sustainability impact management and investment.
Example/Best practices of sustainability impact management and investment for each SDG ESG topics are illustrated.
This month's Breakfast Briefing is focused on the theme of 'low carbon' (or 'clean growth' as it is referred to in the UK governments 'The Grand Challenges').
We will be joined by Tevi, Cornwall New Energy and others to deliver an information packed breakfast briefing that will disseminate information to assist the Owner Manager of the SME in embedding, or further embedding, 'clean growth' into your business ethos. Topics being covered include:
•Cornwall & Isles of Scilly and the low carbon economy – an update
•Overview of the business support available to businesses in Cornwall and Isles of Scilly
•Case studies showing how low carbon projects delivered additional profit and improved a business’ sustainability
•Reducing operating costs
•Enabling new energy costs and services to be brought to the market
•The circular economy and local energy generation – tomorrow’s themes today
•Funding
CROP Infrastructure Corp. (CSE: CROP / OTC: CRXPF) brings capital to invest in land and equipment to increase individual cannabis operators ability to achieve sector growth; by increasing accessibility, efficiency, scalability, and sustainability through attractive leasing programs and ongoing management fees.
Sustainability Unlocked provides firm-wide foundational sustainability education to financial institutions through our innovative on-demand video platform.
Our mission with Sustainability Unlocked is to empower change through education, by embedding sustainability education into the culture of financial services organisations, and helping them to deliver their sustainable transition to net zero.
Get a free trial here: https://l.linklyhq.com/l/e4r5
TPI Polene Public Company Limited, graced the cover of World’s Leaders Magazine as one of the Worlds Best Companies to Work for 2024. Prachai Leophairatana serves as the CEO of TPI Polene Public.
Ricoh Uk Products Ltd Corporate Biodiversity report, showing how the Telford manufacturing site has taken Ricoh's corporate strategy and applied it to both comminuty and on-site biodiversity projects, working closely with Shropshire Wildlfe Trust.
A corporate Biodiversity report for Ricoh's Telford site outlining how working with stakeholders such as the Wildlife Trust has improved the natural capital of site making it a haven for wildlife as well as a functional industrial factory.
UN SDG SDGs Sustainability Impacts KPIs are for the assessment of actual impacts on sustainable development through sustainability impact management and investment.
Example/Best practices of sustainability impact management and investment for each SDG ESG topics are illustrated.
This month's Breakfast Briefing is focused on the theme of 'low carbon' (or 'clean growth' as it is referred to in the UK governments 'The Grand Challenges').
We will be joined by Tevi, Cornwall New Energy and others to deliver an information packed breakfast briefing that will disseminate information to assist the Owner Manager of the SME in embedding, or further embedding, 'clean growth' into your business ethos. Topics being covered include:
•Cornwall & Isles of Scilly and the low carbon economy – an update
•Overview of the business support available to businesses in Cornwall and Isles of Scilly
•Case studies showing how low carbon projects delivered additional profit and improved a business’ sustainability
•Reducing operating costs
•Enabling new energy costs and services to be brought to the market
•The circular economy and local energy generation – tomorrow’s themes today
•Funding
CROP Infrastructure Corp. (CSE: CROP / OTC: CRXPF) brings capital to invest in land and equipment to increase individual cannabis operators ability to achieve sector growth; by increasing accessibility, efficiency, scalability, and sustainability through attractive leasing programs and ongoing management fees.
Sustainability Unlocked provides firm-wide foundational sustainability education to financial institutions through our innovative on-demand video platform.
Our mission with Sustainability Unlocked is to empower change through education, by embedding sustainability education into the culture of financial services organisations, and helping them to deliver their sustainable transition to net zero.
Get a free trial here: https://l.linklyhq.com/l/e4r5
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Muktapishti is a traditional Ayurvedic preparation made from Shoditha Mukta (Purified Pearl), is believed to help regulate thyroid function and reduce symptoms of hyperthyroidism due to its cooling and balancing properties. Clinical evidence on its efficacy remains limited, necessitating further research to validate its therapeutic benefits.
Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMSAkankshaAshtankar
MIP 201T & MPH 202T
ADVANCED BIOPHARMACEUTICS & PHARMACOKINETICS : UNIT 5
APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMS By - AKANKSHA ASHTANKAR
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Oleg Kshivets
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
- Video recording of this lecture in English language: https://youtu.be/kqbnxVAZs-0
- Video recording of this lecture in Arabic language: https://youtu.be/SINlygW1Mpc
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Rasamanikya is a excellent preparation in the field of Rasashastra, it is used in various Kushtha Roga, Shwasa, Vicharchika, Bhagandara, Vatarakta, and Phiranga Roga. In this article Preparation& Comparative analytical profile for both Formulationon i.e Rasamanikya prepared by Kushmanda swarasa & Churnodhaka Shodita Haratala. The study aims to provide insights into the comparative efficacy and analytical aspects of these formulations for enhanced therapeutic outcomes.
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
2. • Incorporated as Pi Health Inc. and registered
as a CRO with the Philippine FDA having
obtained a License to Operate in 2018 and
started operations in 2019
• 100% owned by First Philippine Holdings
• 96 employees and 4 secondees from FPH
• First Philippine Holdings is a Lopez-family owned
publicly listed conglomerate in the Philippines
with investments in power generation, real estate,
and manufacturing
• Currently expanding into fast growing consumer
businesses like education and healthcare
(through PiVOT and the Asian Eye Institute)
Who we are
FPH
Introduction
3. 3
FPH Lopez Family Directors
Upholding high
standards of good and
responsible governance
Click the image for
more information
on FPH’s Mission,
Purpose, and
Chosen Path
Oscar M. Lopez
Federico R. Lopez
Manuel M. Lopez Roberta Lopez Feliciano
Mercedes Lopez-Vargas
Miguel L. Lopez
Mr. Frederico Lopez is the
Chairman and CEO. He has
been a Director of FPH since
February 2006 and was
elevated to CEO in 2010. He
graduated from the
University of Pennsylvania
in 1983 with a Bachelor of
Arts Degree, Double Major in
Economics and
International Relations (Cum
Laude).
4. 4
FPH Senior Officers
Run by a well
experienced professional
management team
Click the image for
more information
on FPH’s Mission,
Purpose, and
Chosen Path
Giles B. Puno
President and Chief Operating Officer
Joaquin E. Quintos IV
Senior VP and Business Development Head
Mr. Puno came from the
Chase Manhattan Bank
after getting an MBA from
Northwestern University’s
Kellogg Graduate School.
Mr. Quintos was as the
Chairman and Country
General Manager of IBM
Philippines. He graduated
from the University of the
Philippines with a Bachelor
of Science degree in
Industrial Engineering cum
laude.
5. 5
Mission
We commit to forging collaborative pathways
for a decarbonized and regenerative future.
Chosen Path
Lead the transition to a decarbonized
energy future
Nurture inclusive, well-tempered, and
creative spaces that elevate
surrounding communities and the
environment
Build infrastructure that creates
resilience and enhances the quality of
life in a complex, climate-changed world
The FPH Identity
Click the image for
more information
on FPH’s Mission,
Purpose, and
Chosen Path
FPH’s Definition of Regenerative
Excerpt from FPH’s Purpose
“ Businesses today must urgently become a
regenerative force that elevates everything
that they touch – customers, employees,
suppliers, contractors, the environment,
communities, and investors…
Our collective success will be measured by
how quickly we can decouple economic and
social prosperity from the destruction of our
planet’s life support systems. ”
6. 6
Investments in healthcare and
education
First Balfour and ThermaPrime as emerging players in
construction and large-scale infrastructure
First Philec’s evolution as solutions provider for
electrical products and services
FPIP’s commitment to improve Filipinos’
standard of living
Rockwell Land’s admired models of integrated and
walkable communities
FPH Mission
Forging collaborative
pathways for a
decarbonized and
regenerative future
With consolidated assets of
NTD 250B and attributable
recurring net income of
NTD 6B in 2022 through
energy, real estate, and
construction, FPH is
strategically positioned to
work with various
stakeholders in accelerating
the transformation to a
decarbonized and
regenerative future.
First Gen and EDC’s leadership in clean, renewable,
and low-carbon energy
FPH Platforms
7. 7
Photo from: Philstar
First Gen and Tokyo Gas partnership for
the development of the Philippines’ first
LNG terminal
Rockwell Land and Mitsui Fudosan partnership for
The Arton’s residential development
KKR’s USD192 million voluntary tender
offer for 12% of First Gen’s common
shares
First Balfour and Acciona partnership for the
landmark Cebu-Cordova Link Expressway
FPH Mission
Forging collaborative
pathways for a
decarbonized and
regenerative future
With consolidated assets of
NTD 250B and attributable
recurring net income of
NTD 6B in 2022 through
energy, real estate, and
construction, FPH is
strategically positioned to
work with various
stakeholders in accelerating
the transformation to a
decarbonized and
regenerative future.
FPH Partnerships
8. 8
Energy
Leading the transition
to a decarbonized
energy future
First Gen and EDC’s clean energy portfolio
Natural Gas
2,017 MW
Clean, flexible, reliable,
efficient, and less carbon
emissions
Geothermal
1,179 MW
Predictable, baseload,
indigenous, and
renewable
Hydro
134 MW
Renewable, indigenous,
and carbon-free
Solar and Wind
162 MW
Renewable, indigenous,
and carbon-free
First Philec’s transformer solutions
* Installed
capacity
Distribution transformers
Substation solutions
Distribution line hardware
Power equipment
Technical services
Digital services
9. 9
Property
Nurturing inclusive,
well-tempered, and
creative spaces that
elevate surrounding
communities and the
environment
FPIP’s manufacturing community
Rockwell Land’s signature developments
Rockwell Center
Rockwell Land’s flagship development which
started with the transformation of an unused
thermal power plant into a thriving, self-
sustained community that seamlessly blends
residences, work spaces, and lifestyle hubs
Aruga Resort and Residences
Rockwell Land’s first premiere residential-resort
development in Cebu along a 200 meter stretch
of white beach and with a mesmerizing view of
the Hilutungan Channel and Magellan Bay
Rockwell South at Carmelray
Rockwell Land’s biggest horizontal
development—a 60-hectare master-planned
property in Laguna integrating nature into
every aspect of the community such as roads
and walkways shaded by trees, a waterway, and
pocket parks & trails
Best in-class
infrastructure &
utilities
FPIP’s first-rate road network,
power supply, industrial
water, wastewater facilities,
and telecommunications
allow operational efficiency
and resilience.
Industry-leading park
management
FPIP continues to set the bar for
park management—covering
construction, maintenance,
security, government liaison,
and environmental compliance—
allowing locators to focus on
growing their business.
Strategic location
FPIP is located near Dyson’s
Calamba site and has access to
the country’s capital, major
trade gateways, thriving
communities as well as a pool of
high-quality manpower.
Backed by industry
leaders
FPIP is a joint venture between
Japanese conglomerate
Sumitomo Corporation and
local conglomerate First
Philippine Holdings (FPH).
10. 10
Construction
Building infrastructure
that creates resilience
and enhances the quality
of life in a complex,
climate-changed world
Complex, high-value, critical infrastructure
Design and construction of an
8.2km expressway that will feature
the main twin cable-stayed bridge
EPC contractor for the civil works
and electrical network of SEA’s
largest wind farm
Design and construction of a 7.3-
km long and 3.1-m diameter
aqueduct
Civil and architectural design &
construction of a 5.7 km elevated
line, including guide ways and
railway stations
EPC for the 43-km transmission
line connecting the Burgos Wind
Farm and substations
Construction of 111 million liters of
water reservoir with three equal
chambers
11. 11
FPH Group CSR
Powered by Good
Mangrove
Reforestation
In First Gen’s Clean
Energy Complex
Pantabangan
Biodiversity Study
OML Center
Climate Change Resiliency
KEITECH
Technical-vocational
educational institution in
Kananga, Leyte
Verde Island
Passage
Conservation and
Scientific Workshop
BINHI
Forest restoration,
threatened native
tree species
propagation, and
biodiversity
protection
Ang Misyon
Nurture talented,
less-privileged
youth through the
transformative
power of orchestral
music
ALERT Building
Advance Local Emergency
Response Team in Batangas City
Create for the Climate
Campaign
Learning session on climate change for businesses
Uplift the lives
unelectrified rural
communities through
innovative and
sustainable renewable
energy (RE) systems
Sikat
Photo from PNA
Photo from:
Batangas City
LGU
FPH has long promoted
socially responsible and
environmentally conscious
actions and decisions as an
integral part of doing
business.
12. • Incorporated as Pi Health Inc. and registered
as a CRO with the Philippine FDA having
obtained a License to Operate in 2018 and
started operations in 2019
• 100% owned by First Philippine Holdings
• 96 employees and 4 secondees from FPH
• First Philippine Holdings is a Lopez-family owned
publicly listed conglomerate in the Philippines
with investments in power generation, real estate,
and manufacturing
• Currently expanding into fast growing consumer
businesses like education and healthcare
(through PiVOT and the Asian Eye Institute)
Who we are
PiVOT
Introduction
13. Incorporated as Pi (Philippine Impact) Health Inc. and
registered as a CRO with the Philippine FDA in 2018
PiVOT
Introduction
Regulatory Requirements
SEC Incorporation
BIR Registration
FDA License to Operate
Good Clinical Practice
Trainings
14. REGULATORY CLIMATE
New Clinical Trial Regulation
and 60-Day FDA Approval
Updated Pharmacovigilance
Regulation by 2020
Mandatory Phase IV Trials for
selected drugs and devices
HEALTHCARE SECTOR
Mainly out of pocket
healthcare system
NTD 640 Billion in 2022
growing 13% CAGR
1.3M births and 10M Filipinos
above 60 in 2022
CLINICAL TRIALS
Strong Experience in Oncology,
Vaccines, & Infectious Diseases
Large treatment naïve-
population pool
English Speaking Healthcare
Professionals
Source: PSA, Population Commission, PH FDA
The Philippine clinical research landscape was ripe
for the entrant of a strong local player
PiVOT
Introduction
15. • Level 3 DOH accredited hospital in Sto. Tomas,
Batangas with catchment area stretching as far as
Mindoro and Quezon Province
• Currently with 5 active studies in ophthalmology,
oncology, and nephrology
• Newly established medical school to inline with
hospital’s research driven strategic direction
• Clinical trial site specializing in ophthalmology with
11 branches in the Philippines
• Conducted over 100 medical drug and device
studies since 2002 with 20 different sponsors
• Currently with 25 active studies in retina, glaucoma,
cataract, and refractive
• Inspected by the US FDA in 2015 with no major
findings
PiVOT is aggressively building relationships with sites across the country
PiVOT
Partners
16. …and working with over 116 KOLs and PIs in major hospitals nationwide.
PiVOT
Partners
Makati Medical Center
The Medical City
Asian Hospital and Medical Center
St. Luke’s Medical Center
Bonifacio Global City
17. PiVOT is already utilizing 23 of the better 46 sites nationwide
with a greater push to develop sites outside of Metro Manila (NCR).
PiVOT
Partners
https://ethics.healthresearch.ph/index.php/level-3-accredited-recs
7/46
Clinical Trial Sites are
in Luzon outside NCR
4/46
are in Davao
6/46
are in the Visayas
29/46
Clinical Trial Sites are
in Metro Manila
18. Over 400 clinical trials in the Philippines since 2015
Trials in the
Philippines
Source: Philippine Health Research Registry 2015-2020
42
13
14
16
16
19
19
21
25
56
57
62
72
0 15 30 45 60 75
Others
Nephrology
Opthalmology
Cardiology
Neurology
Endocrinology
Rheumatology
Dermatology
Immunology
Vaccine
Pulmonology
Infectious Diseases
Oncology
19. PiVOT employs a lean, efficient, and experienced team
Organizational
Structure
President
Clinical Trial Management Finance & Accounting
Business Development
& Sales
Pharmacovigilance
Clinical Research
Associates
Quality Assurance
Regulatory
Executive Secretary
Human Resources & Admin
General Manager
Clinical Trial Support Service
HTA/HEOR
Medical Writing
Trainings
Data Management
20. PiVOT employs a lean, efficient, and experienced team
Organizational
Structure
Rodmar C. Pulido, General Manager
• 23 years experience in the clinical research industry
• President, Philippine Clinical Research Professionals, Inc.
• Former Country Manager, EPS International Philippines Branch
• Former Regional Business Development Manager, EPS International
• Established Clinical Research Center in Makati Medical Center
21. PiVOT employs a lean, efficient, and experienced team
Organizational
Structure
Charles Anthony P. Suarez, RPh, Pharmacovigilance and Regulatory Lead
• Registered pharmacist with over 15 years experience in Pharma Industry
• Experiences include Hospital Clinical Pharmacy, Clinical Research, Regulatory Affairs, and
Pharmacovigilance including Risk Management Plans
• Postgraduate units in International Health from the University of the Philippines focused on
Health Systems Management
• Previous employers include Boehringer-Ingelheim, Novartis Healthcare, Cognizant, Quintiles
(IQVIA), ClinTec, EPS International, and Innovative Trials UK
22. PiVOT employs a lean, efficient, and experienced team
Organizational
Structure
Lizbeth G. Salonga, RMT, Clinical Operations Manager
• 18 years experience in the pharmaceutical clinical research industry with focus on project
management, clinical monitoring, site management, real world evidence, Philippine National
Formulary, and HEOR studies
• Postgraduate units in Public Health from the University of the Philippines
• Experience in Cutaneous Diseases (Lupus), Endocrinology, Infectious Diseases, Neurology,
Oncology, and Vaccines
• Previous employers include Pfizer, Quintiles (IQVIA), IndiPharm, and Innovative Trials UK
23. Despite only 3 years of operation, PiVOT is beaming with activity
Company
Track Record
Besides the individual staff experience, the company as a whole has…
• 14 clinical trials, of which are 9 vaccine related, with over 40,000 patients recruited
• A pipeline of oncology, cardio, and antibiotic trials
• Live pharmacovigilance services with local clients
• Ongoing regulatory support for local and international clients
• Experience working with foreign pharmaceuticals, regional CROs, and global NGOs
• Passed 4 inspections of PH FDA, 2 foreign FDA inspections, and 3 client audits
• Presence in international conferences
24. Typical Clinical Trial Registration Workflow
Clinical Trial
Registration
Institutional Review Board
Ethics Committee
Approval in
45 to 180 Days
Customs
Release of IP
Study Initiation
Estimate SIV
Study Approval and
Import License
in 60 Days
Parallel
Submission
Site Contract
for Review
Clinical Trial
Submission
Dossier
25. Drug and Device Trial Management
Services
• Management of Phase I to IV trials on proof of concept or small scale trials on
drugs, biologics, and devices
• Designed for publication to peer-reviewed journals or to support the decision to
pursue large scale FDA registration trials
• Compliance with applicable requirements such as Data Privacy Laws, Good
Clinical Practice, and applicable regulatory requirements and guidelines
• Services include protocol development, regulatory affairs services, monitoring,
data management and analysis, and report writing
26. Post Marketing Surveillance (PMS) and Real World Evidence (RWE)
Services
• Combined experience in monitoring and processing more than 20,000 subjects
for PMS
• Compliance with applicable requirements such as Data Privacy Laws, Good
Clinical Practice, and applicable regulatory requirements and guidelines
• Services include protocol development, monitoring, data management and
analysis, and report writing
27. Pharmacovigilance
Services
• End-to-end 24 hour monitoring and aggregate regulatory reporting service
• Complemented by a EMA and US FDA compliant software
• Highly experienced staff in adverse event (drug, device, cosmetic) case intake, triage,
case processing, CIOMS form generation, regulatory reporting, and submission
• Available for Medicinal Products and Medical Devices (including technical complaints)
• Pharmacovigilance Training (for internal employees and affiliates)
• Audit & Inspection Preparation and Readiness Program (including System and SOP
audit)
28. Medical Writing and Health Economics and Outcomes Research
Services
Medical Writing
• Accomplishing Company and Drug-focused Risk Management Plans
• Study reports required by regulatory authorities
Health Economics and Outcomes Research (HEOR)
• Evidence identification and KOL validation through HCP/Hospital Survey
• Economic Evaluation including model adaptation, analysis and/or reporting
• Dossier development, including HTA Report for Philippine National Formulary
• Submission and hospital formulary inclusion
29. Investigator-Initiated Research (including registries)
Services
• We help the Filipino researcher write grants and manage the research to reach
deliverables set by the grant agencies
• Our team of experienced individuals can advise researchers on grant application,
research contract negotiations, intellectual property protection and management,
technology transfer, and commercialization
• Journal writing and publication can also be outsourced to PiVOT
30. Other Unique and Specialized Services
Services
Bioavailability (BA) and Bioequivalence (BE) Studies
• GLP Certified BA/BE Partner in Malaysia
• Inspected by the US FDA and the French Regulatory Authority (ANSM)
Experienced staff capable in conducting the following trainings and audits:
• Good Clinical Practice (GCP)
• Good Manufacturing Practice (GMP)
• Good Pharmacovigilance Practice (GPVP)
31. Contact Person:
Joseph Cheng
jocheng@pivot-cro.com
+63 2 8370 5942
+63 917 527 5639
www.pivot-cro.com
Office Address:
6th Floor, Tower 3
Rockwell Business Center
Ortigas Avenue, Pasig City
Metro Manila, Philippines
We hope to hear from you soon
Contact Us