GHI Presentation, March 22nd , 2012, 1:00pm-2:00pm
                             USAID/Washington DC



          Multi-Agency Impact Evaluation

Challenges in Evaluating the Impact of the Scale-up
  of Malaria Interventions: The Tanzania Impact
                   Evaluation

        Yazoume Ye, MEASURE Evaluation/ICF International
Content of the Presentation

         Overview of the Multiagency Impact Evaluation
         Mainland Tanzania impact evaluation
               o Scope
               o Process and methodological approach




GHI Presentation, March 22nd , 2012, USAID/Washington DC
Overview of the Multiagency Impact
            Evaluation
Rationale
   Substantial increase in
    funding    for    malaria
    control in the recent
    decade
   Progressing scaled up of
    key interventions
   What is the effect of the
    scale-up      of      key
    interventions on malaria
    burden?                                                Source: Donor report & Gvt of Tanzania budget




GHI Presentation, March 22nd , 2012, USAID/Washington DC
Institutions Involved
         PMI
               o USAID - Washington, DC and Country RA
               o CDC - Atlanta, GA and Country RA
         ICF International
               o MEASURE Evaluation
               o MEASURE DHS
         National Malaria Control Programs
         National Statistic Bureaus
         In country Research Institution


GHI Presentation, March 22nd , 2012, USAID/Washington DC
Evaluation Questions

       What impact have malaria control interventions had on
        malaria-related morbidity and mortality?


       Can we demonstrate and quantify plausible association
        between intervention and impact?




GHI Presentation, March 22nd , 2012, USAID/Washington DC
Key Indicators
                            Program-based Data                                    Population-based Data




            Inputs               Processes                    Outputs           Outcomes                 Impact

        •   Strategies         • Human                     • Service            • Intervention     • Disease
        •   Policies             resources                   delivery             coverage           burden
        •   Guidelines         • Training                  • Knowledge,         • Use of           • Mortality
        •   Financing          • Commodities                 skills, practice     intervention




                                                                                                 Focus




GHI Presentation, March 22nd , 2012, USAID/Washington DC
What is the Story?
       Linking Morbidity and Mortality Change to Interventions


                                                    Malaria intervention coverage


        Mortality trend scenario 1



                                 Mortality trend scenario 2




           1999                                                                     2010



GHI Presentation, March 22nd , 2012, USAID/Washington DC
Evaluation Scope

            Focus on impact evaluation, NOT program
             effectiveness and efficiency
            Not restricted to PMI-funded malaria control
            Focus on period of malaria control scale-up
             and change in outcomes (1999-present)




GHI Presentation, March 22nd , 2012, USAID/Washington DC
Achieving Collective Ownership
     Prior consultation:
           o Common ownership of SINGLE impact evaluation report
           o Workshop involved NMCP, RBM-MERG, WHO, GFATM, and
             PMI
     Stakeholders review preliminary findings
     TAG: Comprised of RBM members and other international
      experts review first draft
     Disseminate final report nationally and internationally



GHI Presentation, March 22nd , 2012, USAID/Washington DC
Evaluation Design

       Describe trends in intervention coverage
       Describe trends in morbidity and mortality
       Linking these trends
            o “Plausibility” approach
            o Temporal, spatial, age-pattern, “dose-response” associations
            o Use models (LisT) to estimate number of deaths averted
       Multivariate models when possible with available data



GHI Presentation, March 22nd , 2012, USAID/Washington DC
Plausibility Framework
   Indicators



                •   ITN Ownership
                                             • Parasitemia                     All cause under-five
                •   ITN use
                                             • Anaemia (<8g/dL)                 mortality (5q0)
                •   IPTp
                •   Treatment


                                                                                          Decreased
                 Increase in effective                     Decreased                       malaria-
                intervention coverage                      morbidity                      associated
                                                                                          mortality
 Contextual




                                                           • Health intervention   •   Socioeconomic
  factors




                              • Climatic factor            • Health care           •   Education
                              • Rainfall                     utilization           •   Fertility risk
                              • Temperature                • ANC, EPI, Vit A,      •   Housing condition
                                                             PMTCT                 •   Nutrition




GHI Presentation, March 22nd , 2012, USAID/Washington DC
Data Sources

          DHS, MIS, MICS surveys
          Other national/large scale surveys
          HMIS data
          HDSS (if any in the country) - case study
          Studies and reports




GHI Presentation, March 22nd , 2012, USAID/Washington DC
Evaluation Timeline
Angola                 GF     PMI                                  Nov         Jun

Benin          GF                           PMI                          Feb                Feb

Ethiopia       GF                           PMI                          Feb                Feb

Ghana          GF                           PMI                          Feb                Feb

Kenya          GF                           PMI
Liberia        GF                           PMI
Madagascar     GF                           PMI
                              GF     PMI                           Nov         Jun
Malawi
Mali           GF                           PMI
Mozambique     GF                    PMI                                 Feb            Feb

Rwanda         GF                    PMI                                 Feb          Dec

Senegal        GF                    PMI                                 Feb          Dec

Tanzania       GF             PMI                                         Feb

Uganda         GF             PMI                                        Feb                Feb
Zambia         GF                           PMI
Zanzibar                                                                 Feb          Dec

             2003/04   2005   2006   2007   2008   2009   2010   2011          2012          2013   2014
Mainland Tanzania Impact Evaluation
              The Tanzania Impact Evaluation Team



 Alex Mwita            Fabrizio Molteni    Monica Olewe     Rita Njau
 Angelica Rugarabamu   Frank Chaky         Paul Smithson    Rose Lusinde
 Achuyt Bhattarai      Fred Arnold         Peter McElroy    Salim Abdulla
 Christine Hershey     Honorathy Masanja   Renata Mandike   Yazoume Ye
 Erin Eckert           Lia Florey          Rene Salgado
Evaluation Team
         National Malaria Control Program -Tanzania
         National Bureau of Statistics
         Ifakara Health Institute
         PMI
              o USAID -Washington, DC and Tanzania
              o CDC – Atlanta GA and Tanzania
         ICF International
              o MEASURE Evaluation
              o MEASURE DHS


GHI Presentation, March 22nd , 2012, USAID/Washington DC
Data Sources

      “DHS” surveys: 1992, 1996, 1999, 2004/5, 2007/8, 2009/10
      Other national/large scale surveys
            o HBS 2001, 2007; NMCP 2006, 2008; others
      Facility-based data: Rapid impact assessment 2001-2007
      Un/Published studies and report




GHI Presentation, March 22nd , 2012, USAID/Washington DC
Outcome Indicators
    Intervention Indicator                                                           Trends
    ITN                    “Proportion of Households with at Least One ITN”          1999-2009/10
                           “Proportion of children under five reporting sleeping 1999-2009/10
                           under an ITN the night prior to interview”
    IPTp                   “Proportion of women with a live birth in the 2 years     2004/5-2009/10
                           prior to survey who received ≥2 doses of SP during
                           her most recent pregnancy, ≥1 via ANC”

                           Assess the effect of SP stock-out (program data)

    Treatment               “Proportion of under-fives with self-reported fever      1999-2009/10
                           in the previous two weeks treated with first line anti-
                           malarial same/next day after fever onset”




GHI Presentation, March 22nd , 2012, USAID/Washington DC
Impact Indicators
   Health outcome                Indicator                                       Trends
   Morbidity                     Parasitemia prevalence: Proportion of children 2007/08 only +
                                 aged 6-59 months with malaria infection        NMCP surveys


                                 Anemia prevalence: Proportion of children age   2004/5, 2007/8,
                                 6-59 months with a hemoglobin measurement       2009/10
                                 of <8 g/dL
                                 Fever prevalence: Proportion of children aged   1999, 2004/05,
                                 6-59 month with reported fever                  2007/8, 2009/10

   Mortality                     All-cause under five mortality rate (5q0)       1990-2009/10




GHI Presentation, March 22nd , 2012, USAID/Washington DC
Contextual Factors
        Fertility risk, female education, literacy, access to media
        Housing condition
        Nutrition status
        Health care utilization
        Health interventions: ANC, Vaccination, Vit A, PMTCT
        Co-morbidities (ARI, diarrhea)
        Climatic factors-Rainfall pattern from 1990
        Change in GDP


GHI Presentation, March 22nd , 2012, USAID/Washington DC
Plausibility-Morbidity and Mortality

      Timing of the change
      Space, dose-response, age pattern
      Correspondence malaria morbidity and mortality
       change
      Other factors
      LiST deaths averted (magnitude expected)




GHI Presentation, March 22nd , 2012, USAID/Washington DC
Additional Analysis

           District level analysis- HMIS :
                 o Factors associated with malaria case incidence
                 o Factors associated malaria deaths
           Analysis of cross-sectional datasets to assess the
            association of ITN exposure (and other control
            measures) with malaria health outcomes; and
           Survival analysis - ITN exposure and child survival




GHI Presentation, March 22nd , 2012, USAID/Washington DC
Challenges - Technical
    Timing of collection of intervention data compared with
     measurement of outcomes
    Changing drug policies make it difficult to link trends in
     treatment with trends in morbidity/mortality
    Early surveys did not contain standard questions necessary
     for calculating some of these indicators (i.e ITN use)
    Data were not always available for the required period
    Plausibility versus causality



GHI Presentation, March 22nd , 2012, USAID/Washington DC
Challenges - organizational

    Country ownership - Involving country- NMCP
    Getting all partners to agree one approach
    Review process:
          o Consider time to get feedback from the TAG
          o Having the report approved by all partners involved takes time




GHI Presentation, March 22nd , 2012, USAID/Washington DC
Lessons learned
    Country ownership, but need external oversight to move the
     process
    Plausibility approach yes, but further district level analysis
     is needed (where possible with available data) to strengthen
     the results
    National level estimates from Survey are good, but HMIS
     and HDSS data could complement and help tell the story




GHI Presentation, March 22nd , 2012, USAID/Washington DC
MEASURE Evaluation is a MEASURE project funded by the
       U.S. Agency for International Development and implemented by
       the Carolina Population Center at the University of North Carolina
       at Chapel Hill, in partnership with Futures Group International,
       ICF Macro, John Snow, Inc., Management Sciences for Health,
       and Tulane University. Views expressed in this presentation do not
       necessarily reflect the views of USAID or the U.S. Government.
       MEASURE Evaluation is the USAID Global Health Bureau's
       primary vehicle for supporting improvements in monitoring and
       evaluation in population, health and nutrition worldwide.




GHI Presentation, March 22nd , 2012, USAID/Washington DC
Thank You!




GHI Presentation, March 22nd , 2012, USAID/Washington DC

Multi-Agency Impact Evaluation

  • 1.
    GHI Presentation, March22nd , 2012, 1:00pm-2:00pm USAID/Washington DC Multi-Agency Impact Evaluation Challenges in Evaluating the Impact of the Scale-up of Malaria Interventions: The Tanzania Impact Evaluation Yazoume Ye, MEASURE Evaluation/ICF International
  • 2.
    Content of thePresentation  Overview of the Multiagency Impact Evaluation  Mainland Tanzania impact evaluation o Scope o Process and methodological approach GHI Presentation, March 22nd , 2012, USAID/Washington DC
  • 3.
    Overview of theMultiagency Impact Evaluation
  • 4.
    Rationale Substantial increase in funding for malaria control in the recent decade  Progressing scaled up of key interventions  What is the effect of the scale-up of key interventions on malaria burden? Source: Donor report & Gvt of Tanzania budget GHI Presentation, March 22nd , 2012, USAID/Washington DC
  • 5.
    Institutions Involved  PMI o USAID - Washington, DC and Country RA o CDC - Atlanta, GA and Country RA  ICF International o MEASURE Evaluation o MEASURE DHS  National Malaria Control Programs  National Statistic Bureaus  In country Research Institution GHI Presentation, March 22nd , 2012, USAID/Washington DC
  • 6.
    Evaluation Questions  What impact have malaria control interventions had on malaria-related morbidity and mortality?  Can we demonstrate and quantify plausible association between intervention and impact? GHI Presentation, March 22nd , 2012, USAID/Washington DC
  • 7.
    Key Indicators Program-based Data Population-based Data Inputs Processes Outputs Outcomes Impact • Strategies • Human • Service • Intervention • Disease • Policies resources delivery coverage burden • Guidelines • Training • Knowledge, • Use of • Mortality • Financing • Commodities skills, practice intervention Focus GHI Presentation, March 22nd , 2012, USAID/Washington DC
  • 8.
    What is theStory? Linking Morbidity and Mortality Change to Interventions Malaria intervention coverage Mortality trend scenario 1 Mortality trend scenario 2 1999 2010 GHI Presentation, March 22nd , 2012, USAID/Washington DC
  • 9.
    Evaluation Scope  Focus on impact evaluation, NOT program effectiveness and efficiency  Not restricted to PMI-funded malaria control  Focus on period of malaria control scale-up and change in outcomes (1999-present) GHI Presentation, March 22nd , 2012, USAID/Washington DC
  • 10.
    Achieving Collective Ownership  Prior consultation: o Common ownership of SINGLE impact evaluation report o Workshop involved NMCP, RBM-MERG, WHO, GFATM, and PMI  Stakeholders review preliminary findings  TAG: Comprised of RBM members and other international experts review first draft  Disseminate final report nationally and internationally GHI Presentation, March 22nd , 2012, USAID/Washington DC
  • 11.
    Evaluation Design  Describe trends in intervention coverage  Describe trends in morbidity and mortality  Linking these trends o “Plausibility” approach o Temporal, spatial, age-pattern, “dose-response” associations o Use models (LisT) to estimate number of deaths averted  Multivariate models when possible with available data GHI Presentation, March 22nd , 2012, USAID/Washington DC
  • 12.
    Plausibility Framework Indicators • ITN Ownership • Parasitemia All cause under-five • ITN use • Anaemia (<8g/dL) mortality (5q0) • IPTp • Treatment Decreased Increase in effective Decreased malaria- intervention coverage morbidity associated mortality Contextual • Health intervention • Socioeconomic factors • Climatic factor • Health care • Education • Rainfall utilization • Fertility risk • Temperature • ANC, EPI, Vit A, • Housing condition PMTCT • Nutrition GHI Presentation, March 22nd , 2012, USAID/Washington DC
  • 13.
    Data Sources  DHS, MIS, MICS surveys  Other national/large scale surveys  HMIS data  HDSS (if any in the country) - case study  Studies and reports GHI Presentation, March 22nd , 2012, USAID/Washington DC
  • 14.
    Evaluation Timeline Angola GF PMI Nov Jun Benin GF PMI Feb Feb Ethiopia GF PMI Feb Feb Ghana GF PMI Feb Feb Kenya GF PMI Liberia GF PMI Madagascar GF PMI GF PMI Nov Jun Malawi Mali GF PMI Mozambique GF PMI Feb Feb Rwanda GF PMI Feb Dec Senegal GF PMI Feb Dec Tanzania GF PMI Feb Uganda GF PMI Feb Feb Zambia GF PMI Zanzibar Feb Dec 2003/04 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014
  • 15.
    Mainland Tanzania ImpactEvaluation The Tanzania Impact Evaluation Team Alex Mwita Fabrizio Molteni Monica Olewe Rita Njau Angelica Rugarabamu Frank Chaky Paul Smithson Rose Lusinde Achuyt Bhattarai Fred Arnold Peter McElroy Salim Abdulla Christine Hershey Honorathy Masanja Renata Mandike Yazoume Ye Erin Eckert Lia Florey Rene Salgado
  • 16.
    Evaluation Team  National Malaria Control Program -Tanzania  National Bureau of Statistics  Ifakara Health Institute  PMI o USAID -Washington, DC and Tanzania o CDC – Atlanta GA and Tanzania  ICF International o MEASURE Evaluation o MEASURE DHS GHI Presentation, March 22nd , 2012, USAID/Washington DC
  • 17.
    Data Sources  “DHS” surveys: 1992, 1996, 1999, 2004/5, 2007/8, 2009/10  Other national/large scale surveys o HBS 2001, 2007; NMCP 2006, 2008; others  Facility-based data: Rapid impact assessment 2001-2007  Un/Published studies and report GHI Presentation, March 22nd , 2012, USAID/Washington DC
  • 18.
    Outcome Indicators Intervention Indicator Trends ITN “Proportion of Households with at Least One ITN” 1999-2009/10 “Proportion of children under five reporting sleeping 1999-2009/10 under an ITN the night prior to interview” IPTp “Proportion of women with a live birth in the 2 years 2004/5-2009/10 prior to survey who received ≥2 doses of SP during her most recent pregnancy, ≥1 via ANC” Assess the effect of SP stock-out (program data) Treatment “Proportion of under-fives with self-reported fever 1999-2009/10 in the previous two weeks treated with first line anti- malarial same/next day after fever onset” GHI Presentation, March 22nd , 2012, USAID/Washington DC
  • 19.
    Impact Indicators Health outcome Indicator Trends Morbidity Parasitemia prevalence: Proportion of children 2007/08 only + aged 6-59 months with malaria infection NMCP surveys Anemia prevalence: Proportion of children age 2004/5, 2007/8, 6-59 months with a hemoglobin measurement 2009/10 of <8 g/dL Fever prevalence: Proportion of children aged 1999, 2004/05, 6-59 month with reported fever 2007/8, 2009/10 Mortality All-cause under five mortality rate (5q0) 1990-2009/10 GHI Presentation, March 22nd , 2012, USAID/Washington DC
  • 20.
    Contextual Factors  Fertility risk, female education, literacy, access to media  Housing condition  Nutrition status  Health care utilization  Health interventions: ANC, Vaccination, Vit A, PMTCT  Co-morbidities (ARI, diarrhea)  Climatic factors-Rainfall pattern from 1990  Change in GDP GHI Presentation, March 22nd , 2012, USAID/Washington DC
  • 21.
    Plausibility-Morbidity and Mortality  Timing of the change  Space, dose-response, age pattern  Correspondence malaria morbidity and mortality change  Other factors  LiST deaths averted (magnitude expected) GHI Presentation, March 22nd , 2012, USAID/Washington DC
  • 22.
    Additional Analysis  District level analysis- HMIS : o Factors associated with malaria case incidence o Factors associated malaria deaths  Analysis of cross-sectional datasets to assess the association of ITN exposure (and other control measures) with malaria health outcomes; and  Survival analysis - ITN exposure and child survival GHI Presentation, March 22nd , 2012, USAID/Washington DC
  • 23.
    Challenges - Technical  Timing of collection of intervention data compared with measurement of outcomes  Changing drug policies make it difficult to link trends in treatment with trends in morbidity/mortality  Early surveys did not contain standard questions necessary for calculating some of these indicators (i.e ITN use)  Data were not always available for the required period  Plausibility versus causality GHI Presentation, March 22nd , 2012, USAID/Washington DC
  • 24.
    Challenges - organizational  Country ownership - Involving country- NMCP  Getting all partners to agree one approach  Review process: o Consider time to get feedback from the TAG o Having the report approved by all partners involved takes time GHI Presentation, March 22nd , 2012, USAID/Washington DC
  • 25.
    Lessons learned  Country ownership, but need external oversight to move the process  Plausibility approach yes, but further district level analysis is needed (where possible with available data) to strengthen the results  National level estimates from Survey are good, but HMIS and HDSS data could complement and help tell the story GHI Presentation, March 22nd , 2012, USAID/Washington DC
  • 26.
    MEASURE Evaluation isa MEASURE project funded by the U.S. Agency for International Development and implemented by the Carolina Population Center at the University of North Carolina at Chapel Hill, in partnership with Futures Group International, ICF Macro, John Snow, Inc., Management Sciences for Health, and Tulane University. Views expressed in this presentation do not necessarily reflect the views of USAID or the U.S. Government. MEASURE Evaluation is the USAID Global Health Bureau's primary vehicle for supporting improvements in monitoring and evaluation in population, health and nutrition worldwide. GHI Presentation, March 22nd , 2012, USAID/Washington DC
  • 27.
    Thank You! GHI Presentation,March 22nd , 2012, USAID/Washington DC