The movie poster for "My Sister's Keeper" features images of the main characters played by Cameron Diaz and Abigail Breslin prominently at the top, while hiding the character played by Sofia Vassilieva at the bottom, reflecting how her character's story becomes central to the climax of the film. The plain white title allows it to stand out among the images. Text provides information on the main actors and director to give viewers a sense of the film's genre. A blue background connects the photos and references the medical themes in the film, contrasting with the laughing images to play with audience expectations about a lighter story that is ultimately about love, not death.