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Nanobioanalysis: a multidisciplinar challenge 
Montserrat Rivas, 
José Ángel García, José Carlos Martínez
FORC technique 
SPION RF biosensor 
Research environment
Universidad de Oviedo
Prof. Marcos Tejedor 
Magnetism & Magnetic Materials in the University of Oviedo
NanoBioAnalysis 
(NBA) 
Oviedo 
University 
Universitary Central Hospital 
Materials Institute
NanoBioAnalysis 
(NBA) 
Magnetic Materials 
Integrated Optics 
Electrochemical sensors Electrophoresis & Paper-based tech 
Clinical Immunology & Microbiology 
Biotechnology & Biomedical Essays
FORC technique 
SPION RF biosensor 
Research environment
The FORC idea
FORC: First-Order Reversal Curves
SFD: Switching Field Distribution 
푆퐹퐷퐻ext,퐻푟= 휕푚 휕퐻ext 퐻푟
FORC diagram 
휌=− 12 휕2푚 휕퐻푒푥푡휕퐻푟 
J.C. Martínez-García et al., J. Phys. D: Apl. Phys. 47 (2014) 015001
Detection of non-interacting single domain particles using first‐order reversal curve diagrams 
R. Egli et al, Geochemistry, Geophysics, Geosystems 11 (2010) 
FORC diagrams measured on the Lake Ely sediment sample.
Magnetic and Mössbauer Spectral Study of Core/Shell Structured Fe/Au Nanoparticles 
S. J. Cho et al., Chemistry of Materials 18 (2006) 960
Set of FORCs 
J.C. Martínez-García et al., J. Alloy Compd. (2014)
Set of SFDs
FORC differential dissection of soft biphase magnetic ribbons 
J.C. Martínez-García et al., J. Alloy Compd. (2014)
Co nanostructures in ordered templates: comparative FORC analysis 
Co array samples of (a) nanowires with diameters of 65 nm, (b) nanopillars with diameters of 60 nm, and (c) nanotubes with diameters of 65 nm. 
M.P. Proenca, Nanotechnology 24 (2013) 475703
FORC technique 
SPION RF biosensor 
Research environment
Magnetoimpedance-based detection
Magnetoimpedance 
Co70Fe5Si10B15 
amorphous 
ribbon
Samples and methods 
Test fixture ribbon to impedance analyser 
(1-110 MHz) + Helmholz coils (dc field) 
Superparamagnetic 10 nm 
Fe3O4 nanoparticles (SPIONs) 
NPs deposited onto blotting paper strips
NPs detection with Co (GMI)
Magnetoimpedance 
Co70Fe5Si10B15 
amorphous 
ribbon
Cu-based detection
NPs detection with Cu
NPs detection with Cu 
Cu-ribbon 
Co-ribbon
Printed Circuit Board
Printed Circuit Board
NPs detection with PCB1 
PCB1 
Cu-ribbon 
x 5
Meander-line circuit
NPs detection with meander-structure 
Meander 
PCB1 
x 3
Planar spiral-like circuit
NPs detection with spiral-sensor 
PCB1 
Spiral 
x 7
Planar spiral-like circuit
NPs detection with 5-turn spiral 
5-turns 
PCB1 
x 30
Origin of the detection 
Changing magnetic field 
Induced electromotive forces 
Switching magnetic moment
Skin effect 
400 mm 
35 mm 
Active area 
Cross-section of the conductor track
Proximity effect 
Cross-section of three parallel traces
A frequency-related detection
Signal versus SPION mass 
PWB5S
LFT: Lateral Flow Test 
Sample 
Conjugated 
SPIONs 
Test line 
Control line 
Magnetic immunoassay
LFT/SPION rf-detection 
❶ 
❷ 
❸ 
❹ 
❺ 
❻ 
❶ 
❻ 
❷ 
❸ 
❹ 
❺
Magnetic immunoassay
Conclusions
Electromagnetic detection of SPIONs: highly sensitive, low-cost and simple fabrication/handling. 
Biosensing via nanoparticles detection 
Nano 
Bio 
Sensor 
Biomarkers 
NPs synthesis 
Size-effects 
Characterization 
Biotoxins 
Cells 
Antibodies 
Proteins 
Biointerfacing
idemm@uniovi.es
NanoBioAnalysis March 2012 
http://grupos.uniovi.es/web/nba 
Thank you for your kind attention
Nanobioanalysis: A Multidisciplinary Challenge Detection

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Nanobioanalysis: A Multidisciplinary Challenge Detection