A practice based retrospective study of over 10,000 pediatric office visits over eight years showed an 94% reduction of chronic otitis media , a 79% reduction of acute otitis media, and an overall reduction of 76% of all catagories of otitis media.
inflammation of the ear, usually distinguished as otitis externa (of the passage of the outer ear), otitis media (of the middle ear), and otitis interna (of the inner ear; labyrinthitis).
Subcutaneous Immunotherapy: Is it Worth a Shot? Cost-effectiveness of Allerge...KSAAI
This document summarizes a presentation on the health economics of immunotherapy. It discusses trends showing increasing allergic rhinitis prevalence and expenditures dominated by prescription medications. While evidence demonstrates clinical and economic benefits of immunotherapy (SIT), access, coverage, and utilization have not increased. Two studies of Medicaid patients are summarized, finding poor adherence to SCIT and economic benefits of $800-5,400 annually from SIT versus symptomatic treatment. Overall it argues more work is needed to demonstrate SIT value to increase acceptance and adoption.
09 CeoMeeting- Session 4- Medicines for MalariaMLSCF
The document discusses product development partnerships (PDPs) that work to develop medicines and treatments for diseases that disproportionately impact developing countries and have limited commercial incentives. It provides Medicine for Malaria Venture (MMV) as a key example of a PDP focused on developing antimalarial drugs. MMV has developed over a dozen antimalarial candidates and products over its existence, including a pediatric-friendly version of Coartem through partnerships with Novartis. PDPs have grown substantially over the past decade and play a central role in driving neglected disease product pipelines.
Homeopathic medical practice: Long-term results of a cohort study with 3981 p...home
Disease severity and quality of life demonstrated marked and sustained
improvements following homeopathic treatment period. Our findings indicate that homeopathic
medical therapy may play a beneficial role in the long-term care of patients with chronic diseases.
Effects of moderate doses of vitamin A as an adjunct to the treatment of pneu...ISAMI1
Effects of moderate doses of vitamin A as an adjunct to the treatment of pneumonia in underweight and normal-weight children: a randomized, double-blind, placebo-controlled trial
World Health Day 2011 aims to raise awareness about antimicrobial resistance (AMR) and promote action to address it. AMR kills annually and jeopardizes healthcare gains. It is a major challenge for treating diseases like tuberculosis, malaria, and gonorrhea as many pathogens are becoming resistant. Weak surveillance systems, poor infection control, and overuse of antibiotics have contributed to the rise of AMR. While strategies exist, more commitment is needed for implementation. World Health Day 2011 will advocate for priority actions and engage stakeholders to strengthen responses to the growing threat of AMR.
World Health Day 2011 aims to raise awareness about antimicrobial resistance (AMR) and promote action to address it. AMR kills annually and jeopardizes healthcare gains. It is a major challenge for treating tuberculosis, malaria, HIV, methicillin-resistant Staphylococcus aureus, and other drug-resistant infections. Weak surveillance systems, inappropriate antibiotic use, and lack of new antibiotics have contributed to the rise of AMR. World Health Day 2011 will advocate for member states to implement comprehensive national plans and collaborate across sectors to combat AMR.
Friday 2.15 Pm Adolfo Valadez Prevention And Preparedness DivisionNathan Bunker
The document discusses immunization programs in Texas, including:
- The top 10 public health achievements of the 20th century, including vaccinations.
- How immunizations have led to declines in disease incidence and saved lives and costs.
- Vaccine coverage levels in Texas, which are close to national goals.
- Disease incidence trends being lowered by immunizations in Texas.
- The Texas Vaccines for Children Program and ImmTrac immunization registry.
inflammation of the ear, usually distinguished as otitis externa (of the passage of the outer ear), otitis media (of the middle ear), and otitis interna (of the inner ear; labyrinthitis).
Subcutaneous Immunotherapy: Is it Worth a Shot? Cost-effectiveness of Allerge...KSAAI
This document summarizes a presentation on the health economics of immunotherapy. It discusses trends showing increasing allergic rhinitis prevalence and expenditures dominated by prescription medications. While evidence demonstrates clinical and economic benefits of immunotherapy (SIT), access, coverage, and utilization have not increased. Two studies of Medicaid patients are summarized, finding poor adherence to SCIT and economic benefits of $800-5,400 annually from SIT versus symptomatic treatment. Overall it argues more work is needed to demonstrate SIT value to increase acceptance and adoption.
09 CeoMeeting- Session 4- Medicines for MalariaMLSCF
The document discusses product development partnerships (PDPs) that work to develop medicines and treatments for diseases that disproportionately impact developing countries and have limited commercial incentives. It provides Medicine for Malaria Venture (MMV) as a key example of a PDP focused on developing antimalarial drugs. MMV has developed over a dozen antimalarial candidates and products over its existence, including a pediatric-friendly version of Coartem through partnerships with Novartis. PDPs have grown substantially over the past decade and play a central role in driving neglected disease product pipelines.
Homeopathic medical practice: Long-term results of a cohort study with 3981 p...home
Disease severity and quality of life demonstrated marked and sustained
improvements following homeopathic treatment period. Our findings indicate that homeopathic
medical therapy may play a beneficial role in the long-term care of patients with chronic diseases.
Effects of moderate doses of vitamin A as an adjunct to the treatment of pneu...ISAMI1
Effects of moderate doses of vitamin A as an adjunct to the treatment of pneumonia in underweight and normal-weight children: a randomized, double-blind, placebo-controlled trial
World Health Day 2011 aims to raise awareness about antimicrobial resistance (AMR) and promote action to address it. AMR kills annually and jeopardizes healthcare gains. It is a major challenge for treating diseases like tuberculosis, malaria, and gonorrhea as many pathogens are becoming resistant. Weak surveillance systems, poor infection control, and overuse of antibiotics have contributed to the rise of AMR. While strategies exist, more commitment is needed for implementation. World Health Day 2011 will advocate for priority actions and engage stakeholders to strengthen responses to the growing threat of AMR.
World Health Day 2011 aims to raise awareness about antimicrobial resistance (AMR) and promote action to address it. AMR kills annually and jeopardizes healthcare gains. It is a major challenge for treating tuberculosis, malaria, HIV, methicillin-resistant Staphylococcus aureus, and other drug-resistant infections. Weak surveillance systems, inappropriate antibiotic use, and lack of new antibiotics have contributed to the rise of AMR. World Health Day 2011 will advocate for member states to implement comprehensive national plans and collaborate across sectors to combat AMR.
Friday 2.15 Pm Adolfo Valadez Prevention And Preparedness DivisionNathan Bunker
The document discusses immunization programs in Texas, including:
- The top 10 public health achievements of the 20th century, including vaccinations.
- How immunizations have led to declines in disease incidence and saved lives and costs.
- Vaccine coverage levels in Texas, which are close to national goals.
- Disease incidence trends being lowered by immunizations in Texas.
- The Texas Vaccines for Children Program and ImmTrac immunization registry.
Pharmacoepidemiology is the study of the use and effects of drugs in large populations. The document discusses the definition, origins, need and applications of pharmacoepidemiology. Specifically, it notes that pharmacoepidemiology applies epidemiological techniques to study drug use and effects in populations. It also discusses limitations of pre-marketing drug trials that pharmacoepidemiology aims to address through post-marketing surveillance and other techniques.
The document summarizes a workshop on the future of global fresh produce safety for retail and foodservice. It discusses how produce-related foodborne outbreaks have increased in recent decades. It also outlines steps taken by the FDA and other groups to improve produce safety, such as guidance documents, action plans, and regulatory programs in states like California and Florida. The future of produce safety will require consistent standards and practices across the supply chain to prevent contamination and illness.
Day 1 | CME- Trauma Symposium | Bronchiolitis pittengerNorton Healthcare
This document provides an overview and discussion of the diagnosis and management of bronchiolitis. It begins with a brief history of bronchiolitis and how our understanding and treatment of it has evolved over time. It then reviews the typical presentation and risk factors for severe disease. Current guidelines recommend supportive care rather than interventions like bronchodilators or steroids. The document discusses factors that may be influencing rising hospitalization rates and evaluates recent evidence regarding treatments. Implementing evidence-based clinical pathways and decision tools can help standardize care and reduce unnecessary testing and interventions.
The document discusses sustainable approaches for controlling gastrointestinal nematodes (GINs) in ruminant livestock. It notes that current control relies heavily on frequent anthelmintic use, which has led to widespread anthelmintic resistance. More sustainable approaches include targeted selective treatments using diagnostic tools and refugia-based strategies to minimize drug selection pressure. However, uptake of these approaches has been limited. The document argues that understanding farmers' behaviors and improving communication of sustainable guidelines could help promote adoption of new control strategies and reduce anthelmintic resistance issues.
This document provides information from the Centers for Disease Control and Prevention (CDC) regarding immunization and vaccine-preventable diseases. The summary includes:
- The number of diseases prevented by vaccines included in the routine childhood/adolescent immunization schedule has increased from 6 in 1964 to 16 in 2017.
- Vaccination has led to significant decreases in reported cases of diseases like smallpox, diphtheria, measles, and others compared to 20th century annual morbidity.
- CDC estimates that childhood vaccination between 1994-2016 prevented 381 million illnesses, 24.5 million hospitalizations, and 855,000 early deaths, saving $360 billion in direct costs and $1.65 trillion
Abstract— Methicillin-resistant Staphylococcus aureus (MRSA) poses a great risk to burn patients with potential to cause significant morbidity and mortality. This study aimed to find out the prevalence of MRSA and its susceptibility, in burn wound infection/colonization in a Tertiary Care Hospital in North India. A retrospective study was conducted among patients admitted in burn ward of our hospital, between January to December 2012. All the patients irrespective of age, sex, duration of hospital stay, percentage and degree of burn were included in our study. Wound swabs from 1294 patients hospitalized in burn ward were analysed for bacteriological examination. Swabs were inoculated on Blood agar, MacConkey agar and Brain heart infusion broth. Isolates were examined for colony characteristics, Gram staining and biochemical tests. Antimicrobial susceptibility testing was done by modified Stokes disc diffusion method. Detection of MRSA was done by cefoxitin (30g) disc diffusion method. Among the Staphylococcus aureus (S.aureus) isolates, 56.7% (80/141) were found to be MRSA while 43.3% (61/141) were Methicillin Susceptible S.aureus (MSSA). All the MRSA isolates were resistant to penicillin, cephalexin and cefazolin. Resistance to erythromycin, clindamycin, ofloxacin, ciprofloxacin, gentamicin, amikacin, rifampicin, chloramphenicol was found to be 74%, 97.4%, 96%, 100%, 97.4%, 84.6%, 11.5%, 10.3%. All MRSA isolates were found to be sensitive to vancomycin and teicoplanin while 1.3% were resistant to linezolid. Although survival rates for burn patients have improved substantially over the years, nosocomial infections still remain a major challenge in burn care. This concludes that there is high prevalence of nosocomial infections specially the presence of multidrug resistant bacteria like Methicillin Resistant Staphylococcus aureus among burn patients suggest continuous surveillance of burn wound infections and development and stringent implementation of antibiotic policy.
Mitigation strategies for the protection of health care workers and first res...Omar Ha-Redeye
Mitigation strategies for protecting health care workers and first responders from swine flu are discussed. Key points include using personal protective equipment like masks and gowns, isolating confirmed cases, contact tracing, and treating symptomatic individuals and exposed health care workers with antiviral drugs. Stockpiles of antiviral drugs and personal protective equipment have been increased in many countries to prepare for a potential pandemic. There is ongoing debate around certain strategies like the use of masks and social distancing policies.
This document discusses antimicrobial resistance (AMR) surveillance efforts in India, including the IndiaCLEN Invasive Bacterial Infections Surveillance (IBIS) project and Community AMR (CAMR) study. IBIS monitored AMR patterns of Streptococcus pneumoniae and Haemophilus influenzae from invasive disease cases and nasopharyngeal swabs. CAMR studied colonizing strains from healthy children. Both found high resistance to co-trimoxazole. Nasopharyngeal samples showed potential for alternative AMR surveillance. The document calls for policies to address emerging penicillin resistance and continue long-term AMR monitoring to guide treatment and evaluate interventions.
This document discusses guidelines from the Global Initiative for Asthma (GINA) for defining, describing, diagnosing and treating asthma. It provides definitions of asthma as a chronic inflammatory disease of the airways characterized by variable respiratory symptoms. It outlines the criteria for diagnosing asthma based on symptoms, lung function tests and response to treatment. It also discusses evaluating asthma control and severity, and establishing a treatment plan to control symptoms and reduce risks. The goal of treatment is to achieve good symptom control and maintain normal daily activity levels while decreasing risks of exacerbations and adverse effects.
The document discusses definitions, descriptions, diagnosis and treatment of asthma according to GINA and PRACTALL guidelines. It provides definitions of asthma as a chronic inflammatory disease of the airways characterized by variable respiratory symptoms and airflow limitation. Diagnosis is based on symptoms, reversibility testing and variability in lung function. Treatment involves a stepwise approach starting with reliever medication and low-dose inhaled corticosteroids, escalating up treatments based on symptom control and risk of exacerbations. The goal is to achieve good symptom control and reduce risk of exacerbations and side effects.
This document discusses policy making related to blood safety in public health. It makes three key points:
1) Policy making in government is complex, often inconsistent, and influenced by a variety of stakeholders and political factors.
2) Cost-effectiveness is considered in health care spending but blood safety measures have been relatively insulated from this and are supported by high public willingness to pay.
3) Measures to enhance blood safety should continue but scrutiny should also focus on evidence for specific medical therapies.
This document provides guidelines for the global management and prevention of asthma. It summarizes the burden of asthma, factors that influence asthma development and expression, mechanisms of asthma including airway inflammation and pathophysiology. It also outlines recommendations for diagnosing and classifying asthma, as well as treating asthma with medications. The treatment section provides guidance on controller and reliever medications for both adults and children. Additionally, it describes components of asthma management and prevention, including developing patient-doctor partnerships, identifying and reducing risk factors, assessing and monitoring asthma control, managing exacerbations, and special considerations.
The international survey on the management of allergic rhinitis by physicians...Georgi Daskalov
ORIGINAL RESEARCH Open Access
The international survey on the management of
allergic rhinitis by physicians and patients
(ISMAR)
Carlos E Baena-Cagnani
1
†
ˆ
, Giorgio W Canonica
2*
, Mohamed Zaky Helal
3
†
, René Maximiliano Gómez
4
†
,
Enrico Compalati
2
†
, Mario E Zernotti
5
†
, Mario Sanchez-Borges
6
†
, Fabio F Morato Castro
7
†
,
Margarita Murrieta Aguttes
8
†
, Aida López-Garcia
9
†
, Faheem A Tadros
10
†
and ISMAR Study Group
This document provides a 3-sentence summary of the given document:
The document is the 2012 updated Global Strategy for Asthma Management and Prevention report published by the Global Initiative for Asthma (GINA). It outlines recommendations for diagnosing and classifying asthma, as well as treating asthma with medications and managing asthma prevention. The report was updated by the GINA Board of Directors and Science Committee, which include asthma experts from around the world.
This document provides a 3-sentence summary of the Global Strategy for Asthma Management and Prevention 2012 report:
The report is authored by an international board and committee and provides updated clinical recommendations for diagnosing and managing asthma based on assessing, treating, and maintaining asthma control. It describes factors that influence asthma such as genetics, environment, and lifestyle, and covers approaches to developing partnerships with patients, identifying and reducing risk factors, treating asthma with different medication types and delivery methods, and managing exacerbations. The report is intended to help health care professionals provide effective and individualized care for people with asthma globally.
Professor Benedetta Allegranzi,World Health Organisation
Dr. Benedetta Allegranzi is a specialist in infectious diseases, tropical medicine, infection prevention and control and hospital epidemiology. She currently works at the World Health Organization HQ (Service Delivery and Safety department), leading the "Clean Care is Safer Care" programme. Since 2013, Dr Allegranzi has gathered the title of professor of infectious diseases in the official Italian professorship list and is adjunct professor attached to the Institute of Global Health at the Faculty of Medicine, University of Geneva, Switzerland. She closely collaborates with the team at the IPC and WHO Collaborating Center on Patient Safety, University of Geneva Hospitals (Geneva, Switzerland), as well as with the Armstrong Institute for Patient Safety and Quality, John Hopkins University, (Baltimore, USA) for clinical research projects. She is currently involved in the leadership on the WHO Ebola Response in the field of IPC and supervises IPC activities in Sierra Leone and Guinea. She has experience in clinical management of infectious diseases and tropical medicine, and clinical research in healthcare settings in both developing and developed countries. She has thorough skills and experience in training and education.
She is also the author or coauthor of more than 150 scientific publications, including articles published in high-profile medical journal such as the Lancet, Lancet Infectious Diseases, New England Journal of Medicine and the WHO Bulletin, and six book chapters.
The biomechanics of running involves the study of the mechanical principles underlying running movements. It includes the analysis of the running gait cycle, which consists of the stance phase (foot contact to push-off) and the swing phase (foot lift-off to next contact). Key aspects include kinematics (joint angles and movements, stride length and frequency) and kinetics (forces involved in running, including ground reaction and muscle forces). Understanding these factors helps in improving running performance, optimizing technique, and preventing injuries.
Breast cancer: Post menopausal endocrine therapyDr. Sumit KUMAR
Breast cancer in postmenopausal women with hormone receptor-positive (HR+) status is a common and complex condition that necessitates a multifaceted approach to management. HR+ breast cancer means that the cancer cells grow in response to hormones such as estrogen and progesterone. This subtype is prevalent among postmenopausal women and typically exhibits a more indolent course compared to other forms of breast cancer, which allows for a variety of treatment options.
Diagnosis and Staging
The diagnosis of HR+ breast cancer begins with clinical evaluation, imaging, and biopsy. Imaging modalities such as mammography, ultrasound, and MRI help in assessing the extent of the disease. Histopathological examination and immunohistochemical staining of the biopsy sample confirm the diagnosis and hormone receptor status by identifying the presence of estrogen receptors (ER) and progesterone receptors (PR) on the tumor cells.
Staging involves determining the size of the tumor (T), the involvement of regional lymph nodes (N), and the presence of distant metastasis (M). The American Joint Committee on Cancer (AJCC) staging system is commonly used. Accurate staging is critical as it guides treatment decisions.
Treatment Options
Endocrine Therapy
Endocrine therapy is the cornerstone of treatment for HR+ breast cancer in postmenopausal women. The primary goal is to reduce the levels of estrogen or block its effects on cancer cells. Commonly used agents include:
Selective Estrogen Receptor Modulators (SERMs): Tamoxifen is a SERM that binds to estrogen receptors, blocking estrogen from stimulating breast cancer cells. It is effective but may have side effects such as increased risk of endometrial cancer and thromboembolic events.
Aromatase Inhibitors (AIs): These drugs, including anastrozole, letrozole, and exemestane, lower estrogen levels by inhibiting the aromatase enzyme, which converts androgens to estrogen in peripheral tissues. AIs are generally preferred in postmenopausal women due to their efficacy and safety profile compared to tamoxifen.
Selective Estrogen Receptor Downregulators (SERDs): Fulvestrant is a SERD that degrades estrogen receptors and is used in cases where resistance to other endocrine therapies develops.
Combination Therapies
Combining endocrine therapy with other treatments enhances efficacy. Examples include:
Endocrine Therapy with CDK4/6 Inhibitors: Palbociclib, ribociclib, and abemaciclib are CDK4/6 inhibitors that, when combined with endocrine therapy, significantly improve progression-free survival in advanced HR+ breast cancer.
Endocrine Therapy with mTOR Inhibitors: Everolimus, an mTOR inhibitor, can be added to endocrine therapy for patients who have developed resistance to aromatase inhibitors.
Chemotherapy
Chemotherapy is generally reserved for patients with high-risk features, such as large tumor size, high-grade histology, or extensive lymph node involvement. Regimens often include anthracyclines and taxanes.
Pharmacoepidemiology is the study of the use and effects of drugs in large populations. The document discusses the definition, origins, need and applications of pharmacoepidemiology. Specifically, it notes that pharmacoepidemiology applies epidemiological techniques to study drug use and effects in populations. It also discusses limitations of pre-marketing drug trials that pharmacoepidemiology aims to address through post-marketing surveillance and other techniques.
The document summarizes a workshop on the future of global fresh produce safety for retail and foodservice. It discusses how produce-related foodborne outbreaks have increased in recent decades. It also outlines steps taken by the FDA and other groups to improve produce safety, such as guidance documents, action plans, and regulatory programs in states like California and Florida. The future of produce safety will require consistent standards and practices across the supply chain to prevent contamination and illness.
Day 1 | CME- Trauma Symposium | Bronchiolitis pittengerNorton Healthcare
This document provides an overview and discussion of the diagnosis and management of bronchiolitis. It begins with a brief history of bronchiolitis and how our understanding and treatment of it has evolved over time. It then reviews the typical presentation and risk factors for severe disease. Current guidelines recommend supportive care rather than interventions like bronchodilators or steroids. The document discusses factors that may be influencing rising hospitalization rates and evaluates recent evidence regarding treatments. Implementing evidence-based clinical pathways and decision tools can help standardize care and reduce unnecessary testing and interventions.
The document discusses sustainable approaches for controlling gastrointestinal nematodes (GINs) in ruminant livestock. It notes that current control relies heavily on frequent anthelmintic use, which has led to widespread anthelmintic resistance. More sustainable approaches include targeted selective treatments using diagnostic tools and refugia-based strategies to minimize drug selection pressure. However, uptake of these approaches has been limited. The document argues that understanding farmers' behaviors and improving communication of sustainable guidelines could help promote adoption of new control strategies and reduce anthelmintic resistance issues.
This document provides information from the Centers for Disease Control and Prevention (CDC) regarding immunization and vaccine-preventable diseases. The summary includes:
- The number of diseases prevented by vaccines included in the routine childhood/adolescent immunization schedule has increased from 6 in 1964 to 16 in 2017.
- Vaccination has led to significant decreases in reported cases of diseases like smallpox, diphtheria, measles, and others compared to 20th century annual morbidity.
- CDC estimates that childhood vaccination between 1994-2016 prevented 381 million illnesses, 24.5 million hospitalizations, and 855,000 early deaths, saving $360 billion in direct costs and $1.65 trillion
Abstract— Methicillin-resistant Staphylococcus aureus (MRSA) poses a great risk to burn patients with potential to cause significant morbidity and mortality. This study aimed to find out the prevalence of MRSA and its susceptibility, in burn wound infection/colonization in a Tertiary Care Hospital in North India. A retrospective study was conducted among patients admitted in burn ward of our hospital, between January to December 2012. All the patients irrespective of age, sex, duration of hospital stay, percentage and degree of burn were included in our study. Wound swabs from 1294 patients hospitalized in burn ward were analysed for bacteriological examination. Swabs were inoculated on Blood agar, MacConkey agar and Brain heart infusion broth. Isolates were examined for colony characteristics, Gram staining and biochemical tests. Antimicrobial susceptibility testing was done by modified Stokes disc diffusion method. Detection of MRSA was done by cefoxitin (30g) disc diffusion method. Among the Staphylococcus aureus (S.aureus) isolates, 56.7% (80/141) were found to be MRSA while 43.3% (61/141) were Methicillin Susceptible S.aureus (MSSA). All the MRSA isolates were resistant to penicillin, cephalexin and cefazolin. Resistance to erythromycin, clindamycin, ofloxacin, ciprofloxacin, gentamicin, amikacin, rifampicin, chloramphenicol was found to be 74%, 97.4%, 96%, 100%, 97.4%, 84.6%, 11.5%, 10.3%. All MRSA isolates were found to be sensitive to vancomycin and teicoplanin while 1.3% were resistant to linezolid. Although survival rates for burn patients have improved substantially over the years, nosocomial infections still remain a major challenge in burn care. This concludes that there is high prevalence of nosocomial infections specially the presence of multidrug resistant bacteria like Methicillin Resistant Staphylococcus aureus among burn patients suggest continuous surveillance of burn wound infections and development and stringent implementation of antibiotic policy.
Mitigation strategies for the protection of health care workers and first res...Omar Ha-Redeye
Mitigation strategies for protecting health care workers and first responders from swine flu are discussed. Key points include using personal protective equipment like masks and gowns, isolating confirmed cases, contact tracing, and treating symptomatic individuals and exposed health care workers with antiviral drugs. Stockpiles of antiviral drugs and personal protective equipment have been increased in many countries to prepare for a potential pandemic. There is ongoing debate around certain strategies like the use of masks and social distancing policies.
This document discusses antimicrobial resistance (AMR) surveillance efforts in India, including the IndiaCLEN Invasive Bacterial Infections Surveillance (IBIS) project and Community AMR (CAMR) study. IBIS monitored AMR patterns of Streptococcus pneumoniae and Haemophilus influenzae from invasive disease cases and nasopharyngeal swabs. CAMR studied colonizing strains from healthy children. Both found high resistance to co-trimoxazole. Nasopharyngeal samples showed potential for alternative AMR surveillance. The document calls for policies to address emerging penicillin resistance and continue long-term AMR monitoring to guide treatment and evaluate interventions.
This document discusses guidelines from the Global Initiative for Asthma (GINA) for defining, describing, diagnosing and treating asthma. It provides definitions of asthma as a chronic inflammatory disease of the airways characterized by variable respiratory symptoms. It outlines the criteria for diagnosing asthma based on symptoms, lung function tests and response to treatment. It also discusses evaluating asthma control and severity, and establishing a treatment plan to control symptoms and reduce risks. The goal of treatment is to achieve good symptom control and maintain normal daily activity levels while decreasing risks of exacerbations and adverse effects.
The document discusses definitions, descriptions, diagnosis and treatment of asthma according to GINA and PRACTALL guidelines. It provides definitions of asthma as a chronic inflammatory disease of the airways characterized by variable respiratory symptoms and airflow limitation. Diagnosis is based on symptoms, reversibility testing and variability in lung function. Treatment involves a stepwise approach starting with reliever medication and low-dose inhaled corticosteroids, escalating up treatments based on symptom control and risk of exacerbations. The goal is to achieve good symptom control and reduce risk of exacerbations and side effects.
This document discusses policy making related to blood safety in public health. It makes three key points:
1) Policy making in government is complex, often inconsistent, and influenced by a variety of stakeholders and political factors.
2) Cost-effectiveness is considered in health care spending but blood safety measures have been relatively insulated from this and are supported by high public willingness to pay.
3) Measures to enhance blood safety should continue but scrutiny should also focus on evidence for specific medical therapies.
This document provides guidelines for the global management and prevention of asthma. It summarizes the burden of asthma, factors that influence asthma development and expression, mechanisms of asthma including airway inflammation and pathophysiology. It also outlines recommendations for diagnosing and classifying asthma, as well as treating asthma with medications. The treatment section provides guidance on controller and reliever medications for both adults and children. Additionally, it describes components of asthma management and prevention, including developing patient-doctor partnerships, identifying and reducing risk factors, assessing and monitoring asthma control, managing exacerbations, and special considerations.
The international survey on the management of allergic rhinitis by physicians...Georgi Daskalov
ORIGINAL RESEARCH Open Access
The international survey on the management of
allergic rhinitis by physicians and patients
(ISMAR)
Carlos E Baena-Cagnani
1
†
ˆ
, Giorgio W Canonica
2*
, Mohamed Zaky Helal
3
†
, René Maximiliano Gómez
4
†
,
Enrico Compalati
2
†
, Mario E Zernotti
5
†
, Mario Sanchez-Borges
6
†
, Fabio F Morato Castro
7
†
,
Margarita Murrieta Aguttes
8
†
, Aida López-Garcia
9
†
, Faheem A Tadros
10
†
and ISMAR Study Group
This document provides a 3-sentence summary of the given document:
The document is the 2012 updated Global Strategy for Asthma Management and Prevention report published by the Global Initiative for Asthma (GINA). It outlines recommendations for diagnosing and classifying asthma, as well as treating asthma with medications and managing asthma prevention. The report was updated by the GINA Board of Directors and Science Committee, which include asthma experts from around the world.
This document provides a 3-sentence summary of the Global Strategy for Asthma Management and Prevention 2012 report:
The report is authored by an international board and committee and provides updated clinical recommendations for diagnosing and managing asthma based on assessing, treating, and maintaining asthma control. It describes factors that influence asthma such as genetics, environment, and lifestyle, and covers approaches to developing partnerships with patients, identifying and reducing risk factors, treating asthma with different medication types and delivery methods, and managing exacerbations. The report is intended to help health care professionals provide effective and individualized care for people with asthma globally.
Professor Benedetta Allegranzi,World Health Organisation
Dr. Benedetta Allegranzi is a specialist in infectious diseases, tropical medicine, infection prevention and control and hospital epidemiology. She currently works at the World Health Organization HQ (Service Delivery and Safety department), leading the "Clean Care is Safer Care" programme. Since 2013, Dr Allegranzi has gathered the title of professor of infectious diseases in the official Italian professorship list and is adjunct professor attached to the Institute of Global Health at the Faculty of Medicine, University of Geneva, Switzerland. She closely collaborates with the team at the IPC and WHO Collaborating Center on Patient Safety, University of Geneva Hospitals (Geneva, Switzerland), as well as with the Armstrong Institute for Patient Safety and Quality, John Hopkins University, (Baltimore, USA) for clinical research projects. She is currently involved in the leadership on the WHO Ebola Response in the field of IPC and supervises IPC activities in Sierra Leone and Guinea. She has experience in clinical management of infectious diseases and tropical medicine, and clinical research in healthcare settings in both developing and developed countries. She has thorough skills and experience in training and education.
She is also the author or coauthor of more than 150 scientific publications, including articles published in high-profile medical journal such as the Lancet, Lancet Infectious Diseases, New England Journal of Medicine and the WHO Bulletin, and six book chapters.
The biomechanics of running involves the study of the mechanical principles underlying running movements. It includes the analysis of the running gait cycle, which consists of the stance phase (foot contact to push-off) and the swing phase (foot lift-off to next contact). Key aspects include kinematics (joint angles and movements, stride length and frequency) and kinetics (forces involved in running, including ground reaction and muscle forces). Understanding these factors helps in improving running performance, optimizing technique, and preventing injuries.
Breast cancer: Post menopausal endocrine therapyDr. Sumit KUMAR
Breast cancer in postmenopausal women with hormone receptor-positive (HR+) status is a common and complex condition that necessitates a multifaceted approach to management. HR+ breast cancer means that the cancer cells grow in response to hormones such as estrogen and progesterone. This subtype is prevalent among postmenopausal women and typically exhibits a more indolent course compared to other forms of breast cancer, which allows for a variety of treatment options.
Diagnosis and Staging
The diagnosis of HR+ breast cancer begins with clinical evaluation, imaging, and biopsy. Imaging modalities such as mammography, ultrasound, and MRI help in assessing the extent of the disease. Histopathological examination and immunohistochemical staining of the biopsy sample confirm the diagnosis and hormone receptor status by identifying the presence of estrogen receptors (ER) and progesterone receptors (PR) on the tumor cells.
Staging involves determining the size of the tumor (T), the involvement of regional lymph nodes (N), and the presence of distant metastasis (M). The American Joint Committee on Cancer (AJCC) staging system is commonly used. Accurate staging is critical as it guides treatment decisions.
Treatment Options
Endocrine Therapy
Endocrine therapy is the cornerstone of treatment for HR+ breast cancer in postmenopausal women. The primary goal is to reduce the levels of estrogen or block its effects on cancer cells. Commonly used agents include:
Selective Estrogen Receptor Modulators (SERMs): Tamoxifen is a SERM that binds to estrogen receptors, blocking estrogen from stimulating breast cancer cells. It is effective but may have side effects such as increased risk of endometrial cancer and thromboembolic events.
Aromatase Inhibitors (AIs): These drugs, including anastrozole, letrozole, and exemestane, lower estrogen levels by inhibiting the aromatase enzyme, which converts androgens to estrogen in peripheral tissues. AIs are generally preferred in postmenopausal women due to their efficacy and safety profile compared to tamoxifen.
Selective Estrogen Receptor Downregulators (SERDs): Fulvestrant is a SERD that degrades estrogen receptors and is used in cases where resistance to other endocrine therapies develops.
Combination Therapies
Combining endocrine therapy with other treatments enhances efficacy. Examples include:
Endocrine Therapy with CDK4/6 Inhibitors: Palbociclib, ribociclib, and abemaciclib are CDK4/6 inhibitors that, when combined with endocrine therapy, significantly improve progression-free survival in advanced HR+ breast cancer.
Endocrine Therapy with mTOR Inhibitors: Everolimus, an mTOR inhibitor, can be added to endocrine therapy for patients who have developed resistance to aromatase inhibitors.
Chemotherapy
Chemotherapy is generally reserved for patients with high-risk features, such as large tumor size, high-grade histology, or extensive lymph node involvement. Regimens often include anthracyclines and taxanes.
Travel Clinic Cardiff: Health Advice for International TravelersNX Healthcare
Travel Clinic Cardiff offers comprehensive travel health services, including vaccinations, travel advice, and preventive care for international travelers. Our expert team ensures you are well-prepared and protected for your journey, providing personalized consultations tailored to your destination. Conveniently located in Cardiff, we help you travel with confidence and peace of mind. Visit us: www.nxhealthcare.co.uk
“Psychiatry and the Humanities”: An Innovative Course at the University of Mo...Université de Montréal
“Psychiatry and the Humanities”: An Innovative Course at the University of Montreal Expanding the medical model to embrace the humanities. Link: https://www.psychiatrictimes.com/view/-psychiatry-and-the-humanities-an-innovative-course-at-the-university-of-montreal
Osvaldo Bernardo Muchanga-GASTROINTESTINAL INFECTIONS AND GASTRITIS-2024.pdfOsvaldo Bernardo Muchanga
GASTROINTESTINAL INFECTIONS AND GASTRITIS
Osvaldo Bernardo Muchanga
Gastrointestinal Infections
GASTROINTESTINAL INFECTIONS result from the ingestion of pathogens that cause infections at the level of this tract, generally being transmitted by food, water and hands contaminated by microorganisms such as E. coli, Salmonella, Shigella, Vibrio cholerae, Campylobacter, Staphylococcus, Rotavirus among others that are generally contained in feces, thus configuring a FECAL-ORAL type of transmission.
Among the factors that lead to the occurrence of gastrointestinal infections are the hygienic and sanitary deficiencies that characterize our markets and other places where raw or cooked food is sold, poor environmental sanitation in communities, deficiencies in water treatment (or in the process of its plumbing), risky hygienic-sanitary habits (not washing hands after major and/or minor needs), among others.
These are generally consequences (signs and symptoms) resulting from gastrointestinal infections: diarrhea, vomiting, fever and malaise, among others.
The treatment consists of replacing lost liquids and electrolytes (drinking drinking water and other recommended liquids, including consumption of juicy fruits such as papayas, apples, pears, among others that contain water in their composition).
To prevent this, it is necessary to promote health education, improve the hygienic-sanitary conditions of markets and communities in general as a way of promoting, preserving and prolonging PUBLIC HEALTH.
Gastritis and Gastric Health
Gastric Health is one of the most relevant concerns in human health, with gastrointestinal infections being among the main illnesses that affect humans.
Among gastric problems, we have GASTRITIS AND GASTRIC ULCERS as the main public health problems. Gastritis and gastric ulcers normally result from inflammation and corrosion of the walls of the stomach (gastric mucosa) and are generally associated (caused) by the bacterium Helicobacter pylor, which, according to the literature, this bacterium settles on these walls (of the stomach) and starts to release urease that ends up altering the normal pH of the stomach (acid), which leads to inflammation and corrosion of the mucous membranes and consequent gastritis or ulcers, respectively.
In addition to bacterial infections, gastritis and gastric ulcers are associated with several factors, with emphasis on prolonged fasting, chemical substances including drugs, alcohol, foods with strong seasonings including chilli, which ends up causing inflammation of the stomach walls and/or corrosion. of the same, resulting in the appearance of wounds and consequent gastritis or ulcers, respectively.
Among patients with gastritis and/or ulcers, one of the dilemmas is associated with the foods to consume in order to minimize the sensation of pain and discomfort.
PGx Analysis in VarSeq: A User’s PerspectiveGolden Helix
Since our release of the PGx capabilities in VarSeq, we’ve had a few months to gather some insights from various use cases. Some users approach PGx workflows by means of array genotyping or what seems to be a growing trend of adding the star allele calling to the existing NGS pipeline for whole genome data. Luckily, both approaches are supported with the VarSeq software platform. The genotyping method being used will also dictate what the scope of the tertiary analysis will be. For example, are your PGx reports a standalone pipeline or would your lab’s goal be to handle a dual-purpose workflow and report on PGx + Diagnostic findings.
The purpose of this webcast is to:
Discuss and demonstrate the approaches with array and NGS genotyping methods for star allele calling to prep for downstream analysis.
Following genotyping, explore alternative tertiary workflow concepts in VarSeq to handle PGx reporting.
Moreover, we will include insights users will need to consider when validating their PGx workflow for all possible star alleles and options you have for automating your PGx analysis for large number of samples. Please join us for a session dedicated to the application of star allele genotyping and subsequent PGx workflows in our VarSeq software.
STUDIES IN SUPPORT OF SPECIAL POPULATIONS: GERIATRICS E7shruti jagirdar
Unit 4: MRA 103T Regulatory affairs
This guideline is directed principally toward new Molecular Entities that are
likely to have significant use in the elderly, either because the disease intended
to be treated is characteristically a disease of aging ( e.g., Alzheimer's disease) or
because the population to be treated is known to include substantial numbers of
geriatric patients (e.g., hypertension).
Computer in pharmaceutical research and development-Mpharm(Pharmaceutics)MuskanShingari
Statistics- Statistics is the science of collecting, organizing, presenting, analyzing and interpreting numerical data to assist in making more effective decisions.
A statistics is a measure which is used to estimate the population parameter
Parameters-It is used to describe the properties of an entire population.
Examples-Measures of central tendency Dispersion, Variance, Standard Deviation (SD), Absolute Error, Mean Absolute Error (MAE), Eigen Value
The Children are very vulnerable to get affected with respiratory disease.
In our country, the respiratory Disease conditions are consider as major cause for mortality and Morbidity in Child.
Spontaneous Bacterial Peritonitis - Pathogenesis , Clinical Features & Manage...Jim Jacob Roy
In this presentation , SBP ( spontaneous bacterial peritonitis ) , which is a common complication in patients with cirrhosis and ascites is described in detail.
The reference for this presentation is Sleisenger and Fordtran's Gastrointestinal and Liver Disease Textbook ( 11th edition ).
1. Management of Otitis Media An Alternative to Tubes A practice based retrospective study of over 10,000 pediatric office visits over eight years showed an 94% reduction of chronic otitis media , a 79% reduction of acute otitis media, and an overall reduction of 76% of all categories of otitis media. This study was presented during Pediatric Science Day at North Shore University Hospital in Manhasset, New York. The presentation and study were by Dr. R. H. Meth. The study posits and the statistics bear out the premise that chronic otitis media can be relieved by management of allergens without recourse to surgery. Copyright 1998 by R.H.Meth, M.D.
2. Management of Otitis Media Otitis Media Cases in Practice Copyright 1998 by R.H.Meth, M.D. Year Frequency Percent Comments 1991 290 17.15% 1992 269 16.54% 1993 333 19.49% 1994 197 12.49% 1995 160 10.74% 1996 92 9.80% 1997 60 7.62% 1998 24 7.52% (5/12 year)
3. Management of Otitis Media Number of Cases of Otitis Media Per Year 1991-1998 By Specific Diagnosis Copyright 1998 by R.H.Meth, M.D.
4. Management of Otitis Media Number of Cases of Otitis Per Year 1991-1998 By Age Group Copyright 1998 by R.H.Meth, M.D.
6. Management of Otitis Media Allergic Etiologies of Recurring or Persistent Otitis Media by Age Group at Initial Diagnosis Copyright 1998 by R.H.Meth, M.D. > 24 months - non-mucousy child Day Care > 24 months - mucousy child Environmental allergy Household smoker Food allergy 6-12 months Food recently introduced into diet Milk Milk and Soy Other foods, including: eggs, fish, citrus, wheat, nuts 13-24 months Food recently introduced into diet Food recently increased in diet Milk Other < 5 months Milk Through milk-based formula Even through breast milk Milk and Soy Other