5. CHIEF COMPLAINT
Patient complains of missing upper front tooth since 1 week
HISTORY OF PRESENT ILLNESS
Patient gave history of trauma 1 week back while playing, in the maxillary and
mandibular anterior region which resulted in avulsion of 21
There was evidence of bleeding at the site of tooth loss which is not significant
No loss of consciousness
6. Medical history
Past dental history
Personal history
Family history
Patient underwent surgery for unilateral cleft
lip at the age of 6 months
First visit
Patient brushes his teeth once daily with toothpaste
and toothbrush in the morning
No relevant history
7. CLINICAL EXAMINATION
HABITS – No abnormal habits
EXTRA ORAL EXAMINATION –
Shape of head
Facial form
Facial profile
Facial divergence
Lips
Dolicocephalic
Mesoprosopic
convex
posterior
Incompetent and everted
14. TREATMENT PLAN
Root canal treatment irt 31 32 33 41 42 43
Othodontic derotation of 22
Replacement of missing tooth irt 21
15. DISCUSSION
RADICULAR CYST
‘Cyst’……Greek word, ‘Kystis’………‘sac or bladder’
A Cyst is a pathological cavity having fluid, semifluid or gaseous contents
and which is not created by the accumulation of pus (Kramer)
17. Other names Apical Periodontal Cyst
Periapical cyst
Root end cyst
It is a true cyst, since the lesion consists of a pathologic cavity lined by epithelium
and is often fluid-filled
Radicular or periapical cyst is the most common odontogenic cystic lesion of
inflammatory origin, derived from Cell rests of Malassez that proliferate in
response to inflammation , occurring in relation to the apex of a nonvital tooth.
23. A preliminary clinical diagnosis of a periapical cyst can be made based on the
following
(a) The periapical lesion is involved with one or more non-vital teeth,
(b) The lesion is greater than 200 mm2 in size,
(c) The lesion is seen radiographically as a circumscribed, well-defined radiolucent
area bound by a thin radiopaque line
(d) It produces a straw-colored fluid upon aspiration or as drainage through an
accessed root canal system
Eversole LR. Clinical outline of oral pathology: diagnosis and treatment, 2nd ed.
Philadelphia: Lea and Febiger 1984;203-259.
24. The treatment of the cysts can be
Nonsurgical management
Surgical management
marsupialization
enucleation
.
25. The factors that determine the choice of treatment
Age of the patient
Extension of the lesion
Relation with noble structures
Origin
Clinical characteristics of the lesion,
Systemic condition of the patient
Narula H, Ahuja B, Yeluri R, Baliga S, Munshi AK. Conservative non-surgical management of
an infected radicular cyst. Contemporary clinical dentistry. 2011 Oct;2(4):368
26. The nonsurgical treatment options available to manage periapical cysts
Conservative RCT with calcium hydroxide as intra-canal medicament,
Active nonsurgical decompression technique,
Aspiration and irrigation technique,
Lesion sterilization and repair therapy and
Apexum procedure
Sood N, Maheshwari N, Gothi R, Sood N. Treatment of large periapical cyst like lesion: a
noninvasive approach: a report of two cases. International Journal of Clinical Pediatric
Dentistry. 2015 May;8(2):133.
29. Sood N et al (2015) have successfully treated 2 cases of Large Periapical Cyst Like
lesions by Noninvasive Approach and stated that nonsurgical approach should always
be adopted before resorting to surgery.
Sood N, Maheshwari N, Gothi R, Sood N. Treatment of Large Periapical Cyst Like Lesion: A
Noninvasive Approach: A Report of Two Cases. Int J Clin Pediatr Dent 2015;8(2):133-137
30. Deepakraj Dandotikar et al (2013) in their case report of Nonsurgical Management of a
Periapical Cyst, suggested that A well defined treatment protocol must be used that
eliminates their etiology in the root canal system rather than their product, apical true cyst
Dandotikar D, Peddi R, Lakhani B, Lata K, Mathur A, Chowdary U K. Nonsurgical
Management of a Periapical Cyst: A Case Report. J Int Oral Health 2013; 5(3):79-84
31. Shweta Dwivedi et al (2021) managed a case of a large radicular cyst by non-surgical
endodontic approach, concluded that Surgical treatment is indicated only when nonsurgical
treatment is unlikely to provide the desired outcome
Dwivedi S, Dwivedi CD, Chaturvedi TP, Baranwal HC. Management of a large radicular
cyst: A non-surgical endodontic approach. Saudi Endodontic Journal. 2021 Sep 1;4(3):145
32. Maity I et al (2014) in their clinical study found that Single visit nonsurgical
endodontic therapy for periapical cysts was successful in selected cases
Maity I, Meena N, Kumari RA. Single visit nonsurgical endodontic therapy for
periapical cysts: A clinical study. Contemporary clinical dentistry. 2014 Apr;5(2):195.
33.
34. TREATMENT DONE
First appointment
Case history recorded in detail
Investigations ..vitality tests , opg
Medication. …Amoxicillin 500mg bd, hifenac 400mg tid for 1 week
35. Under local anesthesia, access opening was done irt 31 32 33 41 42 43
Necrotic pulp tissue was extirpated, followed by copious irrigation with 3%
sodium hypochlorite and normal saline
Working length determined
Calcium hydroxide with iodoform paste ( metapex ) was injected up to the cystic
lesion through the root canal irt 31 and no intracanal medicament irt remaining
teeth
Access cavity was sealed for a period of 1 week with an intermediate restorative
material
36. After 7 days, patient was recalled, Canals were cleaned and shaped by Protaper
hand files
Irrigation done using 3 % sodium hypochlorite and normal saline
Triple antibiotic paste was placed as intracanal medicament and access cavity
was sealed intermediate restorative material for a period of 3 weeks
The patient was kept on follow up
37. After 1 month of commencement of treatment, Complete debridement and
irrigation of the root canal was done, obturation completed with 6% gutta-
percha
Access cavity is closed by using composite restoration
Patient is put on regular recall visits
39. CONCLUSION
Modern concept of medicine emphasizes prevention and reversal of diseases,
minimum invasive and less time-consuming procedure
Only when these attempts fail, we would take on the unfavorable approaches,
i.e., surgical intervention and restoration with artificial prosthesis.
During the past few years there has been gradual change in the attitude to
surgical treatment of periapical lesions
In the present case, the non surgical management of radicular cyst, is
considered an efficient and feasible alternative that can recover the esthetics
and function, instituting positive attitude towards dental treatment in a
growing child
40. REFERENCES
Sood N, Maheshwari N, Gothi R, Sood N. Treatment of Large Periapical Cyst Like
Lesion: A Noninvasive Approach: A Report of Two Cases. Int J Clin Pediatr Dent
2015;8(2):133-137
Bhaskar SN. Nonsurgical resolution of radicular cysts. Oral Surgery, Oral Medicine,
Oral Pathology. 1972 Sep 1;34(3):458-68.
Dandotikar D, Peddi R, Lakhani B, Lata K, Mathur A, Chowdary U K. Nonsurgical
Management of a Periapical Cyst: A Case Report. J Int Oral Health 2013; 5(3):79-84.
Dwivedi S, Dwivedi CD, Chaturvedi TP, Baranwal HC. Management of a large
radicular cyst: A non-surgical endodontic approach. Saudi Endodontic Journal. 2014
Sep 1;4(3):145
Raisingani D. Apexum: A minimum invasive procedure. International Journal of
Clinical Pediatric Dentistry. 2011 Sep;4(3):224.
41. Mejia JL, Donado JE, Basrani B. Active nonsurgical decompression of large
periapical lesions–3 case reports. J Can Dent Assoc. 2004 Nov 1;70(10):691-4
Barodiya A, Thukral R, Solanki SK, Chauhan SP, Singh S. Comparative Evaluation
for Surgical and Non-Surgical Management of Radicular Cyst-An Original
Research. Annals of the Romanian Society for Cell Biology. 2021 Mar 1:6755-60
Maity I, Meena N, Kumari RA. Single visit nonsurgical endodontic therapy for
periapical cysts: A clinical study. Contemporary clinical dentistry. 2014 Apr;5(2):195
Shafers text book of oral and maxillofacial pathology
Sain S, Reshmi J, Anandaraj S, George S, Issac JS, John SA. Lesion sterilization and
tissue repair-current concepts and practices. International journal of clinical pediatric
dentistry. 2018 Sep;11(5):446.
Editor's Notes
Past dental history and family history is not significant
Suture line present at the upper lip at the site of surgery of cleft
On clinical evaluation,AS 21 is avulsed and 22 is wider mesio distally than usual ,it is thought to be fusion of supernumerary tooth with lateral incisor
As a part of routine investigations, opg was advised and a large radiolucent lesion is seen irt mandibular anterior teeth region. The RL lesion measured about 2.5 x1.5 cm in diameter ,extending superiorly to the apices of canine on one side to canine on other side, inferiorly 1 cm above the lower border of the mandible, laterally to distal aspect of 43 and 33. other findings include labially erupted 23,Avulsed 21 and Rotated 22. based on these findings, a radiographic diagnosis of radicular cyst was given
As there is history of trauma,and periapical radiolucency from 33 to 43, Vitality test was done using electric pulp testing and cold test irt 31 32 33 41 42 43 and 31 responded negative to both tests, while there was delayed response irt 32 33 41 42 43 suggesting there might be pulpal inflammatory reaction . on correlation of history of trauma, clinical features,radiographic interpretation and vitality tests, we arrived at a final diagnosis of RADICULAR CYST
A odontogenic keratocyst is a benign, locally aggressive developmental odontogenic tumor most common in the mandibular ramus and body They expand the cortical bone and erode the cortex .ABCs are rare lesions 0f mandible in children. they present as rapid painless facial swelling and arise after local hemodynamic disturbances from trauma. Traumatic bone cyst lacks epithelial lining ,originate from intramedullary hemorhage caused by trauma
As none of the features of these cysts ,correlated with the lesion in our case, we arrived at final diagnosis of radicular cyst
The word Cyst is derived from a Greek word kystis which means sac or bladder. Cysts of oral cavity can be divided into odontogenic and non odontogenic cysts. among odontogenic cysts ,radicular cysts comprise about 52% to 68% of all the cysts which affect the human jaw
The radicular cyst develops due to the proliferation and subsequent cystic degeneration of the “epithelial cell rests of Malassez”, in the periapical region of a nonvital tooth.
Initiation: During the initiation phase, the bacterial infection of the dental pulp or direct inflammatory effect of necrotic pulpal tissue, in a nonvital tooth causes stimulation of the “cell rest of Malassez” which are present within the bone near the root apex of teeth. Proliferation: The stimulation of the cell rests of Malassez leads to excessive proliferation, which leads to the formation of a large mass of immature proliferating epithelial cells at the periapical region of the affected tooth. Cystification: Once a large cell mass is produced, its peripheral cells get adequate nutritional supply but central cells are deprived of nutritional supply. As a result the central cells undergo ischemic liquefactive necrosis while the peripheral group of cells survive. This gives rise to the formation of a cavity that contains a hollow lumen inside and surrounded peripherally by the mass of the proliferating epithelial cells around it. Enlargement: Once a small cyst is formed, it enlarges gradually enlarges. Higher osmotic tension of the cystic fluid causes progressive increase in the amount of fluid inside its lumen and this causes increased internal hydrostatic tension within the cyst. And results in cyst expansion due to resorption of the surrounding bone.
Cystic cavity is lined by a nonkeratinized, stratified squamous epithelium about 6 to 20 cell layers thickness. The proliferating cystic epithelium grow in a peculiar fashion, by encircling a mass of connective tissue capsule from all sides, called “arcading pattern”. Multiple small, ribbon-shaped or needle shaped, cleft-like spaces are seen in cystic lumen or in the connective tissue capsule of the cyst; these are known as “cholesterol clefts. Normally, cholesterol is derived from breakdown of blood cells and is present in the cyst wall. Rushton bodies” are also found within the cystic lining or in the connective tissue
well defined, unilocular, round shaped radiolucent areas of variable size (few millimeters to several centimeters in diameter) bound by a thin radiopaque line
no matter what choice it might be, the treatment option should be kept as conservative as possible. Clinical studies have confirmed that simple nonsurgical treatment with proper infection control can promote healing of large lesions
Conservative RCT with calcium hydroxide as intra-canal medicament .this is the procedure we followed and will be explained later
1)This procedure involves the use of ENDO EZE VACCUUM SYSTEM. It consists of high volume suction aspirator. After LA administration and rubber dam placement,the vacuum needle is inserted into the canal upto apical third and suction is activated,so that negative pressure is created and leads to decompression of the lesion.this procedure is repeated until exudate is clear and root canal is obturated.2)under mucosal anesthesia,24 g needle is inserted into the ccentre of the lesion through the labial surface until resistance is felt and slow aspiration is done. later 3 % naocl,and normal saline are used to irrigate the lesion.this is followed in subsequent appts until exudate is clear and obturation done after 4 weeks
3)This procedure aims to eliminate bacteria from root canals by sterilising the root canals &promoting hosts natural tissue response.triple antibiotic paste is used.after conventional access cavity preparation, necrotic tissue debridement and irrigation protocol,2mm deep cavity is prepared at the canal orifice for retaining triple ab paste.and access cavity sealed with GIC assuming that the triple ab paste is distributed throughout the canal ,induce sterile zone and promote tissue repair.4)this is based on minimally invasive removal of periapical chronically inflamed tissue through the root canal access.it consists of niiti ablator and pga ablator and a stabiliser. after cleaning and shaping of root canal,apical patency is achieved 1mm coronal to the apex. niti ablator is inserted into canal and pushed into lesion.rotated at 250 rpm for 30 sec to dissolve the contents of the cyst.later pga ablator is inserted and rotates at 5000rpm for 30 sec to dissolve into finer consistency which are then diluted with saline by using 30 g needle and aspirated. when the aspirate is clear then oburation is done.it takes 1-3 m for lesions to heal
A brief description of the available literature that supports non surgical mgt of PA cysts
The non surgical decompression and aspiration irrigation techniques are used to drain cystic fluid from the canals.
These techniques act by decreasing the hydrostatic pressure within the periapical lesion. pre op and18 months follow up radiographs
Non-surgical endodontic therapy was performed using 5% sodium hypochlorite solution as irrigant and Calcium hydroxide as intra canal medicament. A 12 months follow-up radiographic examination revealed progressive involution of periapical radiolucency without any clinical symptoms. pre op ,6months,12 months follow up
Root canal treatment was done together with cystic aspiration of the lesion. The lesion was periodically followed up and significant bone formation was seen at the periapical region of affected teeth and at the palate at about 9 months. 3months,6 months,9 months follow up
Careful case selection, treatment planning with proper technique of cleaning and shaping, right choice of the irrigants and fluid tight seal are important factors for healing of periapical lesion. pre op ,6 months,,12 months follow up
This is a syst review that compares the outcomes of surgical and non surgical mgt of PA lesions.
Based on this systematic review, as evidence, and considering the age and systemic condition of the patient , and present concept of minimal intervention dentistry , we opted for non surgical mgt of the radicular cyst
including, demographic data, medical history ,dental history etc
Triple antibiotic paste is 1:1:1 combination of metronidazole, ciprofloxacin and minocycline Double antibiotic paste consists of metronidazole and ciprofloxacin
Metranidazole binds to DNA and acts on gram + and _org. ciprofloxacin acts on dna gyrase ,gram _ org.minocycline inhibits protein synthesis,collagenases .cause discoloration
intracanal Ca(OH)2 would have a direct effect on periapical inflamed tissue by diffusion of hydroxyl ions (OH–) through the dentinal tubules, and favor periapical healing and encourage osseous repair
This is the post op opg after 3 months .there is slight reduction in the size of the lesion. we need to follow up the case for at least a period of 1 year to appreciate the complete regression of the lesion.