Vincent Grondin compares three mocking frameworks: Moq, JustMock, and Isolator. Mocking frameworks allow developers to isolate code under test from its infrastructure, make code behavior predictable, accelerate unit test execution by simulating code, and facilitate parallel development. Frameworks are either based on dynamic proxies or the .NET Profiler API. Without frameworks, developers must maintain mocks, dependency injection, and testable architecture in code. The document demonstrates mocking with each framework, describing important classes and methods for designating mocked methods and determining return values.