The document discusses open science as a collaborative and transparent approach to research that enhances reproducibility and inclusiveness, emphasizing its role in addressing modern scientific challenges and sustainable development goals. It highlights the significant struggles researchers face with reproducibility across various fields and the necessity of transforming knowledge generation to ensure equitable access to research. Additionally, it outlines how mega-science infrastructures like the Square Kilometre Array (SKA) aim to facilitate open science practices, addressing challenges in data handling and fostering a culture of collaboration among scientists.