New evidences of key factors involved in “silent stones” ethiopathogenesis an...Simona Cavalu
The knowledge of the key factors involved in ethiopathogenesis of the gallstones disease requires chemical, structural and elemental composition analysis.
Cavalu Simona_PMMA/Mg3Al2(SiO4)3 BONE CEMENTS: PRODUCTION, STRUCTURAL CHARACT...Simona Cavalu
The document discusses the production and characterization of acrylic bone cements reinforced with 5% magnesium aluminosilicate (Mg3Al2(SiO4)3). Structural analysis using FTIR and XRD showed the inclusion of the Mg3Al2(SiO4)3 crystalline phase within the PMMA polymer matrix. SEM images revealed the additive created a porous structure in PMMA, facilitating hydroxyapatite formation in vitro. Biocompatibility tests with human fibroblasts showed cell attachment and proliferation on specimens with and without the magnesium aluminosilicate; no cytotoxic effects were observed. The study aims to improve the mechanical and bioactive properties of acrylic bone cements.
New evidences of key factors involved in “silent stones” ethiopathogenesis an...Simona Cavalu
The knowledge of the key factors involved in ethiopathogenesis of the gallstones disease requires chemical, structural and elemental composition analysis.
Cavalu Simona_PMMA/Mg3Al2(SiO4)3 BONE CEMENTS: PRODUCTION, STRUCTURAL CHARACT...Simona Cavalu
The document discusses the production and characterization of acrylic bone cements reinforced with 5% magnesium aluminosilicate (Mg3Al2(SiO4)3). Structural analysis using FTIR and XRD showed the inclusion of the Mg3Al2(SiO4)3 crystalline phase within the PMMA polymer matrix. SEM images revealed the additive created a porous structure in PMMA, facilitating hydroxyapatite formation in vitro. Biocompatibility tests with human fibroblasts showed cell attachment and proliferation on specimens with and without the magnesium aluminosilicate; no cytotoxic effects were observed. The study aims to improve the mechanical and bioactive properties of acrylic bone cements.
SIMONA CAVALU_Biomaterials and regenerative biomedicineSimona Cavalu
This document appears to be listing the authors Iulian Vasile ANTONIAC, Simona CAVALU, and Stefan Ioan VOICU and their affiliation with Biomaterials and Regenerative Biomedicine. It seems to be citing their work but provides no other contextual information about the topic, findings, or purpose of their work within that field.
The knowledge of the key factors involved in ethiopathogenesis of the gallstones disease requires chemical, structural and elemental composition analysis
Simona cavalu_ Adherence Properties of Acrylic Bone Cement to AluminaSimona Cavalu
The aim of this study is to investigate the adherence properties of acrylic cement based on PMMA to alumina
ceramics. These ceramics are suitable for orthopedic and dental applications, as bioinert components in prosthetic
surgery. The surface of alumina specimens were subjected to a special treatment based on acid etched followed by
two dierent uoride treatments: SnF2 and NaBF4, respectively.
This document summarizes research on PMMA/Ag2O acrylic bone cement coated with collagen to improve biomineralization, biocompatibility, and antibacterial properties. Collagen was electrodeposited on cement samples containing 0.5%, 1%, and 2% silver oxide. FTIR analysis showed collagen deposition depended on silver content. In vitro tests in simulated body fluid revealed silver ion release and mineralization of hydroxyapatite on surfaces over 3 weeks. Antimicrobial tests showed inhibition of E. coli and S. aureus growth, with effectiveness depending on silver content.
This document summarizes a study that investigated improving osseointegration of alumina/zirconia ceramic implants through fluoride surface treatment. Specifically, it discusses:
1) Fabricating alumina/zirconia composites and modifying their surface with SnF2 and NaBF4 treatments. Characterization showed the treatments incorporated fluoride onto the surface.
2) Evaluating the treatments in vitro with human fibroblast cultures, which showed better cell proliferation and layer formation on SnF2-treated surfaces.
3) Testing the treatments in vivo with rabbit femur implants, which revealed the SnF2 treatment resulted in better bone-implant contact after 6 weeks.
This document summarizes research on the adsorption behavior of hyaluronidase enzyme onto silver nanoparticles and polymethyl methacrylate (PMMA) bone substitute surfaces. Surface-enhanced Raman scattering (SERS) and infrared (IR) spectroscopy techniques were used to analyze the adsorption. SERS spectra of hyaluronidase adsorbed to silver nanoparticles showed well-resolved Raman signals and indicated oxygen adsorption from functional groups. IR analysis of PMMA incubated with hyaluronidase showed shifts in amide band positions, suggesting changes to secondary structure upon adsorption. Band deconvolution and fitting of amide peaks revealed decreases in α-helix and β-sheet content for adsorbed hyaluronidase, with increases
This document summarizes research on the adsorption behavior of hyaluronidase enzyme onto silver nanoparticles and polymethyl methacrylate (PMMA) bone substitute surfaces. Surface-enhanced Raman scattering (SERS) and infrared (IR) spectroscopy techniques were used to analyze the adsorption. SERS spectra of hyaluronidase adsorbed to silver nanoparticles showed well-resolved Raman signals and suggested oxygen adsorption from functional groups. IR analysis of PMMA incubated with hyaluronidase showed shifts in amide band positions, indicating changes to secondary structure upon adsorption. Band deconvolution and fitting of amide peaks revealed decreases in α-helix and β-sheet content for adsorbed hyaluronidase, with increases
SIMONA CAVALU_ Bone Cement silver joam2007Simona Cavalu
This study evaluated two types of silver-doped bone cement composites for their properties and ability to release silver ions with antibacterial effects. Electrochemical measurements showed both composites reduced calcium ion concentration in simulated body fluid over 14 days, with one composite releasing more silver ions within 5 hours. Scanning electron microscopy images revealed both composites developed hydroxyapatite crystal structures on their surfaces after 14 days, indicating bioactivity. Infrared spectroscopy confirmed mineral deposition and showed one composite absorbed more water over time. The antibiotic-containing composite showed greater mineralization and formation of a calcium phosphate layer, suggesting it may be more suitable for applications requiring bone growth.
This document summarizes a study that compares the microstructure, bioactivity, and biocompatibility of two types of acrylic bone cements: BIOLOS3® and ANTIBIOTIC SIMPLEX®. Electrochemical measurements, SEM imaging, and FTIR spectroscopy were used to analyze the materials after incubation in simulated body fluid for up to 34 days. The results showed that ANTIBIOTIC SIMPLEX® developed a more intense mineralization layer on its surface, as evidenced by greater calcium phosphate formation and water uptake. Hemolysis testing also indicated ANTIBIOTIC SIMPLEX® had better blood compatibility. In conclusion, the antibiotic-containing cement demonstrated superior in vitro bioactivity and bi
SIMONA CAVALU_Surface Modification of Alumina/ Zirconia Ceramics Upon Differe...Simona Cavalu
The aim of this study was to prepare and to characterize the structure of Al2O3–3YSZ composites with 5% TiO2 addition
as well as the surface modification upon treatments with SnF2 and NaBF4, respectively. SEM micrographs showed the
controlled densification of the composites as an effect of 3YSZ and TiO2 addition to alumina matrix. By FTIR and XRD,
the characteristics of Al-O and Zr-O vibrations, respectively, the diffractions lines related to a-corundum and zirconia in
tetragonal phase were discussed. Qualitative and quantitative results obtained by XPS and ATR FTIR demonstrated that the
proposed materials are more sensitive to SnF2 than to NaBF4 treatment.
SIMONA CAVALU_Raman and surface-enhanced Raman spectroscopy of tempyo spin la...Simona Cavalu
Tempyo labelled ovalbumin at different pH values was prepared and investigated using Raman and SERS spectroscopy.
Raman spectra of tempyo labelled ovalbumin in the pH range from 6.7 to 11 were compared to those of the corresponding free
ovalbumin. In the basic pH range from 6.7 to 11 the molecular conformation was found to be unaffected by the tempyo
presence. Adsorption versatility to the colloidal Ag particles of pure- and tempyo labelled ovalbumin was also found to be
unchanged in this basic pH range. As the SERS binding site of protein the a-helix conformation is favourable.
SIMONA CAVALU_Adsorption behavior of hyaluronidase onto silverSimona Cavalu
Surface enhanced Raman scattering (SERS) and ATR-FTIR spectroscopy was applied in this work, in order to get
information about the adsorption behavior of the title macromolecule with respect to different surfaces. In this case, the
silver substrate can be considered as artificial substrate and the investigations regarding the mechanisms of adsorption can
be useful in order to elucidate the active site properties of this enzyme. Our purpose is to study the adsorption mechanism
of hyaluronidase onto silver nanoparticles and PMMA (polymethyl methacrylate) substrates as well as qualitative and
quantitative aspects regarding perturbations of protein secondary structure (α-helix, β-sheet and unordered structures) upon
adsorption, using deconvolution techniques.
SIMONA CAVALU_Bioactivity evaluation of new silver doped bone cementSimona Cavalu
This document summarizes a study that evaluated the bioactivity and antimicrobial properties of two types of silver-doped bone cement composites. Electrochemical measurements and SEM/FTIR analysis were used to analyze the composites after incubation in simulated body fluid for up to 14 days. The results showed that both composites released silver and calcium ions into the fluid over time. One composite released silver ions more rapidly initially but both developed a hydroxyapatite-like surface layer indicating bioactivity. The layer formed more intensely on the surface of the composite also containing antibiotics. The study demonstrates the antimicrobial activity and bone bonding properties of the silver-doped composites.
SIMONA CAVALU_Microstructure and bioactivity of acrylic bone cementsSimona Cavalu
Polymer-ceramic composites based on polymethyl methacrylate are widely used in orthopaedics as suture materials and
fixation devices due to their biocompatibility and ability to support bony growth (osteoconductive) and also bone bioactive
(to form a calcium phosphate layer on its surface). In this study are compared the microstructure, bioactivity and
biocompatibility of two different types of biocomposites: BIOLOS3®and ANTIBIOTIC SIMPLEX®. They are investigated in
vitro in simulated body fluid using electrochemical measurements, SEM microscopy and ATR-FTIR spectroscopy in order to
evaluate the properties of the surface layer.
This document discusses Raman and surface enhanced Raman spectroscopy (SERS) experiments performed on bovine serum albumin and cytochrome c proteins labeled with 2,2,5,5-tetramethyl-3-pyrrolin-1-yloxy-3-carboxamide (tempyo) spin label at various pH values. The Raman and SERS spectra of the labeled proteins are compared to the unlabeled proteins. For bovine serum albumin, the SERS results suggest the α-helix conformation is favored at the binding site and the tempyo label does not significantly impact the vibrational structure. For cytochrome c, SERS enhancement of the porphyrin macrocycle bands indicates N-adsorption of
SIMONA CAVALU_IDENTIFICATION OF THE URINARY STONE COMPOSITION UPON EXTRACORPO...Simona Cavalu
Abstract. The study was carried out to investigate the composition and type of different urinary
stones upon application of extracorporeal shock wave lithotripsy. ATR FTIR spectra revealed the
marker bands of a mixed stone composition containing calcium oxalate monohydrate/ calcium
carbonate, respectively calcium oxalate monohydrate/cystine. The surface morphology of the samples
and elemental analysis was performed by SEM-EDAX confirming the presence of oxalate, carbonate
and cystine in the samples. Combination of FTIR spectroscopy and SEM-EDAX allowed quantitative
and qualitative evaluation of components, the spatial distribution and the percent of major and trace
elements present in a single sample.
“Environmental sanitation means the art and science of applying sanitary, biological and physical science principles and knowledge to improve and control the environment therein for the protection of the health and welfare of the public”.The overall importance of sanitation are to provide a healthy living environment for everyone, to protect the natural resources (such as surface water, groundwater, soil ), and to provide safety, security and dignity for people when they defecate or urinate .Sanitation refers to public health conditions such as drinking clean water, sewage treatment, etc. All the effective tools and actions that help in keeping the environment clean come under sanitation. Sanitation refers to public health conditions such as drinking clean water, sewage treatment. All the effective tools and actions that help in keeping the environment clean and promotes public health is the necessary in todays life.
SIMONA CAVALU_Biomaterials and regenerative biomedicineSimona Cavalu
This document appears to be listing the authors Iulian Vasile ANTONIAC, Simona CAVALU, and Stefan Ioan VOICU and their affiliation with Biomaterials and Regenerative Biomedicine. It seems to be citing their work but provides no other contextual information about the topic, findings, or purpose of their work within that field.
The knowledge of the key factors involved in ethiopathogenesis of the gallstones disease requires chemical, structural and elemental composition analysis
Simona cavalu_ Adherence Properties of Acrylic Bone Cement to AluminaSimona Cavalu
The aim of this study is to investigate the adherence properties of acrylic cement based on PMMA to alumina
ceramics. These ceramics are suitable for orthopedic and dental applications, as bioinert components in prosthetic
surgery. The surface of alumina specimens were subjected to a special treatment based on acid etched followed by
two dierent uoride treatments: SnF2 and NaBF4, respectively.
This document summarizes research on PMMA/Ag2O acrylic bone cement coated with collagen to improve biomineralization, biocompatibility, and antibacterial properties. Collagen was electrodeposited on cement samples containing 0.5%, 1%, and 2% silver oxide. FTIR analysis showed collagen deposition depended on silver content. In vitro tests in simulated body fluid revealed silver ion release and mineralization of hydroxyapatite on surfaces over 3 weeks. Antimicrobial tests showed inhibition of E. coli and S. aureus growth, with effectiveness depending on silver content.
This document summarizes a study that investigated improving osseointegration of alumina/zirconia ceramic implants through fluoride surface treatment. Specifically, it discusses:
1) Fabricating alumina/zirconia composites and modifying their surface with SnF2 and NaBF4 treatments. Characterization showed the treatments incorporated fluoride onto the surface.
2) Evaluating the treatments in vitro with human fibroblast cultures, which showed better cell proliferation and layer formation on SnF2-treated surfaces.
3) Testing the treatments in vivo with rabbit femur implants, which revealed the SnF2 treatment resulted in better bone-implant contact after 6 weeks.
This document summarizes research on the adsorption behavior of hyaluronidase enzyme onto silver nanoparticles and polymethyl methacrylate (PMMA) bone substitute surfaces. Surface-enhanced Raman scattering (SERS) and infrared (IR) spectroscopy techniques were used to analyze the adsorption. SERS spectra of hyaluronidase adsorbed to silver nanoparticles showed well-resolved Raman signals and indicated oxygen adsorption from functional groups. IR analysis of PMMA incubated with hyaluronidase showed shifts in amide band positions, suggesting changes to secondary structure upon adsorption. Band deconvolution and fitting of amide peaks revealed decreases in α-helix and β-sheet content for adsorbed hyaluronidase, with increases
This document summarizes research on the adsorption behavior of hyaluronidase enzyme onto silver nanoparticles and polymethyl methacrylate (PMMA) bone substitute surfaces. Surface-enhanced Raman scattering (SERS) and infrared (IR) spectroscopy techniques were used to analyze the adsorption. SERS spectra of hyaluronidase adsorbed to silver nanoparticles showed well-resolved Raman signals and suggested oxygen adsorption from functional groups. IR analysis of PMMA incubated with hyaluronidase showed shifts in amide band positions, indicating changes to secondary structure upon adsorption. Band deconvolution and fitting of amide peaks revealed decreases in α-helix and β-sheet content for adsorbed hyaluronidase, with increases
SIMONA CAVALU_ Bone Cement silver joam2007Simona Cavalu
This study evaluated two types of silver-doped bone cement composites for their properties and ability to release silver ions with antibacterial effects. Electrochemical measurements showed both composites reduced calcium ion concentration in simulated body fluid over 14 days, with one composite releasing more silver ions within 5 hours. Scanning electron microscopy images revealed both composites developed hydroxyapatite crystal structures on their surfaces after 14 days, indicating bioactivity. Infrared spectroscopy confirmed mineral deposition and showed one composite absorbed more water over time. The antibiotic-containing composite showed greater mineralization and formation of a calcium phosphate layer, suggesting it may be more suitable for applications requiring bone growth.
This document summarizes a study that compares the microstructure, bioactivity, and biocompatibility of two types of acrylic bone cements: BIOLOS3® and ANTIBIOTIC SIMPLEX®. Electrochemical measurements, SEM imaging, and FTIR spectroscopy were used to analyze the materials after incubation in simulated body fluid for up to 34 days. The results showed that ANTIBIOTIC SIMPLEX® developed a more intense mineralization layer on its surface, as evidenced by greater calcium phosphate formation and water uptake. Hemolysis testing also indicated ANTIBIOTIC SIMPLEX® had better blood compatibility. In conclusion, the antibiotic-containing cement demonstrated superior in vitro bioactivity and bi
SIMONA CAVALU_Surface Modification of Alumina/ Zirconia Ceramics Upon Differe...Simona Cavalu
The aim of this study was to prepare and to characterize the structure of Al2O3–3YSZ composites with 5% TiO2 addition
as well as the surface modification upon treatments with SnF2 and NaBF4, respectively. SEM micrographs showed the
controlled densification of the composites as an effect of 3YSZ and TiO2 addition to alumina matrix. By FTIR and XRD,
the characteristics of Al-O and Zr-O vibrations, respectively, the diffractions lines related to a-corundum and zirconia in
tetragonal phase were discussed. Qualitative and quantitative results obtained by XPS and ATR FTIR demonstrated that the
proposed materials are more sensitive to SnF2 than to NaBF4 treatment.
SIMONA CAVALU_Raman and surface-enhanced Raman spectroscopy of tempyo spin la...Simona Cavalu
Tempyo labelled ovalbumin at different pH values was prepared and investigated using Raman and SERS spectroscopy.
Raman spectra of tempyo labelled ovalbumin in the pH range from 6.7 to 11 were compared to those of the corresponding free
ovalbumin. In the basic pH range from 6.7 to 11 the molecular conformation was found to be unaffected by the tempyo
presence. Adsorption versatility to the colloidal Ag particles of pure- and tempyo labelled ovalbumin was also found to be
unchanged in this basic pH range. As the SERS binding site of protein the a-helix conformation is favourable.
SIMONA CAVALU_Adsorption behavior of hyaluronidase onto silverSimona Cavalu
Surface enhanced Raman scattering (SERS) and ATR-FTIR spectroscopy was applied in this work, in order to get
information about the adsorption behavior of the title macromolecule with respect to different surfaces. In this case, the
silver substrate can be considered as artificial substrate and the investigations regarding the mechanisms of adsorption can
be useful in order to elucidate the active site properties of this enzyme. Our purpose is to study the adsorption mechanism
of hyaluronidase onto silver nanoparticles and PMMA (polymethyl methacrylate) substrates as well as qualitative and
quantitative aspects regarding perturbations of protein secondary structure (α-helix, β-sheet and unordered structures) upon
adsorption, using deconvolution techniques.
SIMONA CAVALU_Bioactivity evaluation of new silver doped bone cementSimona Cavalu
This document summarizes a study that evaluated the bioactivity and antimicrobial properties of two types of silver-doped bone cement composites. Electrochemical measurements and SEM/FTIR analysis were used to analyze the composites after incubation in simulated body fluid for up to 14 days. The results showed that both composites released silver and calcium ions into the fluid over time. One composite released silver ions more rapidly initially but both developed a hydroxyapatite-like surface layer indicating bioactivity. The layer formed more intensely on the surface of the composite also containing antibiotics. The study demonstrates the antimicrobial activity and bone bonding properties of the silver-doped composites.
SIMONA CAVALU_Microstructure and bioactivity of acrylic bone cementsSimona Cavalu
Polymer-ceramic composites based on polymethyl methacrylate are widely used in orthopaedics as suture materials and
fixation devices due to their biocompatibility and ability to support bony growth (osteoconductive) and also bone bioactive
(to form a calcium phosphate layer on its surface). In this study are compared the microstructure, bioactivity and
biocompatibility of two different types of biocomposites: BIOLOS3®and ANTIBIOTIC SIMPLEX®. They are investigated in
vitro in simulated body fluid using electrochemical measurements, SEM microscopy and ATR-FTIR spectroscopy in order to
evaluate the properties of the surface layer.
This document discusses Raman and surface enhanced Raman spectroscopy (SERS) experiments performed on bovine serum albumin and cytochrome c proteins labeled with 2,2,5,5-tetramethyl-3-pyrrolin-1-yloxy-3-carboxamide (tempyo) spin label at various pH values. The Raman and SERS spectra of the labeled proteins are compared to the unlabeled proteins. For bovine serum albumin, the SERS results suggest the α-helix conformation is favored at the binding site and the tempyo label does not significantly impact the vibrational structure. For cytochrome c, SERS enhancement of the porphyrin macrocycle bands indicates N-adsorption of
SIMONA CAVALU_IDENTIFICATION OF THE URINARY STONE COMPOSITION UPON EXTRACORPO...Simona Cavalu
Abstract. The study was carried out to investigate the composition and type of different urinary
stones upon application of extracorporeal shock wave lithotripsy. ATR FTIR spectra revealed the
marker bands of a mixed stone composition containing calcium oxalate monohydrate/ calcium
carbonate, respectively calcium oxalate monohydrate/cystine. The surface morphology of the samples
and elemental analysis was performed by SEM-EDAX confirming the presence of oxalate, carbonate
and cystine in the samples. Combination of FTIR spectroscopy and SEM-EDAX allowed quantitative
and qualitative evaluation of components, the spatial distribution and the percent of major and trace
elements present in a single sample.
“Environmental sanitation means the art and science of applying sanitary, biological and physical science principles and knowledge to improve and control the environment therein for the protection of the health and welfare of the public”.The overall importance of sanitation are to provide a healthy living environment for everyone, to protect the natural resources (such as surface water, groundwater, soil ), and to provide safety, security and dignity for people when they defecate or urinate .Sanitation refers to public health conditions such as drinking clean water, sewage treatment, etc. All the effective tools and actions that help in keeping the environment clean come under sanitation. Sanitation refers to public health conditions such as drinking clean water, sewage treatment. All the effective tools and actions that help in keeping the environment clean and promotes public health is the necessary in todays life.
Giloy in Ayurveda - Classical Categorization and SynonymsPlanet Ayurveda
Giloy, also known as Guduchi or Amrita in classical Ayurvedic texts, is a revered herb renowned for its myriad health benefits. It is categorized as a Rasayana, meaning it has rejuvenating properties that enhance vitality and longevity. Giloy is celebrated for its ability to boost the immune system, detoxify the body, and promote overall wellness. Its anti-inflammatory, antipyretic, and antioxidant properties make it a staple in managing conditions like fever, diabetes, and stress. The versatility and efficacy of Giloy in supporting health naturally highlight its importance in Ayurveda. At Planet Ayurveda, we provide a comprehensive range of health services and 100% herbal supplements that harness the power of natural ingredients like Giloy. Our products are globally available and affordable, ensuring that everyone can benefit from the ancient wisdom of Ayurveda. If you or your loved ones are dealing with health issues, contact Planet Ayurveda at 01725214040 to book an online video consultation with our professional doctors. Let us help you achieve optimal health and wellness naturally.
Discover the benefits of homeopathic medicine for irregular periods with our guide on 5 common remedies. Learn how these natural treatments can help regulate menstrual cycles and improve overall menstrual health.
Visit Us: https://drdeepikashomeopathy.com/service/irregular-periods-treatment/
As the world population is aging, Health tourism has become vitally important and will be increased day by day. Because
of the availability of quality health services and more favorable prices as well as to shorten the waiting list for medical
services regionally and internationally. There are some aspects of managing and doing marketing activities in order for
medical tourism to be feasible, in a region called as clustering in a region with main stakeholders groups includes Health
providers, Tourism cluster, etc. There are some related and affecting factors to be considered for the feasibility of medical
tourism within this study such as competitiveness, clustering, Entrepreneurship, SMEs. One of the growth phenomenon
is Health tourism in the city of Izmir and Turkey. The model of five competitive forces of Porter and The Diamond model
that is an economical model that shows the four main factors that affect the competitiveness of a nation and its industries
in this study. The short literature of medical tourism and regional clustering have been mentioned.
PGx Analysis in VarSeq: A User’s PerspectiveGolden Helix
Since our release of the PGx capabilities in VarSeq, we’ve had a few months to gather some insights from various use cases. Some users approach PGx workflows by means of array genotyping or what seems to be a growing trend of adding the star allele calling to the existing NGS pipeline for whole genome data. Luckily, both approaches are supported with the VarSeq software platform. The genotyping method being used will also dictate what the scope of the tertiary analysis will be. For example, are your PGx reports a standalone pipeline or would your lab’s goal be to handle a dual-purpose workflow and report on PGx + Diagnostic findings.
The purpose of this webcast is to:
Discuss and demonstrate the approaches with array and NGS genotyping methods for star allele calling to prep for downstream analysis.
Following genotyping, explore alternative tertiary workflow concepts in VarSeq to handle PGx reporting.
Moreover, we will include insights users will need to consider when validating their PGx workflow for all possible star alleles and options you have for automating your PGx analysis for large number of samples. Please join us for a session dedicated to the application of star allele genotyping and subsequent PGx workflows in our VarSeq software.
Storyboard on Acne-Innovative Learning-M. pharm. (2nd sem.) CosmeticsMuskanShingari
Acne is a common skin condition that occurs when hair follicles become clogged with oil and dead skin cells. It typically manifests as pimples, blackheads, or whiteheads, often on the face, chest, shoulders, or back. Acne can range from mild to severe and may cause emotional distress and scarring in some cases.
**Causes:**
1. **Excess Oil Production:** Hormonal changes during adolescence or certain times in adulthood can increase sebum (oil) production, leading to clogged pores.
2. **Clogged Pores:** When dead skin cells and oil block hair follicles, bacteria (usually Propionibacterium acnes) can thrive, causing inflammation and acne lesions.
3. **Hormonal Factors:** Fluctuations in hormone levels, such as during puberty, menstrual cycles, pregnancy, or certain medical conditions, can contribute to acne.
4. **Genetics:** A family history of acne can increase the likelihood of developing the condition.
**Types of Acne:**
- **Whiteheads:** Closed plugged pores.
- **Blackheads:** Open plugged pores with a dark surface.
- **Papules:** Small red, tender bumps.
- **Pustules:** Pimples with pus at their tips.
- **Nodules:** Large, solid, painful lumps beneath the surface.
- **Cysts:** Painful, pus-filled lumps beneath the surface that can cause scarring.
**Treatment:**
Treatment depends on the severity and type of acne but may include:
- **Topical Treatments:** Such as benzoyl peroxide, salicylic acid, or retinoids to reduce bacteria and unclog pores.
- **Oral Medications:** Antibiotics or oral contraceptives for hormonal acne.
- **Procedures:** Such as chemical peels, extraction of comedones, or light therapy for more severe cases.
**Prevention and Management:**
- **Cleanse:** Regularly wash skin with a gentle cleanser.
- **Moisturize:** Use non-comedogenic moisturizers to keep skin hydrated without clogging pores.
- **Avoid Irritants:** Such as harsh cosmetics or excessive scrubbing.
- **Sun Protection:** Use sunscreen to prevent exacerbation of acne scars and inflammation.
Acne treatment can take time, and consistency in skincare routines and treatments is crucial. Consulting a dermatologist can help tailor a treatment plan that suits individual needs and reduces the risk of scarring or long-term skin damage.
Pictorial and detailed description of patellar instability with sign and symptoms and how to diagnose , what investigations you should go with and how to approach with treatment options . I have presented this slide in my 2nd year junior residency in orthopedics at LLRM medical college Meerut and got good reviews for it
After getting it read you will definitely understand the topic.
Nutritional deficiency Disorder are problems in india.
It is very important to learn about Indian child's nutritional parameters as well the Disease related to alteration in their Nutrition.
CLASSIFICATION OF H1 ANTIHISTAMINICS-
FIRST GENERATION ANTIHISTAMINICS-
1)HIGHLY SEDATIVE-DIPHENHYDRAMINE,DIMENHYDRINATE,PROMETHAZINE,HYDROXYZINE 2)MODERATELY SEDATIVE- PHENARIMINE,CYPROHEPTADINE, MECLIZINE,CINNARIZINE
3)MILD SEDATIVE-CHLORPHENIRAMINE,DEXCHLORPHENIRAMINE
TRIPROLIDINE,CLEMASTINE
SECOND GENERATION ANTIHISTAMINICS-FEXOFENADINE,
LORATADINE,DESLORATADINE,CETIRIZINE,LEVOCETIRIZINE,
AZELASTINE,MIZOLASTINE,EBASTINE,RUPATADINE. Mechanism of action of 2nd generation antihistaminics-
These drugs competitively antagonize actions of
histamine at the H1 receptors.
Pharmacological actions-
Antagonism of histamine-The H1 antagonists effectively block histamine induced bronchoconstriction, contraction of intestinal and other smooth muscle and triple response especially wheal, flare and itch. Constriction of larger blood vessel by histamine is also antagonized.
2) Antiallergic actions-Many manifestations of immediate hypersensitivity (type I reactions)are suppressed. Urticaria, itching and angioedema are well controlled.3) CNS action-The older antihistamines produce variable degree of CNS depression.But in case of 2nd gen antihistaminics there is less CNS depressant property as these cross BBB to significantly lesser extent.
4) Anticholinergic action- many H1 blockers
in addition antagonize muscarinic actions of ACh. BUT IN 2ND gen histaminics there is Higher H1 selectivitiy : no anticholinergic side effects
Selective alpha1 blockers are Prazosin, Terazosin, Doxazosin, Tamsulosin and Silodosin majorly used to treat BPH, also hypertension, PTSD, Raynaud's phenomenon, CHF
- Video recording of this lecture in English language: https://youtu.be/RvdYsTzgQq8
- Video recording of this lecture in Arabic language: https://youtu.be/ECILGWtgZko
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Nano-gold for Cancer Therapy chemistry investigatory projectSIVAVINAYAKPK
chemistry investigatory project
The development of nanogold-based cancer therapy could revolutionize oncology by providing a more targeted, less invasive treatment option. This project contributes to the growing body of research aimed at harnessing nanotechnology for medical applications, paving the way for future clinical trials and potential commercial applications.
Cancer remains one of the leading causes of death worldwide, prompting the need for innovative treatment methods. Nanotechnology offers promising new approaches, including the use of gold nanoparticles (nanogold) for targeted cancer therapy. Nanogold particles possess unique physical and chemical properties that make them suitable for drug delivery, imaging, and photothermal therapy.
Spontaneous Bacterial Peritonitis - Pathogenesis , Clinical Features & Manage...Jim Jacob Roy
In this presentation , SBP ( spontaneous bacterial peritonitis ) , which is a common complication in patients with cirrhosis and ascites is described in detail.
The reference for this presentation is Sleisenger and Fordtran's Gastrointestinal and Liver Disease Textbook ( 11th edition ).