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Challenges in Respecting
OAR
Kanhu Charan Patro
A-ANALYZE
B -BROWSE
C -COMMUNICATE
D-DELIVER
E-EXTRA CARE
Fun he to mann he
Sir Richard Branson
17
Side effects are like mother in law
DO NOT DARE TO SCARE
OAR NEEDS EXTRA CARE
OTHERWISE
RARE WILL NOT BE RARE
PUSHING BACKWARD AND FORWARD AT A TIME
DIFFICULT BUT NOT IMPOSSIBLE
OAR
TARGET
23
DOCTOR : WHAT
TRETMENT YOU HAVE
GIVEN , I AM NOT ABLE
TO EAT PANIPURI.
THAT PANIPURI MOMENT
5/17/2019 24
1. TRISMUS
2. DYSGUESIA
3. XEROSTOMIA
4. DYSPHAGIA
5/17/2019 25
ZEROING THE
XEROSTOMIA
&
DISCARDING
THE DYSPHAGIA
5/17/2019 26
IMPOSSIBLE
5/17/2019 27
LEVEL AND WIDTH FOR DELINEATION
WIDTH
LEVEL
A. Brightness refers to the overall lightness or
darkness of the image.
B. Contrast is the difference
in brightness between objects in the image.
30
Brightness- window level Contrast- window width
31
CORD IS NOT ROD
SPINAL CORD RECOVERY
1st DECEMBER 2017/RE-RTCARSTEN NIEDER/IJROBP/2005
1. With time cord starts forgetting the
irradiated dose.
2. Estimating myelopathy based on
cumulative BED.
3. α/β for cervical and thoracic cord is 2 and
lumbar cord is 4
4. 50% recovery when interval is 2 years and
first course received with conventional
fractionation of 45Gy
5. Volume effects:
A. At 2 Gy equivalent, full
circumference cord dose, at least
25% recovery at 6 months
B. With SBRT (partial cord) 13Gy/1 or
20Gy/3 < 1% risk of myelopathy
6. Higher incidence of myelopathy when
A. Cumulative BED is >135.5Gy2
B. Single course BED is >102Gy2
C. When interval between treatment is
< 6 months
Can you guess the gender of spinal
cord? It is male. With time it forgets the
injury. Girls remember everything and
repeatedly spoil your reputation till
your death even a small injury.
SPINAL CORD INSULT-CONVENTIONAL VS IMRT
2nd DECEMBER 2017/RE-RTJUST CALCULATE
WITH
CONVENTIONAL
PLANNING CORD
GETS 2Gy/# TILL 22#
BED =88Gy2
WITH IMRT SUPPOSE
CORD IS GETTING
35Gy IN 50Gy/ 25#
MEANS 1.4Gy/#
SO BED =59.9Gy2
IT IS A GOOD THING
FOR REIRRADIATION
AND SPINAL CORD
RECOVERY ALSO
ALWAYS
CHOOSE
ADVANCED
TECHNIQUE
WITH IMRT, SPINAL CORD
NOT ONLY GETTING THE LESS
DOSE BUT ALSO BED IS VERY
LESS COMPARED TO
CONVENTIONAL RT.
LESS INSULT WITH IMRT
[BED CALCULATOR]EQD2.COM
conventionalIMRT
α/β for cervical and thoracic cord is
2 and lumbar cord is 4
ARE STEROIDS & NSAIDS ACT AS BALM
FOR DYSPHAGIA PAIN?
NOT PAROTID YOU HAVE TO SAVE CAROTID
REIRRADIATION-CBOS INDEX
SL PARAMETER YES NO
1 CAROTID INVASION >180 1 0
2 PRESENCE OF ULCERATION 1 0
3 LYMPH NODE AREA
IRRADIATION
1 0
3rd DECEMBER 2017/RE-RTHIDEYA YAMAZAKI /RADIOTHERAPY AND ONCOLOGY/2015
CBOS-CAROTID BLOW OUT SYNDROME
Keep below cumulative
BED of 110Gy
<180
>180
Normal tissues of interest: Brachial Plexus
Hall WH et al. IJROBP 2008:72(5):1362-7.
Cervical vertebrae: C1 – C7
Cervical nerves: C1 – C8
Dose constraints:
Very safe: Max < 60 Gy Considered
safe in most studies: Max < 66 Gy
below cricoid Max < 70 Gy above
cricoid
CAT STRACTURE FOR LARYNX
•Cricoid
•Aretynoid
•Thyroid
v
Midline block
Normal tissues of interest: Larynx
Dose constraints:
Mean < 40 Gy
Practice varies:
Whole larynx avoidance?
Arytenoids?
Pharyngeal constrictors?
Normal tissues of interest: Parotid Gland
Dose Constraints:
Mean < 26 Gy
At least 50% of each gland < 30 Gy At
least 20cc combined < 30 Gy
QUANTEC update:
Single mean < 20 Gy
Bilateral mean < 25 Gy
Dose Constraints:
Uninvolved with no IB coverage
Mean < 39 Gy
Normal tissues of interest: Submandibular Gland
Normal tissues of interest: Spinal Cord
Dose
Constraints:
Mean < 45 Gy
Max < 50 Gy (0.3 cc)
SBRT Dose Constraints:
Dmax 13 Gy (1 fraction)
Dmax 20 Gy (3
fractions)
Normal tissues of interest: Brainstem
Dose Constraints:
Mean < 54 Gy
Max < 60 Gy (0.3 cc)
SBRT Dose Constraints:
Dmax 12.5 Gy (1 fraction)
Normal tissues of interest: Cochlea
Often one contour:
Cochlea
Vestibular apparatus
Normal tissues of interest: Cochlea
Dose constraints (combo):
Max < 45 Gy
Typically conservative < 35 Gy
Also consider use of cisplatin.
SBRT Dose Constraints:
Dmax 12-14 Gy
Normal tissues of interest: Optic Structures
Dose constraints (optic nerves):
Mean < 54 Gy
Max < 60 Gy (0.3 cc)
Dose constraints (lens):
ALARA
Dose constraints (optic chiasm):
Mean < 50 Gy
Max < 55-60 Gy (0.3 cc)
Normal tissues of interest: Optic Structures
Dose constraints (optic nerves):
Mean < 54 Gy
Max < 60 Gy (0.3 cc)
Dose constraints (lens):
ALARA
Dose constraints (optic chiasm):
Mean < 50 Gy
Max < 55-60 Gy (0.3 cc)
Normal tissues of interest: Optic Structures
Dose constraints (optic nerves):
Mean < 54 Gy
Max < 60 Gy (0.3 cc)
Dose constraints (lens):
ALARA
Dose constraints (optic chiasm):
Mean < 50 Gy
Max < 55-60 Gy (0.3 cc)
Normal tissues of interest: Pharyngeal Constrictors
Eisbruch et al.
Pharyngeal constrictors:
Lateral & posterior pharyngeal walls
Superior: To pterygoid plates
Middle: To hyoid bone
Inferior: To thyroid cartilage
Normal tissues of interest: Pharyngeal Constrictors
Practice brachytherapy
If you really want to respect the OAR
• Start practice brachytherapy in early cancer
Sir Richard Branson

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OAR HEAD AND NECK

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  • 7. Fun he to mann he
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  • 18. Side effects are like mother in law
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  • 21. DO NOT DARE TO SCARE OAR NEEDS EXTRA CARE OTHERWISE RARE WILL NOT BE RARE
  • 22.
  • 23. PUSHING BACKWARD AND FORWARD AT A TIME DIFFICULT BUT NOT IMPOSSIBLE OAR TARGET 23
  • 24. DOCTOR : WHAT TRETMENT YOU HAVE GIVEN , I AM NOT ABLE TO EAT PANIPURI. THAT PANIPURI MOMENT 5/17/2019 24
  • 25. 1. TRISMUS 2. DYSGUESIA 3. XEROSTOMIA 4. DYSPHAGIA 5/17/2019 25
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  • 29.
  • 30. LEVEL AND WIDTH FOR DELINEATION WIDTH LEVEL A. Brightness refers to the overall lightness or darkness of the image. B. Contrast is the difference in brightness between objects in the image. 30
  • 31. Brightness- window level Contrast- window width 31
  • 32.
  • 33. CORD IS NOT ROD
  • 34. SPINAL CORD RECOVERY 1st DECEMBER 2017/RE-RTCARSTEN NIEDER/IJROBP/2005 1. With time cord starts forgetting the irradiated dose. 2. Estimating myelopathy based on cumulative BED. 3. α/β for cervical and thoracic cord is 2 and lumbar cord is 4 4. 50% recovery when interval is 2 years and first course received with conventional fractionation of 45Gy 5. Volume effects: A. At 2 Gy equivalent, full circumference cord dose, at least 25% recovery at 6 months B. With SBRT (partial cord) 13Gy/1 or 20Gy/3 < 1% risk of myelopathy 6. Higher incidence of myelopathy when A. Cumulative BED is >135.5Gy2 B. Single course BED is >102Gy2 C. When interval between treatment is < 6 months Can you guess the gender of spinal cord? It is male. With time it forgets the injury. Girls remember everything and repeatedly spoil your reputation till your death even a small injury.
  • 35.
  • 36.
  • 37. SPINAL CORD INSULT-CONVENTIONAL VS IMRT 2nd DECEMBER 2017/RE-RTJUST CALCULATE WITH CONVENTIONAL PLANNING CORD GETS 2Gy/# TILL 22# BED =88Gy2 WITH IMRT SUPPOSE CORD IS GETTING 35Gy IN 50Gy/ 25# MEANS 1.4Gy/# SO BED =59.9Gy2 IT IS A GOOD THING FOR REIRRADIATION AND SPINAL CORD RECOVERY ALSO ALWAYS CHOOSE ADVANCED TECHNIQUE WITH IMRT, SPINAL CORD NOT ONLY GETTING THE LESS DOSE BUT ALSO BED IS VERY LESS COMPARED TO CONVENTIONAL RT. LESS INSULT WITH IMRT [BED CALCULATOR]EQD2.COM conventionalIMRT α/β for cervical and thoracic cord is 2 and lumbar cord is 4
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  • 48.
  • 49. ARE STEROIDS & NSAIDS ACT AS BALM FOR DYSPHAGIA PAIN?
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  • 55.
  • 56.
  • 57.
  • 58. NOT PAROTID YOU HAVE TO SAVE CAROTID
  • 59.
  • 60. REIRRADIATION-CBOS INDEX SL PARAMETER YES NO 1 CAROTID INVASION >180 1 0 2 PRESENCE OF ULCERATION 1 0 3 LYMPH NODE AREA IRRADIATION 1 0 3rd DECEMBER 2017/RE-RTHIDEYA YAMAZAKI /RADIOTHERAPY AND ONCOLOGY/2015 CBOS-CAROTID BLOW OUT SYNDROME Keep below cumulative BED of 110Gy <180 >180
  • 61.
  • 62.
  • 63. Normal tissues of interest: Brachial Plexus Hall WH et al. IJROBP 2008:72(5):1362-7. Cervical vertebrae: C1 – C7 Cervical nerves: C1 – C8 Dose constraints: Very safe: Max < 60 Gy Considered safe in most studies: Max < 66 Gy below cricoid Max < 70 Gy above cricoid
  • 64.
  • 65. CAT STRACTURE FOR LARYNX •Cricoid •Aretynoid •Thyroid
  • 66. v
  • 67.
  • 69. Normal tissues of interest: Larynx Dose constraints: Mean < 40 Gy Practice varies: Whole larynx avoidance? Arytenoids? Pharyngeal constrictors?
  • 70. Normal tissues of interest: Parotid Gland Dose Constraints: Mean < 26 Gy At least 50% of each gland < 30 Gy At least 20cc combined < 30 Gy QUANTEC update: Single mean < 20 Gy Bilateral mean < 25 Gy
  • 71. Dose Constraints: Uninvolved with no IB coverage Mean < 39 Gy Normal tissues of interest: Submandibular Gland
  • 72. Normal tissues of interest: Spinal Cord Dose Constraints: Mean < 45 Gy Max < 50 Gy (0.3 cc) SBRT Dose Constraints: Dmax 13 Gy (1 fraction) Dmax 20 Gy (3 fractions)
  • 73. Normal tissues of interest: Brainstem Dose Constraints: Mean < 54 Gy Max < 60 Gy (0.3 cc) SBRT Dose Constraints: Dmax 12.5 Gy (1 fraction)
  • 74. Normal tissues of interest: Cochlea Often one contour: Cochlea Vestibular apparatus
  • 75. Normal tissues of interest: Cochlea Dose constraints (combo): Max < 45 Gy Typically conservative < 35 Gy Also consider use of cisplatin. SBRT Dose Constraints: Dmax 12-14 Gy
  • 76. Normal tissues of interest: Optic Structures Dose constraints (optic nerves): Mean < 54 Gy Max < 60 Gy (0.3 cc) Dose constraints (lens): ALARA Dose constraints (optic chiasm): Mean < 50 Gy Max < 55-60 Gy (0.3 cc)
  • 77. Normal tissues of interest: Optic Structures Dose constraints (optic nerves): Mean < 54 Gy Max < 60 Gy (0.3 cc) Dose constraints (lens): ALARA Dose constraints (optic chiasm): Mean < 50 Gy Max < 55-60 Gy (0.3 cc)
  • 78. Normal tissues of interest: Optic Structures Dose constraints (optic nerves): Mean < 54 Gy Max < 60 Gy (0.3 cc) Dose constraints (lens): ALARA Dose constraints (optic chiasm): Mean < 50 Gy Max < 55-60 Gy (0.3 cc)
  • 79. Normal tissues of interest: Pharyngeal Constrictors Eisbruch et al. Pharyngeal constrictors: Lateral & posterior pharyngeal walls Superior: To pterygoid plates Middle: To hyoid bone Inferior: To thyroid cartilage
  • 80. Normal tissues of interest: Pharyngeal Constrictors
  • 81.
  • 82. Practice brachytherapy If you really want to respect the OAR • Start practice brachytherapy in early cancer
  • 83.