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ANUPAM SAHA
1st YEAR, 2nd SEM
ROLL NO:27720218022
REG NO:182772310003
M.Pharm, Pharmacology
Under the guidance of
Respected Dr. SHOUVIK ROY
Associate Professor, Department of
Pharmacology.
NSHM College Of Pharmaceutical
Technology, Kolkata.
 Obsessive-Compulsive Disorder (OCD) is a
common neuropsychiatric disorder.
 OCD can affect in all age groups.
 Some studies suggest that almost 60% of OCD
patients wait too long to seek treatment or do not
receive treatment due to a lack of identification of
OCD.
 It is an anxiety disorder characterized by presence of
two distinct phenomena: obsessions and
compulsions.
 It is almost equally common in males and females.
 Males have significant earlier age of onset than females.
 Early age of onset was associated with presence of
sexual obsessions, hoarding repeating rituals and need
to touch compulsions.
 Women more often have compulsive washings (66%)
and avoidance (26%).
 Obsessions refer to recurrent intrusive unwanted
thoughts, images or urges (e.g. fear of contamination).
 Compulsions are repetitive physical/mental actions that
are often responses to the obsessions or rigid rituals of
their own accord (e.g. disproportionate hand-washing
behaviors).
A. Either obsessions or compulsions:
1. Recurrent and persistent thoughts, impulses, or images
that are experienced, at some time during the disturbance,
as intrusive and inappropriate and that cause marked
anxiety or distress.
2. The thoughts, impulses, or images are not simply
excessive worries about real-life problems.
3. The person attempts to ignore or suppress such thoughts,
impulses, or images, or to neutralize them with some
other thought or action.
4. The person recognizes that the obsession thoughts,
impulses, or images are a product of his or her own mind
(not imposed from without as in thought insertion).
B. At some point during the course of the disorder, the
person has recognized that the obsessions or
compulsions are excessive or unreasonable.
C. The obsessions or compulsions cause marked distress,
are time consuming (take more than 1 hour a day), or
significantly interfere with the person’s normal routine,
occupational (or academic) functioning, or usual social
activities or relationships.
D. If another Axis I disorder is present, the content of the
obsessions or compulsions is not restricted to it.
E. The disturbance is not due to the direct physiological
effects of a substance (e.g. a drug of abuse, a
medication) or a general medical condition.
The Cycle of OCD
Warning Signs of OCD
 Cognitive–Behavioral Therapy (CBT) ought to be
the primary decision treatment.
 Serotonin Reuptake Blocker
1. Clomipramine Hydrochloride (Anafranil).
 Atypical Antipsychotics
1. Olanzapine (2.5mg, 5mg, 10mg) depending upon
severity.
2. Haloperidol at low day by day portions of 0.5 mg to 5
mg.
3. Risperidone.
 Anti-anxiety Agents
1. Buspirone Hydrochloride.
• CBT is a
momentary objective
arranged
psychotherapy that
is utilized to the
show people how
their sentiments,
thought and conduct
work arbitrary.
• Where people can
sort of create
individual adapting
aptitudes that can be
utilized to change
pessimistic
examples of
reasoning.
 Haloperidol, Buspirone Hydrochloride, Olanzapine,
Risperidone are a few instances of medications
utilized in OCD.
 Psychological conduct treatment or CBT is
essential.
 CBT is a momentary objective arranged
psychotherapy that is utilized to the show people
how their sentiments, thought and conduct work
arbitrary.
 OCD is an Fanatical urgent turmoil.
1. Alvarenga PGD., Mastrorosa RS., Rosário MCD. Obsessive Compulsive
Disorder In Children And Adolescents. IACAPAP Textbook of Child and
Adolescent Mental Health. 2012; F3: 1 – 17.
2. Rajashekharaiah M, Verma P. Phenomenology of obsessions and
compulsions in Indian patients. International Journal of Contemporary
Medical Research. 2016; 3(7): 2139 – 2143.
3. Moongaa SS., Pinkhasov A., Singh D. Obsessive-Compulsive Disorder in a
19-Year-Old Female Adolescent With Turner Syndrome. J Clin Med Res.
2017; 9(12): 1026 – 1028.
4. Stein DJ. Obsessive compulsive disorder. SAJP. 2013; 19(3): 180 – 186.
5. Fenske JN., Petersen K. Obsessive-Compulsive Disorder: Diagnosis and
Management. American Family Physician. 2015; 92(10): 896 – 903.
6. Neel JL., Stevens VM., Stewart JE. Obsessive-compulsive disorder:
Identification, neurobiology, and treatment. JAOA. 2002; 102(2): 81 – 86.
7. Wheaton MG., DeSantis SM., Simpson HB. Network meta-analyses and
treatment recommendations for obsessive-compulsive disorder.
Correspondence. 2016; 3: 920.
 Manhattan Psychology Group, Obsessive Compulsive
Disorder Treatment in Children & Adolescents, Available
From - https://manhattanpsychologygroup.com/obsessive-
compulsive-disorder/
 American Acedemy Of Child And Adolescent Psychiatry,
Obsessive Compulsive Disorder Resource Center, Available
From -
https://www.aacap.org/aacap/families_and_youth/resource_c
enters/Obsessive_Compulsive_Disorder_Resource_Center/O
CD_Resource_Center.aspx
 The Straits Times, The tragedy of obsessive compulsive
disorder that goes untreated, Available From -
https://www.straitstimes.com/opinion/the-tragedy-of-
obsessive-compulsive-disorder-that-goes-untreated
Obsessive Compulsive Disorder

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Obsessive Compulsive Disorder

  • 1. ANUPAM SAHA 1st YEAR, 2nd SEM ROLL NO:27720218022 REG NO:182772310003 M.Pharm, Pharmacology Under the guidance of Respected Dr. SHOUVIK ROY Associate Professor, Department of Pharmacology. NSHM College Of Pharmaceutical Technology, Kolkata.
  • 2.  Obsessive-Compulsive Disorder (OCD) is a common neuropsychiatric disorder.  OCD can affect in all age groups.  Some studies suggest that almost 60% of OCD patients wait too long to seek treatment or do not receive treatment due to a lack of identification of OCD.  It is an anxiety disorder characterized by presence of two distinct phenomena: obsessions and compulsions.
  • 3.  It is almost equally common in males and females.  Males have significant earlier age of onset than females.  Early age of onset was associated with presence of sexual obsessions, hoarding repeating rituals and need to touch compulsions.  Women more often have compulsive washings (66%) and avoidance (26%).  Obsessions refer to recurrent intrusive unwanted thoughts, images or urges (e.g. fear of contamination).  Compulsions are repetitive physical/mental actions that are often responses to the obsessions or rigid rituals of their own accord (e.g. disproportionate hand-washing behaviors).
  • 4. A. Either obsessions or compulsions: 1. Recurrent and persistent thoughts, impulses, or images that are experienced, at some time during the disturbance, as intrusive and inappropriate and that cause marked anxiety or distress. 2. The thoughts, impulses, or images are not simply excessive worries about real-life problems. 3. The person attempts to ignore or suppress such thoughts, impulses, or images, or to neutralize them with some other thought or action. 4. The person recognizes that the obsession thoughts, impulses, or images are a product of his or her own mind (not imposed from without as in thought insertion).
  • 5. B. At some point during the course of the disorder, the person has recognized that the obsessions or compulsions are excessive or unreasonable. C. The obsessions or compulsions cause marked distress, are time consuming (take more than 1 hour a day), or significantly interfere with the person’s normal routine, occupational (or academic) functioning, or usual social activities or relationships. D. If another Axis I disorder is present, the content of the obsessions or compulsions is not restricted to it. E. The disturbance is not due to the direct physiological effects of a substance (e.g. a drug of abuse, a medication) or a general medical condition.
  • 8.
  • 9.  Cognitive–Behavioral Therapy (CBT) ought to be the primary decision treatment.  Serotonin Reuptake Blocker 1. Clomipramine Hydrochloride (Anafranil).  Atypical Antipsychotics 1. Olanzapine (2.5mg, 5mg, 10mg) depending upon severity. 2. Haloperidol at low day by day portions of 0.5 mg to 5 mg. 3. Risperidone.  Anti-anxiety Agents 1. Buspirone Hydrochloride.
  • 10. • CBT is a momentary objective arranged psychotherapy that is utilized to the show people how their sentiments, thought and conduct work arbitrary. • Where people can sort of create individual adapting aptitudes that can be utilized to change pessimistic examples of reasoning.
  • 11.
  • 12.  Haloperidol, Buspirone Hydrochloride, Olanzapine, Risperidone are a few instances of medications utilized in OCD.  Psychological conduct treatment or CBT is essential.  CBT is a momentary objective arranged psychotherapy that is utilized to the show people how their sentiments, thought and conduct work arbitrary.  OCD is an Fanatical urgent turmoil.
  • 13.
  • 14. 1. Alvarenga PGD., Mastrorosa RS., Rosário MCD. Obsessive Compulsive Disorder In Children And Adolescents. IACAPAP Textbook of Child and Adolescent Mental Health. 2012; F3: 1 – 17. 2. Rajashekharaiah M, Verma P. Phenomenology of obsessions and compulsions in Indian patients. International Journal of Contemporary Medical Research. 2016; 3(7): 2139 – 2143. 3. Moongaa SS., Pinkhasov A., Singh D. Obsessive-Compulsive Disorder in a 19-Year-Old Female Adolescent With Turner Syndrome. J Clin Med Res. 2017; 9(12): 1026 – 1028. 4. Stein DJ. Obsessive compulsive disorder. SAJP. 2013; 19(3): 180 – 186. 5. Fenske JN., Petersen K. Obsessive-Compulsive Disorder: Diagnosis and Management. American Family Physician. 2015; 92(10): 896 – 903. 6. Neel JL., Stevens VM., Stewart JE. Obsessive-compulsive disorder: Identification, neurobiology, and treatment. JAOA. 2002; 102(2): 81 – 86. 7. Wheaton MG., DeSantis SM., Simpson HB. Network meta-analyses and treatment recommendations for obsessive-compulsive disorder. Correspondence. 2016; 3: 920.
  • 15.  Manhattan Psychology Group, Obsessive Compulsive Disorder Treatment in Children & Adolescents, Available From - https://manhattanpsychologygroup.com/obsessive- compulsive-disorder/  American Acedemy Of Child And Adolescent Psychiatry, Obsessive Compulsive Disorder Resource Center, Available From - https://www.aacap.org/aacap/families_and_youth/resource_c enters/Obsessive_Compulsive_Disorder_Resource_Center/O CD_Resource_Center.aspx  The Straits Times, The tragedy of obsessive compulsive disorder that goes untreated, Available From - https://www.straitstimes.com/opinion/the-tragedy-of- obsessive-compulsive-disorder-that-goes-untreated