PacGenomics provides you with the most art-of-the-state genetic testing
technolgies. Our genetic laboratory provides both microarray-based
Preimplantation Genetic Screening (PGS) and FISH-based Preimplantation
Genetic Diagnosis (PGD) services.
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PGS and PGD
1. PGS and PGD
PacGenomics provides you with the most art-of-the-state genetic testing
technolgies. Our genetic laboratory provides both microarray-based
Preimplantation Genetic Screening (PGS) and FISH-based Preimplantation
Genetic Diagnosis (PGD) services.
Some reasons you may consider using PGS/PGD are:
• You’re a woman over 35 years old
• Have experienced multiple miscarriages
• Have had multiple pregnancies with a chromosome abnormality
• Have had several unsuccessful IVF cycles
• You or your partner carry a unbalanced structural
chromosome rearrangement
• You want to balance the gender in your family
PGS with Chromosomal Microarray Analysis (CMA)
Technology
CMA testing is a new generation of genetic testing tools to detect small gains and losses of chromosomes.
With CMA testing technologies, PacGenomics overcomes the limitations and combines the strengths of
karyotyping and FISH, to offer you a wide range of high-resolution tests.
The PGS services offered by PacGenomics have several unique features:
• One-stop shopping: including embryo biopsy, embryo cell loading, DNA amplification, array
hybridization and interpretation to ensure a full quality control of all steps.
• Fast turn-around time: 95% of the PGS cases are reported within 16~24 hours after sample receipt.
• Super-clean environment: DNA amplification from a single cell is carried out in a class-100 cleanroom
to eliminate possible DNA contaminations.
• Quality Assurance protocols: All critical technical steps are double-checked independently by a
PacGenomics scientist. Data analysis and final report are reviewed by two senior scientists before
director reviews and signs off.
PGS Services available at PacGenomics:
• Aneuploidy Screening for IVF
The aneuploidy screening is a comprehensive test that examines all 24 chromosomes including autosomes
1-22 and sex chromosomes (X, Y) using high-density Oligo and/or SNP array.
• Detecting Unbalanced Translocation for IVF
An unbalanced translocation occurs when an embryo (or a child) inherits a chromosome with extra, or
missing genetic material from a parent with a balanced translocation. Unbalanced translocation can cause
cancer, birth defect and infertility. PGS with CMA is used to detect chromosomal deletion and duplication
larger than 2Mb in size in our genetic laboratory.
* PGS and PGD testings are for Research Use Only (RUO).
Village Medical Center
166 N. Moorpark Road, Suite 203
Thousand Oaks, CA 91360
www.PacGenomics.com • (310) 956-4829
2. PGD with FISH Technology for Aneuploidy
Fluorescence in situ hybridization (FISH) is a technology used to
identify a specific chromosomal region that contains a sequence
complemented with a cloned segment of DNA. FISH is used to detect
an abnormal number of chromosomes and a structural abnormality in
one or more chromosomes.
PGD with FISH for aneuploidy and unbalanced translocation is
provided through our strategic partner PGD Science, Inc.
Full PGD-FISH laboratory services include but not limited to:
• Embryo sex determination (2 chromosome panel) – chromosomes X, Y
• Aneuploidy screening (5 chromosome panel) – chromosomes 13, 18, 21, X, Y
• Aneuploidy screening (10 chromosome panel) – chromosomes 8, 9, 13, 15, 16, 18, 21, 22, X, Y
• Translocation and Inversions study
• Translocation and Inversions study plus Aneuploidy screening (5 chromosome panel)
• Sperm sex determination, aneuploidy analysis, and translocation study
* PGS and PGD testings are for Research Use Only (RUO).
Village Medical Center
166 N. Moorpark Road, Suite 203
Thousand Oaks, CA 91360
www.PacGenomics.com • (310) 956-4829