Raised blood pressure is a leading global cause of death, responsible for over 9 million deaths per year. While awareness and treatment of hypertension has increased worldwide, control rates remain low, especially in lower-income countries. Combination drug therapy is generally needed to control blood pressure, and clinical trials have demonstrated certain two-drug combinations are more effective than others. Single pill combinations may further improve adherence and blood pressure control compared to free-drug combinations. Overall, optimizing hypertension management through effective drug combinations can help reduce the global burden of cardiovascular disease.