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Studies on mixing of pharmaceutical powders
Abstract

The mixing of salicylic acid and wheat starch powders was studied using a V-type mixer. After the optimum
operating conditions of the mixer were examined, the mixing characteristics relating to dilution ratio,
particle size of active ingredient and addition ratio of lubricants were investigated. The coefficient of
variation was expressed by a power law relating to the dilution ratio and the particle size of active
ingredient. Furthermore, the comparison of results with the theoretically estimated values of mixing index
suggested that the mixing of cohesive pharmaceutical powders is a complex stochastic process and cannot
be explained fully by a simple theory based on a complete random mixing.

Keywords Mixing-of multicomponent powders evaluation of homogeneity using a mixing index
based on statistical analysis - Salicylic acid-powders mixed with wheat starch for homogeneity
evaluation, Mixer-the optimum operating conditions of a V-type mixer - Lubricants—the effect of
magnesium stearate and talc on the mixing

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Mixing of pharmaceutical powders

  • 1. Studies on mixing of pharmaceutical powders Abstract The mixing of salicylic acid and wheat starch powders was studied using a V-type mixer. After the optimum operating conditions of the mixer were examined, the mixing characteristics relating to dilution ratio, particle size of active ingredient and addition ratio of lubricants were investigated. The coefficient of variation was expressed by a power law relating to the dilution ratio and the particle size of active ingredient. Furthermore, the comparison of results with the theoretically estimated values of mixing index suggested that the mixing of cohesive pharmaceutical powders is a complex stochastic process and cannot be explained fully by a simple theory based on a complete random mixing. Keywords Mixing-of multicomponent powders evaluation of homogeneity using a mixing index based on statistical analysis - Salicylic acid-powders mixed with wheat starch for homogeneity evaluation, Mixer-the optimum operating conditions of a V-type mixer - Lubricants—the effect of magnesium stearate and talc on the mixing