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12.4.2 final mahoning county project re directory 2012
News release sent to Youngstown-area local media on April 2, 2012 regarding a phone directory recycling program at several Mahoning County-area schools.
201304 chef for open stack overview
This document provides an overview of using Chef to deploy and manage OpenStack. It discusses why Chef is useful for infrastructure as code and its declarative interface. The document outlines the current state of the Chef for OpenStack project, including contributors, available cookbooks, and roadmap. It promotes the project as a way to collaboratively deploy OpenStack in a standardized, automated way and reduce fragmentation.
13.4.1 brown county chamber of commerce chamber weekly connected car
The document announces the grand re-opening and ribbon cutting ceremony for the River Breeze Café located at 30 Main Street in Ripley, OH on Friday, April 5th at 2:00 PM. It provides the date, time, location and purpose of the event.
15.4.23 dayton area chamber of commerce newsletter - grzybicki event
The document is a newsletter from the Dayton Area Chamber of Commerce announcing upcoming events in April and May, including a Legislative Day trip to Columbus on April 30th to discuss redistricting and marijuana legalization with state lawmakers, and various breakfast briefings and roundtables on topics like doing business with Romania, transitioning Ohio's economy to focus on IP, and logistics. It also highlights an upcoming trip to Italy in October offered by the Chamber at an early-booking discount.
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AT&T has expanded its 4G LTE network to parts of Licking County, Ohio including Newark and Heath. The expansion brings faster internet speeds up to 10 times faster than 3G as well as more reliable connectivity. Local politicians commended AT&T for the investment in improving infrastructure and technology for the region. AT&T's 4G LTE network has been recognized as the fastest and most reliable by independent tests.
Workshop 1 8 fei vienam workshop festival timelines
This document contains summaries of 14 chapters that provide guidance on event planning and management. The chapters discuss general planning, business planning, team structure, budgets, financial planning, programming, legal issues, insurance, event production, communications, marketing, visitor research, and post-event activities. The guidance is intended to help event organizers successfully plan, budget, market, operate and evaluate their events.
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12.4.2 final mahoning county project re directory 2012
News release sent to Youngstown-area local media on April 2, 2012 regarding a phone directory recycling program at several Mahoning County-area schools.
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13.4.1 brown county chamber of commerce chamber weekly connected car
The document announces the grand re-opening and ribbon cutting ceremony for the River Breeze Café located at 30 Main Street in Ripley, OH on Friday, April 5th at 2:00 PM. It provides the date, time, location and purpose of the event.
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The document is a newsletter from the Dayton Area Chamber of Commerce announcing upcoming events in April and May, including a Legislative Day trip to Columbus on April 30th to discuss redistricting and marijuana legalization with state lawmakers, and various breakfast briefings and roundtables on topics like doing business with Romania, transitioning Ohio's economy to focus on IP, and logistics. It also highlights an upcoming trip to Italy in October offered by the Chamber at an early-booking discount.
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AT&T has expanded its 4G LTE network to parts of Licking County, Ohio including Newark and Heath. The expansion brings faster internet speeds up to 10 times faster than 3G as well as more reliable connectivity. Local politicians commended AT&T for the investment in improving infrastructure and technology for the region. AT&T's 4G LTE network has been recognized as the fastest and most reliable by independent tests.
Workshop 1 8 fei vienam workshop festival timelines
This document contains summaries of 14 chapters that provide guidance on event planning and management. The chapters discuss general planning, business planning, team structure, budgets, financial planning, programming, legal issues, insurance, event production, communications, marketing, visitor research, and post-event activities. The guidance is intended to help event organizers successfully plan, budget, market, operate and evaluate their events.
Analysis on changing scenario in retail banking
This document analyzes trends in the retail banking sector. It discusses how retail banking aims to provide various financial services to individual customers through branches and new distribution channels. The key drivers of retail banking are improving customer access, offering more services, and increasing loyalty while reducing dissatisfaction. Major banks in the Indian retail banking sector are discussed. A SWOT analysis identifies strengths like large customer databases, but also weaknesses such as resistance to change and threats from increased competition. The conclusion is that retail banking is growing rapidly in India, with many customers still preferring government banks due to the benefits they provide. Suggestions include improving processes at government banks and providing more security and assurance at private banks.
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AT&T announced the availability of faster internet speeds of up to 45 Mbps downstream and 6 Mbps upstream for U-verse customers in Cleveland as part of its Project VIP investment plan. The new U-verse High Speed Internet Power is available at introductory rates starting at $49.95 per month when bundled with TV and voice services. The speed upgrade is aimed at supporting customers' growing demand for high-speed internet access and mobile, app, and cloud-based services.
Final hh - 12.4.3 columbus job shadow 100 k release
The document summarizes AT&T's Job Shadow Initiative which has connected over 100,000 US high school students with AT&T employees to help reduce dropout rates. It discusses how Columbus area students have benefited from the program. It also announces AT&T's expansion of its Aspire educational commitment through a $250 million investment to help more students graduate ready for college and careers.
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Final Library Notes
The document provides instructions for using the library resources at St. Thomas university. It explains how to access the library from the school's website, search the library catalog by author, title or subject, identify materials by call number, distinguish the catalog from databases and the internet, search databases for journal articles using keywords alone or with Boolean operators, and tips for narrowing searches.
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2nd-generation Antihistaminic Part I.pptx
CLASSIFICATION OF H1 ANTIHISTAMINICS-
FIRST GENERATION ANTIHISTAMINICS-
1)HIGHLY SEDATIVE-DIPHENHYDRAMINE,DIMENHYDRINATE,PROMETHAZINE,HYDROXYZINE 2)MODERATELY SEDATIVE- PHENARIMINE,CYPROHEPTADINE, MECLIZINE,CINNARIZINE
3)MILD SEDATIVE-CHLORPHENIRAMINE,DEXCHLORPHENIRAMINE
TRIPROLIDINE,CLEMASTINE
SECOND GENERATION ANTIHISTAMINICS-FEXOFENADINE,
LORATADINE,DESLORATADINE,CETIRIZINE,LEVOCETIRIZINE,
AZELASTINE,MIZOLASTINE,EBASTINE,RUPATADINE. Mechanism of action of 2nd generation antihistaminics-
These drugs competitively antagonize actions of
histamine at the H1 receptors.
Pharmacological actions-
Antagonism of histamine-The H1 antagonists effectively block histamine induced bronchoconstriction, contraction of intestinal and other smooth muscle and triple response especially wheal, flare and itch. Constriction of larger blood vessel by histamine is also antagonized.
2) Antiallergic actions-Many manifestations of immediate hypersensitivity (type I reactions)are suppressed. Urticaria, itching and angioedema are well controlled.3) CNS action-The older antihistamines produce variable degree of CNS depression.But in case of 2nd gen antihistaminics there is less CNS depressant property as these cross BBB to significantly lesser extent.
4) Anticholinergic action- many H1 blockers
in addition antagonize muscarinic actions of ACh. BUT IN 2ND gen histaminics there is Higher H1 selectivitiy : no anticholinergic side effects
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Receptor Discordance in Breast Carcinoma During the Course of Life
Definition:
Receptor discordance refers to changes in the status of hormone receptors (estrogen receptor ERα, progesterone receptor PgR, and HER2) in breast cancer tumors over time or between primary and metastatic sites.
Causes:
Tumor Evolution:
Genetic and epigenetic changes during tumor progression can lead to alterations in receptor status.
Treatment Effects:
Therapies, especially endocrine and targeted therapies, can selectively pressure tumor cells, causing shifts in receptor expression.
Heterogeneity:
Inherent heterogeneity within the tumor can result in subpopulations of cells with different receptor statuses.
Impact on Treatment:
Therapeutic Resistance:
Loss of ERα or PgR can lead to resistance to endocrine therapies.
HER2 discordance affects the efficacy of HER2-targeted treatments.
Treatment Adjustment:
Regular reassessment of receptor status may be necessary to adjust treatment strategies appropriately.
Clinical Implications:
Prognosis:
Receptor discordance is often associated with a poorer prognosis.
Biopsies:
Obtaining biopsies from metastatic sites is crucial for accurate receptor status assessment and effective treatment planning.
Monitoring:
Continuous monitoring of receptor status throughout the disease course can guide personalized therapy adjustments.
Understanding and managing receptor discordance is essential for optimizing treatment outcomes and improving the prognosis for breast cancer patients.
TEST BANK For Brunner and Suddarth's Textbook of Medical-Surgical Nursing, 14...
TEST BANK For Brunner and Suddarth's Textbook of Medical-Surgical Nursing, 14th Edition (Hinkle, 2017) Verified Chapter's 1 - 73 Complete.pdf
TEST BANK For Brunner and Suddarth's Textbook of Medical-Surgical Nursing, 14th Edition (Hinkle, 2017) Verified Chapter's 1 - 73 Complete.pdf
TEST BANK For Brunner and Suddarth's Textbook of Medical-Surgical Nursing, 14th Edition (Hinkle, 2017) Verified Chapter's 1 - 73 Complete.pdf
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Fexofenadine is sold under the brand name Allegra.
It is a selective peripheral H1 blocker. It is classified as a second-generation antihistamine because it is less able to pass the blood–brain barrier and causes lesser sedation, as compared to first-generation antihistamines.
It is on the World Health Organization's List of Essential Medicines. Fexofenadine has been manufactured in generic form since 2011.
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Allopurinol, a uric acid synthesis inhibitor acts by inhibiting Xanthine oxidase competitively as well as non- competitively, Whereas Oxypurinol is a non-competitive inhibitor of xanthine oxidase.
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AT&T announced the availability of faster internet speeds of up to 45 Mbps downstream and 6 Mbps upstream for U-verse customers in Cleveland as part of its Project VIP investment plan. The new U-verse High Speed Internet Power is available at introductory rates starting at $49.95 per month when bundled with TV and voice services. The speed upgrade is aimed at supporting customers' growing demand for high-speed internet access and mobile, app, and cloud-based services.
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The document summarizes AT&T's Job Shadow Initiative which has connected over 100,000 US high school students with AT&T employees to help reduce dropout rates. It discusses how Columbus area students have benefited from the program. It also announces AT&T's expansion of its Aspire educational commitment through a $250 million investment to help more students graduate ready for college and careers.
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Final Library Notes
The document provides instructions for using the library resources at St. Thomas university. It explains how to access the library from the school's website, search the library catalog by author, title or subject, identify materials by call number, distinguish the catalog from databases and the internet, search databases for journal articles using keywords alone or with Boolean operators, and tips for narrowing searches.
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The island of Eigg in Scotland has successfully transitioned to renewable energy sources for its power needs. The island now generates electricity from solar, wind, and hydro power, making it a self-sufficient green energy community. This case study details Eigg's journey to develop its own renewable energy network over 15 years and become a model for sustainable living off the grid.
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In this presentation , SBP ( spontaneous bacterial peritonitis ) , which is a common complication in patients with cirrhosis and ascites is described in detail.
The reference for this presentation is Sleisenger and Fordtran's Gastrointestinal and Liver Disease Textbook ( 11th edition ).
2nd-generation Antihistaminic Part I.pptx
CLASSIFICATION OF H1 ANTIHISTAMINICS-
FIRST GENERATION ANTIHISTAMINICS-
1)HIGHLY SEDATIVE-DIPHENHYDRAMINE,DIMENHYDRINATE,PROMETHAZINE,HYDROXYZINE 2)MODERATELY SEDATIVE- PHENARIMINE,CYPROHEPTADINE, MECLIZINE,CINNARIZINE
3)MILD SEDATIVE-CHLORPHENIRAMINE,DEXCHLORPHENIRAMINE
TRIPROLIDINE,CLEMASTINE
SECOND GENERATION ANTIHISTAMINICS-FEXOFENADINE,
LORATADINE,DESLORATADINE,CETIRIZINE,LEVOCETIRIZINE,
AZELASTINE,MIZOLASTINE,EBASTINE,RUPATADINE. Mechanism of action of 2nd generation antihistaminics-
These drugs competitively antagonize actions of
histamine at the H1 receptors.
Pharmacological actions-
Antagonism of histamine-The H1 antagonists effectively block histamine induced bronchoconstriction, contraction of intestinal and other smooth muscle and triple response especially wheal, flare and itch. Constriction of larger blood vessel by histamine is also antagonized.
2) Antiallergic actions-Many manifestations of immediate hypersensitivity (type I reactions)are suppressed. Urticaria, itching and angioedema are well controlled.3) CNS action-The older antihistamines produce variable degree of CNS depression.But in case of 2nd gen antihistaminics there is less CNS depressant property as these cross BBB to significantly lesser extent.
4) Anticholinergic action- many H1 blockers
in addition antagonize muscarinic actions of ACh. BUT IN 2ND gen histaminics there is Higher H1 selectivitiy : no anticholinergic side effects
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Receptor Discordance in Breast Carcinoma During the Course of Life
Definition:
Receptor discordance refers to changes in the status of hormone receptors (estrogen receptor ERα, progesterone receptor PgR, and HER2) in breast cancer tumors over time or between primary and metastatic sites.
Causes:
Tumor Evolution:
Genetic and epigenetic changes during tumor progression can lead to alterations in receptor status.
Treatment Effects:
Therapies, especially endocrine and targeted therapies, can selectively pressure tumor cells, causing shifts in receptor expression.
Heterogeneity:
Inherent heterogeneity within the tumor can result in subpopulations of cells with different receptor statuses.
Impact on Treatment:
Therapeutic Resistance:
Loss of ERα or PgR can lead to resistance to endocrine therapies.
HER2 discordance affects the efficacy of HER2-targeted treatments.
Treatment Adjustment:
Regular reassessment of receptor status may be necessary to adjust treatment strategies appropriately.
Clinical Implications:
Prognosis:
Receptor discordance is often associated with a poorer prognosis.
Biopsies:
Obtaining biopsies from metastatic sites is crucial for accurate receptor status assessment and effective treatment planning.
Monitoring:
Continuous monitoring of receptor status throughout the disease course can guide personalized therapy adjustments.
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Nutritional deficiency Disorder are problems in india.
It is very important to learn about Indian child's nutritional parameters as well the Disease related to alteration in their Nutrition.
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Fexofenadine is sold under the brand name Allegra.
It is a selective peripheral H1 blocker. It is classified as a second-generation antihistamine because it is less able to pass the blood–brain barrier and causes lesser sedation, as compared to first-generation antihistamines.
It is on the World Health Organization's List of Essential Medicines. Fexofenadine has been manufactured in generic form since 2011.
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This presentation gives information on the pharmacology of Prostaglandins, Thromboxanes and Leukotrienes i.e. Eicosanoids. Eicosanoids are signaling molecules derived from polyunsaturated fatty acids like arachidonic acid. They are involved in complex control over inflammation, immunity, and the central nervous system. Eicosanoids are synthesized through the enzymatic oxidation of fatty acids by cyclooxygenase and lipoxygenase enzymes. They have short half-lives and act locally through autocrine and paracrine signaling.
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