This document summarizes a report on local approaches to the opioid overdose epidemic in Massachusetts. It describes how community substance abuse prevention coalitions have formed across the state to address the crisis through multi-sector collaboration. The report is based on interviews with 21 coalition coordinators. It finds that coalitions vary in funding, membership, activities, and effectiveness. Coordinators feel passionate about their work but isolated and at risk of burnout without more support. The report makes recommendations for policymakers, including providing reliable funding and technical assistance to coalitions, improving information sharing, and convening more in-person meetings between coordinators.