The document discusses proven strategies for improving patient safety based on rigorous research evidence. It recommends implementing two strategies - using antibiotic prophylaxis to prevent infections and establishing a critical care outreach team to prevent failures to rescue. While there is strong evidence that antibiotic prophylaxis reduces infections, the evidence for critical care outreach teams is less certain. Effective implementation and supportive organizational contexts are also important for success. The document advocates testing interventions on a small scale first to adapt them locally before broader spread.