30. LEVEL AND WIDTH FOR DELINEATION
WIDTH
LEVEL
A. Brightness refers to the overall lightness or
darkness of the image.
B. Contrast is the difference
in brightness between objects in the image.
30
34. SPINAL CORD RECOVERY
1st DECEMBER 2017/RE-RTCARSTEN NIEDER/IJROBP/2005
1. With time cord starts forgetting the
irradiated dose.
2. Estimating myelopathy based on
cumulative BED.
3. α/β for cervical and thoracic cord is 2 and
lumbar cord is 4
4. 50% recovery when interval is 2 years and
first course received with conventional
fractionation of 45Gy
5. Volume effects:
A. At 2 Gy equivalent, full
circumference cord dose, at least
25% recovery at 6 months
B. With SBRT (partial cord) 13Gy/1 or
20Gy/3 < 1% risk of myelopathy
6. Higher incidence of myelopathy when
A. Cumulative BED is >135.5Gy2
B. Single course BED is >102Gy2
C. When interval between treatment is
< 6 months
Can you guess the gender of spinal
cord? It is male. With time it forgets the
injury. Girls remember everything and
repeatedly spoil your reputation till
your death even a small injury.
35.
36.
37. SPINAL CORD INSULT-CONVENTIONAL VS IMRT
2nd DECEMBER 2017/RE-RTJUST CALCULATE
WITH
CONVENTIONAL
PLANNING CORD
GETS 2Gy/# TILL 22#
BED =88Gy2
WITH IMRT SUPPOSE
CORD IS GETTING
35Gy IN 50Gy/ 25#
MEANS 1.4Gy/#
SO BED =59.9Gy2
IT IS A GOOD THING
FOR REIRRADIATION
AND SPINAL CORD
RECOVERY ALSO
ALWAYS
CHOOSE
ADVANCED
TECHNIQUE
WITH IMRT, SPINAL CORD
NOT ONLY GETTING THE LESS
DOSE BUT ALSO BED IS VERY
LESS COMPARED TO
CONVENTIONAL RT.
LESS INSULT WITH IMRT
[BED CALCULATOR]EQD2.COM
conventionalIMRT
α/β for cervical and thoracic cord is
2 and lumbar cord is 4
60. REIRRADIATION-CBOS INDEX
SL PARAMETER YES NO
1 CAROTID INVASION >180 1 0
2 PRESENCE OF ULCERATION 1 0
3 LYMPH NODE AREA
IRRADIATION
1 0
3rd DECEMBER 2017/RE-RTHIDEYA YAMAZAKI /RADIOTHERAPY AND ONCOLOGY/2015
CBOS-CAROTID BLOW OUT SYNDROME
Keep below cumulative
BED of 110Gy
<180
>180
61.
62.
63. Normal tissues of interest: Brachial Plexus
Hall WH et al. IJROBP 2008:72(5):1362-7.
Cervical vertebrae: C1 – C7
Cervical nerves: C1 – C8
Dose constraints:
Very safe: Max < 60 Gy Considered
safe in most studies: Max < 66 Gy
below cricoid Max < 70 Gy above
cricoid
69. Normal tissues of interest: Larynx
Dose constraints:
Mean < 40 Gy
Practice varies:
Whole larynx avoidance?
Arytenoids?
Pharyngeal constrictors?
70. Normal tissues of interest: Parotid Gland
Dose Constraints:
Mean < 26 Gy
At least 50% of each gland < 30 Gy At
least 20cc combined < 30 Gy
QUANTEC update:
Single mean < 20 Gy
Bilateral mean < 25 Gy
72. Normal tissues of interest: Spinal Cord
Dose
Constraints:
Mean < 45 Gy
Max < 50 Gy (0.3 cc)
SBRT Dose Constraints:
Dmax 13 Gy (1 fraction)
Dmax 20 Gy (3
fractions)
73. Normal tissues of interest: Brainstem
Dose Constraints:
Mean < 54 Gy
Max < 60 Gy (0.3 cc)
SBRT Dose Constraints:
Dmax 12.5 Gy (1 fraction)
74. Normal tissues of interest: Cochlea
Often one contour:
Cochlea
Vestibular apparatus
75. Normal tissues of interest: Cochlea
Dose constraints (combo):
Max < 45 Gy
Typically conservative < 35 Gy
Also consider use of cisplatin.
SBRT Dose Constraints:
Dmax 12-14 Gy
76. Normal tissues of interest: Optic Structures
Dose constraints (optic nerves):
Mean < 54 Gy
Max < 60 Gy (0.3 cc)
Dose constraints (lens):
ALARA
Dose constraints (optic chiasm):
Mean < 50 Gy
Max < 55-60 Gy (0.3 cc)
77. Normal tissues of interest: Optic Structures
Dose constraints (optic nerves):
Mean < 54 Gy
Max < 60 Gy (0.3 cc)
Dose constraints (lens):
ALARA
Dose constraints (optic chiasm):
Mean < 50 Gy
Max < 55-60 Gy (0.3 cc)
78. Normal tissues of interest: Optic Structures
Dose constraints (optic nerves):
Mean < 54 Gy
Max < 60 Gy (0.3 cc)
Dose constraints (lens):
ALARA
Dose constraints (optic chiasm):
Mean < 50 Gy
Max < 55-60 Gy (0.3 cc)
79. Normal tissues of interest: Pharyngeal Constrictors
Eisbruch et al.
Pharyngeal constrictors:
Lateral & posterior pharyngeal walls
Superior: To pterygoid plates
Middle: To hyoid bone
Inferior: To thyroid cartilage