Lotus Domino is an IBM email and collaboration server that is being migrated to Microsoft Exchange Server. Migrating from Domino to Exchange can decrease costs, solve configuration issues, provide employees with a better interface, make data management easier, and simplify bulk emailing. The document discusses four types of migrations - from Notes to Outlook, Notes to Exchange, Domino to Outlook, and Domino to Exchange. It encourages the reader to contact the company for mailbox migration services if they have any doubts or questions during the migration process.