Anand Chaudhary
             Associate Professor
    Department of Rasa Shastra
            Faculty of Ayurveda 
   Institute of Medical Sciences 
       Banaras Hindu University
                        Varanasi
email‐anandayubhu@gmail.com
Questions /Contents 

01‐ Are the principles of herbal drug processing and mineral 
  drug processing same ?
02‐Are there any parameters to know the physical change 
  in source material ?
03‐What are the reasons for selection of particular process 
   of particular drug ?
04‐What is the basis of selection of particular drugs for 
   particular formulations  ?




    CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune   25 July ,2011   3
Contd.

05 ‐What is the relevance of repetition cycles especially for 
   production of Bhasma and Khalviya rasa kalpa ?

06‐Principles of Stability are based on what logic ? 

07‐Is there any co relation between principles of 
   formulations applied to Ayurvedic drugs and modern 
   drugs ?




    CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune   25 July ,2011   4
Herbal Drug – Ayurvedic 
Medicine 




  CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune   25 July ,2011   5
Authoritative Authentication 


 Classical considerations



 Contemporary  contemplations




    CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune   25 July ,2011   6
Sanitization & Storage 


 Separation


 Segregation 


 Sustainable     




    CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune   25 July ,2011   7
Processing 




CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune   25 July ,2011   8
Container Consensus 


 Primary dosage forms 


 Secondary dosage forms 




   CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune   25 July ,2011   9
Comminution

                                         Size Reduction




Mechanical Pressure                          Solvency Procedures                     



    CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune   25 July ,2011   10
Extraction

 Universal Solvent 
 Other Solutions
 Suspensions 
 Nano suspensions 




   CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune   25 July ,2011   11
Energy Agenda  




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Solvents




CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune   25 July ,2011   13
Completion Criteria 



                       As per different dosage forms 




CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune   25 July ,2011   14
Procurement & Packing 



                      As per Prepared Medicaments 




CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune   25 July ,2011   15
Delivery & Dispensing 



                     As per indications of Physicians 




CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune   25 July ,2011   16
Mineral Drug – Ayurvedic 
Medicine  




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Individualistic 
  Identification

 Conventional  connotations 


 Current  conjectures  




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Processing 




CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune   25 July ,2011   20
Contd .




CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune   25 July ,2011   21
Adaptations

    Modification –

   Physical    (Heterogeneous to homogenous)

   Chemical  Conversion

   Enhancement




       CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune
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Impacts

 Purification

 Reduction in adverse effects 

 Induction of trace elements

 Alteration in Constituencies




       CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune
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Metallographic findings 




Metallographic figure of Raw                                         Metallographic figure of Shodhita
Swarna Makshika (M= 400X).                                           Swarna Makshika (M= 400X).


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Initial Stride




CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune
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Marana

•   Sukshmikaran (Fine powdering)

•   Chakrika Nirmana (Pellet formation)‐ With other ingredients.

•   Samputi Karana (Sealing in earthen vessels)

•   Puta




           CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune
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Intrinsic Worth 

•   Maximum Temperature range
•   Duration of Maximum temperature
•   Self Cooling
•   Repetition of process 
        1. Hardness
        2. Particle size
        3. Chemical Constituents




     CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune
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Vividness




CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune
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Explicitness


                 1200

                 1000
temperature




                   800
                                                                                                      Temperature
                   600
                                                                                                      (0C)
                   400

                   200

                        0
                             1        4       7      10      13      16       19
                                 time in min. (1 = 15 units)




              CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune
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Magnitude

   Conversion 

   Potentiation

   Elimination

   Safety



      CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune
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Makshika




SEM Feature of Raw S. M                                             SEM Feature of Bhasma S. M




  CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune
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Lauha Bhasma




Neetu Singh et al , Chemical Characterization of Lauha Bhasma by X-Ray Diffraction
and Vibrating Sample Magnetometry International Journal of Ayurvedic Medicine,
2010, 1(3), 143-149
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Rasa Sindoor




Transmission electron microscopy (TEM) images (a, b, and c) along with
selected area electron diffraction pattern (SAED) pattern (d) showing the
presence of sub-micron size, agglomerated, and crystalline particles in the drug
Rasa-Sindoor. S K Singh et al 2011 ,dept of Physics, BHU
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Rasa Sindoor




Scanning electron microscopy (SEM) image of the Rasa-Sindoor
showing the plate like porous surface morphology. Inset to the figure
shows the tiny voids presents in the material, S K Singh et al ,2011, Dept
of Physics ,BHU

  CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune
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Miscellaneous 

 Procurement                                                Packing 




                                                             Dispensing 




      CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune   25 July ,2011   35
Recent Researches 


Manufacturing 


Characterization 


Safety & Efficacy




      CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune   25 July ,2011   36
Observations
Scientific Approach                                                          Stakeholders 

                                                            Deptt of AYUSH,GOI
                                                            Deptt of DST,GOI
                                                            Academic Institutes 
                                                            Research Organizations
                                                            ???????




   CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune
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Characterizations
                                                         IIT ,Rooraki
                                                             Kumar A

                                                         IIT, Mumbai
                                                             Bellare Jayesh

                                                         IIT ,Kharagpur
                                                             Roy Subrato




CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune
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Safety
                                                         Schedule Y , D & C Rule 
                                                          1945

                                                         Rule 170 , D & C Rule 
                                                             1945 – 24 Dec , 2008




CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune
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Rays of 
Radiance 

 CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune   25 July ,2011   40
Selective Selection 

Artificial Addition                                                   Inherent   Innate 




  CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune   25 July ,2011   41
Supervises Solubility 

Developmental Doctrine                                      Progressive  Preferences  




      CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune   25 July ,2011   42
Probable  Postulation 

Bio accumulation                                                   Bio detoxification 




 CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune   25 July ,2011   43
Reductionist Relativity  

Contour  Conversion                                              Eternal  Endowment 




  CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune   25 July ,2011   44
Procedural Principal 

     Blending                                                      Thermodynamics 




CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune   25 July ,2011   45
Assertive Assumptions 

Visionary  Validation                                             Rational Realization 




   CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune   25 July ,2011   46
Extended Elegance 

  Explanation                                                            Elucidation 




CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune   25 July ,2011   47
Prominent  Paramount  
Herculean  Herbal                                               Metamorphic  Metal 




 CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune   25 July ,2011   48
Absolve  Absorption 

Organic  Order                                                         Actual  Accomplishment 




       CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune   25 July ,2011   49
Pragmatic Paradigms 
Momentous   Mercury                                                       Poise  Parada




   CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune   25 July ,2011   50
Authentic Authenticity




CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune
                                                                                    25 July ,2011   51
Bhasma as Nano‐medicine 

Global  Guidance                                                                             Crucial  Clause 




       CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune   25 July ,2011        52
Stop Press
Additional GMP                                                 Additional Certification 




 CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune
                                                                                     25 July ,2011   54
Enlighten Endorsement

Causative Consultation                            Comprehensive  communication 




         CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune   25 July ,2011   55
Special Submission 




CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune   25 July ,2011   56
Exigency in Education 




CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune   25 July ,2011   57
Take Home Message  

Indian Inheritance                                           Authoritative  Agenda 




       CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune   25 July ,2011   58
Conclusion 

Ayurveda is Super Science!
Rasa Shastra is Super Chemistry!

                                            All is Well 

         Dosage forms of Rasa Shastra & Bhaishjya
                 Kalpana ‐ Super Pharmaceutics ?  


   CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune   25 July ,2011   59
Acknowledgement 
 Prof A Wele ,Head , Dept of Rasa Shastra, 
  College of Ayurveda, Bharati Vidyapeetha
  ,Pune

 All Team Rasa Shastra , BV ,Pune

 All Scholastic Scholars of Rasa Shastra at 
  Pune from 25/07/2011 to 30/07/2011 


   CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune   25 July ,2011   60
Thanks & All Good Wishes ‐‐
‐‐‐




      CME for Teachers  in Rasa Shastra , College of Ayurveda 
                                  ,Bharati Vidyapeetha,Pune      25 July ,2011   61

Pharmaceutical processings in ay