- A Phase III trial of 400 patients with malignant pleural mesothelioma found that treatment with NGR-hTNF in combination with chemotherapy led to a 40% improvement in overall survival and progression-free survival compared to chemotherapy alone.
- Survival times were particularly improved for patients who received at least three months of NGR-hTNF therapy, with a median survival of 16.5 months compared to 9.8 months for the control group.
- Additional Phase II trials found NGR-hTNF improved survival rates when combined with chemotherapy for sarcoma and ovarian cancer patients.
An innovative clinical trail study design _First comprehensive report of impact of genomic alterations, chemotherapy, targeted therapy and immunotherapy on outcomes in the genomics driven squamous master protocol LungMAP.
Multicentric and multifocal versus unifocal breast cancer: differences in the...Enrique Moreno Gonzalez
The aim of this study was to evaluate the expression of the cell adhesion-related glycoproteins MUC-1, β-catenin and E-cadherin in multicentric/multifocal breast cancer in comparison to unifocal disease in order to identify potential differences in the biology of these tumor types.
This paper was presented at the EORTC-NCI-AACR meeting last week. The poster shows data on NOTCH expression in cell lines and evaluated the effects of NOCH inhibition.
Incidence of pneumonia and risk factors among patients with head and neck can...Enrique Moreno Gonzalez
This study investigated the incidence and patient- and treatment-related risk factors related to pneumonia acquired during radiotherapy (PNRT) in head and neck cancer (HNC) patients.
Acute myeloid leukemia (AML) is a hematopoietic malignancy with a dismal outcome in the majority of cases. A detailed understanding of the genetic alterations and gene expression changes that contribute to its pathogenesis is important to improve prognostication, disease monitoring, and therapy. In this context, leukemia-associated misexpression of microRNAs (miRNAs) has been studied, but no coherent picture has emerged yet, thus warranting further investigations.
Differences in microRNA expression during tumor development in the transition...Enrique Moreno Gonzalez
The prostate is divided into three glandular zones, the peripheral zone (PZ), the transition zone (TZ), and the central zone. Most prostate tumors arise in the peripheral zone (70-75%) and in the transition zone (20-25%) while only 10% arise in the central zone. The aim of this study was to investigate if differences in miRNA expression could be a possible explanation for the difference in propensity of tumors in the zones of the prostate.
Overexpression of YAP 1 contributes to progressive features and poor prognosi...Enrique Moreno Gonzalez
Yes-associated protein 1 (YAP 1), the nuclear effector of the Hippo pathway, is a key regulator of organ size and a candidate human oncogene in multiple tumors. However, the expression dynamics of YAP 1 in urothelial carcinoma of the bladder (UCB) and its clinical/prognostic significance are unclear.
Clinical and experimental studies regarding the expression and diagnostic val...Enrique Moreno Gonzalez
Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is a multifunctional Ig-like cell adhesion molecule that has a wide range of biological functions. According to previous reports, serum CEACAM1 is dysregulated in different malignant tumours and associated with tumour progression. However, the serum CEACAM1 expression in nonsmall-cell lung carcinomas (NSCLC) is unclear. The different expression ratio of CEACAM1-S and CEACAM1-L isoform has seldom been investigated in NSCLC. This research is intended to study the serum CEACAM1 and the ratio of CEACAM1-S/L isoforms in NSCLC.
This presentation gives an overview on available and future therapies for Small Cell Lung Cancer (SCLC). It covers topics on potential therapeutic targets, genomics, translational medicine, clinical research and market analysis.
Dose selection trial of metronomic oral vinorelbine monotherapy in patients w...Enrique Moreno Gonzalez
Metronomic chemotherapy is considered an anti-angiogenic therapy that involves chronic administration of low-dose chemotherapy at regular short intervals. We investigated the optimal metronomic dose of oral vinorelbine when given as monotherapy in patients with metastatic cancer.
Recently, a phase II clinical trial in hepatocellular carcinoma (HCC) has suggested that the combination of sorafenib and 5-fluorouracil (5-FU) is feasible and side effects are manageable. However, preclinical experimental data explaining the interaction mechanism(s) are lacking. Our objective is to investigate the anticancer efficacy and mechanism of combined sorafenib and 5-FU therapy in vitro in HCC cell lines MHCC97H and SMMC-7721.
MolMed ASCO Prolonged Survival Times Patients With Acute Leukaemia Treated Wi...social_molmed
Long-term data presented at ASCO confirm prolonged survival times of patients with acute leukaemia treated with TK cell therapy
The use of TK has enabled the execution of haploidentical donor transplants, with an overall survival similar to transplants from fully compatible donors
MolMed expects to file a request for Conditional Marketing Authorisation of TK to the European Authority in 2013
An innovative clinical trail study design _First comprehensive report of impact of genomic alterations, chemotherapy, targeted therapy and immunotherapy on outcomes in the genomics driven squamous master protocol LungMAP.
Multicentric and multifocal versus unifocal breast cancer: differences in the...Enrique Moreno Gonzalez
The aim of this study was to evaluate the expression of the cell adhesion-related glycoproteins MUC-1, β-catenin and E-cadherin in multicentric/multifocal breast cancer in comparison to unifocal disease in order to identify potential differences in the biology of these tumor types.
This paper was presented at the EORTC-NCI-AACR meeting last week. The poster shows data on NOTCH expression in cell lines and evaluated the effects of NOCH inhibition.
Incidence of pneumonia and risk factors among patients with head and neck can...Enrique Moreno Gonzalez
This study investigated the incidence and patient- and treatment-related risk factors related to pneumonia acquired during radiotherapy (PNRT) in head and neck cancer (HNC) patients.
Acute myeloid leukemia (AML) is a hematopoietic malignancy with a dismal outcome in the majority of cases. A detailed understanding of the genetic alterations and gene expression changes that contribute to its pathogenesis is important to improve prognostication, disease monitoring, and therapy. In this context, leukemia-associated misexpression of microRNAs (miRNAs) has been studied, but no coherent picture has emerged yet, thus warranting further investigations.
Differences in microRNA expression during tumor development in the transition...Enrique Moreno Gonzalez
The prostate is divided into three glandular zones, the peripheral zone (PZ), the transition zone (TZ), and the central zone. Most prostate tumors arise in the peripheral zone (70-75%) and in the transition zone (20-25%) while only 10% arise in the central zone. The aim of this study was to investigate if differences in miRNA expression could be a possible explanation for the difference in propensity of tumors in the zones of the prostate.
Overexpression of YAP 1 contributes to progressive features and poor prognosi...Enrique Moreno Gonzalez
Yes-associated protein 1 (YAP 1), the nuclear effector of the Hippo pathway, is a key regulator of organ size and a candidate human oncogene in multiple tumors. However, the expression dynamics of YAP 1 in urothelial carcinoma of the bladder (UCB) and its clinical/prognostic significance are unclear.
Clinical and experimental studies regarding the expression and diagnostic val...Enrique Moreno Gonzalez
Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is a multifunctional Ig-like cell adhesion molecule that has a wide range of biological functions. According to previous reports, serum CEACAM1 is dysregulated in different malignant tumours and associated with tumour progression. However, the serum CEACAM1 expression in nonsmall-cell lung carcinomas (NSCLC) is unclear. The different expression ratio of CEACAM1-S and CEACAM1-L isoform has seldom been investigated in NSCLC. This research is intended to study the serum CEACAM1 and the ratio of CEACAM1-S/L isoforms in NSCLC.
This presentation gives an overview on available and future therapies for Small Cell Lung Cancer (SCLC). It covers topics on potential therapeutic targets, genomics, translational medicine, clinical research and market analysis.
Dose selection trial of metronomic oral vinorelbine monotherapy in patients w...Enrique Moreno Gonzalez
Metronomic chemotherapy is considered an anti-angiogenic therapy that involves chronic administration of low-dose chemotherapy at regular short intervals. We investigated the optimal metronomic dose of oral vinorelbine when given as monotherapy in patients with metastatic cancer.
Recently, a phase II clinical trial in hepatocellular carcinoma (HCC) has suggested that the combination of sorafenib and 5-fluorouracil (5-FU) is feasible and side effects are manageable. However, preclinical experimental data explaining the interaction mechanism(s) are lacking. Our objective is to investigate the anticancer efficacy and mechanism of combined sorafenib and 5-FU therapy in vitro in HCC cell lines MHCC97H and SMMC-7721.
MolMed ASCO Prolonged Survival Times Patients With Acute Leukaemia Treated Wi...social_molmed
Long-term data presented at ASCO confirm prolonged survival times of patients with acute leukaemia treated with TK cell therapy
The use of TK has enabled the execution of haploidentical donor transplants, with an overall survival similar to transplants from fully compatible donors
MolMed expects to file a request for Conditional Marketing Authorisation of TK to the European Authority in 2013
Gastric cancer was until the 1980s the most frequent diagnosed cancer all around the world, and it still remains even nowadays one of the most frequent and aggressive malignant tumors, having the power to cause annually an amazingly high number of deaths and affected people. Even if it went through some difficult phases for more 11 years, the stomach surgery managed to become today quite well defined even if it is not yet fully outlined.
Gastric cancer was until the 1980s the most frequent diagnosed cancer all around the world, and it still remains even nowadays one of the most frequent and aggressive malignant tumors, having the power to cause annually an amazingly high number of deaths and affected people. Even if it went through some difficult phases for more 11 years, the stomach surgery managed to become today quite well defined even if it is not yet fully outlined.
List of New Anti-cancer Drugs Approved By FDA In The First Half of 2023.pdfDoriaFang
What are the new anti-cancer drugs approved in the first half of the year? The new drugs approved covered a variety of solid tumors and blood tumor types.
Mol med ad asco 2015 incremento della sopravvivenza con ngr htnf nella fase i...social_molmed
Presentazione orale ad ASCO 2015 dei dati sulla sopravvivenza dei pazienti a prognosi sfavorevole ottenuti nello studio di fase III sul trattamento con NGR-hTNF del mesotelioma pleurico
Milano, 1 giugno 2015 - MolMed S.p.A. (MLM.MI) annuncia che i risultati completi dello studio di fase III con il proprio farmaco sperimentale NGR-hTNF nel trattamento del mesotelioma sono stati presentati e discussi oralmente nella sessione “Lung Cancer-NSCLC local-regional/SCLC/Other Thoracic Cancers” al 51° convegno annuale della American Society of Clinical Oncology (ASCO), in corso dal 29 Maggio al 2 Giugno a Chicago (IL,USA).
MolMed NGRhTNF: Nuovi Dati Presentati Ad ASCO Incremento Sopravvivenza Globalesocial_molmed
Un incremento statisticamente significativo del 40% della sopravvivenza globale e libera da malattia in un’ampia popolazione di pazienti, identificata mediante un’analisi pre-specificata basata sull’intervallo libero da terapia e caratterizzata da una prognosi particolarmente sfavorevole, è stato riportato da MolMed SpA (MLM.MI) questo fine settimana al 50° congresso annuale della American Society of Clinical Oncology (ASCO).
MolMed annuncia i risultati di NGR-hTNF nello studio di Fase III nel mesoteli...social_molmed
MolMed S.p.A. (MLM.MI) ha annunciato oggi i risultati dello studio in doppio cieco, controllato con placebo di Fase III su NGR-hTNF verso la migliore opzione terapeutica in 400 pazienti affetti da mesotelioma pleurico maligno che avevano fallito la chemioterapia di prima linea.
Agenzia europea medicinali ha validato la sottomissione domanda conditional a...social_molmed
MolMed S.p.A. (MLM.MI) annuncia che l’EMA, l’Agenzia Europea dei Medicinali, ha validato la sottomissione di domanda per Conditional Marketing Authorisation relativa a TK, la terapia cellulare-genica sperimentale proprietaria. Inizia oggi il processo di valutazione del dossier.
MolMed Approved The Interim Financial Report At 30 September 2013social_molmed
The Board of Directors of MolMed S.p.A., chaired by Prof. Claudio Bordignon, today reviewed and approved the interim financial report at 30 September 2013. The most important elements were: TK: expansion in the US of the pivotal Phase III trial for high-risk leukaemia patients; NGR-TNF: continuation of the clinical development program; the increase of revenues to € 3.1 million from development of new cell and gene therapy treatments for third parties.
MolMed Approvato Resoconto Intermedio Gestione 30 Settembre 2013social_molmed
Il Consiglio di Amministrazione di MolMed S.p.A., riunitosi oggi sotto la presidenza del Professor Claudio Bordignon, ha esaminato ed approvato il resoconto intermedio di gestione al 30 settembre 2013. Gli elementi più salienti sono stati: TK:espansione negli Stati Uniti dello studio registrativo di Fase III per il trattamento delle leucemie ad alto rischio; NGR-hTNF: prosecuzione del programma di studi clinici; aumento dei ricavi a € 3,1 milioni dall’attività conto terzi riguardante lo sviluppo di nuovi trattamenti di terapia genica e cellulare.
European cancer congress mol med nuovi dati su ngr htnf aumento sopravvivenza...social_molmed
MolMed, nuovi dati presentati allo European Cancer Congress mostrano un aumento statisticamente significativo della sopravvivenza in pazienti affetti da sarcoma trattati con NGR-hTNF
MolMed TK ASCO Sicurezza e sopravvivenza a lungo termine con TKsocial_molmed
Dati a lungo termine presentati ad ASCO confermano una estensione della sopravvivenza in pazienti con leucemia acuta trattati con la terapia cellulare TK
Il Consiglio di Amministrazione di MolMed approva il resoconto intermedio di ...social_molmed
Il Consiglio di Amministrazione di MolMed S.p.A. (MLM.MI), riunitosi oggi sotto la presidenza del Professor Claudio Bordignon, ha esaminato ed approvato il resoconto intermedio di gestione al 31 marzo 2013.
MolMed: outcome of Shareholders’ meeting and first meeting of new Board of Di...social_molmed
MolMed Shareholders’ Meeting approves the Financial Statements 2012 and appoints members of Board of Directors and Board of Statutory AuditorsMeeting of the new Board of Directors: appointment of the Chief Executive Officer and of the members of the Board Committees
MolMed TK: Esito Assemblea Azionisti e prima riunione nuovo Consiglio di Ammi...social_molmed
L’Assemblea degli Azionisti di Molmed approva il Bilancio 2012 e nomina i componenti del Consiglio di Amministrazione e del Collegio Sindacale
Riunione del nuovo Consiglio di Amministrazione: nomina dell’Amministratore Delegato e dei componenti dei Comitati consiliari
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Ocular injury ppt Upendra pal optometrist upums saifai etawah
MolMed NGRhTNF ASCO New Data Show Significantly Extended Survival
1. New data presented at ASCO on NGR-hTNF show
significantly extended survival in very poor-
prognosis mesothelioma and sarcoma patient
populations
A statistically significant 40% improvement of both overall survival and progression-free
survival in a large population of patients, identified by a pre-specified analysis on the prior
treatment-free interval, and who presented a very dismal prognosis was reported by
MolMed S.p.A. (MLM.MI) this weekend, at the 50th
ASCO annual meeting.
These efficacy results were observed in an international randomized Phase III study evalu-
ating the investigational drug NGR-hTNF in combination with best investigator choice in
400 patients with malignant pleural mesothelioma (MPM) who had previously failed a first-
line chemotherapy.
The magnitude of treatment effect increased with NGR-hTNF duration and was particularly
marked in patients receiving at least three months of therapy, with a median survival time
nearly doubled in patients treated with NGR-hTNF compared to control patients: 16.5 vs
9.8 months, respectively.
Claudio Bordignon, Chairman and CEO of MolMed, commented: “The results presented at
ASCO on the efficacy of NGR-hTNF in the treatment of the patient affected by the more
aggressive form of malignant pleural mesothelioma confirm, in a large Phase III trial, the
therapeutic potential of this molecule already observed in Phase II in chemo-resistant
squamous NSCL carcinoma, soft-tissue sarcoma, and ovarian carcinoma. Having been able
to extend the median survival time to more than 16 months in patients treated for at least
12 weeks is a success for the study and, more important, offers the perspective of a relev-
ant clinical benefit to patients affected by the more aggressive form of mesothelioma.
These results represent for MolMed the basis to aggressively pursue the next crucial steps
for the future of this molecule: the definition of the best and fastest registration path, and
the identification of a suitable partner for offering to NGR-hTNF the possibility to express
its full potential as an anti-cancer agent of broad application.”
2. The data reported at ASCO, mainly obtained in combination with either gemcitabine or
vinorelbine in a very aggressive and chemo-resistant disease, assume particular relevance
as they are confirmatory of the efficacy previously shown by NGR-hTNF plus gemcitabine
in the first-line Phase II study in squamous lung cancer patients.
Furthermore, NGR-hTNF confirmed in this large patient population its very favourable tol-
erability profile in combination with the three different chemotherapeutic agents admin-
istered in this study (gemcitabine, vinorelbine and doxorubicin).
An additional two randomized Phase II studies reported at ASCO meeting clearly estab-
lished the effect of NGR-hTNF on survival.
In the four-arm randomized Phase II study in sarcoma patients, the low-dose weekly NGR-
hTNF plus doxorubicin regimen induced a statistically significant doubled survival time, as
compared with the other schedules given at high dose in combination with doxorubicin or
as monotherapy at low or high dose. The 3-year survival rate with this schedule exceeded
40% and, notably, similar results were reported for both chemo-naïve and pretreated pa-
tients, thus confirming the elevated NGR-hTNF efficacy in more aggressive, chemo-resist-
ant disease.
In the randomized Phase II study in resistant / refractory ovarian cancer patients, NGR-hT-
NF in combination with an anthracycline improved overall survival in patients with normal
or high baseline lymphocyte counts, as compared to patients receiving an anthracycline
alone.
Taken together, these clinical evidences are also consistent with the drug mechanism of
action, based on both an increased intratumoral chemotherapy uptake and interaction with
host immune system.
About NGR-hTNF
NGR-hTNF is a novel therapeutic agent for solid tumours which displays antitumor activity
through its specific binding to blood vessels feeding the tumour mass. NGR-hTNF is being
3. investigated in a large clinical program, including a Phase III trial in malignant pleural
mesothelioma (second line), a Phase II trial in malignant pleural mesothelioma (first-line
maintenance therapy) and five Phase II trials in colorectal, lung (small-cell and non-small-
cell), liver and ovarian cancer, and soft tissue sarcomas.
NGR-hTNF has been granted Orphan Drug designation for the treatment of mesothelioma
and liver cancer in both the EU and the US.
This press release is written in compliance with public disclosure obligations established by
CONSOB (Italian securities & exchange commission) resolution no. 11971 of 14 May 1999,
as subsequently amended.
About MolMed
MolMed S.p.A. is a biotechnology company focused on research, development and clinical
validation of novel anticancer therapies. MolMed’s pipeline includes two antitumour thera-
peutics in clinical development: TK, a cell-based therapy enabling bone marrow trans-
plants from partially compatible donors, in absence of post-transplant immune-suppres-
sion, in Phase III in high-risk acute leukaemia; NGR-hTNF, a novel vascular targeting
agent, in Phase III in malignant pleural mesothelioma and in Phase II in six more indica-
tions: colorectal, lung (small-cell and non-small-cell), liver and ovarian cancer, and soft tis-
sue sarcomas. MolMed also offers top-level expertise in cell and gene therapy to third
parties to develop, conduct and validate projects from preclinical to Phase III trials, includ-
ing scale-up and cGMP production of clinical-grade viral vectors, and manufacturing of pa-
tient-specific genetically engineered cells. MolMed is headquartered at the San Raffaele
Biomedical Science Park in Milan, Italy. The Company’s shares are listed on the main mar-
ket (MTA) of the Milan Stock Exchange. (Ticker Reuters: MLMD.MI)
FONTE: MolMed.com