"In 1987, Michael L Riordan, at age 29, started a small biotech firm and then raised $20 million in venture capital and private equity financing, paving the way for an IPO in 1992."
Article by Tyler Laundon.
From Startup to Blue Chip: The Success Story of Gilead Sciences Inc.RobertsDissertation
Gilead Sciences is a biotechnology company founded in 1987 that focuses on antiviral drugs and therapies for HIV, hepatitis B, and influenza. It took several years of operating at a loss through research and development before Gilead obtained its first private financing in 1991 and went public in 1992. Gilead's first drug, Vistide, received FDA approval in 1996. Tamiflu, approved in 1999, became widely used and stockpiled for flu pandemics. More recently, Gilead's drug Sovaldi for hepatitis C achieved a 90% cure rate but also faced controversy over its high $84,000 price for a full treatment. Despite this issue, Gilead has continued to succeed,
Aarti Drugs Ltd is an API manufacturer with facilities in India. It produces a wide range of drugs including vitamins, antibiotics, anti-fungals, and more. The company is expected to see strong revenue and profit growth over the next few years driven by expanding capacity and new product additions. Key growth segments are expected to be antibiotics, growing at a 21% CAGR, and anti-protozoals like metronidazole, expanding capacity 100%. Overall revenues are forecast to increase 16% annually to Rs. 1481 crores by FY17. The report initiates coverage with a buy rating and target price of Rs. 675 per share.
Weekly News Wrap-Up on Health Care Industry (Europe, North America, Asia/Pacific) showing the latest development of most striking fundamental economic and financial news
BioAnalysis_April 2016_Introducing The PfizerKline Empire_Raj GunashekarRaj Gunashekar
1) Industry analysts believe that a potential acquisition of GSK by Pfizer, dubbed "PfizerKline", could generate major tax benefits for Pfizer by allowing it to move its legal address to the UK and lower its corporate tax rate.
2) The deal would be valued at $146 billion and provide Pfizer access to GSK's respiratory and vaccine portfolios, potentially making the combined company a leader in those fields.
3) However, Pfizer may face political opposition to the deal in the UK, as it did with its attempted acquisition of AstraZeneca in 2014. The key issue would be the impact on the UK economy and job losses at one of its major employers.
We are given a buy recommendation for Gilead Sciences. While Gilead has seen significant revenue growth in recent years due to two hepatitis C drugs, their future revenue growth is expected to slow. Speculation around future performance and new competition has led the market to undervalue Gilead. However, the company maintains a broad product portfolio and pipeline, and low costs provide strong margins. If Gilead can successfully manage competition through new drugs and pricing strategies, while pursuing M&A, they are positioned to outperform current market expectations.
The best stock broker and share broker in India, Rudra Shares & Stock Brokers Ltd. is member of all the leading Equity & commodity exchanges in India, dealing in stocks, shares, commodity & currency serving clientele in 18 states through 225 business partners. Rudra Shares Fundamental Call Report which will brief about Fundamental coverage of CADILA Healthcare Ltd
From Startup to Blue Chip: The Success Story of Gilead Sciences Inc.RobertsDissertation
Gilead Sciences is a biotechnology company founded in 1987 that focuses on antiviral drugs and therapies for HIV, hepatitis B, and influenza. It took several years of operating at a loss through research and development before Gilead obtained its first private financing in 1991 and went public in 1992. Gilead's first drug, Vistide, received FDA approval in 1996. Tamiflu, approved in 1999, became widely used and stockpiled for flu pandemics. More recently, Gilead's drug Sovaldi for hepatitis C achieved a 90% cure rate but also faced controversy over its high $84,000 price for a full treatment. Despite this issue, Gilead has continued to succeed,
Aarti Drugs Ltd is an API manufacturer with facilities in India. It produces a wide range of drugs including vitamins, antibiotics, anti-fungals, and more. The company is expected to see strong revenue and profit growth over the next few years driven by expanding capacity and new product additions. Key growth segments are expected to be antibiotics, growing at a 21% CAGR, and anti-protozoals like metronidazole, expanding capacity 100%. Overall revenues are forecast to increase 16% annually to Rs. 1481 crores by FY17. The report initiates coverage with a buy rating and target price of Rs. 675 per share.
Weekly News Wrap-Up on Health Care Industry (Europe, North America, Asia/Pacific) showing the latest development of most striking fundamental economic and financial news
BioAnalysis_April 2016_Introducing The PfizerKline Empire_Raj GunashekarRaj Gunashekar
1) Industry analysts believe that a potential acquisition of GSK by Pfizer, dubbed "PfizerKline", could generate major tax benefits for Pfizer by allowing it to move its legal address to the UK and lower its corporate tax rate.
2) The deal would be valued at $146 billion and provide Pfizer access to GSK's respiratory and vaccine portfolios, potentially making the combined company a leader in those fields.
3) However, Pfizer may face political opposition to the deal in the UK, as it did with its attempted acquisition of AstraZeneca in 2014. The key issue would be the impact on the UK economy and job losses at one of its major employers.
We are given a buy recommendation for Gilead Sciences. While Gilead has seen significant revenue growth in recent years due to two hepatitis C drugs, their future revenue growth is expected to slow. Speculation around future performance and new competition has led the market to undervalue Gilead. However, the company maintains a broad product portfolio and pipeline, and low costs provide strong margins. If Gilead can successfully manage competition through new drugs and pricing strategies, while pursuing M&A, they are positioned to outperform current market expectations.
The best stock broker and share broker in India, Rudra Shares & Stock Brokers Ltd. is member of all the leading Equity & commodity exchanges in India, dealing in stocks, shares, commodity & currency serving clientele in 18 states through 225 business partners. Rudra Shares Fundamental Call Report which will brief about Fundamental coverage of CADILA Healthcare Ltd
Hem recommend this pharma scrip on Q4FY15 operating profits of Rs495.87crIndiaNotes.com
Zydus Cadila is a fully integrated healthcare company with strengths across the pharmaceutical value chain. In the recent quarter, the company's revenues grew 16% to Rs. 2288 crores and operating profit grew 38.3% to Rs. 495.87 crores. Key growth drivers include the US business which grew 56% and the company's global expansion efforts through new product filings and launches across geographies. The report recommends buying the stock with a target price of Rs. 2150 based on attractive valuation and expectations for double-digit growth from new technologies and global expansion.
BASIC INFORMATIONEli Lilly and Company is one of the largest glo.docxgarnerangelika
Eli Lilly and Company is one of the largest global pharmaceutical companies founded in 1876. It has offices in 18 countries and sells products in 125 countries. The company generates billions in annual revenue and earnings growth. The document discusses Eli Lilly's major products, financial performance, acquisitions, partnerships, and competitive positioning in the pharmaceutical industry. It also provides an overview of the company's management, governance, and the broader industry environment.
BASIC INFORMATIONEli Lilly and Company is one of the largest glo.docxjasoninnes20
BASIC INFORMATION
Eli Lilly and Company is one of the largest global pharmaceutical companies in the world. Eli Lilly also has offices in Puerto Rico and 17 other countries, and its products are sold to about 125 countries. It was founded by Eli Lilly, a pharmacist, in 1876. Eli Lilly ’s main products include Ractopamine, Prozac, the antipsychotic drug, Zyprexa, and ADHD drugs Strattera, etc. The company’s ticker symbol is NYSE:LLY, the S&P 500 Index is the primary exchange upon which its shares are traded. In 2019, the company achieved revenue of US $ 22.319 billion, a year-on-year increase of 3.8%. Achieve continuous net operating profit was US $ 4.638 billion, a year-on-year increase of 47.2%. The current EPS (GAAP) reached 8.89 USD. I think it is time to invest and overweight stocks. Now the current stock price is 161.29 and the target stock price is 184.29 with the increasing market share and development of the pharmaceutical industry due to Covid-19.
INVESTMENT SUMMARY
"Lilly is in the early phase of an exciting period of growth for the company. The combination of strong revenue growth from our newer medicines and prudent expense control across our business enabled Lilly to invest more in our R&D pipeline and still deliver impressive earnings growth in the fourth quarter and full-year 2019," said David A. Ricks, Lilly's chairman, and CEO.
According to the DCF model, it displays the stock price can be reached 184.29. However, the stock price is 161.29 now. Our stock price estimate is higher than the S&P 500 market price(161.29), indicating that we believe that the stock is slightly undervalued. Lilly announced a definitive agreement to acquire Dermira, Inc. for approximately $1.1 billion in 2020. The acquisition will expand Lilly's immunology pipeline with the addition of lebrikizumab, a novel, investigational, monoclonal antibody. At the same time, Lilly's first lower-priced insulin, Insulin Lispro Injection, was made available in May 2019 at a 50 percent lower list price than Humalog. Lily also announced a global commercialization agreement to integrate DexCom, Inc. products into Lilly's personalized diabetes management system, currently in development to advance the treatment of diabetes. Under the terms of the non-exclusive agreement, Lilly will use Dexcom's continuous glucose monitoring (CGM) devices in both the pen- and pump-based platforms of the system being designed to help improve diabetes management. And Lilly and Boehringer Ingelheim modernized their alliance to focus their combined expertise and investment on the continued development and commercialization of Jardiance in type 2 diabetes, heart failure, and chronic kidney disease. The development prospects bring the company higher market space and competitiveness.
BUSINESS DESCRIPTION
The company's core product lines include: Basaglar (Insulin Glargine), Jardiance (Engligliflozin), Trulicity (Duraglutide), Cyramza (ramucirumab), Emgality (galcanezumab), Olumiant (baricit ...
Global Impact in Hepatitis-C Market with-In Pakistan and Internationally due ...Pharm Net
The document discusses the global impact of hepatitis C treatment drugs launched by pharmaceutical companies. It provides information on hepatitis C, including key facts about transmission and prevalence in different countries. It analyzes the hepatitis C treatment market globally and regionally, including major players and drug classes. It also discusses the response of different countries like Pakistan, Indonesia, and India to changes in hepatitis C treatment guidelines and availability of generic drugs.
The biotechnology industry had an unprecedented year in 2014, reaching new highs in revenues, R&D spending, profits, financing amounts, and market capitalization. Strong product sales and approvals helped boost investor sentiment and company valuations. A surge in IPOs and follow-on financings provided the industry with historic levels of capital to fund innovation.
Gilead Sciences is a leading biopharmaceutical company focused on antiviral drugs for HIV and hepatitis. The document analyzes Gilead's product portfolio and financials, providing sales forecasts and discussing key drugs. It recommends buying Gilead stock, citing strong performance of new drugs Harvoni and Zydelig, large cash reserves, and a robust pipeline to offset upcoming patent expirations. However, it also notes risks include litigation over drug prices and patents, intensifying competition, and potential "discount wars" among hepatitis treatments.
The document discusses the growth of the global generics market from 1998-2008. It notes that major pharmaceutical companies are increasingly entering the generics market as the patents on many brand-name drugs expire. This has led to consolidation in the generics industry as large companies acquire smaller generics producers. The generics market is also shifting production to countries like India and Southeast Asia to take advantage of lower manufacturing costs.
The document discusses the growth of the global generics market from 1998-2008. It notes that major pharmaceutical companies are increasingly entering the generics market as the patents on many brand-name drugs expire. This has led to consolidation in the generics industry as large companies acquire smaller generics producers. The generics market is also shifting production to countries like India and Southeast Asia to take advantage of lower manufacturing costs.
The document provides an overview of the global and Indian pharmaceutical industries. It discusses key metrics like global sales, R&D spending, mergers and acquisitions, and future projections. The global pharmaceutical market experienced slow growth in 2012 due to many blockbuster drug patents expiring, but sales are expected to steadily increase to $895 billion by 2018. The Indian pharmaceutical market is also growing, driven by factors like increasing demand from emerging markets, greater acceptance of medical treatment, and a growing elderly population in India.
Gilead has signed agreements with 11 Indian generic drug companies to produce generic versions of Gilead's hepatitis C drugs for 101 developing countries. The agreements allow the generic companies to set their own prices and provide a full technology transfer to quickly scale up production. Royalties from the generic companies will support developing world access programs. Gilead is also working directly with local manufacturers in Egypt and Pakistan and offers reduced prices for branded drugs in these countries to help expand access to hepatitis C treatment.
Rem de sivir - a classic analysis of desperate measures during desperate timesDr Siddharth Dutta
1. The document analyzes the rise in demand for the drug remdesivir as a COVID-19 treatment. It suggests the demand was driven more by public perception, preferences of pharmaceutical companies, and promotion rather than scientific data.
2. Key events that promoted remdesivir usage included its emergency use authorization in the US and a statement by Dr. Fauci promoting it. This led to a surge in orders and deals by pharmaceutical companies to distribute it globally despite limited evidence of its effectiveness.
3. Questions are raised about whether remdesivir's efficacy was proven given conflicting trial results, the high price paid for it, and whether remaining stocks will be used after shortages were reported in Europe.
Research Report on Cipla Limited on the basis of Company Profile, Management, Shareholding Pattern, SWOT Analysis, Competitive Analysis and Way forward.
Markets around the globe are rallying on news that Pfizer’s Covid-19 vaccine is more than 90% effective in preventing the disease. How can you best profit from the Covid-19 vaccine market rally?
https://youtu.be/G6Zd-uFbCNU
This document brings together a set
of latest data points and publicly
available information relevant for
Healthcare Industry. We are very
excited to share this content and
believe that readers will benefit from this periodic publication immensely.
- Cordlife Group saw its stock price decline after its Chief Executive Officer resigned abruptly in March due to failing to improve earnings and issues with his contract.
- The company appointed a new CEO in July and possesses substantial market share in Asian regions, benefiting from positive market trends like increasing birth rates.
- While Cordlife has high debt levels, it has over 5 times more current assets than current liabilities, and opportunities for significant revenue growth through expanding into developing Asian markets.
This annual report summarizes BD's financial and operational performance in fiscal year 2006. Key points include:
- Revenues increased 7.8% to $5.8 billion and income from continuing operations grew 9.1% to $755 million.
- Two acquisitions were announced that expand BD's positions in molecular diagnostics and cancer diagnostics.
- Innovation efforts were increased with a 13% rise in R&D spending to fuel new product development.
- Community involvement and social responsibility efforts helped BD be named one of the "100 Best Corporate Citizens."
This annual report summarizes BD's financial and operational performance in fiscal year 2006. Key points include:
- Revenues increased 7.8% to $5.8 billion and income from continuing operations grew 9.1% to $755 million.
- Two acquisitions were completed that expand BD's positions in molecular diagnostics and cancer diagnostics.
- Innovation efforts were increased with a 13% rise in R&D spending to fuel new product development.
- Community involvement and social responsibility efforts helped BD be named one of the "100 Best Corporate Citizens."
How to Control Your Asthma Tips by gokuldas hospital.Gokuldas Hospital
Respiratory issues like asthma are the most sensitive issue that is affecting millions worldwide. It hampers the daily activities leaving the body tired and breathless.
The key to a good grip on asthma is proper knowledge and management strategies. Understanding the patient-specific symptoms and carving out an effective treatment likewise is the best way to keep asthma under control.
Computer in pharmaceutical research and development-Mpharm(Pharmaceutics)MuskanShingari
Statistics- Statistics is the science of collecting, organizing, presenting, analyzing and interpreting numerical data to assist in making more effective decisions.
A statistics is a measure which is used to estimate the population parameter
Parameters-It is used to describe the properties of an entire population.
Examples-Measures of central tendency Dispersion, Variance, Standard Deviation (SD), Absolute Error, Mean Absolute Error (MAE), Eigen Value
More Related Content
Similar to Michael L Riordan Started Gilead Sciences in 1987: Nasdaq article "Gilead Sciences: A Biotech Powerhouse"
Hem recommend this pharma scrip on Q4FY15 operating profits of Rs495.87crIndiaNotes.com
Zydus Cadila is a fully integrated healthcare company with strengths across the pharmaceutical value chain. In the recent quarter, the company's revenues grew 16% to Rs. 2288 crores and operating profit grew 38.3% to Rs. 495.87 crores. Key growth drivers include the US business which grew 56% and the company's global expansion efforts through new product filings and launches across geographies. The report recommends buying the stock with a target price of Rs. 2150 based on attractive valuation and expectations for double-digit growth from new technologies and global expansion.
BASIC INFORMATIONEli Lilly and Company is one of the largest glo.docxgarnerangelika
Eli Lilly and Company is one of the largest global pharmaceutical companies founded in 1876. It has offices in 18 countries and sells products in 125 countries. The company generates billions in annual revenue and earnings growth. The document discusses Eli Lilly's major products, financial performance, acquisitions, partnerships, and competitive positioning in the pharmaceutical industry. It also provides an overview of the company's management, governance, and the broader industry environment.
BASIC INFORMATIONEli Lilly and Company is one of the largest glo.docxjasoninnes20
BASIC INFORMATION
Eli Lilly and Company is one of the largest global pharmaceutical companies in the world. Eli Lilly also has offices in Puerto Rico and 17 other countries, and its products are sold to about 125 countries. It was founded by Eli Lilly, a pharmacist, in 1876. Eli Lilly ’s main products include Ractopamine, Prozac, the antipsychotic drug, Zyprexa, and ADHD drugs Strattera, etc. The company’s ticker symbol is NYSE:LLY, the S&P 500 Index is the primary exchange upon which its shares are traded. In 2019, the company achieved revenue of US $ 22.319 billion, a year-on-year increase of 3.8%. Achieve continuous net operating profit was US $ 4.638 billion, a year-on-year increase of 47.2%. The current EPS (GAAP) reached 8.89 USD. I think it is time to invest and overweight stocks. Now the current stock price is 161.29 and the target stock price is 184.29 with the increasing market share and development of the pharmaceutical industry due to Covid-19.
INVESTMENT SUMMARY
"Lilly is in the early phase of an exciting period of growth for the company. The combination of strong revenue growth from our newer medicines and prudent expense control across our business enabled Lilly to invest more in our R&D pipeline and still deliver impressive earnings growth in the fourth quarter and full-year 2019," said David A. Ricks, Lilly's chairman, and CEO.
According to the DCF model, it displays the stock price can be reached 184.29. However, the stock price is 161.29 now. Our stock price estimate is higher than the S&P 500 market price(161.29), indicating that we believe that the stock is slightly undervalued. Lilly announced a definitive agreement to acquire Dermira, Inc. for approximately $1.1 billion in 2020. The acquisition will expand Lilly's immunology pipeline with the addition of lebrikizumab, a novel, investigational, monoclonal antibody. At the same time, Lilly's first lower-priced insulin, Insulin Lispro Injection, was made available in May 2019 at a 50 percent lower list price than Humalog. Lily also announced a global commercialization agreement to integrate DexCom, Inc. products into Lilly's personalized diabetes management system, currently in development to advance the treatment of diabetes. Under the terms of the non-exclusive agreement, Lilly will use Dexcom's continuous glucose monitoring (CGM) devices in both the pen- and pump-based platforms of the system being designed to help improve diabetes management. And Lilly and Boehringer Ingelheim modernized their alliance to focus their combined expertise and investment on the continued development and commercialization of Jardiance in type 2 diabetes, heart failure, and chronic kidney disease. The development prospects bring the company higher market space and competitiveness.
BUSINESS DESCRIPTION
The company's core product lines include: Basaglar (Insulin Glargine), Jardiance (Engligliflozin), Trulicity (Duraglutide), Cyramza (ramucirumab), Emgality (galcanezumab), Olumiant (baricit ...
Global Impact in Hepatitis-C Market with-In Pakistan and Internationally due ...Pharm Net
The document discusses the global impact of hepatitis C treatment drugs launched by pharmaceutical companies. It provides information on hepatitis C, including key facts about transmission and prevalence in different countries. It analyzes the hepatitis C treatment market globally and regionally, including major players and drug classes. It also discusses the response of different countries like Pakistan, Indonesia, and India to changes in hepatitis C treatment guidelines and availability of generic drugs.
The biotechnology industry had an unprecedented year in 2014, reaching new highs in revenues, R&D spending, profits, financing amounts, and market capitalization. Strong product sales and approvals helped boost investor sentiment and company valuations. A surge in IPOs and follow-on financings provided the industry with historic levels of capital to fund innovation.
Gilead Sciences is a leading biopharmaceutical company focused on antiviral drugs for HIV and hepatitis. The document analyzes Gilead's product portfolio and financials, providing sales forecasts and discussing key drugs. It recommends buying Gilead stock, citing strong performance of new drugs Harvoni and Zydelig, large cash reserves, and a robust pipeline to offset upcoming patent expirations. However, it also notes risks include litigation over drug prices and patents, intensifying competition, and potential "discount wars" among hepatitis treatments.
The document discusses the growth of the global generics market from 1998-2008. It notes that major pharmaceutical companies are increasingly entering the generics market as the patents on many brand-name drugs expire. This has led to consolidation in the generics industry as large companies acquire smaller generics producers. The generics market is also shifting production to countries like India and Southeast Asia to take advantage of lower manufacturing costs.
The document discusses the growth of the global generics market from 1998-2008. It notes that major pharmaceutical companies are increasingly entering the generics market as the patents on many brand-name drugs expire. This has led to consolidation in the generics industry as large companies acquire smaller generics producers. The generics market is also shifting production to countries like India and Southeast Asia to take advantage of lower manufacturing costs.
The document provides an overview of the global and Indian pharmaceutical industries. It discusses key metrics like global sales, R&D spending, mergers and acquisitions, and future projections. The global pharmaceutical market experienced slow growth in 2012 due to many blockbuster drug patents expiring, but sales are expected to steadily increase to $895 billion by 2018. The Indian pharmaceutical market is also growing, driven by factors like increasing demand from emerging markets, greater acceptance of medical treatment, and a growing elderly population in India.
Gilead has signed agreements with 11 Indian generic drug companies to produce generic versions of Gilead's hepatitis C drugs for 101 developing countries. The agreements allow the generic companies to set their own prices and provide a full technology transfer to quickly scale up production. Royalties from the generic companies will support developing world access programs. Gilead is also working directly with local manufacturers in Egypt and Pakistan and offers reduced prices for branded drugs in these countries to help expand access to hepatitis C treatment.
Rem de sivir - a classic analysis of desperate measures during desperate timesDr Siddharth Dutta
1. The document analyzes the rise in demand for the drug remdesivir as a COVID-19 treatment. It suggests the demand was driven more by public perception, preferences of pharmaceutical companies, and promotion rather than scientific data.
2. Key events that promoted remdesivir usage included its emergency use authorization in the US and a statement by Dr. Fauci promoting it. This led to a surge in orders and deals by pharmaceutical companies to distribute it globally despite limited evidence of its effectiveness.
3. Questions are raised about whether remdesivir's efficacy was proven given conflicting trial results, the high price paid for it, and whether remaining stocks will be used after shortages were reported in Europe.
Research Report on Cipla Limited on the basis of Company Profile, Management, Shareholding Pattern, SWOT Analysis, Competitive Analysis and Way forward.
Markets around the globe are rallying on news that Pfizer’s Covid-19 vaccine is more than 90% effective in preventing the disease. How can you best profit from the Covid-19 vaccine market rally?
https://youtu.be/G6Zd-uFbCNU
This document brings together a set
of latest data points and publicly
available information relevant for
Healthcare Industry. We are very
excited to share this content and
believe that readers will benefit from this periodic publication immensely.
- Cordlife Group saw its stock price decline after its Chief Executive Officer resigned abruptly in March due to failing to improve earnings and issues with his contract.
- The company appointed a new CEO in July and possesses substantial market share in Asian regions, benefiting from positive market trends like increasing birth rates.
- While Cordlife has high debt levels, it has over 5 times more current assets than current liabilities, and opportunities for significant revenue growth through expanding into developing Asian markets.
This annual report summarizes BD's financial and operational performance in fiscal year 2006. Key points include:
- Revenues increased 7.8% to $5.8 billion and income from continuing operations grew 9.1% to $755 million.
- Two acquisitions were announced that expand BD's positions in molecular diagnostics and cancer diagnostics.
- Innovation efforts were increased with a 13% rise in R&D spending to fuel new product development.
- Community involvement and social responsibility efforts helped BD be named one of the "100 Best Corporate Citizens."
This annual report summarizes BD's financial and operational performance in fiscal year 2006. Key points include:
- Revenues increased 7.8% to $5.8 billion and income from continuing operations grew 9.1% to $755 million.
- Two acquisitions were completed that expand BD's positions in molecular diagnostics and cancer diagnostics.
- Innovation efforts were increased with a 13% rise in R&D spending to fuel new product development.
- Community involvement and social responsibility efforts helped BD be named one of the "100 Best Corporate Citizens."
Similar to Michael L Riordan Started Gilead Sciences in 1987: Nasdaq article "Gilead Sciences: A Biotech Powerhouse" (20)
How to Control Your Asthma Tips by gokuldas hospital.Gokuldas Hospital
Respiratory issues like asthma are the most sensitive issue that is affecting millions worldwide. It hampers the daily activities leaving the body tired and breathless.
The key to a good grip on asthma is proper knowledge and management strategies. Understanding the patient-specific symptoms and carving out an effective treatment likewise is the best way to keep asthma under control.
Computer in pharmaceutical research and development-Mpharm(Pharmaceutics)MuskanShingari
Statistics- Statistics is the science of collecting, organizing, presenting, analyzing and interpreting numerical data to assist in making more effective decisions.
A statistics is a measure which is used to estimate the population parameter
Parameters-It is used to describe the properties of an entire population.
Examples-Measures of central tendency Dispersion, Variance, Standard Deviation (SD), Absolute Error, Mean Absolute Error (MAE), Eigen Value
STUDIES IN SUPPORT OF SPECIAL POPULATIONS: GERIATRICS E7shruti jagirdar
Unit 4: MRA 103T Regulatory affairs
This guideline is directed principally toward new Molecular Entities that are
likely to have significant use in the elderly, either because the disease intended
to be treated is characteristically a disease of aging ( e.g., Alzheimer's disease) or
because the population to be treated is known to include substantial numbers of
geriatric patients (e.g., hypertension).
Osvaldo Bernardo Muchanga-GASTROINTESTINAL INFECTIONS AND GASTRITIS-2024.pdfOsvaldo Bernardo Muchanga
GASTROINTESTINAL INFECTIONS AND GASTRITIS
Osvaldo Bernardo Muchanga
Gastrointestinal Infections
GASTROINTESTINAL INFECTIONS result from the ingestion of pathogens that cause infections at the level of this tract, generally being transmitted by food, water and hands contaminated by microorganisms such as E. coli, Salmonella, Shigella, Vibrio cholerae, Campylobacter, Staphylococcus, Rotavirus among others that are generally contained in feces, thus configuring a FECAL-ORAL type of transmission.
Among the factors that lead to the occurrence of gastrointestinal infections are the hygienic and sanitary deficiencies that characterize our markets and other places where raw or cooked food is sold, poor environmental sanitation in communities, deficiencies in water treatment (or in the process of its plumbing), risky hygienic-sanitary habits (not washing hands after major and/or minor needs), among others.
These are generally consequences (signs and symptoms) resulting from gastrointestinal infections: diarrhea, vomiting, fever and malaise, among others.
The treatment consists of replacing lost liquids and electrolytes (drinking drinking water and other recommended liquids, including consumption of juicy fruits such as papayas, apples, pears, among others that contain water in their composition).
To prevent this, it is necessary to promote health education, improve the hygienic-sanitary conditions of markets and communities in general as a way of promoting, preserving and prolonging PUBLIC HEALTH.
Gastritis and Gastric Health
Gastric Health is one of the most relevant concerns in human health, with gastrointestinal infections being among the main illnesses that affect humans.
Among gastric problems, we have GASTRITIS AND GASTRIC ULCERS as the main public health problems. Gastritis and gastric ulcers normally result from inflammation and corrosion of the walls of the stomach (gastric mucosa) and are generally associated (caused) by the bacterium Helicobacter pylor, which, according to the literature, this bacterium settles on these walls (of the stomach) and starts to release urease that ends up altering the normal pH of the stomach (acid), which leads to inflammation and corrosion of the mucous membranes and consequent gastritis or ulcers, respectively.
In addition to bacterial infections, gastritis and gastric ulcers are associated with several factors, with emphasis on prolonged fasting, chemical substances including drugs, alcohol, foods with strong seasonings including chilli, which ends up causing inflammation of the stomach walls and/or corrosion. of the same, resulting in the appearance of wounds and consequent gastritis or ulcers, respectively.
Among patients with gastritis and/or ulcers, one of the dilemmas is associated with the foods to consume in order to minimize the sensation of pain and discomfort.
PGx Analysis in VarSeq: A User’s PerspectiveGolden Helix
Since our release of the PGx capabilities in VarSeq, we’ve had a few months to gather some insights from various use cases. Some users approach PGx workflows by means of array genotyping or what seems to be a growing trend of adding the star allele calling to the existing NGS pipeline for whole genome data. Luckily, both approaches are supported with the VarSeq software platform. The genotyping method being used will also dictate what the scope of the tertiary analysis will be. For example, are your PGx reports a standalone pipeline or would your lab’s goal be to handle a dual-purpose workflow and report on PGx + Diagnostic findings.
The purpose of this webcast is to:
Discuss and demonstrate the approaches with array and NGS genotyping methods for star allele calling to prep for downstream analysis.
Following genotyping, explore alternative tertiary workflow concepts in VarSeq to handle PGx reporting.
Moreover, we will include insights users will need to consider when validating their PGx workflow for all possible star alleles and options you have for automating your PGx analysis for large number of samples. Please join us for a session dedicated to the application of star allele genotyping and subsequent PGx workflows in our VarSeq software.
Spontaneous Bacterial Peritonitis - Pathogenesis , Clinical Features & Manage...Jim Jacob Roy
In this presentation , SBP ( spontaneous bacterial peritonitis ) , which is a common complication in patients with cirrhosis and ascites is described in detail.
The reference for this presentation is Sleisenger and Fordtran's Gastrointestinal and Liver Disease Textbook ( 11th edition ).
Know the difference between Endodontics and Orthodontics.Gokuldas Hospital
Your smile is beautiful.
Let’s be honest. Maintaining that beautiful smile is not an easy task. It is more than brushing and flossing. Sometimes, you might encounter dental issues that need special dental care. These issues can range anywhere from misalignment of the jaw to pain in the root of teeth.
acne vulgaris -Mpharm (2nd semester) Cosmetics and cosmeceuticals
Michael L Riordan Started Gilead Sciences in 1987: Nasdaq article "Gilead Sciences: A Biotech Powerhouse"
1. /#/Nasdaq
PUBLISHER
Minyanville
PUBLISHED
SEP 4, 2013
12:25PM EDT
MARKET ACTIVITY NEWS+ INSIGHTS SOLUTIONS ABOUT SEARCH
MARKETS
Gi ead Sciences: A Biotech Powerhouse
In 1987, Michael Riordan, at age 29, started a small biotech firm and then raised $20
million in venture capital and private equity financing, paving the way for an IPO in
1992. After spending more than $90 million on drug R&D over eight years, his
company- Gilead Sciences ( GILD )-introduced its first product, which targeted an
AIDS-related eye disease called CMV retinitis.
Gilead then introduced a number of new drugs that rapidly gained market share.
Tamiflu, which would gain some notoriety in 2005 when the bird flu pandemic struck,
was an influenza treatment. And Viread was introduced in 2001 to treat HIV/AlDS.
Both antiviral drugs were smashing successes.
The company's HIV/AIDS, hepatitis B (and more recently hepatitis C) treatments
would catapult the company forward, generating rapid revenue growth and profitable
operations throughout the next decade.
Just over a decade ago, it wasn't possible to treat HIV/AIDS with pills. Today, Gilead
has six different pills to treat the diseases and its pipeline includes a number of high
potential tablets.
Its focus on developing single-pill treatments, such as Atripla, which is the first single
pill HIV treatment approved by the FDA, has helped this line of business considerably.
This franchise is a cash cow and generates high margins and steady growth as a result
of its dominant position in the market. In fact, Gilead's HIV franchise generates 75%
of the company's revenues.
Today, Gilead is an $86 billion company with highly successful drug treatments for
these life-threatening diseases. With sales still growing-and with three more drugs
well along in the HIV franchise pipeline-Gilead looks to be able to dominate in this
space for years to come.
Gilead is on the threshold of major growth in the treatment for chronic hepatitis B
and C, largely as a result of its controversial $11 billion acquisition of Pharmasset in
2011. At the time, the acquisition price was more than one-third of Gilead's market
cap.
However, since the acquisition, Gilead's stock has risen by 225%. The acquisition of
Pharmasset helped Gilead build up its pipeline of liver disease treatments including
hepatitis B and C, especially in the area of all-oral regimens.
While liver treatments currently make up less than 25% of the company's revenues,
the company is building a global power house in this area.
The engine behind this machine is the hepatitis C drug candidate Sofosbuvir, which is
currently under FDA review, with a ruling due out in December of this year. Based on
the success in trials to date, we should expect Sofosbuvir to gain approval and go
into production in 2014.
In fact, many analysts expect the drug to become the leading therapy in hepatitis C,
with revenue potential approaching $8 billion by 2020, a number equal to more than
80% of company-wide sales in 2012.
Gilead has proven itself to be one of the leading biotechnology firms in the world; its
management has steered the company in the right direction time and time again.
And even though shares have been a standout performer, Gilead has been buying
shares back, indicating that despite the climb, management believes shares are still
undervalued.
It's entirely reasonable to expect the company's sales to accelerate over the next five
years as new drugs come on the market. I'm looking for at least 20% average annual
revenue growth and 25°/o average annual net income growth over the next five years.
My near-term price target on shares is $70.00, and I expect to raise this target as
Gilead makes progress with both its HIV/AIDS and liver lines of business.
Editor's Note: Thisarticle was written by Tyler Laundon of Top Stock Insights for
MoneyShow.