12 weeks Switch to Vaping: Science of Vaping Fontem Ventures
A randomised, parallel group clinical study was performed to evaluate the safety profile of an e-vapour
product (EVP; 2.0% nicotine) in smokers of conventional cigarettes (CCs) switching to use the EVP for 12
weeks.
Reductions in biomarkers of exposure (BoE) to harmful constituents (HPHCs) following partial or complete substitution of cigarettes with electronic cigarettes in adult smokers
E-Cigarette Summit Speaker: Dr. Jacques Le HouezecLindsay Fox
Nicotine safety in the context of e-cigarette use and tobacco dependence
Slides from Dr. Jacques Le Houezec's presentation at the E-Cigarette Summit, London November 12, 2013.
Full summary of the E-Cigarette Summit: http://ecigarettereviewed.com/e-cigarette-summit-london-summary
12 weeks Switch to Vaping: Science of Vaping Fontem Ventures
A randomised, parallel group clinical study was performed to evaluate the safety profile of an e-vapour
product (EVP; 2.0% nicotine) in smokers of conventional cigarettes (CCs) switching to use the EVP for 12
weeks.
Reductions in biomarkers of exposure (BoE) to harmful constituents (HPHCs) following partial or complete substitution of cigarettes with electronic cigarettes in adult smokers
E-Cigarette Summit Speaker: Dr. Jacques Le HouezecLindsay Fox
Nicotine safety in the context of e-cigarette use and tobacco dependence
Slides from Dr. Jacques Le Houezec's presentation at the E-Cigarette Summit, London November 12, 2013.
Full summary of the E-Cigarette Summit: http://ecigarettereviewed.com/e-cigarette-summit-london-summary
Our aim was to illustrate a short story which Nadia and I have invented in a Language III lesson.
This presentation is the result of the efforts we have made.
Enjoy!
A presentation on how to speak effectively.
This publication will get you started in becoming the speaker you want to be and the speaker your audience wants to hear.
The relative risk of cancer from smoking and vaping nicotine yfzsc5g7nm
Switching from smoking to vaping nicotine reduces your lifetime risk of cancer by over 99%.
Most of the carcinogens in smoke are absent in vapour. Those present are at very low doses.
Presentation at Prince of Wales Hospital, Medical Ground Rounds
Dr Colin Mendelsohn
22 November 2023
Innovation for Consumers: E-cigarettes and novel tobacco products - Part of t...Clive Bates
Clive Bates presentation at a seminar in the European Parliament organised by Monika Beňová MEP
European Commission DG SANTE - Matus Ferech
Patient Access Partnership - Dr. Stanimir Hasurdjiev
Pretty Nasty - Phthalates in European Cosmetic Products v2zq
Pretty Nasty - Phthalates in European Cosmetic Products - Resources for Healthy Children www.scribd.com/doc/254613619 - For more information, Please see Organic Edible Schoolyards & Gardening with Children www.scribd.com/doc/254613963 - Gardening with Volcanic Rock Dust www.scribd.com/doc/254613846 - Double Food Production from your School Garden with Organic Tech www.scribd.com/doc/254613765 - Free School Gardening Art Posters www.scribd.com/doc/254613694 - Increase Food Production with Companion Planting in your School Garden www.scribd.com/doc/254609890 - Healthy Foods Dramatically Improves Student Academic Success www.scribd.com/doc/254613619 - City Chickens for your Organic School Garden www.scribd.com/doc/254613553 - Huerto Ecológico, Tecnologías Sostenibles, Agricultura Organica www.scribd.com/doc/254613494 - Simple Square Foot Gardening for Schools - Teacher Guide www.scribd.com/doc/254613410 - Free Organic Gardening Publications www.scribd.com/doc/254609890 ~ noharm-uscanada.org
Electronic Cigarettes: Evidenced Based Decision Making PresentationKaylaRobinson29
An assignment for Dental Hygiene Theory 1 was to create an annotated bibliography for a research topic of our choice. This project was designed to challenge our critical thinking and decision making skills. I chose to research electronic cigarettes and their effects on oral health. It was interesting to compare different literature on this subject and the validity that they held. Most of the articles were very similar in the information portrayed and were very educational.
Our aim was to illustrate a short story which Nadia and I have invented in a Language III lesson.
This presentation is the result of the efforts we have made.
Enjoy!
A presentation on how to speak effectively.
This publication will get you started in becoming the speaker you want to be and the speaker your audience wants to hear.
The relative risk of cancer from smoking and vaping nicotine yfzsc5g7nm
Switching from smoking to vaping nicotine reduces your lifetime risk of cancer by over 99%.
Most of the carcinogens in smoke are absent in vapour. Those present are at very low doses.
Presentation at Prince of Wales Hospital, Medical Ground Rounds
Dr Colin Mendelsohn
22 November 2023
Innovation for Consumers: E-cigarettes and novel tobacco products - Part of t...Clive Bates
Clive Bates presentation at a seminar in the European Parliament organised by Monika Beňová MEP
European Commission DG SANTE - Matus Ferech
Patient Access Partnership - Dr. Stanimir Hasurdjiev
Pretty Nasty - Phthalates in European Cosmetic Products v2zq
Pretty Nasty - Phthalates in European Cosmetic Products - Resources for Healthy Children www.scribd.com/doc/254613619 - For more information, Please see Organic Edible Schoolyards & Gardening with Children www.scribd.com/doc/254613963 - Gardening with Volcanic Rock Dust www.scribd.com/doc/254613846 - Double Food Production from your School Garden with Organic Tech www.scribd.com/doc/254613765 - Free School Gardening Art Posters www.scribd.com/doc/254613694 - Increase Food Production with Companion Planting in your School Garden www.scribd.com/doc/254609890 - Healthy Foods Dramatically Improves Student Academic Success www.scribd.com/doc/254613619 - City Chickens for your Organic School Garden www.scribd.com/doc/254613553 - Huerto Ecológico, Tecnologías Sostenibles, Agricultura Organica www.scribd.com/doc/254613494 - Simple Square Foot Gardening for Schools - Teacher Guide www.scribd.com/doc/254613410 - Free Organic Gardening Publications www.scribd.com/doc/254609890 ~ noharm-uscanada.org
Electronic Cigarettes: Evidenced Based Decision Making PresentationKaylaRobinson29
An assignment for Dental Hygiene Theory 1 was to create an annotated bibliography for a research topic of our choice. This project was designed to challenge our critical thinking and decision making skills. I chose to research electronic cigarettes and their effects on oral health. It was interesting to compare different literature on this subject and the validity that they held. Most of the articles were very similar in the information portrayed and were very educational.
Marike Kolossa-Gehring: The Chemical Challenge - How HBM4EU Can HelpTHL
Marike Kolossa-Gehring, Coordinator of HBM4EU, German Environment Agency, at Europe That Protects - Safeguarding Our Planet, Safeguarding Our Health EU side event, 3-4 Dec 2019, THL, Helsinki
Little over a decade since their launch, electronic cigarettes (ECs) today represent a global
industry with sales exceeding US$6 billion last year. Yet the devices have increasingly
generated heated debate surrounding their safety, efficacy and regulatory control, while
advocates of the immediate formal use of ECs opine their usefulness in reducing the
burden of smoking-related disease – other experts urge caution until more information
and better evidence become available. Dr Robert Combes reports.
NYU College of Global Health - E-cigarette seminar - New YorkClive Bates
E-Cigarettes: The Tectonic Shift in Nicotine and Tobacco Consumption: Opportunity or Threat to Saving Lives?
Clive Bates
Friday, October 19, 2018
NYU School of Law, Greenberg Lounge
40 Washington Square South, New York, New York
24 04-2020 Bds third year lecture on smoking and periodontiumDr. Mamta Singh
Periodontitis is a group of inflammatory diseases affecting the supporting tissues of the tooth (periodontium). The periodontium consists of four tissues : gingiva, alveolar bone and periodontal ligaments. Tobbaco use is one of the modifiable risk factors and has enormous influance on the development, progres and tretmen results of periodontal disease. The relationship between smoking and periodontal health was investigated as early as the miiddle of last century. Smoking is an independent risk factor for the initiation, extent and severity of periodontal disease. Additionally, smoking can lower the chances for successful tretment. Tretmans in patients with periodontal disease must be focused on understanding the relationship between genetic and environmental factors. Only with individual approach we can identify our pacients risks and achieve better results.
Proposed Changes to How E-Cigarettes Are Regulated - Prof. Linda BauldLindsay Fox
Proposed changes to how e-cigarettes are regulated: UK and EU context
Slides from Prof. Linda Bauld's presentation at the E-Cigarette Summit, London November 12, 2013.
Full summary of the E-Cigarette Summit: http://ecigarettereviewed.com/e-cigarette-summit-london-summary
Similar to New e-inhalation products and potential health risks: The case for regulation (20)
Science of Flavors in Tobacco Products Sept 2023UCT ICO
This seminar aims to unravel the role of flavoring agents in enhancing the appeal of inhalable tobacco and nicotine products. Flavors are present in almost all tobacco/nicotine products and play a crucial role in their appeal and use behaviors but are poorly regulated. Dr. Krishnan-Sarin will discuss the sensory processes underlying the perception of flavoring agents, known pharmacological targets for flavor chemicals, and evidence of the potential toxicity of flavoring agents. She will also highlight the implications of the state of the science of flavoring agents for future research and regulation.
Developing the evidence base for an intervention to address tobacco and canna...UCT ICO
Why tobacco and cannabis? High smoking rates amongst those with SUD (Guydish et al, 2016)
Used together but clinically separated
Unintended consequence of tobacco addiction
Poorer cessation outcomes for co-users (Peters et al, 2012)
Increasing concern about impact of cannabis use; potency increased (EMCDDA, 2018, Freeman et al 2018, 2019)
Unique, complex relationship
La importancia del empaquetado en el consumo de los productos del tabaco: inv...UCT ICO
Juan Miguel Rey-Pino
Departamento de Comercialización e Investigación de Mercados
Universidad de Granada
Blanca Lacave-García
Departamento de Marketing y Comunicación
Universidad de Cádiz
Propuesta para empaquetado neutro en MéxicoUCT ICO
El Dr. Horacio Rubio (UNAM) hace una magistral disertación sobre la importancia del control del tabaquismo y qué posibles pasos aún no se han implementado. También hacer un repaso de la situación del tabaquismo en México
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Factory Supply Best Quality Pmk Oil CAS 28578–16–7 PMK Powder in Stockrebeccabio
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Hot Selling Organic intermediates
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
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New e-inhalation products and potential health risks: The case for regulation
1. 10/25/2016
New e-inhalation products and
potential health risks:
The case for regulation
Dr. Martina Pötschke-Langer, Dr. Katrin Schaller
Unit of Cancer Prevention,
WHO Collaborating Centre for Tobacco Control,
German Cancer Research Center (DKFZ)
2. 18.07.2014|
Dr. M. Pötschke-Langer
New e-inhalation products Overview
• The new growing market for electronic inhalation products
• Potential health risks
• The case for regulation
3. 18.07.2014|
Dr. M. Pötschke-Langer
New e-inhalation products
Electronic inhalation products
1
2 3
4
5 6
Components of an e-cigarette
8
(1) (Rechargeable)
battery
(2) (Manual) switch
(3) Vaporizer
(4) Mouthpiece
(5) Air-permeable
insulating material
(6) Heating coil
(7) Wick
(8) Liquid container
7
4. 18.07.2014|
Dr. M. Pötschke-Langer
New e-inhalation products
One way e-cigarettes
http://www.riccardo-zigarette.de/Riccardo-Einwegzigarette:::91.html
R200 TT one way e-cigarette
http://www.ttzig.eu/index.php?page=shop.product_de
tails&flypage=flypage.tpl&product_id=1&category_id=
1&vmcchk=1&option=com_virtuemart&Itemid=240
Electronic inhalation products
5. 18.07.2014|
Dr. M. Pötschke-Langer
New e-inhalation products
Refillable e-cigarettes
http://www.red-kiwi.de/products/e-
zigarette-red-kiwi-es-504-t/
http://www.red-kiwi.de/products/e-
zigarette-red-kiwi-rocket-ii-s-line/
red kiwi
Rocket II S-Line
red kiwi
ES-504 T
http://dampferins
el.de/zubehoer/a
kkus/444/ego-
akku-650mah-
strass?c=1238
e cig battery ego-k electronic
http://www.dhgate.com/store/product/colourful-
eGo Akku 650mAh Strass
Electronic inhalation products
7. 18.07.2014|
Dr. M. Pötschke-Langer
New e-inhalation products
http://www.steamo.de/epipe/ http://www.besserdampfen.de/Akkutraeger/1507/Vision-E-Kross http://future-smoke.de/Omar-
FARBEN-MOD-fuer-Ihre-E-
Pfeife-FS852-und-FS852M
http://future-smoke.de/12er-Pack-FS-
Einwegzigarre-V2-FS-Cuban-18-mg
http://www.123e-zigarette.de/E-Zigarre/Profi-e-Zigarette-Elektrische-
Zigarre-E-Zigarre-mit-24-Depots-S::52.html
Electronic inhalation products
Pipes and cigars
8. 18.07.2014|
Dr. M. Pötschke-Langer
New e-inhalation products
www.kaya-shisha.de
• Same principle as e-cigarettes
• Sometimes different mouthpiece
• 500 – 1500 puffs
• Also as refillable pens
http://www.wasserpfeife-shisha.comar
http://www.shisha-dreams.de/E-Shisha/Shisha-EMPIRE-E-
Shisha/Shisha-Empire-E-Shisha-nachfuellbar::2313.html
Electronic inhalation products
E-Shisha
9. 18.07.2014|
Dr. M. Pötschke-Langer
New e-inhalation products
• Mostly without nicotine
• On the internet also availablbe with nicotine
E-Shisha
Electronic inhalation products
http://www.hookah-shisha.com/p-13147-starbuzz-e-cig-tobacco-free-electronic-cigarette.html
10. 18.07.2014|
Dr. M. Pötschke-Langer
New e-inhalation products
http://www.stern.de/digital/homeentertainment/elektronisch-kiffen-vergessen-sie-die-e-zigarette-der-e-joint-ist-da-2119011.html
E-Joint
• No tobacco
• No nicotine
• No THC
• E-Joints with cannabis concentrate
announced by the manufacturer
Electronic inhalation products
12. 18.07.2014|
Dr. M. Pötschke-Langer
New e-inhalation products
Huge range of flavours – attractive to youth
Liquids
for e-inhalation products
Example: E-cigarette liquids
http://www.riccardo-zigarette.de/Riccardo-Liquid:::73.html
13. 18.07.2014|
Dr. M. Pötschke-Langer
New e-inhalation products
Huge range of flavours - attractive to youth
http://shisha-swag.de/index.php?PHPSESSID=8cf6ac5577d0c9d29e4ad4c3b77a06f0
Liquids
for e-inhalation products
Example:
E-shisha liquids
14. 18.07.2014|
Dr. M. Pötschke-Langer
New e-inhalation products
Liquids
Ingredients
• Propylene glycol
• Glycerol
• Flavours
• Nicotine
http://flavourart.de/index.php
Potential health risks
16. 18.07.2014|
Dr. M. Pötschke-Langer
New e-inhalation products
Glycerol
• Authorized as food additive (humectant, stablilizing agent)
• Unknown long-term effect of repeated inhalation
Potential health risks
18. 18.07.2014|
Dr. M. Pötschke-Langer
New e-inhalation products
• Formaldehyde
• Acetaldehyde
• Acroleine
• Metals (nickel, chromium, lead)
• Appear to be produced during heating
Refs.:
Trehy ML, et al., J Liquid Chrom Rel Tech, 2011. 34(14):1442-1458; Laugesen M Safety Report on the Ruyan® e-cigarette Cartridge and Inhaled Aerosol. 2008;
Goniewicz ML, et al., Tob Control, 2013, in press ; Uchiyama S et al., J. Chromatography A, 2010. 1217(26):4383-4388; Sobczak A et al., Poster presented at
the SRNT conference. 2013; Goniewicz ML et al., Poster presented at the SRNT conference. 2013.Williams M et al., PLoS One, 2013. 8(3):e57987; IARC.
Agents Classified by the IARC Monographs, Volumes 1-107. 2013 last update: 10 April 2013;; DFG, MAK- und BAT-Werte-Liste 2008; Hutzler et al., 2014 Arch
Toxikol published online
Potential health risks
Carcinogenic substances in vapour
19. 18.07.2014|
Dr. M. Pötschke-Langer
New e-inhalation products
Nicotine
• Toxic
• Harms the unborn
• Tumor promoting
• Possibly carcinogenic
• Addictive
Grando SA , Connections of nicotine to cancer Nat Recv Cancer 2014, published online 15 May 2014
Counotte DS et al, The yin and yang of nicotine: harmful during development, beneficial in adult patient populations FrontPharmacol 2012 (3): 180. doi: 10.3389/fphar.2012.00180
Benowitz NL, Clinical pharmacology of nicotine Clin Pharmacol Ther 2008 (83/4):531-541
Potential health risks
21. 18.07.2014|
Dr. M. Pötschke-Langer
New e-inhalation products
Intoxication
Potential health risks
• Increasing reports on intoxication of children
• Symptoms are mild and transient – so far
• Risk of overdosing (too many puffs, too deep inhalation)
Cantrell FL, Adverse effects of e-cigarette exposures J Community Health: published online 15 Dec 2013;
Ordonez J et al., Electronic cigarette exposures reported to poison centers, Meeting Abstract 242. Clin Toxicol 51:685–685;
Hua M et al., Health-Related Effects Reported by Electronic Cigarette Users in Online Forums, J Med Internet Res (2013)15:e59
22. 18.07.2014|
Dr. M. Pötschke-Langer
New e-inhalation products
Directive 40/2014/EU Directive 40/2014/EUNot included Not included Not included Not included
Regulation by and beyond
directive 2014/40/EU
23. 18.07.2014|
Dr. M. Pötschke-Langer
New e-inhalation products
Regulation by directive 40/2014/EU
Proposal
leaflet + package!
• Helvetica, black, 9 Point
• Hazard symbols
Directive 2014/40/EU, article 20 electronic cigarettes
(4) Member States shall ensure that
a) unit packets of electronic cigarettes and refill containers include a leaflet with
information on:
24. 18.07.2014|
Dr. M. Pötschke-Langer
New e-inhalation products
www.easysmokers.ch
Directive 2014/40/EU, article 20 electronic cigarettes
3 g) electronic cigarettes and refill containers are child- and tamper-proof, are
protected against breakage and leakage and have a mechanism that ensures
refilling without leakage
Regulation by directive 40/2014/EU
Proposal
Only pre-filled containers that can‘t be opened
(such as ink cartridges)
25. 18.07.2014|
Dr. M. Pötschke-Langer
New e-inhalation products
Proposal
A precise list of banned additives
(according to art.7(6))
• Vitamins/ additives implicating health benefits:
fruit flavours
• Flavours associated with energy and vitality:
green tea, coffee, energy, etc.
• Additives that facilitate inhalation or nicotine uptake:
Menthol.
It can be assumed that the physiological effects of menthol
are the same for e-cigarette use as for tobacco cigarettes.
www.germanflavours.de
Directive 2014/40/EU, article 20 electronic cigarettes
3 c) the nicotine-containing liquid does not contain additives listed in Article 7(6)
Regulation by directive 40/2014/EU
26. 18.07.2014|
Dr. M. Pötschke-Langer
New e-inhalation products
Regulation beyond
directive 2014/40/EU
Objective
Protection against health hazards of inhalation of the
chemical mixture of electronic inhalation products
Proposal
Sales ban to minors (<18 years)
Protection of youth
27. 18.07.2014|
Dr. M. Pötschke-Langer
New e-inhalation products
Proposal
• Standardised packaging
• Standardised product design
• Ban of flavours that are attractive
to youth
Objective
Protection against new lifestyle products
that may facilitate initiation to nicotine and
tobacco products
http://www.supersmokerbluetooth.de
Protection of youth
Regulation beyond
directive 2014/40/EU
www.happy-liquid.com, www.flavourart.nl
28. 18.07.2014|
Dr. M. Pötschke-Langer
New e-inhalation products
Proposal
• Ban of e-cigarette use in non-smoking areas
Objective
• Protection against indoor air pollution
• Prevention of the renormalisation of smoking
Regulation beyond
directive 2014/40/EU
Protection against emissions
29. 18.07.2014|
Dr. M. Pötschke-Langer
New e-inhalation products
Objective
• No hazardous waste
• Promotion of recycling
Proposal
• Obligation to repurchase
• Special tax for the environment (?)
Regulation beyond
directive 2014/40/EU
Protection of the evironment
30. 18.07.2014|
Dr. M. Pötschke-Langer
New e-inhalation products
Directive 40/2014/EU Directive 40/2014/EUNot included Not included Not included Not included
Regulation by and beyond
directive 2014/40/EU